Sangamo Therapeutics (SGMO) 10-Q 8 May 23 2023 Q1 Quarterly report Financial data

Cover

Cover - shares	3 Months Ended
	Mar. 31, 2023	May 04, 2023
Cover [Abstract]
Document Type	10-Q
Document Quarterly Report	true
Document Period End Date	Mar. 31, 2023
Document Transition Report	false
Entity File Number	000-30171
Entity Registrant Name	SANGAMO THERAPEUTICS, INC.
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	68-0359556
Entity Address, Address Line One	7000 Marina Blvd.
Entity Address, City or Town	Brisbane
Entity Address, State or Province	CA
Entity Address, Postal Zip Code	94005
City Area Code	510
Local Phone Number	970-6000
Title of 12(b) Security	Common Stock, par value $0.01 per share
Trading Symbol	SGMO
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Large Accelerated Filer
Entity Small Business	false
Entity Emerging Growth Company	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		171,825,530
Amendment Flag	false
Document Fiscal Year Focus	2023
Document Fiscal Period Focus	Q1
Entity Central Index Key	0001001233
Current Fiscal Year End Date	--12-31

CONDENSED CONSOLIDATED BALANCE

CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Current assets:
Cash and cash equivalents	$ 78,241	$ 100,444
Marketable securities	127,146	177,188
Interest receivable	1,023	794
Accounts receivable	7,026	3,678
Prepaid expenses and other current assets	13,651	18,223
Total current assets	227,087	300,327
Marketable securities, non-current	35,610	29,845
Property and equipment, net	59,877	63,531
Intangible assets	51,555	50,729
Goodwill	0	37,552
Operating lease right-of-use assets	48,696	62,002
Other non-current assets	16,242	17,023
Restricted cash	1,500	1,500
Total assets	440,567	562,509
Current liabilities:
Accounts payable	19,920	22,418
Accrued compensation and employee benefits	12,949	21,506
Other accrued liabilities	15,395	16,007
Deferred revenues	9,575	51,780
Total current liabilities	57,839	111,711
Deferred revenues, non-current	1,816	109,377
Long-term portion of lease liabilities	37,701	38,986
Deferred income tax	6,372	6,270
Other non-current liabilities	1,229	1,207
Total liabilities	104,957	267,551
Commitments and contingencies
Stockholders’ equity:
Preferred stock	0	0
Common stock	1,718	1,668
Additional paid-in capital	1,467,062	1,450,239
Accumulated deficit	(1,127,412)	(1,148,545)
Accumulated other comprehensive loss	(5,758)	(8,404)
Total stockholders’ equity	335,610	294,958
Total liabilities and stockholders’ equity	$ 440,567	$ 562,509

CONDENSED CONSOLIDATED STATEMEN

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Revenues:
Revenues	$ 157,957	$ 28,231
Operating expenses:
Research and development	63,216	58,584
General and administrative	18,136	14,908
Impairment of goodwill	38,138	0
Impairment of long-lived assets	20,433	0
Total operating expenses	139,923	73,492
Income (loss) from operations	18,034	(45,261)
Interest and other income, net	3,293	1,342
Income (loss) before income taxes	21,327	(43,919)
Income tax expense	194	58
Net income (loss)	$ 21,133	$ (43,977)
Net income (loss) per share
Basic (in dollars per share)	$ 0.13	$ (0.30)
Diluted (in dollars per share)	$ 0.12	$ (0.30)
Shares used in computing net income (loss) per share
Basic (in shares)	168,533	146,218
Diluted (in shares)	169,181	146,218

CONDENSED CONSOLIDATED STATEM_2

CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Statement of Comprehensive Income [Abstract]
Net income (loss)	$ 21,133	$ (43,977)
Foreign currency translation adjustment	2,045	(1,904)
Net pension (loss) gain	(3)	19
Unrealized gain (loss) on marketable securities, net of tax	604	(1,083)
Comprehensive income (loss)	$ 23,779	$ (46,945)

CONDENSED CONSOLIDATED STATEM_3

CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands	Total	Common Stock	Additional Paid-in Capital	Accumulated Deficit	Accumulated Other Comprehensive Income (Loss)
Beginning balance (in shares) at Dec. 31, 2021		145,921,530
Beginning balance at Dec. 31, 2021	$ 375,343	$ 1,459	$ 1,334,138	$ (956,267)	$ (3,987)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, net of tax (in shares)		743,230
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, net of tax	(1,567)	$ 8	(1,575)
Stock-based compensation	7,691		7,691
Foreign currency translation adjustment	(1,904)				(1,904)
Net pension (loss) gain	19				19
Net unrealized gain on marketable securities, net of tax	(1,083)				(1,083)
Net income (loss)	(43,977)			(43,977)
Ending balance (in shares) at Mar. 31, 2022		146,664,760
Ending balance at Mar. 31, 2022	334,522	$ 1,467	1,340,254	(1,000,244)	(6,955)
Beginning balance (in shares) at Dec. 31, 2022		166,793,320
Beginning balance at Dec. 31, 2022	294,958	$ 1,668	1,450,239	(1,148,545)	(8,404)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock under public offering, net of issuance costs (in shares)		3,962,430
Issuance of common stock in connection with at-the-market offering, net of offering expenses	9,705	$ 40	9,665
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, net of tax (in shares)		1,015,818
Issuance of common stock upon exercise of stock options and in connection with restricted stock units, net of tax	(1,109)	$ 10	(1,119)
Stock-based compensation	8,277		8,277
Foreign currency translation adjustment	2,045				2,045
Net pension (loss) gain	(3)				(3)
Net unrealized gain on marketable securities, net of tax	604				604
Net income (loss)	21,133			21,133
Ending balance (in shares) at Mar. 31, 2023		171,771,568
Ending balance at Mar. 31, 2023	$ 335,610	$ 1,718	$ 1,467,062	$ (1,127,412)	$ (5,758)

CONDENSED CONSOLIDATED STATEM_4

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Operating Activities:
Net income (loss)	$ 21,133	$ (43,977)
Adjustments to reconcile net income (loss) to net cash used in operating activities:
Impairment of goodwill	38,138	0
Impairment of long-lived assets	20,433	0
Depreciation and amortization	3,489	2,832
(Accretion of discounts) amortization of premium on marketable securities	(1,048)	164
Amortization and other changes in operating lease right-of-use assets	2,092	2,106
Stock-based compensation	8,277	7,691
Net changes in operating assets and liabilities:
Interest receivable	(229)	(7)
Accounts receivable	(3,348)	(925)
Prepaid expenses and other assets	6,223	(241)
Accounts payable and other accrued liabilities	(1,905)	3,609
Accrued compensation and employee benefits	(8,599)	(8,270)
Deferred revenues	(149,766)	(21,004)
Lease liabilities	(1,212)	(972)
Other non-current liabilities	22	19
Net cash used in operating activities	(66,300)	(58,975)
Investing Activities:
Purchases of marketable securities	(36,225)	(65,756)
Maturities of marketable securities	82,153	70,300
Purchases of property and equipment	(10,200)	(2,839)
Net cash provided by investing activities	35,728	1,705
Financing Activities:
Taxes paid related to net share settlement of equity awards	(1,109)	(1,641)
Proceeds from exercise of stock options	0	74
Net cash provided by (used in) financing activities	8,002	(1,567)
Effect of exchange rate changes on cash, cash equivalents, and restricted cash	367	222
Net decrease in cash, cash equivalents, and restricted cash	(22,203)	(58,615)
Cash, cash equivalents, and restricted cash, beginning of period	101,944	180,372
Cash, cash equivalents, and restricted cash, end of period	79,741	121,757
Supplemental cash flow disclosures:
Property and equipment included in unpaid liabilities	5,184	2,257
Tenant improvement allowance included in contra-lease liability	243	0
At the Market Offering
Financing Activities:
Proceeds from at-the market offering/ issuance of common stock	$ 9,111	$ 0

ORGANIZATION, BASIS OF PRESENTA

ORGANIZATION, BASIS OF PRESENTATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES	3 Months Ended
	Mar. 31, 2023
Organization, Consolidation and Presentation of Financial Statements [Abstract]
ORGANIZATION, BASIS OF PRESENTATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES	ORGANIZATION, BASIS OF PRESENTATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES Organization and Description of Business Sangamo Therapeutics, Inc. (“Sangamo” or “the Company”) was incorporated in the State of Delaware in June 1995 and changed its name from Sangamo Biosciences, Inc. in January 2017. Sangamo is a clinical-stage genomic medicine company committed to translating ground-breaking science into medicines that transform the lives of patients with serious diseases. Basis of Presentation The accompanying unaudited Condensed Consolidated Financial Statements have been prepared in accordance with generally accepted accounting principles in the United States of America (“U.S. GAAP”) for interim financial information and pursuant to the rules and regulations of the Securities and Exchange Commission (“SEC”). Accordingly, they do not include all of the information and footnotes required by U.S. GAAP for complete financial statements. In the opinion of management, all adjustments (consisting only of normal recurring adjustments) considered necessary for a fair presentation of these financial statements for the periods presented have been included. Operating results for the three months ended March 31, 2023 are not necessarily indicative of the results that may be expected for the year ending December 31, 2023. The Condensed Consolidated Balance Sheet data at December 31, 2022 was derived from the audited Consolidated Financial Statements included in Sangamo’s Annual Report on Form 10-K for the year ended December 31, 2022 (the “2022 Annual Report”) as filed with the SEC on February 23, 2023. The accompanying Condensed Consolidated Financial Statements include the accounts of the Company and its subsidiaries. All intercompany balances and transactions have been eliminated in the Condensed Consolidated Financial Statements. The accompanying Condensed Consolidated Financial Statements and related financial information should be read together with the audited Consolidated Financial Statements and footnotes for the year ended December 31, 2022, included in the 2022 Annual Report. Liquidity, Capital Resources and Management’s Plans Sangamo is currently working on a number of long-term development projects that involve experimental technologies. The projects may require several years and substantial expenditures to complete and ultimately may be unsuccessful. In recent years, the Company’s operations have been funded primarily through collaborations and strategic partnerships, research grants and from the issuance of equity securities. As of March 31, 2023, the Company had capital resources of $241.0 million consisting of cash, cash equivalents, and marketable securities. Management believes that the Company’s existing cash, cash equivalents, and marketable securities in combination with other planned cost reduction initiatives will be sufficient to fund its operations for at least the next 12 months from the date these Condensed Consolidated Financial Statements are issued. Under Accounting Standard Codification (“ASC”) Topic 205-40, Presentation of Financial Statements—Going Concern (“ASC Topic 205-40”), the Company has the responsibility to evaluate whether conditions and/or events raise substantial doubt about its ability to meet its future financial obligations as they become due within one year after the date that the Condensed Consolidated Financial Statements are issued. As required under ASC Topic 205-40, management’s evaluation should initially not take into consideration the potential mitigating effects of management’s plans that have not been fully implemented as of the date the Condensed Consolidated Financial Statements are issued. Substantial Doubt Raised In performing the first step of the evaluation, the Company concluded that the following conditions raised substantial doubt about its ability to continue as a going concern: • Although the Company reported net income of $21.1 million for the three months ended March 31, 2023 primarily due to the termination of a collaboration agreement, the Company has a history of recurring net losses, including $192.3 million and $178.3 million for the years ended December 31, 2022 and 2021, respectively; and • The Company had an accumulated deficit of $1,127.4 million and $1,148.5 million as of March 31, 2023 and December 31, 2022, respectively. Consideration of Management’s Plans In performing the second step of this assessment, the Company is required to evaluate whether it is probable that its plans will be effectively implemented within one year after the Condensed Consolidated Financial Statements are issued and whether it is probable those plans will alleviate the substantial doubt about its ability to continue as a going concern. The Company has identified several actions, including cost reduction measures that already have been initiated or that would be initiated in a timely manner, to address the Company’s liquidity needs over the twelve-month period from the date the Condensed Consolidated Financial Statements are issued, as follows: • Deferral and reprioritization of certain research and development programs that would involve reduced program and headcount spend; • Reduction in force that would be intended to extend the cash runway necessary to fund operations; • Pause on any new hiring and reduction in ancillary expenses such as travel and recruitment expenses; and • Reduction in non-critical capital and operating expenditures including additional equipment, lab improvements, efficiency projects, and business support spend. Management Assessment of Ability to Continue as a Going Concern The Company believes management’s plans, as described more fully above, will provide sufficient liquidity to meet its financial obligations and maintain levels of liquidity over the twelve-month period from the date the Condensed Consolidated Financial Statements are issued. Therefore, management has concluded these plans alleviate the substantial doubt that was raised about the Company’s ability to continue as a going concern for at least twelve months from the date that the Condensed Consolidated Financial Statements are issued. Determining the extent to which conditions or events raise substantial doubt about the Company’s ability to continue as a going concern and the extent to which mitigating plans sufficiently alleviate any such substantial doubt requires significant judgment and estimation by the Company. The Company makes assumptions that management’s plans will be effectively implemented and alleviate substantial doubt and its ability to continue as a going concern. The Company believes that the estimated values used in its going concern analysis are based on reasonable assumptions. However, such assumptions are inherently uncertain and actual results could differ materially from those estimates. The accompanying Condensed Consolidated Financial Statements have been prepared assuming the Company will continue to operate as a going concern, which contemplates the realization of assets and the settlement of liabilities in the normal course of business. The Condensed Consolidated Financial Statements do not include any adjustments to reflect the possible future effects on the recoverability and classification of assets or the amounts of liabilities that may result from uncertainty related to the Company’s ability to continue as a going concern. Future Plans and Considerations The Company will be required to raise substantial additional capital to fund its operations and support its research and development endeavors. In this regard, the Company is actively seeking substantial additional capital, including through public or private equity or debt financings, royalty financings or other sources, such as strategic collaborations. However, additional capital may not be available to the Company, on terms that are acceptable or at all. If adequate funds are not available to the Company on a timely basis, or at all, the Company will be required to take additional actions to address its liquidity needs, including additional cost reduction measures such as further reducing operating expenses and delaying, reducing the scope of, discontinuing or altering its research and development activities, which could have a material adverse effect on the Company’s business. If the Company raises additional capital through public or private equity offerings, including sales pursuant to the Company’s at-the-market offering program with Jefferies LLC, the ownership interest of its existing stockholders will be diluted, and such dilution may be substantial, and the terms of any new equity securities may have a preference over, and include rights superior to, the Company’s common stock. If the Company raises additional capital through royalty financings or other collaborations, strategic alliances or licensing arrangements with third parties, it may need to relinquish certain valuable rights to its product candidates, technologies, future revenue streams or research programs or grant licenses on terms that may not be favorable. If the Company raises additional capital through debt financing, the Company may be subject to specified financial covenants or covenants limiting or restricting its ability to take specific actions, such as incurring additional debt, making capital expenditures or pursuing certain transactions, any of which could restrict the Company’s ability to commercialize its product candidates or operate as a business. In addition, management’s cost reduction plans are intended to reduce the Company’s operating expenses and optimize its cash resources. Based on the timing of these cost reduction plans, the Company expects to start realizing the benefit of its efforts beginning in the second quarter of 2023; however, there can be no assurance that the Company will realize the benefits of the cost reduction plans on the anticipated timeline, or at all. Summary of Significant Accounting Policies Use of Estimates The preparation of Condensed Consolidated Financial Statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported in the Condensed Consolidated Financial Statements and the accompanying notes. On an ongoing basis, management evaluates its estimates including critical accounting policies or estimates related to revenue recognition, clinical trial accruals, income taxes, fair value of assets and liabilities, including from acquisitions, useful lives and impairment of long-lived assets, and stock-based compensation. Estimates are based on historical experience and on various other market specific and other relevant assumptions that the Company believes to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. Actual results could differ from those estimates. In March 2023, the Company recorded an adjustment to revenue related to a change in estimate in connection with the collaboration agreement with Kite Pharma, Inc. This adjustment was driven by a reduction in the estimated future level of the Company’s research and development services and as a result, future project costs. This resulted in an increase in proportional cumulative performance on this collaboration and an increase in revenue of $8.9 million, an increase in net income of $8.9 million, and an increase in the Company’s basic and diluted earnings per share of $0.06 and $0.05, respectively, for the three months ended March 31, 2023. Revenue Recognition The Company accounts for its revenues pursuant to the provisions of Accounting Standards Codification Topic 606, Revenue from Contracts with Customers (“ASC Topic 606”). The Company’s contract revenues are derived from collaboration agreements including licensing arrangements and research services. Research and licensing agreements typically include nonrefundable upfront signing or license fees, payments at negotiated rates for time incurred by Company researchers, third-party cost reimbursements, additional target selection fees, sublicense fees, milestone payments tied to ongoing development and product commercialization, and royalties on future licensees’ product sales. All funds received from the Company’s collaboration partners are generally not refundable. Non-refundable upfront fees are fixed at the commencement of the contract. All other fees represent variable consideration in contracts. One of the Company’s contracts also contains a provision where the Company reimburses its customer for certain costs they incur which is accounted for as a reduction to the contract transaction price as the Company does not acquire any distinct goods or services in exchange for such payments. Deferred revenue primarily represents the portion of nonrefundable upfront fees or milestone payments received but not earned. In determining the appropriate amount of revenue to be recognized as the Company fulfills its obligations under its agreements, the Company performs the following steps: (i) identification of the promised goods or services in the contract; (ii) determination of whether the promised goods or services are performance obligations, including whether they are distinct in the context of the contract; (iii) measurement of the transaction price, including the constraint on variable consideration; (iv) allocation of the transaction price to the performance obligations based on estimated selling prices; and (v) recognition of revenue when (or as) the Company satisfies each performance obligation. Most of the Company’s performance obligations in its collaboration agreements represent distinct bundles of licenses of intellectual property and research and development services, with these components being individually non-distinct. Options to license the Company’s intellectual property and/or acquire research and development services also represent performance obligations when they grant customers a material right, e.g., a right to a discount the customer would not have received if they did not purchase the Company’s services under the existing contract. Revenues from bundles of licenses of intellectual property and research and development services are recognized over time using a proportional performance method. Under this method, revenue is recognized by measuring progress towards satisfaction of the relevant performance obligation using a measure that best depicts the progress towards satisfaction of the relevant performance obligation. For most of the Company’s agreements the measure of progress is an input measure based on a level of effort incurred, which includes the value of actual time by Company researchers plus third-party cost reimbursements. Consideration allocated to options that include material rights is deferred until the options are exercised or expire. The exercise of such options is accounted for as contract continuation, with target selection fees and estimated variable consideration included in the transaction price at that time and allocated specifically to the respective target’s performance obligation. Significant management judgment is required to determine the level of effort required under an arrangement, and the period over which the Company expects to complete its performance obligations under the arrangement. Changes in these estimates can have a material effect on revenue recognized. If the Company cannot reasonably estimate when its performance obligations either are completed or become inconsequential, then revenue recognition is deferred until the Company can reasonably make such estimates. For variable consideration, the amount included in the transaction price is constrained to the amount for which it is probable that a significant reversal of cumulative revenue recognized will not occur. At the end of each subsequent reporting period, the Company re-evaluates the estimated variable consideration included in the transaction price and any related constraint and, if necessary, adjusts its estimate of the overall transaction price. A cumulative catch-up is then recorded in the current period to reflect the updated transaction price and the updated measure of progress. The estimated period of performance and level of effort, including the value of Company researchers’ time and third-party costs, are reviewed quarterly and adjusted, as needed, to reflect the Company’s current expectations. As part of the accounting for these arrangements, the Company must develop assumptions that require judgment to determine the stand-alone selling price of each performance obligation identified in the contract. The Company uses key assumptions to determine the stand-alone selling price, which may include forecasted revenues, development timelines, discount rates and probabilities of exercise of technical and regulatory success, and the expected level of effort for research and development services. Contract modifications occur when the price and/or scope of an arrangement changes. If the modification consists of adding new distinct goods or services in exchange for consideration that reflects standalone selling prices of these goods and services, the modification is accounted for as a separate contract with the customer. Otherwise, if the remaining goods and services are distinct from those previously provided, the existing contract is considered terminated, and the remaining consideration is allocated to the remaining goods and services as if this was a newly signed contract. If the remaining goods and services are not distinct from those previously provided, the effects of the modification are accounted for in a manner similar to the effect of a change in the estimated measure of progress, with cumulative catch-up in revenue recorded at the time of the modification. If some of the remaining goods and services are distinct from those previously provided and others are not, to account for the effects of the modification the Company applies principles consistent with the objectives of the modification accounting. Revenues from major collaboration agreements and research activity grants as a percentage of total revenues were as follows: Three Months Ended 2023 2022 Biogen MA, Inc. 84 % 40 % Kite Pharma, Inc. 8 % 22 % Novartis Institutes for BioMedical Research, Inc. 6 % 32 % Sanofi S.A. — % 5 % Impairment of Goodwill, Intangible Assets and Long-lived Assets Goodwill represents the excess of consideration transferred over the fair values of assets acquired and liabilities assumed in a business combination. Intangible assets with indefinite useful lives are related to purchased in-process research and development (“IPR&D”) projects and are measured at their respective fair values as of the acquisition date. Goodwill and intangible assets with indefinite useful lives are not amortized. Intangible assets related to IPR&D projects are considered to be indefinite-lived until the completion or abandonment of the associated research and development efforts. If and when development is complete, which generally occurs if and when regulatory approval to market a product is obtained, the associated assets would be deemed finite-lived and would then be amortized based on their respective estimated useful lives at that point in time. Goodwill and indefinite-lived intangible assets are assessed for impairment on an annual basis and whenever events and circumstances indicate that these assets may be impaired. The Company evaluates the fair value of long-lived assets, which include property and equipment, leasehold improvements and right-of-use assets, for impairment whenever events or changes in circumstances indicate that the carrying amounts of the asset may not be fully recoverable. In testing for goodwill impairment, the Company has the option of first performing a qualitative assessment to determine whether it is more likely than not that the fair value of the reporting unit is less than its carrying amount. If the Company elects to bypass the qualitative assessment, or if a qualitative assessment indicates it is more likely than not that the carrying value exceeds its fair value, the Company performs a quantitative goodwill impairment test to compare the fair value of its reporting unit to its carrying value, including goodwill. If the carrying value, including goodwill, exceeds the reporting unit’s fair value, the Company will recognize an impairment loss for the amount by which the carrying amount exceeds the reporting unit’s fair value (but not in excess of the carrying value of goodwill). Prior to testing goodwill for impairment, the Company also tests impairment for its other indefinite-lived and long-lived assets. The long-lived asset evaluation is performed at the asset group level, i.e., the lowest level for which identifiable cash flows are largely independent of the cash flows of other assets and liabilities. Recoverability of these assets is measured by a comparison of the carrying amounts of an asset group to the future undiscounted cash flows the assets are expected to generate from the use and eventual disposition. If such a review indicates that the carrying amount of the asset group is not recoverable, an impairment loss shall be measured as the amount by which the carrying amount of an asset group exceeds its fair value. Any impairment loss is allocated to the long-lived assets of the group on a pro rata basis using the relative carrying amounts of those assets, except that the carrying amount of an individual asset shall not be reduced below its fair value. Factors that may indicate potential impairment and trigger an impairment test include, but are not limited to, general macroeconomic conditions, conditions specific to the industry and market, an adverse change in legal factors, business climate or operational performance of the business, and sustained decline in the stock price and market capitalization compared to the net book value. Calculating the fair value of a reporting unit, an asset group and an individual asset involves significant estimates and assumptions. These estimates and assumptions include, among others, projected future cash flows, risk-adjusted discount rates, future economic and market conditions, and the determination of appropriate market comparables. Changes in these factors and assumptions used can materially affect the amount of impairment loss recognized in the period the asset was considered impaired. Cash, Cash Equivalents, and Restricted Cash Sangamo considers all highly liquid investments purchased with original maturities of three months or less at the purchase date to be cash equivalents. Cash and cash equivalents consist of cash, deposits in demand money market accounts and U.S. government-sponsored entity debt securities. Restricted cash consists of a letter of credit for $1.5 million, representing a deposit for the lease of the corporate headquarters in Brisbane, California. A reconciliation of cash, cash equivalents, and restricted cash reported within the Condensed Consolidated Balance Sheets to the amounts reported within the accompanying Condensed Consolidated Statements of Cash Flows is as follows (in thousands): March 31, December 31, March 31, December 31, Cash and cash equivalents $ 78,241 $ 100,444 $ 120,257 $ 178,872 Non-current restricted cash 1,500 1,500 1,500 1,500 Cash, cash equivalents, and restricted cash as reported within the accompanying Condensed Consolidated Statements of Cash Flows $ 79,741 $ 101,944 $ 121,757 $ 180,372 Leases The Company determines if an arrangement is or contains a lease at inception by assessing whether the arrangement contains an identified asset and whether it has the right to control the identified asset. Right-of-use assets represent the Company’s right to use an underlying asset for the lease term and lease liabilities represent the Company’s obligation to make lease payments arising from the lease. Lease liabilities are recognized at the lease commencement date based on the present value of future lease payments over the lease term. Right-of-use assets are based on the measurement of the lease liability and also include any lease payments made prior to or on lease commencement and exclude lease incentives and initial direct costs incurred, as applicable. As the implicit rate in the Company’s leases is generally unknown, the Company uses its incremental borrowing rate based on the information available at the lease commencement date in determining the present value of remaining lease payments. The incremental borrowing rate represents an estimate of the interest rate the Company would incur at lease commencement to borrow an amount equal to the lease payments on a collateralized basis over the term of a lease in a similar economic environment. The Company considers its credit risk, term of the lease, and total lease payments and adjusts for the impacts of collateral, as necessary, when calculating its incremental borrowing rates. The lease terms may include options to extend or terminate the lease when it is reasonably certain the Company will exercise any such options. Rent expense for the Company’s operating leases is recognized on a straight-line basis over the lease term. The Company will evaluate the lease arrangement for impairment whenever events or changes in circumstances indicate that the carrying amounts of the right-of-use asset may not be fully recoverable. To the extent an impairment of the right-of-use asset is recognized, the Company will recognize lease impairment and subsequently amortize the remaining lease asset on a straight-line basis (unless another systematic basis is more representative of the pattern in which the Company expects to consume the future economic benefits from the asset) from the date of impairment to the earlier of the end of the right-of-use asset’s useful life or the end of the lease term. The Company has elected not to separate lease and non-lease components for its real estate and copier leases and, as a result, accounts for any lease and non-lease components as a single lease component. The Company has also elected not to apply the recognition requirement to any leases with a term of 12 months or less and does not include an option to purchase the underlying asset that the Company is reasonably certain to exercise. Recently Adopted Accounting Pronouncements None.

FAIR VALUE MEASUREMENTS

FAIR VALUE MEASUREMENTS	3 Months Ended
	Mar. 31, 2023
Fair Value Disclosures [Abstract]
FAIR VALUE MEASUREMENTS	FAIR VALUE MEASUREMENTS The Company measures certain financial assets and liabilities at fair value on a recurring basis, including cash equivalents and marketable securities. Fair value is determined based on a three-tier hierarchy under the authoritative guidance for fair value measurements and disclosures that prioritizes the inputs used in measuring fair value as follows: Level 1: Unadjusted quoted prices in active markets that are accessible at the measurement date for identical, unrestricted assets or liabilities; Level 2: Quoted prices in markets that are not active or inputs which are observable, either directly or indirectly, for substantially the full term of the asset or liability; and Level 3: Prices or valuation techniques that require inputs that are both significant to the fair value measurements and unobservable (i.e., supported by little or no market activity). The fair value measurements of the Company’s cash equivalents and marketable securities are identified at the following levels within the fair value hierarchy (in thousands): March 31, 2023 Fair Value Measurements Total Level 1 Level 2 Level 3 Assets: Cash equivalents: Money market funds $ 34,474 $ 34,474 $ — $ — Total 34,474 34,474 — — Marketable securities: U.S. government-sponsored entity debt securities 33,720 — 33,720 — Commercial paper securities 70,836 — 70,836 — Corporate debt securities 8,311 — 8,311 — Asset-backed securities 14,613 — 14,613 — U.S. treasury bills 5,596 — 5,596 — Certificates of deposit 29,680 — 29,680 — Total 162,756 — 162,756 — Total cash equivalents and marketable securities $ 197,230 $ 34,474 $ 162,756 $ — December 31, 2022 Fair Value Measurements Total Level 1 Level 2 Level 3 Assets: Cash equivalents: Money market funds $ 50,820 $ 50,820 $ — $ — Total 50,820 50,820 — — Marketable securities: U.S. government-sponsored entity debt securities 18,417 — 18,417 — Commercial paper securities 101,165 — 101,165 — Corporate debt securities 11,670 — 11,670 — Asset-backed securities 24,792 — 24,792 — U.S. treasury bills 7,938 — 7,938 — Certificates of deposit 37,461 — 37,461 — Agency bonds 5,590 — 5,590 — Total 207,033 — 207,033 — Total cash equivalents and marketable securities $ 257,853 $ 50,820 $ 207,033 $ — Cash Equivalents and Marketable Securities The Company generally classifies its marketable securities as Level 2. Instruments are classified as Level 2 when observable market prices for identical securities that are traded in less active markets are used. When observable market prices for identical securities are not available, such instruments are priced using benchmark curves, benchmarking of like securities, sector groupings, matrix pricing and valuation models. These valuation models are proprietary to the pricing providers or brokers and incorporate a number of inputs, including in approximate order of priority: benchmark yields, reported trades, broker/dealer quotes, issuer spreads, two-sided markets, benchmark securities, bids, offers and reference data including market research publications. For certain security types, additional inputs may be used, or some of the standard inputs may not be applicable. Evaluators may prioritize inputs differently on any given day for any security based on market conditions, and not all inputs listed are available for use in the evaluation process for each security evaluation on any given day.

CASH EQUIVALENTS AND MARKETABLE

CASH EQUIVALENTS AND MARKETABLE SECURITIES	3 Months Ended
	Mar. 31, 2023
Investments, Debt and Equity Securities [Abstract]
CASH EQUIVALENTS AND MARKETABLE SECURITIES	CASH EQUIVALENTS AND MARKETABLE SECURITIES The table below summarizes the Company’s cash equivalents and marketable securities (in thousands): Amortized Gross Gross Estimated March 31, 2023 Assets Cash equivalents: Money market funds $ 34,474 $ — $ — $ 34,474 Total 34,474 — — 34,474 Marketable securities: U.S. government-sponsored entity debt securities 33,753 94 (127) 33,720 Commercial paper securities 70,906 9 (79) 70,836 Corporate debt securities 8,335 — (24) 8,311 Asset-backed securities 14,689 — (76) 14,613 U.S. treasury bills 5,598 — (2) 5,596 Certificates of deposit 29,761 2 (83) 29,680 Total 163,042 105 (391) 162,756 Total cash equivalents and marketable securities $ 197,516 $ 105 $ (391) $ 197,230 December 31, 2022 Assets Cash equivalents: Money market funds $ 50,820 $ — $ — $ 50,820 Total 50,820 — — 50,820 Marketable securities: U.S. government-sponsored entity debt securities 18,710 — (293) 18,417 Commercial paper securities 101,336 22 (193) 101,165 Corporate debt securities 11,760 — (90) 11,670 Asset-backed securities 24,970 2 (180) 24,792 U.S. treasury bills 7,950 — (12) 7,938 Certificates of deposit 37,599 4 (142) 37,461 Agency bonds 5,598 — (8) 5,590 Total 207,923 28 (918) 207,033 Total cash equivalents and marketable securities $ 258,743 $ 28 $ (918) $ 257,853 The fair value of marketable securities by contractual maturity were as follows (in thousands): March 31, December 31, Maturing in one year or less $ 127,147 $ 177,188 Maturing after one year through five years 35,609 29,845 Total $ 162,756 $ 207,033 There were no realized gains and losses on the sales of investments during the three months ended March 31, 2023. Realized gains and losses on the sales of investments were not material during the three months ended March 31, 2022. Total unrealized gains for securities with net gains in accumulated other comprehensive income were not material for the three months ended March 31, 2023. The Company manages credit risk associated with its investment portfolio through its investment policy, which limits purchases to high-quality issuers and also limits the amount of its portfolio that can be invested in a single issuer. The Company did not record an allowance for credit losses or other impairment charges related to its marketable securities for the three months ended March 31, 2023 and 2022. The Company had unrealized losses related to its marketable securities for the three months ended March 31, 2023 and 2022. The Company had no material unrealized losses, individually and in the aggregate, for marketable securities that are in a continuous unrealized loss position for greater than 12 months as of March 31, 2023 and December 31, 2022. Based on the scheduled maturities of its investments, the Company determined that it was more likely than not that it will hold these investments for a period of time sufficient for a recovery of its amortized cost basis. These unrealized losses were not attributed to credit risk and were associated with changes in market conditions. The Company periodically reviews its marketable securities for indications of credit losses. The Company considers factors such as the duration, the magnitude and the reason for the decline in value, the potential recovery period, creditworthiness of the issuers of the securities and its intent to sell. For marketable securities, it also considers whether (i) it is more likely than not that the Company will be required to sell the debt securities before recovery of their amortized cost basis, and (ii) the amortized cost basis cannot be recovered as a result of credit losses. No significant facts or circumstances have arisen to indicate that there has been any significant deterioration in the creditworthiness of the issuers of the securities held by the Company. Based on the Company’s review of these securities, including the assessment of the duration and severity of the unrealized losses and the Company’s ability and intent to hold the investments until maturity, the Company determined that no allowance for credit losses related to its marketable securities was required at either March 31, 2023 or December 31, 2022.

BASIC AND DILUTED NET INCOME (L

BASIC AND DILUTED NET INCOME (LOSS) PER SHARE	3 Months Ended
	Mar. 31, 2023
Earnings Per Share [Abstract]
BASIC AND DILUTED NET INCOME (LOSS) PER SHARE	BASIC AND DILUTED NET INCOME (LOSS) PER SHARE Basic net income (loss) per share has been computed by dividing net income (loss) by the weighted-average number of shares of common stock outstanding during the period. Diluted net income (loss) per share is calculated by dividing net income (loss) by the weighted-average number of shares of common stock plus potentially dilutive securities outstanding during the period. The components of basic and diluted net income (loss) per share are as follows (in thousands, except per share amounts): Three Months Ended 2023 2022 Numerator: Net income (loss) $ 21,133 $ (43,977) Denominator: Basic: Weighted average number of common shares outstanding - basic 168,533 146,218 Diluted: Weighted average number of common shares outstanding - basic 168,533 146,218 Dilutive effect of restricted stock units 300 — Dilutive effect of common stock pursuant to employee stock purchase plan 348 — Weighted average number of common shares outstanding - diluted 169,181 146,218 Net income (loss) per share: Basic $ 0.13 $ (0.30) Diluted $ 0.12 $ (0.30)

MAJOR CUSTOMERS, PARTNERSHIPS A

MAJOR CUSTOMERS, PARTNERSHIPS AND STRATEGIC ALLIANCES	3 Months Ended
	Mar. 31, 2023
Organization, Consolidation and Presentation of Financial Statements [Abstract]
MAJOR CUSTOMERS, PARTNERSHIPS AND STRATEGIC ALLIANCES	MAJOR CUSTOMERS, PARTNERSHIPS AND STRATEGIC ALLIANCES Novartis Institutes for BioMedical Research, Inc. On July 27, 2020, the Company entered into a collaboration and license agreement with Novartis Institutes for BioMedical Research, Inc. (“Novartis”) for the research, development and commercialization of gene regulation therapies to treat three neurodevelopmental disorders. Under the agreement, which was effective upon execution, the Company granted Novartis an exclusive, royalty bearing and worldwide license, under its relevant patents and know-how, to develop, manufacture and commercialize certain of its zinc finger (“ZF”) transcriptional regulators (“ZF-TRs”) targeted to three undisclosed genes that are associated with certain neurodevelopmental disorders, including autism spectrum disorder and intellectual disability. The Company was performing early research activities over the collaboration period for each gene target and manufacture the ZF-TRs required for such research, costs of which are funded by Novartis. Novartis was responsible for additional research activities, studies enabling INDs, clinical development, regulatory approvals, manufacturing of preclinical, clinical and approved products, and global commercialization. Subject to certain exceptions set forth in the agreement, the Company was prohibited from developing, manufacturing or commercializing any therapeutic product targeting any of the three genes that are the subject of the collaboration. Novartis also had the option to license certain of the Company’s proprietary adeno-associated viruses (“AAVs”) for the sole purpose of developing, manufacturing and commercializing licensed products arising from the collaboration. In March 2023, Novartis notified the Company of its termination for convenience, effective June 11, 2023 (the “Novartis Termination Date”), of the collaboration agreement. Novartis has indicated to the Company that the termination relates to a recent strategic review. As of the Novartis Termination Date, the collaboration agreement will be terminated in its entirety and following the Novartis Termination Date, the Company will not be entitled to receive any further milestone payments or royalties from Novartis. As of the Novartis Termination Date, the parties will have no further obligations to develop or to fund the development of any collaboration research programs under the collaboration agreement. Upon entering the agreement, Novartis paid the Company a $75.0 million upfront license fee. Novartis was also obligated to pay the Company for the use of its resources and reimburse third-party costs incurred in the Company’s conduct of early research activities. The Company was also eligible to earn from Novartis development and commercial milestones and royalties on potential commercial sales of licensed products arising from the collaboration, none of which have been triggered or earned. The agreement was going to continue, on a product-by-product and country-by-country basis, until the expiration of the applicable royalty term. All payments received under the agreement are non-refundable and non-creditable. The transaction price of $95.1 million includes the upfront license fee of $75.0 million and research costs of $20.1 million. All clinical or regulatory milestone amounts were considered fully constrained throughout the term of the agreement. The Company assessed the agreement with Novartis in accordance with ASC Topic 606 and concluded that Novartis was a customer. The Company has identified a single performance obligation within this arrangement as a license to the technology and ongoing research services. The Company concluded that the license was not discrete as it did not have stand-alone value to Novartis apart from the research services to be performed pursuant to the agreement. As a result, the Company recognized revenue from the upfront payment based on proportional performance of the ongoing research services through the estimated research period. The estimation of progress towards the satisfaction of performance obligation and project cost was reviewed quarterly and adjusted, as needed, to reflect the Company’s current assumptions regarding the timing of its performance obligation. The notice of termination was accounted for as a modification of the contract, as it changed both the scope of the Company’s remaining services and the consideration to which the Company was entitled. The effect of the modification was not material, as the Company was nearing the completion of its assigned early research activities, and consequently, of its sole performance obligation. As of March 31, 2023 and December 31, 2022, the Company had a receivable of $2.1 million and $2.2 million, respectively, and deferred revenue of $1.9 million and $9.6 million, respectively, related to this agreement. The deferred revenue is expected to be recognized during the quarter ended June 30, 2023. Revenues recognized under the agreement were as follows (in thousands): Three Months Ended 2023 2022 Revenue related to Novartis agreement: Recognition of upfront license fee $ 7,696 $ 7,018 Research services 2,059 1,877 Total $ 9,755 $ 8,895 The Company paid $1.5 million for financial advisory fees during the year ended December 31, 2020, equal to 2% of $75.0 million received for the upfront license fee related to the collaboration and license agreement with Novartis. The Company recognized $1.5 million as a contract asset as such amount represents a cost of obtaining the agreement. This balance is released into general and administrative expenses on a systematic basis consistent with the transfer of the services to Novartis in accordance with ASC Topic 340, Other Assets and Deferred Costs (“ASC Topic 340”). The Company recognized as expense $0.2 million and $0.1 million during the three months ended March 31, 2023 and 2022, respectively. Biogen MA, Inc. In February 2020, the Company entered into a collaboration and license agreement with Biogen MA, Inc. (“BIMA”) and Biogen International GmbH (together with BIMA, “Biogen”) for the research, development and commercialization of gene regulation therapies for the treatment of neurological diseases. The companies planned to leverage the Company’s proprietary ZF technology delivered via AAV to modulate expression of key genes involved in neurological diseases. Concurrently with the execution of the collaboration agreement, the Company entered into a stock purchase agreement with BIMA, pursuant to which BIMA agreed to purchase 24,420,157 shares of the Company’s common stock (the “Biogen Shares”), at a price per share of $9.2137, for an aggregate purchase price of approximately $225.0 million. The collaboration agreement became effective in April 2020. In March 2023, Biogen notified the Company of its termination for convenience, effective June 15, 2023 (the “Biogen Termination Date”), of the collaboration agreement. Biogen has indicated to the Company that the termination relates to a recent strategic review. As of the Biogen Termination Date, the collaboration agreement will be terminated in its entirety and following the Biogen Termination Date, the Company will not be entitled to receive any further milestone payments or royalties from Biogen. As of the Biogen Termination Date, the parties will have no further obligations to develop or to fund the development of any collaboration research programs under the collaboration agreement. Under the collaboration agreement, Biogen paid the Company an upfront license fee of $125.0 million in May 2020. The Company was also eligible to receive target selection, research, development, regulatory and commercial milestone payments and royalties on potential net commercial sales of licensed products arising from the collaboration, none of which have been triggered or earned. Under the collaboration agreement, the Company granted to Biogen an exclusive, royalty bearing and worldwide license, under its relevant patents and know-how, to develop, manufacture and commercialize ZF and/or AAV-based products directed to certain neurological disease gene targets selected by Biogen. Biogen had selected four targets over the course of the collaboration and had exclusive rights to nominate up to seven additional targets. These rights will expire upon the Biogen Termination Date. For each gene target selected by Biogen, the Company performed early research activities, costs of which were shared by the companies, aimed at the development of the combination of proprietary central nervous system delivery vectors and ZF-TRs (or potential other ZF products) targeting therapeutically relevant genes. The Company assessed the collaboration agreement with Biogen in accordance with ASC Topic 606 and concluded that Biogen is a customer. The transaction price included the upfront license fee of $125.0 million and the excess consideration from the stock purchase of $79.6 million, which represented the difference between the $225.0 million received for the purchase of the Biogen Shares and the $145.4 million estimated fair value of the equity issued. The equity issued to Biogen was valued using an option pricing model to reflect certain holding period restrictions. None of the clinical or regulatory milestones were included in the transaction price, as all such amounts were fully constrained throughout the term of the collaboration agreement. The transaction price also included actual and estimated cost-sharing payments by Biogen for the work by Company researchers and reimbursement of the Company’s costs incurred with third parties. The amounts paid and expected to be paid to Biogen for the use of Biogen’s resources and its expenses were consideration paid to a customer. Since the Company did not acquire distinct goods or services in exchange for these payments, they reduced the transaction price and were recorded as reduction in revenue. The Company used the expected value method to estimate cost sharing payments, taking into account the impact of the constraint. Variable consideration was included in the transaction price only to the extent it was probable a significant reversal of cumulative revenues recognized would not occur. The Company re-evaluated the transaction price as uncertain events were resolved or other changes in circumstances occurred. The Company concluded that the licenses to its intellectual property for each target were not distinct from the related research and development activities, as the licensed technology was not shared with and could not be utilized by Biogen without the research services to be performed by the Company pursuant to the agreement. On the other hand, each combination of a license to the Company's intellectual property as applied to a specific target and the related research and development activities are a discrete research project that is distinct from any other target’s project. The targets Biogen could select were options that provided Biogen with material rights, as the exercise of the options did not require payment of a fee commensurate with the value of the incremental license rights. As a result, such options also represented performance obligations. At contract inception, the Company allocated fixed consideration of $204.6 million included in the initial transaction price to the existing targets’ license and research services performance obligations and those performance obligations for options that include material rights, based on their relative standalone selling prices. Through March 31, 2023, one material right had expired, and seven material rights remained outstanding and are expected to expire during the quarter ending June 30, 2023. The notice of termination was accounted for as a modification of the contract, as it changed both the scope of the Company’s remaining services and the consideration to which the Company was entitled. The remaining research and development activities to be undertaken by the Company after the notice of termination were not distinct from the related activities performed prior to the modification on the same targets but were distinct from the activities on other targets. The remaining material rights were also distinct from the prior research and development activities. To account for the effects of the modification, the Company updated its estimate of the transaction price and allocated the remaining transaction consideration based on the relative standalone selling prices of the remaining distinct goods and services. Progress for each ongoing performance obligation was then remeasured using an updated estimate of the total level of effort required for each performance obligation and the total revised transaction price and a cumulative catch-up in revenue was recorded. The modification resulted in an increase in revenue of $127.1 million. As of March 31, 2023 and December 31, 2022, the Company had a receivable of $0.7 million and $0.5 million, respectively, and deferred revenue of $1.5 million and $132.2 million, respectively, related to this agreement. Changes in deferred revenue balances during the three months ended March 31, 2023 relate primarily to the impact of the contract modification. The amounts of transaction price remaining to be recognized were $1.7 million and $151.3 million as of March 31, 2023 and December 31, 2022, respectively. The amounts remaining at March 31, 2023 are expected to be recognized during the quarter ending June 30, 2023. Revenues recognized under the agreement were as follows (in thousands): Three Months Ended 2023 2022 Revenue related to Biogen agreement: Recognition of license and other fixed consideration $ 130,630 $ 7,306 Cost-sharing payments for research services, net variable consideration 1,672 3,887 Total $ 132,302 $ 11,193 The Company paid $7.0 million for financial advisory fees during the year ended December 31, 2020, equal to 2% of $225.0 million received for the sale of shares and 2% of $125.0 million received for the upfront fee. The fees incurred related to both the collaboration agreement with Biogen and the stock purchase agreement for the sale of shares. The Company believes that the allocation of fees on a relative fair value basis between the two agreements is reasonable. The Company recognized $4.1 million, which represents 2% of the initial transaction price of $204.6 million, as a contract cost asset. This balance is released into general and administrative expenses on a systematic basis consistent with the transfer of the services to Biogen in accordance with ASC Topic 340. The Company recognized as expense $2.6 million and $0.1 million during the three months ended March 31, 2023 and 2022, respectively. The Company recognized $2.9 million, which represented 2% of the $145.4 million estimated fair value of the equity issued, as a share issuance cost and recorded this amount in equity as a reduction in net proceeds during the year ended December 31, 2020. Kite Pharma, Inc. In February 2018, the Company entered into a global collaboration and license agreement with Kite Pharma, Inc. (“Kite”), a Gilead Sciences, Inc. subsidiary, which became effective on April 5, 2018 (“Effective Date”), and was amended and restated in September 2019, for the research, development, and commercialization of potential engineered cell therapies for cancer. In this collaboration, Sangamo is working together with Kite on a research program under which the companies are designing zinc finger nucleases (“ZFNs”) and viral vectors to disrupt and insert certain genes in T-cells and natural killer cells (“NK-cells”) including the insertion of genes that encode chimeric antigen receptors (“CARs”), T-cell receptors (“TCRs”), and NK-cell receptors (“NKRs”) directed to mutually agreed targets. Kite is responsible for all clinical development, manufacturing and commercialization of any resulting products. Subject to the terms of this agreement, the Company granted Kite an exclusive, royalty-bearing, worldwide sublicensable license under the Company’s relevant patents and know-how to develop, manufacture and commercialize, for the purpose of treating cancer, specific cell therapy products that may result from the research program and that are engineered ex vivo using selected ZFNs and viral vectors developed under the research program to express CARs, TCRs or NKRs directed to candidate targets. During the research program term and subject to certain exceptions, the Company is prohibited from researching, developing, manufacturing and commercializing, for the purpose of treating cancer, any cell therapy product that, as a result of ex vivo genome editing, expresses a CAR, TCR or NKR that is directed to a target expressed on or in a human cancer cell. After the research program term concludes and subject to certain exceptions, the Company will be prohibited from developing, manufacturing and commercializing, for the purpose of treating cancer, any cell therapy product that, as a result of ex vivo genome editing, expresses a CAR, TCR or NKR that is directed to a candidate target. Following the Effective Date, the Company received a $150.0 million upfront payment from Kite. In addition, Kite reimburses the Company’s direct costs to conduct the joint research program. Sangamo is also eligible to receive contingent development- and sales-based milestone payments that could total up to $3.0 billion if all of the specified milestones set forth in this agreement are achieved. Of this amount, approximately $1.3 billion relates to the achievement of specified research, clinical development, regulatory and first commercial sale milestones, and approximately $1.8 billion relates to the achievement of specified sales-based milestones if annual worldwide net sales of licensed products reach specified levels. Each development- and sales-based milestone payment is payable (i) only once for each licensed product, regardless of the number of times that the associated milestone event is achieved by such licensed product, and (ii) only for the first 10 times that the associated milestone event is achieved regardless of the number of licensed products that may achieve such milestone event. In addition, the Company is entitled to receive escalating, tiered royalty payments with a percentage in the single digits based on future annual worldwide net sales of licensed products. These royalty payments are subject to reduction due to patent expiration, entry of biosimilar products to the market and payments made under certain licenses for third-party intellectual property. The initial research term in the agreement is six years from the Effective Date. Kite has an option to extend the research term for up to two additional one-year periods for a separate upfront fee of $10.0 million per year. All contingent payments under the agreement, when earned, will be non-refundable and non-creditable. Through the amendment and restatement of the agreement in September 2019, the Company and Kite agreed to expand the scope of the collaboration program to incorporate the use of lentiviral or retroviral vectors provided by Kite. Kite has the right to terminate this agreement in its entirety or on a per licensed product or per candidate target basis for any reason after a specified notice period. Each party has the right to terminate this agreement on account of the other party’s bankruptcy or material, uncured breach. The Company assessed the agreement with Kite in accordance with ASC Topic 606 and concluded that Kite is a customer. The transaction price includes the upfront license fee of $150.0 million and estimated reimbursable service costs for the research projects over the estimated performance period. None of the clinical or regulatory milestones have been included in the transaction price, as none of the milestones have yet been achieved, and all amounts are fully constrained. As part of its evaluation of the constraint, the Company considered numerous factors, including the fact that achievement of the milestones at this time is uncertain and contingent upon future periods when the uncertainty related to the variable consideration is resolved. The transaction price also includes actual and estimated payments by Kite for the work by Company researchers and reimbursement of the Company’s costs incurred with third-parties. The Company uses the expected value method to estimate payments related to the Company’s researchers’ work, taking into account the impact of constraint. Variable consideration is included in the transaction price only to the extent it is probable a significant reversal of cumulative revenues recognized would not occur. The Company will re-evaluate the transaction price including the estimated variable consideration included in the transaction price and all constrained amounts in each reporting period and as uncertain events are resolved or other changes in circumstances occur. The Company has identified four performance obligations within the Kite agreement as follows: (1) a license to the technology combined with the obligation to perform research and development services to apply the Company’s technology to Kite-selected targets; (2) production of research materials; and (3-4) two material rights, each for an extension of the research period for an additional one-year term. Such extensions contain material rights because their exercise does not require payment of a fee that is commensurate with the value of the incremental research term. The license to the Company’s intellectual property is not distinct from the related research and development activities as the licensed technology is not shared with and cannot be utilized by Kite without the research services performed by the Company. The Company allocated variable consideration (payments by Kite for the work performed by the Company’s researchers and third-party costs, as well as any future milestones and royalties) to the specific performance obligations to which they relate, as such allocation would meet the allocation objective in ASC Topic 606. The Company allocated the fixed consideration of $150.0 million to the performance obligations based on their relative standalone selling prices. Standalone selling prices of optional research years are similar to those of the initial year, but additionally take into account the intrinsic value of the discount upon exercise and the likelihood of exercise. Fees allocated to options with material rights are deferred until the options are exercised or expire. The exercise of options is accounted for as contract continuation, with target selection fees and estimated variable consideration included in the transaction price at that time and allocated specifically to the respective target’s performance obligation. Revenue for the combined license and research services performance obligations is recognized over time, as Kite consumes the benefit of such services as they are being performed by the Company. For the license combined with research and development services performance obligation, the Company recognizes revenue based on proportional performance of the ongoing research services over the period during which the Company performs the services. The estimation of progress towards the satisfaction of this performance obligation and project costs are reviewed quarterly and adjusted, as needed, to reflect the Company’s assumptions regarding the estimated volume of required activities. The production of research materials performance obligation is accounted for under the right to invoice practical expedient, as the Company has the right to invoice Kite for these services in an amount that corresponds directly with the value of the services. As of March 31, 2023 and December 31, 2022, the Company had a receivable of $1.0 million and $0.7 million, respectively, and deferred revenue of $8.0 million and $19.4 million, respectively, related to this agreement. Changes in deferred revenue balances during the three months ended March 31, 2023 relate to a reduction in the estimated future level of the Company's research and development services, as well as ongoing normal progress in the delivery of the performance obligations. The amounts of transaction price (excluding the amounts recognized as invoiced for the production of research materials performance obligation) remaining to be recognized were $8.6 million and $21.2 million, of which $1.5 million relates to fees allocated to options with material rights, as of March 31, 2023 and December 31, 2022, respectively. These amounts are expected to be recognized over the period through 2024. The timing of recognition will be affected by the volume of annual activity under the agreement and by whether and when Kite exercises options for additional years of services and could be subject to significant changes. Revenues recognized under the agreement were as follows (in thousands): Three Months Ended 2023 2022 Revenue related to Kite agreement: Recognition of license fee fixed consideration $ 11,440 $ 6,159 Research services variable consideration 868 149 Total $ 12,308 $ 6,308 In March 2023, the Company recorded an adjustment to revenue related to a change in estimate in connection with the collaboration agreement with Kite. This adjustment was driven by a reduction in the estimated future level of the Company’s research and development services and as a result, future project costs. This resulted in an increase in proportional cumulative performance on this collaboration and an increase in revenue of $8.9 million, an increase in net income of $8.9 million, and an increase in the Company’s basic and diluted earnings per share of $0.06 and $0.05, respectively, for the three months ended March 31, 2023. Sanofi S.A. In January 2014, the Company entered into an exclusive worldwide collaboration and license agreement (“2014 Collaboration Agreement”) to develop therapeutics for hemoglobinopathies, focused on beta thalassemia and sickle cell disease (“SCD”). The 2014 Collaboration Agreement was originally signed with BIMA, who subsequently assigned it to Bioverativ Inc., which was later acquired by Sanofi S.A (“Sanofi”). Under the 2014 Collaboration Agreement, the Company was originally jointly conducting two research programs: a beta thalassemia program, which was discontinued in the third quarter of 2021, and the SCD program, which resulted in the development of SAR445136 (now known as BIVV003), a ZFN, gene-edited cell therapy product candidate for the treatment of SCD. In December 2021, Sanofi notified the Company of its termination for convenience, effective June 28, 2022 (the “Termination Date”), of the 2014 Collaboration Agreement. A termination and transition agreement (the “Termination and Transition Agreement”) was executed by the parties on September 6, 2022. In the SCD program, the Company and Sanofi were jointly responsible for research and development activities prior to filing of an IND, but Sanofi was responsible for subsequent worldwide clinical development, manufacturing and commercialization of licensed products developed under the agreement. Subject to the terms of the agreement, the Company had granted Sanofi an exclusive, royalty-bearing license, with the right to grant sublicenses, to use certain ZF and other technology controlled by the Company for the purpose of researching, developing, manufacturing and commercializing licensed products developed under the agreement. The Company had also granted Sanofi a non-exclusive worldwide, royalty-free fully paid license with the right to grant sublicenses, under the Company’s interest in certain other intellectual property developed pursuant to the agreement. During the term of the agreement, the Company was not permitted to research, develop, manufacture or commercialize, outside of the agreement, certain gene therapy products that target genes relevant to the licensed products. Under the 2014 Collaboration Agreement, the Company received an upfront license fee of $20.0 million and was eligible to receive additional payments upon the achievement of specified clinical development, regulatory milestones, and sales milestones, as well as royalty payments for each licensed product based on net sales of such product. Sanofi was also to reimburse Sangamo for agreed upon costs incurred in connection with research and development activities conducted by Sangamo. Through the Termination Date, a total of $13.5 million was received based on achievement of clinical development milestones. No products have been approved and therefore no royalty fees have been or will be earned under the 2014 Collaboration Agreement. In its termination notice to the Company, Sanofi indicated that its termination relates to Sanofi’s change in strategic direction to focus on allogeneic universal genomic medicine approaches rather than autologous personalized cell therapies. As of the Termination Date, the 2014 Collaboration Agreement was terminated in its entirety and following the Termination Date, the Company will not be entitled to receive any further milestone payments or royalties from Sanofi. As of the Termination Date, Sanofi has no further obligations under the 2014 Collaboration Agreement to develop or to fund the development of any collaboration research programs under the 2014 Collaboration Agreement. The licenses granted to Sanofi under the 2014 Collaboration Agreement have been terminated, and the license rights have reverted to the Company. As part of the Termination and Transition Agreement, Sanofi granted to the Company exclusive, worldwide, fully paid, royalty-free, perpetual, irrevocable licenses, with the right to grant sublicenses through multiple tiers, to certain of its intellectual property, to develop, manufacture, have manufactured, use, sell, offer to sell, import and otherwise commercialize BIVV003, the product candidate in development under the SCD program. The Company agreed to take on responsibilities for all clinical trials related to BIVV003, including completion of the ongoing clinical trial and the related long-term follow-up study. The Company also assumed all regulatory responsibilities related to BIVV003. Sanofi transferred and assigned to the Company all documentation, materials and contracts with third parties related to BIVV003, and the right to use certain Sanofi-owned or leased equipment related to BIVV003. Sanofi has also agreed to reimburse the Company for the costs of conducting the ongoing clinical trial of BIVV003 and the costs of the long-term follow-up study through December 31, 2023, up to $7.0 million. In addition, should the Company elect not to continue the development of BIVV003 past December 31, 2023, Sanofi will become obligated to reimburse the Company for the costs of the long-term follow-up study incurred after 2023, up to $5.3 million. Sanofi’s reimbursement obligations will terminate upon certain triggering events, including the Company’s entering into a contract with a third party for collaboration, partnership, sale, licensing, or divestiture of BIVV003, or if the FDA permits early closure of the clinical trial and/or the long-term follow-up study. The Company assessed the 2014 Collaboration Agreement in accordance with ASC Topic 606 and concluded that Sanofi was a customer under that arrangement. The Company identified the performance obligation within this arrangement as a license to the technology combined with ongoing research services activities. The Company concluded that the license was not distinct as it did not have stand-alone value to Sanofi without the research services. As a result, the Company recognized revenue from the upfront payment and the milestones based on progress of performance of the ongoing research services. The estimation of progress towards the satisfaction of the performance obligation and project cost was reviewed quarterly and adjusted, as needed, to reflect the Company’s then current assumptions regarding the timing of its deliverables. Related costs and expenses under these arrangements have historically approximated the revenues recognized. Sanofi’s December 2021 notice of termination of the 2014 Collaboration Agreement represented a modification that reduced the expected scope of the Company’s services and the estimated transaction price and shortened the remaining performance timeline. Consistent with this change, all services provided by the Company under the 2014 Collaboration Agreement were completed by June 28, 2022, and all amounts ultimately included in the transaction price were recognized by such date. The final transaction price of $96.3 million included t

IMPAIRMENT OF GOODWILL AND LONG

IMPAIRMENT OF GOODWILL AND LONG-LIVED ASSETS	3 Months Ended
	Mar. 31, 2023
Goodwill and Intangible Assets Disclosure [Abstract]
IMPAIRMENT OF GOODWILL AND LONG-LIVED ASSETS	IMPAIRMENT OF GOODWILL AND LONG-LIVED ASSETS During the three months ended March 31, 2023, as a result of the sustained decline in the Company’s stock price and related market capitalization, termination of the collaboration agreements with Biogen and Novartis, and a general decline in equity values in the biotechnology industry, the Company performed an impairment assessment of goodwill, indefinite-lived intangible assets, and long-lived assets. The Company operates as a single reporting unit based on its business and reporting structure. For goodwill, a quantitative impairment assessment was performed using a market approach, whereby the Company’s fair value of equity was compared to its carrying value. The fair value of equity was derived using both the market capitalization of the Company and an estimate of a reasonable range of values of a control premium applied to the Company’s implied business enterprise value. The control premium was estimated based upon control premiums observed in comparable market transactions. This represents a level 2 nonrecurring fair value measurement. Based on this analysis, the Company recognized a non-cash, pre-tax goodwill impairment charge of $38.1 million during the three months ended March 31, 2023. As a result, the goodwill was fully impaired as of March 31, 2023. Before completing the goodwill impairment assessment, the Company first tested its indefinite-lived intangible assets and then its long-lived assets for impairment. The Company determined its indefinite-lived intangible assets were not impaired, as their carrying values were not in excess of their individual fair values. The Company determined all of its long-lived assets represent one asset group for purposes of long-lived asset impairment assessment. The Company concluded that the carrying value of the single asset group is not recoverable as it exceeded the future undiscounted cash flows the assets are expected to generate from the use and eventual disposition. To allocate and recognize the impairment loss, the Company determined individual fair value of long-lived assets. The Company, with the assistance of a third-party valuation firm, applied a discounted cash flow method to estimate fair values of its leasehold improvements and right-of-use assets, including leasehold improvements in the process of construction. This represents a level 3 nonrecurring fair value measurement. Based on this analysis, the Company recognized non-cash, pre-tax long-lived asset impairment charges of $11.2 million on the right-of-use assets, $5.0 million on the related leasehold improvements, and $4.2 million on construction-in-progress, during the three months ended March 31, 2023. No impairment was recognized on the remaining long-lived assets as their carrying values were not in excess of their fair values.

STOCK-BASED COMPENSATION

STOCK-BASED COMPENSATION	3 Months Ended
	Mar. 31, 2023
Share-Based Payment Arrangement [Abstract]
STOCK-BASED COMPENSATION	STOCK-BASED COMPENSATION The following table shows total stock-based compensation expense recognized in the accompanying Condensed Consolidated Statements of Operations (in thousands): Three Months Ended 2023 2022 Research and development $ 4,873 $ 4,670 General and administrative 3,404 3,021 Total stock-based compensation expense $ 8,277 $ 7,691

STOCKHOLDERS' EQUITY

STOCKHOLDERS' EQUITY	3 Months Ended
	Mar. 31, 2023
Equity [Abstract]
STOCKHOLDERS' EQUITY	STOCKHOLDERS’ EQUITY At-the-Market Offering Agreement In August 2020, the Company entered into an Open Market Sale Agreement℠ with Jefferies LLC (“Jefferies”) with respect to an at-the-market offering program under which the Company may offer and sell, from time to time at its sole discretion, shares of the Company’s common stock having an aggregate offering price of up to $150.0 million through Jefferies as the Company’s sales agent or principal. In December 2022, the Company entered into Amendment No. 2 to the Open Market Sale Agreement℠ which increased the aggregate offering price under the at-the-market offering program by an additional $175.0 million. The Company is not obligated to sell any shares under the sales agreement. During the three months ended March 31, 2023, the Company sold 3,962,430 shares of its common stock for net proceeds of approximately $9.7 million, of which approximately $0.6 million was received in April 2023 and recorded within prepaid expenses and other current assets on the Company’s Condensed Consolidated Balance Sheet as of March 31, 2023. No shares were sold under the sales agreement during the three months ended March 31, 2022.

INCOME TAXES

INCOME TAXES	3 Months Ended
	Mar. 31, 2023
Income Tax Disclosure [Abstract]
INCOME TAXES	INCOME TAXES The Company’s provision for income taxes for interim periods is determined using an estimate of its annual effective tax rate, adjusted for discrete items, if any, that arise during the period. Each quarter, the Company updates its estimate of the annual effective tax rate, and if the estimated annual effective tax rate changes, the Company makes a cumulative adjustment in such period. During the three months ended March 31, 2023 and 2022, the Company recorded income tax expense of $0.2 million and $0.1 million, respectively. The Company continues to maintain a full valuation allowance on its U.S. federal and state net deferred tax assets and on the Sangamo France net deferred tax assets, as the Company believes it is not more likely than not that these benefits will be realized. The tax expense for the three months ended March 31, 2023 was primarily due to foreign income tax expense. On August 16, 2022, the Inflation Reduction Act of 2022 was signed into law, and became effective in 2023, with tax provisions primarily focused on implementing a 15% minimum tax on global adjusted financial statement income and a 1% excise tax on share repurchases. The Company has evaluated the provisions of the tax law and noted that the law change would not have a material impact on the Condensed Consolidated Financial Statements.

SUBSEQUENT EVENTS

SUBSEQUENT EVENTS	3 Months Ended
	Mar. 31, 2023
Subsequent Events [Abstract]
SUBSEQUENT EVENTS	SUBSEQUENT EVENTSIn April 2023, the Company announced a restructuring of operations and corresponding reduction in workforce (the “Restructuring”), designed to reduce costs and increase focus on its key strategic priorities. Sangamo expects the Restructuring to result in the elimination of approximately 120 roles in the United States, or approximately 27% of its total United States workforce. The Company currently estimates that it will incur approximately $5 million to $7 million in cash-based expenses related to employee severance and notice period payments, benefits and related costs in connection with the Restructuring. The Company expects that the majority of the Restructuring charges will be incurred in the second quarter of 2023 and that the execution of the Restructuring will be substantially complete by the end of the third quarter of 2024. The Company may also incur other charges or cash expenditures not currently contemplated due to events that may occur as a result of, or associated with, the Restructuring.

ORGANIZATION, BASIS OF PRESEN_2

ORGANIZATION, BASIS OF PRESENTATION, AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Policies)	3 Months Ended
	Mar. 31, 2023
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Basis of Presentation	Basis of Presentation The accompanying unaudited Condensed Consolidated Financial Statements have been prepared in accordance with generally accepted accounting principles in the United States of America (“U.S. GAAP”) for interim financial information and pursuant to the rules and regulations of the Securities and Exchange Commission (“SEC”). Accordingly, they do not include all of the information and footnotes required by U.S. GAAP for complete financial statements. In the opinion of management, all adjustments (consisting only of normal recurring adjustments) considered necessary for a fair presentation of these financial statements for the periods presented have been included. Operating results for the three months ended March 31, 2023 are not necessarily indicative of the results that may be expected for the year ending December 31, 2023. The Condensed Consolidated Balance Sheet data at December 31, 2022 was derived from the audited Consolidated Financial Statements included in Sangamo’s Annual Report on Form 10-K for the year ended December 31, 2022 (the “2022 Annual Report”) as filed with the SEC on February 23, 2023. The accompanying Condensed Consolidated Financial Statements include the accounts of the Company and its subsidiaries. All intercompany balances and transactions have been eliminated in the Condensed Consolidated Financial Statements. The accompanying Condensed Consolidated Financial Statements and related financial information should be read together with the audited Consolidated Financial Statements and footnotes for the year ended December 31, 2022, included in the 2022 Annual Report.
Use of Estimates	Use of Estimates The preparation of Condensed Consolidated Financial Statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported in the Condensed Consolidated Financial Statements and the accompanying notes. On an ongoing basis, management evaluates its estimates including critical accounting policies or estimates related to revenue recognition, clinical trial accruals, income taxes, fair value of assets and liabilities, including from acquisitions, useful lives and impairment of long-lived assets, and stock-based compensation. Estimates are based on historical experience and on various other market specific and other relevant assumptions that the Company believes to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. Actual results could differ from those estimates.
Revenue Recognition	Revenue Recognition The Company accounts for its revenues pursuant to the provisions of Accounting Standards Codification Topic 606, Revenue from Contracts with Customers (“ASC Topic 606”). The Company’s contract revenues are derived from collaboration agreements including licensing arrangements and research services. Research and licensing agreements typically include nonrefundable upfront signing or license fees, payments at negotiated rates for time incurred by Company researchers, third-party cost reimbursements, additional target selection fees, sublicense fees, milestone payments tied to ongoing development and product commercialization, and royalties on future licensees’ product sales. All funds received from the Company’s collaboration partners are generally not refundable. Non-refundable upfront fees are fixed at the commencement of the contract. All other fees represent variable consideration in contracts. One of the Company’s contracts also contains a provision where the Company reimburses its customer for certain costs they incur which is accounted for as a reduction to the contract transaction price as the Company does not acquire any distinct goods or services in exchange for such payments. Deferred revenue primarily represents the portion of nonrefundable upfront fees or milestone payments received but not earned. In determining the appropriate amount of revenue to be recognized as the Company fulfills its obligations under its agreements, the Company performs the following steps: (i) identification of the promised goods or services in the contract; (ii) determination of whether the promised goods or services are performance obligations, including whether they are distinct in the context of the contract; (iii) measurement of the transaction price, including the constraint on variable consideration; (iv) allocation of the transaction price to the performance obligations based on estimated selling prices; and (v) recognition of revenue when (or as) the Company satisfies each performance obligation. Most of the Company’s performance obligations in its collaboration agreements represent distinct bundles of licenses of intellectual property and research and development services, with these components being individually non-distinct. Options to license the Company’s intellectual property and/or acquire research and development services also represent performance obligations when they grant customers a material right, e.g., a right to a discount the customer would not have received if they did not purchase the Company’s services under the existing contract. Revenues from bundles of licenses of intellectual property and research and development services are recognized over time using a proportional performance method. Under this method, revenue is recognized by measuring progress towards satisfaction of the relevant performance obligation using a measure that best depicts the progress towards satisfaction of the relevant performance obligation. For most of the Company’s agreements the measure of progress is an input measure based on a level of effort incurred, which includes the value of actual time by Company researchers plus third-party cost reimbursements. Consideration allocated to options that include material rights is deferred until the options are exercised or expire. The exercise of such options is accounted for as contract continuation, with target selection fees and estimated variable consideration included in the transaction price at that time and allocated specifically to the respective target’s performance obligation. Significant management judgment is required to determine the level of effort required under an arrangement, and the period over which the Company expects to complete its performance obligations under the arrangement. Changes in these estimates can have a material effect on revenue recognized. If the Company cannot reasonably estimate when its performance obligations either are completed or become inconsequential, then revenue recognition is deferred until the Company can reasonably make such estimates. For variable consideration, the amount included in the transaction price is constrained to the amount for which it is probable that a significant reversal of cumulative revenue recognized will not occur. At the end of each subsequent reporting period, the Company re-evaluates the estimated variable consideration included in the transaction price and any related constraint and, if necessary, adjusts its estimate of the overall transaction price. A cumulative catch-up is then recorded in the current period to reflect the updated transaction price and the updated measure of progress. The estimated period of performance and level of effort, including the value of Company researchers’ time and third-party costs, are reviewed quarterly and adjusted, as needed, to reflect the Company’s current expectations. As part of the accounting for these arrangements, the Company must develop assumptions that require judgment to determine the stand-alone selling price of each performance obligation identified in the contract. The Company uses key assumptions to determine the stand-alone selling price, which may include forecasted revenues, development timelines, discount rates and probabilities of exercise of technical and regulatory success, and the expected level of effort for research and development services. Contract modifications occur when the price and/or scope of an arrangement changes. If the modification consists of adding new distinct goods or services in exchange for consideration that reflects standalone selling prices of these goods and services, the modification is accounted for as a separate contract with the customer. Otherwise, if the remaining goods and services are distinct from those previously provided, the existing contract is considered terminated, and the remaining consideration is allocated to the remaining goods and services as if this was a newly signed contract. If the remaining goods and services are not distinct from those previously provided, the effects of the modification are accounted for in a manner similar to the effect of a change in the estimated measure of progress, with cumulative catch-up in revenue recorded at the time of the modification. If some of the remaining goods and services are distinct from those previously provided and others are not, to account for the effects of the modification the Company applies principles consistent with the objectives of the modification accounting. Revenues from major collaboration agreements and research activity grants as a percentage of total revenues were as follows: Three Months Ended 2023 2022 Biogen MA, Inc. 84 % 40 % Kite Pharma, Inc. 8 % 22 % Novartis Institutes for BioMedical Research, Inc. 6 % 32 % Sanofi S.A. — % 5 %
Impairment of Goodwill, Intangible Assets and Long-lived Assets	Impairment of Goodwill, Intangible Assets and Long-lived Assets Goodwill represents the excess of consideration transferred over the fair values of assets acquired and liabilities assumed in a business combination. Intangible assets with indefinite useful lives are related to purchased in-process research and development (“IPR&D”) projects and are measured at their respective fair values as of the acquisition date. Goodwill and intangible assets with indefinite useful lives are not amortized. Intangible assets related to IPR&D projects are considered to be indefinite-lived until the completion or abandonment of the associated research and development efforts. If and when development is complete, which generally occurs if and when regulatory approval to market a product is obtained, the associated assets would be deemed finite-lived and would then be amortized based on their respective estimated useful lives at that point in time. Goodwill and indefinite-lived intangible assets are assessed for impairment on an annual basis and whenever events and circumstances indicate that these assets may be impaired. The Company evaluates the fair value of long-lived assets, which include property and equipment, leasehold improvements and right-of-use assets, for impairment whenever events or changes in circumstances indicate that the carrying amounts of the asset may not be fully recoverable. In testing for goodwill impairment, the Company has the option of first performing a qualitative assessment to determine whether it is more likely than not that the fair value of the reporting unit is less than its carrying amount. If the Company elects to bypass the qualitative assessment, or if a qualitative assessment indicates it is more likely than not that the carrying value exceeds its fair value, the Company performs a quantitative goodwill impairment test to compare the fair value of its reporting unit to its carrying value, including goodwill. If the carrying value, including goodwill, exceeds the reporting unit’s fair value, the Company will recognize an impairment loss for the amount by which the carrying amount exceeds the reporting unit’s fair value (but not in excess of the carrying value of goodwill). Prior to testing goodwill for impairment, the Company also tests impairment for its other indefinite-lived and long-lived assets. The long-lived asset evaluation is performed at the asset group level, i.e., the lowest level for which identifiable cash flows are largely independent of the cash flows of other assets and liabilities. Recoverability of these assets is measured by a comparison of the carrying amounts of an asset group to the future undiscounted cash flows the assets are expected to generate from the use and eventual disposition. If such a review indicates that the carrying amount of the asset group is not recoverable, an impairment loss shall be measured as the amount by which the carrying amount of an asset group exceeds its fair value. Any impairment loss is allocated to the long-lived assets of the group on a pro rata basis using the relative carrying amounts of those assets, except that the carrying amount of an individual asset shall not be reduced below its fair value. Factors that may indicate potential impairment and trigger an impairment test include, but are not limited to, general macroeconomic conditions, conditions specific to the industry and market, an adverse change in legal factors, business climate or operational performance of the business, and sustained decline in the stock price and market capitalization compared to the net book value. Calculating the fair value of a reporting unit, an asset group and an individual asset involves significant estimates and assumptions. These estimates and assumptions include, among others, projected future cash flows, risk-adjusted discount rates, future economic and market conditions, and the determination of appropriate market comparables. Changes in these factors and assumptions used can materially affect the amount of impairment loss recognized in the period the asset was considered impaired.
Cash, Cash Equivalents and Restricted Cash	Cash, Cash Equivalents, and Restricted Cash Sangamo considers all highly liquid investments purchased with original maturities of three months or less at the purchase date to be cash equivalents. Cash and cash equivalents consist of cash, deposits in demand money market accounts and U.S. government-sponsored entity debt securities. Restricted cash consists of a letter of credit for $1.5 million, representing a deposit for the lease of the corporate headquarters in Brisbane, California.
Leases	Leases The Company determines if an arrangement is or contains a lease at inception by assessing whether the arrangement contains an identified asset and whether it has the right to control the identified asset. Right-of-use assets represent the Company’s right to use an underlying asset for the lease term and lease liabilities represent the Company’s obligation to make lease payments arising from the lease. Lease liabilities are recognized at the lease commencement date based on the present value of future lease payments over the lease term. Right-of-use assets are based on the measurement of the lease liability and also include any lease payments made prior to or on lease commencement and exclude lease incentives and initial direct costs incurred, as applicable. As the implicit rate in the Company’s leases is generally unknown, the Company uses its incremental borrowing rate based on the information available at the lease commencement date in determining the present value of remaining lease payments. The incremental borrowing rate represents an estimate of the interest rate the Company would incur at lease commencement to borrow an amount equal to the lease payments on a collateralized basis over the term of a lease in a similar economic environment. The Company considers its credit risk, term of the lease, and total lease payments and adjusts for the impacts of collateral, as necessary, when calculating its incremental borrowing rates. The lease terms may include options to extend or terminate the lease when it is reasonably certain the Company will exercise any such options. Rent expense for the Company’s operating leases is recognized on a straight-line basis over the lease term. The Company will evaluate the lease arrangement for impairment whenever events or changes in circumstances indicate that the carrying amounts of the right-of-use asset may not be fully recoverable. To the extent an impairment of the right-of-use asset is recognized, the Company will recognize lease impairment and subsequently amortize the remaining lease asset on a straight-line basis (unless another systematic basis is more representative of the pattern in which the Company expects to consume the future economic benefits from the asset) from the date of impairment to the earlier of the end of the right-of-use asset’s useful life or the end of the lease term. The Company has elected not to separate lease and non-lease components for its real estate and copier leases and, as a result, accounts for any lease and non-lease components as a single lease component. The Company has also elected not to apply the recognition requirement to any leases with a term of 12 months or less and does not include an option to purchase the underlying asset that the Company is reasonably certain to exercise.
Recently Adopted Accounting Pronouncements	Recently Adopted Accounting Pronouncements None.
Fair Value Measurements	FAIR VALUE MEASUREMENTS The Company measures certain financial assets and liabilities at fair value on a recurring basis, including cash equivalents and marketable securities. Fair value is determined based on a three-tier hierarchy under the authoritative guidance for fair value measurements and disclosures that prioritizes the inputs used in measuring fair value as follows: Level 1: Unadjusted quoted prices in active markets that are accessible at the measurement date for identical, unrestricted assets or liabilities; Level 2: Quoted prices in markets that are not active or inputs which are observable, either directly or indirectly, for substantially the full term of the asset or liability; and Level 3: Prices or valuation techniques that require inputs that are both significant to the fair value measurements and unobservable (i.e., supported by little or no market activity).

ORGANIZATION, BASIS OF PRESEN_3

ORGANIZATION, BASIS OF PRESENTATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Tables)	3 Months Ended
	Mar. 31, 2023
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Schedule of Revenue from Strategic Partnering Collaboration Agreements and Research Activity Grants as a Percentage of Total Revenues	Revenues from major collaboration agreements and research activity grants as a percentage of total revenues were as follows: Three Months Ended 2023 2022 Biogen MA, Inc. 84 % 40 % Kite Pharma, Inc. 8 % 22 % Novartis Institutes for BioMedical Research, Inc. 6 % 32 % Sanofi S.A. — % 5 %
Schedule of Cash and Cash Equivalents	A reconciliation of cash, cash equivalents, and restricted cash reported within the Condensed Consolidated Balance Sheets to the amounts reported within the accompanying Condensed Consolidated Statements of Cash Flows is as follows (in thousands): March 31, December 31, March 31, December 31, Cash and cash equivalents $ 78,241 $ 100,444 $ 120,257 $ 178,872 Non-current restricted cash 1,500 1,500 1,500 1,500 Cash, cash equivalents, and restricted cash as reported within the accompanying Condensed Consolidated Statements of Cash Flows $ 79,741 $ 101,944 $ 121,757 $ 180,372
Restrictions on Cash and Cash Equivalents	A reconciliation of cash, cash equivalents, and restricted cash reported within the Condensed Consolidated Balance Sheets to the amounts reported within the accompanying Condensed Consolidated Statements of Cash Flows is as follows (in thousands): March 31, December 31, March 31, December 31, Cash and cash equivalents $ 78,241 $ 100,444 $ 120,257 $ 178,872 Non-current restricted cash 1,500 1,500 1,500 1,500 Cash, cash equivalents, and restricted cash as reported within the accompanying Condensed Consolidated Statements of Cash Flows $ 79,741 $ 101,944 $ 121,757 $ 180,372

FAIR VALUE MEASUREMENTS (Tables

FAIR VALUE MEASUREMENTS (Tables)	3 Months Ended
	Mar. 31, 2023
Fair Value Disclosures [Abstract]
Summary of Fair Value Measurements of Cash Equivalents and Marketable Securities	The fair value measurements of the Company’s cash equivalents and marketable securities are identified at the following levels within the fair value hierarchy (in thousands): March 31, 2023 Fair Value Measurements Total Level 1 Level 2 Level 3 Assets: Cash equivalents: Money market funds $ 34,474 $ 34,474 $ — $ — Total 34,474 34,474 — — Marketable securities: U.S. government-sponsored entity debt securities 33,720 — 33,720 — Commercial paper securities 70,836 — 70,836 — Corporate debt securities 8,311 — 8,311 — Asset-backed securities 14,613 — 14,613 — U.S. treasury bills 5,596 — 5,596 — Certificates of deposit 29,680 — 29,680 — Total 162,756 — 162,756 — Total cash equivalents and marketable securities $ 197,230 $ 34,474 $ 162,756 $ — December 31, 2022 Fair Value Measurements Total Level 1 Level 2 Level 3 Assets: Cash equivalents: Money market funds $ 50,820 $ 50,820 $ — $ — Total 50,820 50,820 — — Marketable securities: U.S. government-sponsored entity debt securities 18,417 — 18,417 — Commercial paper securities 101,165 — 101,165 — Corporate debt securities 11,670 — 11,670 — Asset-backed securities 24,792 — 24,792 — U.S. treasury bills 7,938 — 7,938 — Certificates of deposit 37,461 — 37,461 — Agency bonds 5,590 — 5,590 — Total 207,033 — 207,033 — Total cash equivalents and marketable securities $ 257,853 $ 50,820 $ 207,033 $ —

CASH EQUIVALENTS AND MARKETAB_2

CASH EQUIVALENTS AND MARKETABLE SECURITIES - (Tables)	3 Months Ended
	Mar. 31, 2023
Investments, Debt and Equity Securities [Abstract]
Marketable Securities	The table below summarizes the Company’s cash equivalents and marketable securities (in thousands): Amortized Gross Gross Estimated March 31, 2023 Assets Cash equivalents: Money market funds $ 34,474 $ — $ — $ 34,474 Total 34,474 — — 34,474 Marketable securities: U.S. government-sponsored entity debt securities 33,753 94 (127) 33,720 Commercial paper securities 70,906 9 (79) 70,836 Corporate debt securities 8,335 — (24) 8,311 Asset-backed securities 14,689 — (76) 14,613 U.S. treasury bills 5,598 — (2) 5,596 Certificates of deposit 29,761 2 (83) 29,680 Total 163,042 105 (391) 162,756 Total cash equivalents and marketable securities $ 197,516 $ 105 $ (391) $ 197,230 December 31, 2022 Assets Cash equivalents: Money market funds $ 50,820 $ — $ — $ 50,820 Total 50,820 — — 50,820 Marketable securities: U.S. government-sponsored entity debt securities 18,710 — (293) 18,417 Commercial paper securities 101,336 22 (193) 101,165 Corporate debt securities 11,760 — (90) 11,670 Asset-backed securities 24,970 2 (180) 24,792 U.S. treasury bills 7,950 — (12) 7,938 Certificates of deposit 37,599 4 (142) 37,461 Agency bonds 5,598 — (8) 5,590 Total 207,923 28 (918) 207,033 Total cash equivalents and marketable securities $ 258,743 $ 28 $ (918) $ 257,853
Fair value of investments available-for-sale	The fair value of marketable securities by contractual maturity were as follows (in thousands): March 31, December 31, Maturing in one year or less $ 127,147 $ 177,188 Maturing after one year through five years 35,609 29,845 Total $ 162,756 $ 207,033

BASIC AND DILUTED NET INCOME _2

BASIC AND DILUTED NET INCOME (LOSS) PER SHARE (Tables)	3 Months Ended
	Mar. 31, 2023
Earnings Per Share [Abstract]
Components of Basic and Diluted Net Income (Loss) per Share	The components of basic and diluted net income (loss) per share are as follows (in thousands, except per share amounts): Three Months Ended 2023 2022 Numerator: Net income (loss) $ 21,133 $ (43,977) Denominator: Basic: Weighted average number of common shares outstanding - basic 168,533 146,218 Diluted: Weighted average number of common shares outstanding - basic 168,533 146,218 Dilutive effect of restricted stock units 300 — Dilutive effect of common stock pursuant to employee stock purchase plan 348 — Weighted average number of common shares outstanding - diluted 169,181 146,218 Net income (loss) per share: Basic $ 0.13 $ (0.30) Diluted $ 0.12 $ (0.30)

MAJOR CUSTOMERS, PARTNERSHIPS_2

MAJOR CUSTOMERS, PARTNERSHIPS AND STRATEGIC ALLIANCES (Tables)	3 Months Ended
	Mar. 31, 2023
Novartis Institutes for BioMedical Research, Inc.
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues Recognized under Agreement	Revenues recognized under the agreement were as follows (in thousands): Three Months Ended 2023 2022 Revenue related to Novartis agreement: Recognition of upfront license fee $ 7,696 $ 7,018 Research services 2,059 1,877 Total $ 9,755 $ 8,895
Biogen MA, Inc.
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues Recognized under Agreement	Revenues recognized under the agreement were as follows (in thousands): Three Months Ended 2023 2022 Revenue related to Biogen agreement: Recognition of license and other fixed consideration $ 130,630 $ 7,306 Cost-sharing payments for research services, net variable consideration 1,672 3,887 Total $ 132,302 $ 11,193
Kite Pharma, Inc.
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues Recognized under Agreement	Revenues recognized under the agreement were as follows (in thousands): Three Months Ended 2023 2022 Revenue related to Kite agreement: Recognition of license fee fixed consideration $ 11,440 $ 6,159 Research services variable consideration 868 149 Total $ 12,308 $ 6,308
Sanofi S.A.
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues Recognized under Agreement	Revenues recognized under the 2014 Collaboration Agreement were as follows (in thousands): Three Months Ended 2023 2022 Revenue related to Sanofi agreement: Recognition of upfront fee $ — $ 311 Research services — 978 Milestone achievement — 210 Total $ — $ 1,499

STOCK-BASED COMPENSATION (Table

STOCK-BASED COMPENSATION (Tables)	3 Months Ended
	Mar. 31, 2023
Share-Based Payment Arrangement [Abstract]
Stock-Based Compensation Expense	The following table shows total stock-based compensation expense recognized in the accompanying Condensed Consolidated Statements of Operations (in thousands): Three Months Ended 2023 2022 Research and development $ 4,873 $ 4,670 General and administrative 3,404 3,021 Total stock-based compensation expense $ 8,277 $ 7,691

ORGANIZATION, BASIS OF PRESEN_4

ORGANIZATION, BASIS OF PRESENTATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands	1 Months Ended	3 Months Ended		12 Months Ended
	Mar. 31, 2023	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2022	Dec. 31, 2021
Change in Accounting Estimate [Line Items]
Capital resources	$ 241,000	$ 241,000
Net income (loss)		21,133	$ (43,977)	$ (192,300)	$ (178,300)
Accumulated deficit	1,127,412	1,127,412		$ 1,148,545
Letter of credit established as a deposit	1,500	$ 1,500
Kite Pharma, Inc.
Change in Accounting Estimate [Line Items]
Change in estimate of transaction price, increase in revenue	8,900
Increase in net income	$ 8,900
Increased earnings per share, basic (in dollars per share)	$ 0.06
Increased earnings per share, diluted (in dollars per share)	$ 0.05

ORGANIZATION, BASIS OF PRESEN_5

ORGANIZATION, BASIS OF PRESENTATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - Revenues from Strategic Partnering Collaboration Agreements and Research Activity Grants (Details) - Revenue from contract with customer - Customer concentration risk	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Biogen MA, Inc.
Concentration Risk [Line Items]
Percentage of revenues	84%	40%
Kite Pharma, Inc.
Concentration Risk [Line Items]
Percentage of revenues	8%	22%
Novartis Institutes for BioMedical Research, Inc.
Concentration Risk [Line Items]
Percentage of revenues	6%	32%
Sanofi S.A.
Concentration Risk [Line Items]
Percentage of revenues	0%	5%

ORGANIZATION, BASIS OF PRESEN_6

ORGANIZATION, BASIS OF PRESENTATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - Reconciliation of Cash and Cash Equivalents (Details) - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022	Mar. 31, 2022	Dec. 31, 2021
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Cash and cash equivalents	$ 78,241	$ 100,444	$ 120,257	$ 178,872
Non-current restricted cash	1,500	1,500	1,500	1,500
Cash, cash equivalents, and restricted cash as reported within the accompanying Condensed Consolidated Statements of Cash Flows	$ 79,741	$ 101,944	$ 121,757	$ 180,372

FAIR VALUE MEASUREMENTS (Detail

FAIR VALUE MEASUREMENTS (Details) - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	$ 162,756	$ 207,033
Money market funds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total cash equivalents	34,474	50,820
U.S. government-sponsored entity debt securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	33,720	18,417
Commercial paper securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	70,836	101,165
Corporate debt securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	8,311	11,670
Asset-backed securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	14,613	24,792
U.S. treasury bills
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	5,596	7,938
Certificates of deposit
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	29,680	37,461
Agency bonds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities		5,590
Fair value on recurring basis
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total cash equivalents	34,474	50,820
Total marketable securities	162,756	207,033
Total cash equivalents and marketable securities and free shares asset	197,230	257,853
Fair value on recurring basis | Money market funds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total cash equivalents	34,474	50,820
Fair value on recurring basis | U.S. government-sponsored entity debt securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	33,720	18,417
Fair value on recurring basis | Commercial paper securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	70,836	101,165
Fair value on recurring basis | Corporate debt securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	8,311	11,670
Fair value on recurring basis | Asset-backed securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	14,613	24,792
Fair value on recurring basis | U.S. treasury bills
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	5,596	7,938
Fair value on recurring basis | Certificates of deposit
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	29,680	37,461
Fair value on recurring basis | Agency bonds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities		5,590
Fair value on recurring basis | Level 1
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total cash equivalents	34,474	50,820
Total marketable securities	0	0
Total cash equivalents and marketable securities and free shares asset	34,474	50,820
Fair value on recurring basis | Level 1 | Money market funds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total cash equivalents	34,474	50,820
Fair value on recurring basis | Level 1 | U.S. government-sponsored entity debt securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	0	0
Fair value on recurring basis | Level 1 | Commercial paper securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	0	0
Fair value on recurring basis | Level 1 | Corporate debt securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	0	0
Fair value on recurring basis | Level 1 | Asset-backed securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	0	0
Fair value on recurring basis | Level 1 | U.S. treasury bills
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	0	0
Fair value on recurring basis | Level 1 | Certificates of deposit
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	0	0
Fair value on recurring basis | Level 1 | Agency bonds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities		0
Fair value on recurring basis | Level 2
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total cash equivalents	0	0
Total marketable securities	162,756	207,033
Total cash equivalents and marketable securities and free shares asset	162,756	207,033
Fair value on recurring basis | Level 2 | Money market funds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total cash equivalents	0	0
Fair value on recurring basis | Level 2 | U.S. government-sponsored entity debt securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	33,720	18,417
Fair value on recurring basis | Level 2 | Commercial paper securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	70,836	101,165
Fair value on recurring basis | Level 2 | Corporate debt securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	8,311	11,670
Fair value on recurring basis | Level 2 | Asset-backed securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	14,613	24,792
Fair value on recurring basis | Level 2 | U.S. treasury bills
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	5,596	7,938
Fair value on recurring basis | Level 2 | Certificates of deposit
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	29,680	37,461
Fair value on recurring basis | Level 2 | Agency bonds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities		5,590
Fair value on recurring basis | Level 3
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total cash equivalents	0	0
Total marketable securities	0	0
Total cash equivalents and marketable securities and free shares asset	0	0
Fair value on recurring basis | Level 3 | Money market funds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total cash equivalents	0	0
Fair value on recurring basis | Level 3 | U.S. government-sponsored entity debt securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	0	0
Fair value on recurring basis | Level 3 | Commercial paper securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	0	0
Fair value on recurring basis | Level 3 | Corporate debt securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	0	0
Fair value on recurring basis | Level 3 | Asset-backed securities
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	0	0
Fair value on recurring basis | Level 3 | U.S. treasury bills
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	0	0
Fair value on recurring basis | Level 3 | Certificates of deposit
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities	$ 0	0
Fair value on recurring basis | Level 3 | Agency bonds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total marketable securities		$ 0

CASH EQUIVALENTS AND MARKETAB_3

CASH EQUIVALENTS AND MARKETABLE SECURITIES - Summary of Cash Equivalents and Available-for-Sale Securities (Details) - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022	Mar. 31, 2022	Dec. 31, 2021
ASSETS
Cash and cash equivalents, at carrying value, total	$ 78,241	$ 100,444	$ 120,257	$ 178,872
Available-for-sale securities, amortized cost	163,042	207,923
Available-for-sale securities, gross unrealized gains	105	28
Available-for-sale securities, gross unrealized (Losses)	(391)	(918)
Available-for-sale securities, estimated fair value	162,756	207,033
Total cash equivalents and available-for-sale securities, amortized cost	197,516	258,743
Total cash equivalents and available-for-sale securities, gross unrealized gains	105	28
Total cash equivalents and available-for-sale securities, gross unrealized (losses)	(391)	(918)
Total cash equivalents and available-for-sale securities, estimated fair value	197,230	257,853
Money market funds
ASSETS
Cash and cash equivalents, at carrying value, total	34,474	50,820
Cash equivalents, gross unrealized gains	0	0
Cash and cash equivalents accumulated gross unrealized loss before tax	0	0
Cash equivalents, estimated fair value	34,474	50,820
Cash equivalents:
ASSETS
Cash and cash equivalents, at carrying value, total	34,474	50,820
Cash equivalents, gross unrealized gains	0	0
Cash and cash equivalents accumulated gross unrealized loss before tax	0	0
Cash equivalents, estimated fair value	34,474	50,820
U.S. government-sponsored entity debt securities
ASSETS
Available-for-sale securities, amortized cost	33,753	18,710
Available-for-sale securities, gross unrealized gains	94	0
Available-for-sale securities, gross unrealized (Losses)	(127)	(293)
Available-for-sale securities, estimated fair value	33,720	18,417
Commercial paper securities
ASSETS
Available-for-sale securities, amortized cost	70,906	101,336
Available-for-sale securities, gross unrealized gains	9	22
Available-for-sale securities, gross unrealized (Losses)	(79)	(193)
Available-for-sale securities, estimated fair value	70,836	101,165
Corporate debt securities
ASSETS
Available-for-sale securities, amortized cost	8,335	11,760
Available-for-sale securities, gross unrealized gains	0	0
Available-for-sale securities, gross unrealized (Losses)	(24)	(90)
Available-for-sale securities, estimated fair value	8,311	11,670
Asset-backed securities
ASSETS
Available-for-sale securities, amortized cost	14,689	24,970
Available-for-sale securities, gross unrealized gains	0	2
Available-for-sale securities, gross unrealized (Losses)	(76)	(180)
Available-for-sale securities, estimated fair value	14,613	24,792
U.S. treasury bills
ASSETS
Available-for-sale securities, amortized cost	5,598	7,950
Available-for-sale securities, gross unrealized gains	0	0
Available-for-sale securities, gross unrealized (Losses)	(2)	(12)
Available-for-sale securities, estimated fair value	5,596	7,938
Certificates of deposit
ASSETS
Available-for-sale securities, amortized cost	29,761	37,599
Available-for-sale securities, gross unrealized gains	2	4
Available-for-sale securities, gross unrealized (Losses)	(83)	(142)
Available-for-sale securities, estimated fair value	$ 29,680	37,461
Agency bonds
ASSETS
Available-for-sale securities, amortized cost		5,598
Available-for-sale securities, gross unrealized gains		0
Available-for-sale securities, gross unrealized (Losses)		(8)
Available-for-sale securities, estimated fair value		$ 5,590

CASH EQUIVALENTS AND MARKETAB_4

CASH EQUIVALENTS AND MARKETABLE SECURITIES - Summary of Available-for-Sale Securities by Contractual Maturity (Details) - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Investments, Debt and Equity Securities [Abstract]
Maturing in one year or less	$ 127,147	$ 177,188
Maturing after one year through five years	35,609	29,845
Total	$ 162,756	$ 207,033

CASH EQUIVALENTS AND MARKETAB_5

CASH EQUIVALENTS AND MARKETABLE SECURITIES - Additional Information (Details) - USD ($)	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2022
Investments, Debt and Equity Securities [Abstract]
Realized investment gains (losses)	$ 0	$ 0
Allowance for credit loss related to marketable securities, not previously recorded	0	0
Other impairment charges related to marketable securities	0	$ 0
Allowance for credit loss related to marketable securities	$ 0		$ 0

BASIC AND DILUTED NET INCOME _3

BASIC AND DILUTED NET INCOME (LOSS) PER SHARE - Components of Basic and Diluted Net Income (Loss) per Share (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands	3 Months Ended		12 Months Ended
	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2022	Dec. 31, 2021
Numerator:
Net income (loss)	$ 21,133	$ (43,977)	$ (192,300)	$ (178,300)
Basic:
Weighted average number of common shares outstanding - basic (in shares)	168,533	146,218
Diluted:
Weighted average number of common shares outstanding - basic (in shares)	168,533	146,218
Weighted average number of common shares outstanding - diluted (in shares)	169,181	146,218
Net income (loss) per share:
Basic (in dollars per share)	$ 0.13	$ (0.30)
Diluted (in dollars per share)	$ 0.12	$ (0.30)
Restricted Stock Units (RSUs)
Diluted:
Dilutive effect of share-based payment arrangements (in shares)	300	0
Share-Based Payment Arrangement
Diluted:
Dilutive effect of share-based payment arrangements (in shares)	348	0

BASIC AND DILUTED NET INCOME _4

BASIC AND DILUTED NET INCOME (LOSS) PER SHARE - Narrative (Details) - shares shares in Millions	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Earnings Per Share [Abstract]
Antidilutive securities (in shares)	14.7	19.1

MAJOR CUSTOMERS, PARTNERSHIPS_3

MAJOR CUSTOMERS, PARTNERSHIPS AND STRATEGIC ALLIANCES - Novartis Institutes for BioMedical Research, Inc. (Details) - USD ($) $ in Thousands		1 Months Ended	3 Months Ended		12 Months Ended
	Jul. 27, 2020	Aug. 31, 2020	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2020	Dec. 31, 2022
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Accounts receivable			$ 7,026			$ 3,678
Novartis Institutes for BioMedical Research, Inc.
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Capitalized contract cost, amortization expense			200	$ 100
Novartis Institutes for BioMedical Research, Inc. | Collaboration And License Agreement
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Proceeds from collaborators		$ 75,000
Collaborative arrangement transaction price	$ 95,100
Collaborative arrangement, license fee	75,000
Collaborative arrangement estimated reimbursable service costs	$ 20,100
Accounts receivable			2,100			2,200
Deferred revenue			$ 1,900			$ 9,600
Financial advisory fees					$ 1,500
Percent of initial recognition					2%

MAJOR CUSTOMERS, PARTNERSHIPS_4

MAJOR CUSTOMERS, PARTNERSHIPS AND STRATEGIC ALLIANCES - Revenues Recognized under Agreement (Details) - USD ($) $ in Thousands	3 Months Ended		102 Months Ended
	Mar. 31, 2023	Mar. 31, 2022	Jun. 28, 2022
Revenue related to Sanofi agreement:
Revenues	$ 157,957	$ 28,231
Novartis Institutes for BioMedical Research, Inc.
Revenue related to Sanofi agreement:
Revenues	9,755	8,895
Novartis Institutes for BioMedical Research, Inc. | License and Service
Revenue related to Sanofi agreement:
Revenues	7,696	7,018
Novartis Institutes for BioMedical Research, Inc. | Research services
Revenue related to Sanofi agreement:
Revenues	2,059	1,877
Biogen MA, Inc.
Revenue related to Sanofi agreement:
Revenues	132,302	11,193
Biogen MA, Inc. | License
Revenue related to Sanofi agreement:
Revenues	130,630	7,306
Biogen MA, Inc. | Research services
Revenue related to Sanofi agreement:
Revenues	1,672	3,887
Kite Pharma, Inc.
Revenue related to Sanofi agreement:
Revenues	12,308	6,308
Kite Pharma, Inc. | License
Revenue related to Sanofi agreement:
Revenues	11,440	6,159
Kite Pharma, Inc. | Research services
Revenue related to Sanofi agreement:
Revenues	868	149
Sanofi S.A.
Revenue related to Sanofi agreement:
Revenues	0	1,499	$ 13,500
Sanofi S.A. | License and Service
Revenue related to Sanofi agreement:
Revenues	0	311
Sanofi S.A. | Research services
Revenue related to Sanofi agreement:
Revenues	0	978
Sanofi S.A. | Milestone achievement
Revenue related to Sanofi agreement:
Revenues	$ 0	$ 210

MAJOR CUSTOMERS, PARTNERSHIPS_5

MAJOR CUSTOMERS, PARTNERSHIPS AND STRATEGIC ALLIANCES - Biogen MA, Inc. (Details) $ / shares in Units, $ in Thousands	1 Months Ended		3 Months Ended		12 Months Ended
	May 31, 2020 USD ($)	Apr. 30, 2020 USD ($) product_target $ / shares shares	Mar. 31, 2023 USD ($)	Mar. 31, 2022 USD ($)	Dec. 31, 2020 USD ($)	Dec. 31, 2022 USD ($) material_right
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Accounts receivable			$ 7,026			$ 3,678
General and administrative expense			18,136	$ 14,908
Biogen MA, Inc.
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Change in estimate of transaction price, increase in revenue			127,100
Biogen MA, Inc. | License and Service
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Fixed consideration		$ 204,600
Number of material rights expired | material_right						1
Number of material rights outstanding | material_right						7
Remaining performance obligation amount			1,700			$ 151,300
General and administrative expense			2,600	$ 100
Biogen MA, Inc. | Stock Purchase Agreement
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Sale of stock, number of shares issued in transaction (in shares) | shares		24,420,157
Sale of stock, price per share (in dollars per share) | $ / shares		$ 9.2137
Consideration received on transaction		$ 225,000
Sale of stock, excess consideration received on transaction		79,600
Collaboration agreement, equity issued		145,400
Accounts receivable			700			500
Deferred revenue			1,500			$ 132,200
Net pension losses					$ 2,900
Biogen MA, Inc. | Collaboration And License Agreement
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Proceeds from collaborators	$ 125,000	$ 125,000
Number of neurological disease gene targets selected by counterparty (in product targets) | product_target		4
Number of additional neurological disease gene targets (in product targets) | product_target		7
Financial advisory fees					$ 7,000
Percent of initial recognition		2%
Contract with customer, asset, after allowance for credit Loss			$ 4,100

MAJOR CUSTOMERS, PARTNERSHIPS_6

MAJOR CUSTOMERS, PARTNERSHIPS AND STRATEGIC ALLIANCES - Kite Pharma, Inc. (Details) $ / shares in Units, $ in Thousands	1 Months Ended
	Mar. 31, 2023 USD ($) $ / shares	Sep. 30, 2019 USD ($) performance_obligation material_right	Apr. 30, 2018 USD ($) milestone option	Dec. 31, 2022 USD ($)
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Accounts receivable	$ 7,026			$ 3,678
Kite Pharma, Inc.
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Change in estimate of transaction price, increase in revenue	8,900
Increased net income	$ 8,900
Increased earnings per share, basic (in dollars per share) | $ / shares	$ 0.06
Increased earnings per share, diluted (in dollars per share) | $ / shares	$ 0.05
Kite Pharma, Inc. | License and Service
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Contract with customer liability			$ 150,000
Number of remaining performance obligations | performance_obligation		4
Number of material rights for renewal of research period | material_right		2
Renewal period		1 year
Fixed consideration		$ 150,000
Remaining performance obligation amount	$ 8,600			21,200
Remaining performance obligation amount, related to material rights	1,500			1,500
Kite Pharma, Inc. | Collaboration And License Agreement
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Milestone payments received			$ 150,000
Initial research term of agreement			6 years
Number of options to extend initial research term | option			2
Extended research term of agreement			1 year
Separate fee for additional term			$ 10,000
Contract with customer liability	8,000			19,400
Accounts receivable	$ 1,000			$ 700
Kite Pharma, Inc. | Collaboration And License Agreement | Achievement of specified research, clinical development, regulatory and first commercial sale milestones
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Contingent development and sales-based milestone payments to be received			1,300,000
Kite Pharma, Inc. | Collaboration And License Agreement | Achievement of specified sales-based milestones if annual worldwide net sales of licensed products reach specified levels
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Contingent development and sales-based milestone payments to be received			$ 1,800,000
Maximum amount of achieved milestones to receive payment | milestone			10
Kite Pharma, Inc. | Collaboration And License Agreement | Maximum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Development and sales-based milestone payments to be received			$ 3,000,000

MAJOR CUSTOMERS, PARTNERSHIPS_7

MAJOR CUSTOMERS, PARTNERSHIPS AND STRATEGIC ALLIANCES - Sanofi S.A. (Details)		1 Months Ended	3 Months Ended		102 Months Ended
	Sep. 06, 2022 USD ($)	Jan. 31, 2014 USD ($) program	Mar. 31, 2023 USD ($) product milestone	Mar. 31, 2022 USD ($)	Jun. 28, 2022 USD ($)	Dec. 31, 2022 USD ($)
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues			$ 157,957,000	$ 28,231,000
Accounts receivable			7,026,000			$ 3,678,000
Prepaid Expenses and Other Current Assets
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Decrease in research and development expense			500,000
Sanofi S.A.
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Number of research programs | program		2
Revenues under agreement		$ 20,000,000
Revenues			$ 0	$ 1,499,000	$ 13,500,000
Number of products approved | product			0
Expenses reimbursable through December 31, 2023 (up to)	$ 7,000,000
Expenses reimbursable after December 31, 2023 (up to)	$ 5,300,000
Sanofi S.A. | Collaboration And License Agreement
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues under agreement					20,000,000
Number of milestones included in transaction price | milestone			0
Collaborative arrangement transaction price					96,300,000
Collaborative arrangement estimated reimbursable service costs					62,800,000
Accounts receivable			$ 0			0
Contract with customer liability			$ 0			$ 0
Sanofi S.A. | Collaboration And License Agreement | Milestone Three
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Milestone revenue receivable					$ 13,500,000

MAJOR CUSTOMERS, PARTNERSHIPS_8

MAJOR CUSTOMERS, PARTNERSHIPS AND STRATEGIC ALLIANCES - Pfizer Inc. (Details)	1 Months Ended			3 Months Ended		12 Months Ended	64 Months Ended	71 Months Ended
	Sep. 30, 2020 USD ($)	Dec. 31, 2017 USD ($)	May 31, 2017 USD ($)	Mar. 31, 2023 USD ($)	Mar. 31, 2022 USD ($)	Dec. 31, 2020 USD ($)	Mar. 31, 2023 USD ($) milestone product	Mar. 31, 2023 USD ($) milestone product
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues				$ 157,957,000	$ 28,231,000
Pfizer Inc.
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Agreement termination, term			15 years
Pfizer Inc. | S B Five Two Five And Other Products
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues under agreement			$ 70,000,000
Potential amount to be funded for achievement of specified commercialized and sales milestones			266,500,000
Milestone revenue receivable			300,000,000
Pfizer Inc. | S B Five Two Five And Other Products | Achievement of specified clinical development intellectual property and regulatory milestones
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Development and sales-based milestone payments to be received			208,500,000
Pfizer Inc. | S B Five Two Five And Other Products | Achievement of first commercial sale milestones
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Development and sales-based milestone payments to be received			475,000,000
Pfizer Inc. | Other products
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Milestone revenue receivable			$ 175,000,000
Pfizer Inc. | License and Service | Minimum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Percentage of net sales per developed licensed product which will trigger royalties by counterparty		14%	14%
Pfizer Inc. | License and Service | Maximum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Percentage of net sales per developed licensed product which will trigger royalties by counterparty		20%	20%
Pfizer Inc. | C9ORF72
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues under agreement		$ 5,000,000				$ 5,000,000
Development and sales-based milestone payments to be received	$ 5,000,000
Collaborative arrangement transaction price		$ 17,000,000
Pfizer SB-525
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues under agreement								$ 55,000,000
Collaborative arrangement transaction price								134,000,000
Research service fees								$ 79,000,000
Revenues				0	0
Pfizer SB-525 | S B Five Two Five And Other Products
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Collaborative arrangement, number of milestones achieved | milestone								2
Milestone payments received								$ 55,000,000
Number of products approved | product								0
Number of milestones included in transaction price | milestone								0
Pfizer C9ORF72
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Agreement termination, term		15 years
Milestone payments received		$ 12,000,000					$ 5,000,000
Number of products approved | product							0
Number of milestones included in transaction price | milestone							0
Pfizer C9ORF72 | C9ORF72
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenues under agreement		12,000,000
Revenues				$ 0	$ 0
Pfizer C9ORF72 | C9ORF72 | Achievement Of Specified Preclinical Development Clinical Development And First Commercial Sale Milestones | Maximum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Development and sales-based milestone payments to be received		60,000,000
Pfizer C9ORF72 | C9ORF72 | Achievement Of Commercial Milestones | Maximum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Development and sales-based milestone payments to be received		$ 90,000,000

IMPAIRMENT OF GOODWILL AND LO_2

IMPAIRMENT OF GOODWILL AND LONG-LIVED ASSETS (Details) $ in Thousands	3 Months Ended
	Mar. 31, 2023 USD ($) asset_group	Mar. 31, 2022 USD ($)
Impaired Long-Lived Assets Held and Used [Line Items]
Impairment of goodwill	$ 38,138	$ 0
Long-lived assets, number of assets groups | asset_group	1
Impairment on right-of-use assets	$ 11,200
Impairment of long-lived assets	20,433	$ 0
Leasehold Improvements
Impaired Long-Lived Assets Held and Used [Line Items]
Impairment of long-lived assets	5,000
Construction in Progress
Impaired Long-Lived Assets Held and Used [Line Items]
Impairment of long-lived assets	$ 4,200

STOCK-BASED COMPENSATION - Stoc

STOCK-BASED COMPENSATION - Stock-Based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Total stock-based compensation expense	$ 8,277	$ 7,691
Research and development
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Total stock-based compensation expense	4,873	4,670
General and administrative
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Total stock-based compensation expense	$ 3,404	$ 3,021

STOCKHOLDERS' EQUITY (Details)

STOCKHOLDERS' EQUITY (Details) - Jefferies LLC - At-The-Market Offering Agreement - USD ($) $ in Millions	1 Months Ended			3 Months Ended
	Apr. 30, 2023	Dec. 31, 2022	Aug. 31, 2020	Mar. 31, 2023	Mar. 31, 2022
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock offering program, maximum value			$ 150
Stock offering program, increase to aggregate offering price		$ 175
Issuance of common stock under public offering, net of issuance costs (in shares)				3,962,430	0
Consideration received on transaction				$ 9.7
Subsequent Event
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Consideration received on transaction	$ 0.6

INCOME TAXES (Details)

INCOME TAXES (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Income Tax Disclosure [Abstract]
Income tax expense	$ 194	$ 58

SUBSEQUENT EVENTS (Details)

SUBSEQUENT EVENTS (Details) - Subsequent Event $ in Millions	1 Months Ended
	Apr. 30, 2023 USD ($) employee
Subsequent Event [Line Items]
Number of positions eliminated in restructuring | employee	120
Percentage of positions eliminated in restructuring	27%
Minimum
Subsequent Event [Line Items]
Restructuring expected cost	$ 5
Maximum
Subsequent Event [Line Items]
Restructuring expected cost	$ 7