Opaleye Management

Date	Owner	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
12 Feb 25	Opaleye Management	Common Stock, par value $0.001 per share	Buy	Acquire P	Yes	No	3.9955	15,000	59.93 k	8,705,000
11 Feb 25	Opaleye Management	Common Stock, par value $0.001 per share	Buy	Acquire P	Yes	No	4.112	12,500	51.40 k	8,690,000
10 Feb 25	Opaleye Management	Common Stock, par value $0.001 per share	Buy	Acquire P	Yes	No	4.1844	22,500	94.15 k	8,677,500
31 Jan 25	Opaleye Management	Common Stock, par value $0.001 per share	Buy	Acquire P	Yes	No	4.293	45,000	193.19 k	8,655,000
30 Jan 25	Opaleye Management	Common Stock, par value $0.001 per share	Buy	Acquire P	Yes	No	4.4891	20,000	89.78 k	8,610,000
22 Jan 25	Opaleye Management	Common Stock, par value $0.001 per share	Sell	Dispose S	Yes	No	35.5907	20,000	711.81 k	155,000
31 Dec 24	Opaleye Management	Common Stock, par value $0.001 per share	Buy	Acquire P	Yes	No	4.6603	10,000	46.60 k	8,590,000
30 Dec 24	Opaleye Management	Common Stock, par value $0.001 per share	Buy	Acquire P	Yes	No	4.6969	35,000	164.39 k	8,580,000
1 Nov 24	Opaleye Management	Common Stock, par value $0.001 per share	Buy	Acquire P	Yes	No	15.1963	8,002	121.60 k	12,002
1 Nov 24	Opaleye Management	Common Stock, par value $0.001 per share	Buy	Acquire P	Yes	No	15.1963	7,998	121.54 k	960,000

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.