Zynerba Pharmaceuticals (ZYNE)

Cash burn rate (est.)	Burn method: Change in cash		Burn method: Operating income		Burn method: FCF (opex + capex)
	Last Q	Avg 4Q	Last Q	Avg 4Q	Last Q	Avg 4Q
Cash on hand (at last report)	35.97 mm	35.97 mm	35.97 mm	35.97 mm	35.97 mm	35.97 mm
Cash burn (monthly)	2.81 mm	2.21 mm	3.71 mm	3.23 mm	2.81 mm	2.64 mm
Cash used (since last report)	57.07 mm	44.87 mm	75.37 mm	65.62 mm	56.97 mm	53.54 mm
Cash remaining	-21.10 mm	-8.91 mm	-39.40 mm	-29.66 mm	-21.00 mm	-17.57 mm
Runway (months of cash)	-7.5	-4.0	-10.6	-9.2	-7.5	-6.7

Beta Read what these cash burn values mean

Financial data from company earnings reports.

Institutional ownership, Q3 2023

ZYNE institutional ownership history Ownership history

35.4% owned by funds/institutions

13F holders	Current	Prev Q	Change
Total holders	44	41	+7.3%
Opened positions	19	5	+280.0%
Closed positions	16	8	+100.0%
Increased positions	3	7	-57.1%
Reduced positions	11	11	–

13F shares	Current	Prev Q	Change
Total value	13.16 bn	1.44 bn	+815.8%
Total shares	19.10 mm	5.33 mm	+258.2%
Total puts	18.30 k	100.00	+18200.0%
Total calls	0.00	25.50 k	EXIT
Total put/call ratio	Infinity	0.0	+Infinity%

Largest owners	Shares	Value	Change
HRMY Harmony Biosciences	7.59 mm	$0.00	NEW
Beryl Capital Management	4.90 mm	$6.25 bn	NEW
Highbridge Capital Management	2.28 mm	$2.91 bn	NEW
Yakira Capital Management	620.02 k	$790.52 mm	NEW
Renaissance Technologies	605.70 k	$772.00 k	-12.2%
CSS	476.83 k	$607.96 mm	NEW
Deltec Asset Management	475.00 k	$605.63 mm	NEW
Millennium Management	325.24 k	$413.05 mm	+158.5%
Jane Street	282.48 k	$360.16 mm	NEW
Crystalline Management	230.82 k	$294.29 mm	NEW

Largest transactions	Shares	Bought/sold	Change
HRMY Harmony Biosciences	7.59 mm	+7.59 mm	NEW
Beryl Capital Management	4.90 mm	+4.90 mm	NEW
Highbridge Capital Management	2.28 mm	+2.28 mm	NEW
Vanguard	0.00	-2.18 mm	EXIT
BLK BlackRock	0.00	-740.52 k	EXIT
Yakira Capital Management	620.02 k	+620.02 k	NEW
CSS	476.83 k	+476.83 k	NEW
Deltec Asset Management	475.00 k	+475.00 k	NEW
Geode Capital Management	37.93 k	-349.41 k	-90.2%
Jane Street	282.48 k	+282.48 k	NEW

Data from 13F filings, for the last complete 13F reporting period. For most recent data, click the ownership history button. Values as filed, not updated for current price. Long positions only.

Recent insider trades

ZYNE insider ownership history Insider history

Date	Owner	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
10 Oct 23	Kenneth T Jones	Common Stock		Dispose U	No	No	0	75,000	0.00	0
10 Oct 23	Kenneth T Jones	Common Stock	Grant	Acquire A	No	No	0	30,000	0.00	75,000
10 Oct 23	Kenneth T Jones	Common Stock		Dispose U	No	No	0	40,520	0.00	45,000
10 Oct 23	Kenneth T Jones	Stock Option Common Stock	Sale back to company	Dispose D	No	No	2.41	21,250	51.21 k	0
10 Oct 23	Brian Rosenberger	Common Stock		Dispose U	No	No	0	300,000	0.00	0
10 Oct 23	Brian Rosenberger	Common Stock	Grant	Acquire A	No	No	0	120,000	0.00	300,000
10 Oct 23	Brian Rosenberger	Common Stock		Dispose U	No	No	0	69,559	0.00	180,000
10 Oct 23	Brian Rosenberger	Stock Option Common Stock	Sale back to company	Dispose D	No	No	2.41	90,000	216.90 k	0
10 Oct 23	Federici William J	Common Stock		Dispose U	No	No	0	47,824	0.00	0
10 Oct 23	Federici William J	Common Stock		Dispose U	No	No	0	27,954	0.00	47,824

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.