Structure Therapeutics (GPCR)

Annapurna Bio Pty Limited • Annapurna Bio, Inc. • Basecamp Bio Hong Kong Limited • Basecamp Bio Inc. • Basecamp Bio USA Inc. • Gasherbrum Bio, Inc. • Lhotse Bio, Inc. • Shanghai Basecamp Biotechnology Co., Ltd. • Shanghai ShouTi Biotechnology Co., Ltd. • ShouTi Hong Kong Limited ...

IRS number

981480821

GPCR stock data

1M 3M 6M 1Y

Analyst ratings and price targets

Last 3 months

Citizens Capital Markets

Latest filings (excl ownership)

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S-8

Registration of securities for employees

27 Feb 25

Structure Therapeutics Reports Fourth Quarter and Full Year 2024 Financial Results and Recent Highlights

27 Feb 25

8-K

Structure Therapeutics Announces Selection of Lead Oral Small Molecule Amylin Receptor Agonist ACCG-2671 for the Treatment of Obesity

13 Nov 24

Structure Therapeutics Reports Third Quarter 2024 Financial Results and Recent Highlights

13 Nov 24

8-K

Structure Therapeutics Strengthens Executive Team with Promotion of Blai Coll, M.D., Ph.D. to Chief Medical Officer and Appointment of Ashley Hall, J.D. as Chief Development Officer

17 Sep 24

8-K

Departure of Directors or Certain Officers

8 Aug 24

Structure Therapeutics Reports Second Quarter 2024 Financial Results and Recent Highlights

8 Aug 24

Latest ownership filings

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JANUS HENDERSON GROUP PLC

14 Feb 25

Change in insider ownership

10 Feb 25

SC 13G

Deep Track Capital, LP

13 Jan 25

SC 13G/A

RA CAPITAL MANAGEMENT, L.P.

14 Nov 24

Financial summary

Financial statements Chart GPCR financial data

Quarter (USD)	Dec 24	Sep 24	Jun 24	Mar 24
Revenue
Cost of revenue
Operating income
Operating margin
Net income
Net profit margin
Cash on hand
Change in cash
Diluted EPS

Annual (USD)	Dec 24	Dec 23	Dec 22
Revenue
Cost of revenue
Operating income
Operating margin
Net income
Net profit margin
Cash on hand
Change in cash
Diluted EPS

Cash burn rate (est.)	Burn method: Change in cash		Burn method: Operating income		Burn method: FCF (opex + capex)
	Last Q	Avg 4Q	Last Q	Avg 4Q	Last Q	Avg 4Q
Cash on hand (at last report)	169.51 mm	169.51 mm	169.51 mm	169.51 mm	169.51 mm	169.51 mm
Cash burn (monthly)	873.33 k	(no burn)	15.69 mm	13.19 mm	12.16 mm	9.72 mm
Cash used (since last report)	3.15 mm	n/a	56.62 mm	47.59 mm	43.87 mm	35.08 mm
Cash remaining	166.36 mm	n/a	112.89 mm	121.92 mm	125.64 mm	134.43 mm
Runway (months of cash)	190.5	n/a	7.2	9.2	10.3	13.8

Beta Read what these cash burn values mean

Financial data from company earnings reports.

Institutional ownership, Q4 2024

GPCR institutional ownership history Ownership history

13F holders	Current	Prev Q	Change
Total holders	167	162	+3.1%
Opened positions	31	26	+19.2%
Closed positions	26	38	-31.6%
Increased positions	63	68	-7.4%
Reduced positions	50	34	+47.1%

13F shares	Current	Prev Q	Change
Total value	1.59 tn	2.53 tn	-37.3%
Total shares	63.07 mm	63.32 mm	-0.4%
Total puts	518.80 k	330.10 k	+57.2%
Total calls	973.40 k	414.20 k	+135.0%
Total put/call ratio	0.5	0.8	-33.1%

Largest owners	Shares	Value	Change
Wellington Management	7.79 mm	$211.15 bn	+0.2%
FMR	6.08 mm	$164.86 bn	-0.8%
JHG Janus Henderson	4.16 mm	$112.82 bn	+5.1%
Capital Research Global Investors	3.54 mm	$95.93 bn	+0.2%
Deep Track Capital	2.80 mm	$75.94 bn	+129.4%
Biotechnology Value Fund L P	2.44 mm	$82.51 mm	0.0%
Driehaus Capital Management	2.06 mm	$55.80 bn	-18.6%
FHI Federated Hermes	2.05 mm	$55.49 bn	-15.2%
BVF	1.77 mm	$48.04 bn	-20.9%
Vestal Point Capital	1.73 mm	$46.78 bn	+50.0%

Largest transactions	Shares	Bought/sold	Change
Deep Track Capital	2.80 mm	+1.58 mm	+129.4%
Octagon Capital Advisors	0.00	-1.20 mm	EXIT
PFG Principal Financial	791.13 k	+791.13 k	NEW
Point72 Asset Management	476.70 k	-761.57 k	-61.5%
T. Rowe Price Investment Management	0.00	-715.97 k	EXIT
T. Rowe Price	1.39 mm	-690.38 k	-33.1%
Vestal Point Capital	1.73 mm	+575.00 k	+50.0%
Catalio Capital Management	569.40 k	+569.40 k	NEW
Logos Global Management	700.00 k	-550.00 k	-44.0%
Boxer Capital Management	500.00 k	+500.00 k	NEW

Data from 13F filings, for the last complete 13F reporting period. For most recent data, click the ownership history button. Values as filed, not updated for current price. Long positions only.

Recent insider trades

GPCR insider ownership history Insider history

Date	Owner	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
15 Mar 25	Crespo Blas Coll	Ordinary Shares	Grant	Acquire A	No	No	0	116,988	0.00	219,588
15 Mar 25	Crespo Blas Coll	Employee Stock Option Ordinary Shares	Grant	Acquire A	No	No	7.02	284,241	2.00 mm	284,241
15 Mar 25	Ashley Hall	Ordinary Shares	Grant	Acquire A	No	No	0	51,048	0.00	118,338
15 Mar 25	Ashley Hall	Employee Stock Option Ordinary Shares	Grant	Acquire A	No	No	7.02	124,032	870.70 k	124,032
15 Mar 25	Yingli Ma	Ordinary Shares	Grant	Acquire A	No	No	0	63,810	0.00	100,539
15 Mar 25	Yingli Ma	Employee Stock Option Ordinary Shares	Grant	Acquire A	No	No	7.02	155,040	1.09 mm	155,040
15 Mar 25	Xichen Lin	Ordinary Shares	Grant	Acquire A	No	No	0	80,829	0.00	166,536
15 Mar 25	Xichen Lin	Employee Stock Option Ordinary Shares	Grant	Acquire A	No	No	7.02	196,386	1.38 mm	196,386
15 Mar 25	Jun Yoon	Ordinary Shares	Grant	Acquire A	No	No	0	170,166	0.00	1,293,299
15 Mar 25	Jun Yoon	Employee Stock Option Ordinary Shares	Grant	Acquire A	No	No	7.02	413,445	2.90 mm	413,445