13F shares	Current	Prev Q	Change
Total value	448.41 bn	603.27 bn	-25.7%
Total shares	27.85 mm	27.46 mm	+1.4%
Total puts	172.70 k	132.50 k	+30.3%
Total calls	162.50 k	194.70 k	-16.5%
Total put/call ratio	1.1	0.7	+56.2%

Largest owners	Shares	Value	Change
FHI Federated Hermes	4.69 mm	$79.66 bn	0.0%
BlackRock	2.99 mm	$50.73 bn	+1.3%
CMTDF Sumitomo Mitsui Trust	2.07 mm	$35.04 bn	-9.3%
Nikko Asset Management Americas	2.07 mm	$34.94 bn	-10.8%
ARK Investment Management	1.93 mm	$32.82 bn	-8.0%
Vanguard	1.68 mm	$28.59 bn	+6.8%
STT State Street	1.33 mm	$22.50 bn	-10.0%
RARE Ultragenyx Pharmaceutical	1.20 mm	$53.48 mm	0.0%
Schonfeld Strategic Advisors	849.08 k	$14.41 bn	+129.7%
Woodline Partners	806.91 k	$13.69 bn	+3.5%

Largest transactions	Shares	Bought/sold	Change
Balyasny Asset Management	548.76 k	+548.76 k	NEW
Schonfeld Strategic Advisors	849.08 k	+479.48 k	+129.7%
J. Goldman & Co	296.05 k	+296.05 k	NEW
MS Morgan Stanley	538.49 k	+271.57 k	+101.7%
Nikko Asset Management Americas	2.07 mm	-250.24 k	-10.8%
MPM Oncology Impact Management	459.94 k	+240.44 k	+109.5%
Millennium Management	0.00	-236.07 k	EXIT
CMTDF Sumitomo Mitsui Trust	2.07 mm	-210.67 k	-9.3%
Ikarian Capital	200.00 k	+200.00 k	NEW
ARK Investment Management	1.93 mm	-167.19 k	-8.0%

Data from 13F filings, for the last complete 13F reporting period. For most recent data, click the ownership history button. Values as filed, not updated for current price. Long positions only.

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