Javier B. Szwarcberg

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
16 Dec 24	SPRB Spruce Biosciences	Common Stock	Payment of exercise	Dispose F	No	No	0.3887	39,605	15.39 k	467,191
16 Dec 24	SPRB Spruce Biosciences	Common Stock	Option exercise	Acquire M	No	No	0	111,000	0.00	506,796
16 Dec 24	SPRB Spruce Biosciences	Common Stock	Payment of exercise	Dispose F	No	No	0.3887	32,005	12.44 k	395,796
16 Dec 24	SPRB Spruce Biosciences	Common Stock	Option exercise	Acquire M	No	No	0	89,700	0.00	427,801
16 Dec 24	SPRB Spruce Biosciences	RSU Common Stock	Option exercise	Dispose M	No	No	0	111,000	0.00	222,000
16 Dec 24	SPRB Spruce Biosciences	RSU Common Stock	Option exercise	Dispose M	No	No	0	89,700	0.00	269,100
10 Dec 24	SPRB Spruce Biosciences	Common Stock	Payment of exercise	Dispose F	No	No	0.537	128,020	68.75 k	338,101
10 Dec 24	SPRB Spruce Biosciences	Common Stock	Option exercise	Acquire M	No	No	0	358,800	0.00	466,121
10 Dec 24	SPRB Spruce Biosciences	RSU Common Stock	Option exercise	Dispose M	No	No	0	358,800	0.00	358,800
14 Mar 24	SPRB Spruce Biosciences	RSU Common Stock	Grant	Acquire A	No	No	0	358,800	0.00	358,800

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.