Xenon Pharmaceuticals (XENE)

Cash burn rate (est.)	Burn method: Change in cash		Burn method: Operating income		Burn method: FCF (opex + capex)
	Last Q	Avg 4Q	Last Q	Avg 4Q	Last Q	Avg 4Q
Cash on hand (at last report)	87.62 mm	87.62 mm	87.62 mm	87.62 mm	87.62 mm	87.62 mm
Cash burn (monthly)	16.37 mm	996.08 k	24.56 mm	21.29 mm	17.05 mm	13.05 mm
Cash used (since last report)	65.85 mm	4.01 mm	98.78 mm	85.65 mm	68.58 mm	52.50 mm
Cash remaining	21.77 mm	83.61 mm	-11.16 mm	1.98 mm	19.05 mm	35.12 mm
Runway (months of cash)	1.3	83.9	-0.5	0.1	1.1	2.7

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Financial data from company earnings reports.

Institutional ownership, Q3 2024

XENE institutional ownership history Ownership history

99.9% owned by funds/institutions

13F holders	Current	Prev Q	Change
Total holders	202	211	-4.3%
Opened positions	15	24	-37.5%
Closed positions	24	25	-4.0%
Increased positions	75	76	-1.3%
Reduced positions	60	69	-13.0%

13F shares	Current	Prev Q	Change
Total value	2.80 tn	2.74 tn	+2.0%
Total shares	76.14 mm	75.37 mm	+1.0%
Total puts	28.80 k	60.70 k	-52.6%
Total calls	88.30 k	59.70 k	+47.9%
Total put/call ratio	0.3	1.0	-67.9%

Largest owners	Shares	Value	Change
FMR	6.92 mm	$272.35 bn	+2.2%
Avoro Capital Advisors	5.67 mm	$223.10 bn	0.0%
Driehaus Capital Management	4.60 mm	$180.93 bn	+4.0%
Wellington Management	3.84 mm	$151.32 bn	+0.4%
Braidwell	2.71 mm	$106.58 bn	+5.7%
Commodore Capital	2.70 mm	$106.30 bn	-2.0%
Capital World Investors	2.68 mm	$105.57 bn	0.0%
Capital International Investors	2.58 mm	$101.62 bn	+4.3%
JHG Janus Henderson	2.55 mm	$100.51 bn	+144.2%
Polar Capital	2.44 mm	$96.25 bn	-3.6%

Largest transactions	Shares	Bought/sold	Change
BlackRock	2.11 mm	+2.11 mm	NEW
BLK BlackRock	0.00	-2.10 mm	EXIT
Paradigm Biocapital Advisors	0.00	-2.04 mm	EXIT
JHG Janus Henderson	2.55 mm	+1.51 mm	+144.2%
JPM JPMorgan Chase & Co.	976.78 k	+905.13 k	+1263.2%
Siren, L.L.C.	743.77 k	+743.77 k	NEW
IVZ Invesco	215.82 k	-650.96 k	-75.1%
Artal	0.00	-381.55 k	EXIT
Samlyn Capital	1.02 mm	+380.52 k	+59.5%
Logos Global Management	0.00	-375.00 k	EXIT

Data from 13F filings, for the last complete 13F reporting period. For most recent data, click the ownership history button. Values as filed, not updated for current price. Long positions only.

Recent insider trades

XENE insider ownership history Insider history

Date	Owner	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
27 Jan 25	Mortimer Ian	Common Shares	Sell	Dispose S	No	Yes	41.07	1,149	47.19 k	31,302
27 Jan 25	Mortimer Ian	Common Shares	Option exercise	Acquire M	No	No	17.76	1,149	20.41 k	32,451
27 Jan 25	Mortimer Ian	Common Shares	Sell	Dispose S	No	Yes	40.46	15,166	613.62 k	31,302
27 Jan 25	Mortimer Ian	Common Shares	Option exercise	Acquire M	No	No	17.76	15,166	269.35 k	46,468
27 Jan 25	Mortimer Ian	Stock Option Common Shares	Option exercise	Dispose M	No	No	17.76	16,315	289.75 k	0
24 Jan 25	Mortimer Ian	Common Shares	Sell	Dispose S	No	Yes	40.2	22,468	903.21 k	31,302
24 Jan 25	Mortimer Ian	Common Shares	Option exercise	Acquire M	No	No	17.76	22,468	399.03 k	53,770
24 Jan 25	Mortimer Ian	Stock Option Common Shares	Option exercise	Dispose M	No	No	17.76	22,468	399.03 k	16,315
23 Jan 25	Mortimer Ian	Common Shares	Sell	Dispose S	No	Yes	40.08	16,217	649.98 k	31,302
23 Jan 25	Mortimer Ian	Common Shares	Option exercise	Acquire M	No	No	17.76	16,217	288.01 k	47,519