Ralph William Charlton III

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
16 Dec 24	SPRB Spruce Biosciences	Common Stock	Payment of exercise	Dispose F	No	No	0.3887	11,329	4.40 k	161,339
16 Dec 24	SPRB Spruce Biosciences	Common Stock	Option exercise	Acquire M	No	No	0	31,750	0.00	172,668
16 Dec 24	SPRB Spruce Biosciences	Common Stock	Payment of exercise	Dispose F	No	No	0.3887	9,491	3.69 k	140,918
16 Dec 24	SPRB Spruce Biosciences	Common Stock	Option exercise	Acquire M	No	No	0	26,600	0.00	150,409
16 Dec 24	SPRB Spruce Biosciences	RSU Common Stock	Option exercise	Dispose M	No	No	0	31,750	0.00	63,500
16 Dec 24	SPRB Spruce Biosciences	RSU Common Stock	Option exercise	Dispose M	No	No	0	26,600	0.00	79,800
10 Dec 24	SPRB Spruce Biosciences	Common Stock	Payment of exercise	Dispose F	No	No	0.537	37,964	20.39 k	123,809
10 Dec 24	SPRB Spruce Biosciences	Common Stock	Option exercise	Acquire M	No	No	0	106,400	0.00	161,773
10 Dec 24	SPRB Spruce Biosciences	RSU Common Stock	Option exercise	Dispose M	No	No	0	106,400	0.00	106,400
14 Mar 24	SPRB Spruce Biosciences	RSU Common Stock	Grant	Acquire A	No	No	0	106,400	0.00	106,400

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.