Opaleye Management

Date	Owner	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
30 Dec 22	Opaleye Management	Common Stock, par value $0.001 per share	Sell	Acquire S	Yes	No	2.7111	2,300	6.24 k	130,000
30 Dec 22	Opaleye Management	Common Stock, par value $0.001 per share	Sell	Acquire S	Yes	No	2.7111	13,173	35.71 k	2,562,594
14 Dec 22	Opaleye Management	Common Stock, par value $0.001 per share	Buy	Acquire P	Yes	No	10.52	16,183	170.25 k	175,000
14 Dec 22	Opaleye Management	Common Stock, par value $0.001 per share	Buy	Acquire P	Yes	No	10.52	415,000	4.37 mm	3,600,000
14 Dec 22	Opaleye Management	Common Stock, par value $0.001 per share	Buy	Acquire P	Yes	No	1.2382	27,500	34.05 k	440,000
14 Dec 22	Opaleye Management	Common Stock, par value $0.001 per share	Buy	Acquire P	Yes	No	1.2559	140,000	175.83 k	4,150,000
6 Dec 22	Opaleye Management	Common Stock, par value $0.01 per share	Sell	Dispose S	Yes	No	1.44	1,539	2.22 k	4,010,000
6 Dec 22	Opaleye Management	Common Stock, par value $0.01 per share		Acquire X	Yes	No	0.01	221,539	2.22 k	4,011,539
6 Dec 22	Opaleye Management	Prefunded Warrants Common Stock		Dispose X	Yes	No	0.01	221,539	2.22 k	1,667,974
3 Nov 22	Opaleye Management	Common Stock, par value $0.001 per share	Buy	Acquire P	Yes	No	7.8119	1,262	9.86 k	124,813

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.