Spruce Biosciences (SPRB)

Cash burn rate (est.)	Burn method: Change in cash		Burn method: Operating income		Burn method: FCF (opex + capex)
	Last Q	Avg 4Q	Last Q	Avg 4Q	Last Q	Avg 4Q
Cash on hand (at last report)	60.09 mm	60.09 mm	60.09 mm	60.09 mm	60.09 mm	60.09 mm
Cash burn (monthly)	3.21 mm	3.23 mm	3.14 mm	3.60 mm	3.07 mm	3.87 mm
Cash used (since last report)	16.25 mm	16.35 mm	15.88 mm	18.24 mm	15.57 mm	19.62 mm
Cash remaining	43.84 mm	43.74 mm	44.21 mm	41.85 mm	44.52 mm	40.47 mm
Runway (months of cash)	13.7	13.5	14.1	11.6	14.5	10.4

Beta Read what these cash burn values mean

Financial data from company earnings reports.

Institutional ownership, Q3 2024

SPRB institutional ownership history Ownership history

66.3% owned by funds/institutions

13F holders	Current	Prev Q	Change
Total holders	27	44	-38.6%
Opened positions	2	5	-60.0%
Closed positions	19	17	+11.8%
Increased positions	4	7	-42.9%
Reduced positions	8	14	-42.9%

13F shares	Current	Prev Q	Change
Total value	5.63 bn	7.80 bn	-27.9%
Total shares	27.37 mm	30.77 mm	-11.0%
Total puts	0.00	59.30 k	EXIT
Total calls	0.00	26.90 k	EXIT
Total put/call ratio	–	2.2	–

Largest owners	Shares	Value	Change
5AM Opportunities II	4.14 mm	$10.63 mm	0.0%
HealthCap VIII	3.69 mm	$3.10 mm	0.0%
RiverVest Venture Management	2.94 mm	$1.39 bn	0.0%
CG The Carlyle Group Inc.	2.90 mm	$1.32 bn	0.0%
Rock Springs Capital Management	2.61 mm	$1.24 bn	0.0%
Omega Fund VI	2.16 mm	$52.53 mm	0.0%
RiverVest Venture Fund III	1.80 mm	$4.52 mm	0.0%
Acadian Asset Management	1.26 mm	$597.00 k	-8.0%
Steve Elms	1.21 mm	$29.31 mm	0.0%
Aisling Capital V	1.21 mm	$4.14 mm	0.0%

Largest transactions	Shares	Bought/sold	Change
Rosalind Advisors	0.00	-1.51 mm	EXIT
Altium Capital Management	0.00	-811.17 k	EXIT
Almitas Capital	0.00	-396.51 k	EXIT
ExodusPoint Capital Management	0.00	-386.70 k	EXIT
Renaissance Technologies	609.70 k	+243.60 k	+66.5%
Radoff Bradley Louis	175.00 k	+175.00 k	NEW
683 Capital Management	0.00	-140.93 k	EXIT
UBS UBS	13.00	-131.91 k	-100.0%
BlackRock	124.73 k	+124.73 k	NEW
BLK BlackRock	0.00	-124.73 k	EXIT

Data from 13F filings, for the last complete 13F reporting period. For most recent data, click the ownership history button. Values as filed, not updated for current price. Long positions only.

Recent insider trades

SPRB insider ownership history Insider history

Date	Owner	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
16 Dec 24	Ralph William Charlton III	Common Stock	Payment of exercise	Dispose F	No	No	0.3887	11,329	4.40 k	161,339
16 Dec 24	Ralph William Charlton III	Common Stock	Option exercise	Acquire M	No	No	0	31,750	0.00	172,668
16 Dec 24	Ralph William Charlton III	Common Stock	Payment of exercise	Dispose F	No	No	0.3887	9,491	3.69 k	140,918
16 Dec 24	Ralph William Charlton III	Common Stock	Option exercise	Acquire M	No	No	0	26,600	0.00	150,409
16 Dec 24	Ralph William Charlton III	RSU Common Stock	Option exercise	Dispose M	No	No	0	31,750	0.00	63,500
16 Dec 24	Ralph William Charlton III	RSU Common Stock	Option exercise	Dispose M	No	No	0	26,600	0.00	79,800
16 Dec 24	Javier B. Szwarcberg	Common Stock	Payment of exercise	Dispose F	No	No	0.3887	39,605	15.39 k	467,191
16 Dec 24	Javier B. Szwarcberg	Common Stock	Option exercise	Acquire M	No	No	0	111,000	0.00	506,796
16 Dec 24	Javier B. Szwarcberg	Common Stock	Payment of exercise	Dispose F	No	No	0.3887	32,005	12.44 k	395,796
16 Dec 24	Javier B. Szwarcberg	Common Stock	Option exercise	Acquire M	No	No	0	89,700	0.00	427,801