| Document and Entity Information | Apr. 28, 2021 |
| Document and Entity Information [Abstract] | |
| Document Type | 8-K |
| Document Period End Date | Apr. 28, 2021 |
| Entity File Number | 001-33357 |
| Entity Registrant Name | Protalix BioTherapeutics, Inc. |
| Entity Incorporation, State or Country Code | DE |
| Entity Tax Identification Number | 65-0643773 |
| Entity Address, Address Line One | 2 University Plaza |
| Entity Address, Adress Line Two | Suite 100 |
| Entity Address, State or Province | NJ |
| Entity Address, City or Town | Hackensack |
| Entity Address, Postal Zip Code | 07601 |
| City Area Code | 201 |
| Local Phone Number | 696-9345 |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Title of 12(b) Security | Common stock, $0.001 par value |
| Trading Symbol | PLX |
| Security Exchange Name | NYSEAMER |
| Entity Emerging Growth Company | false |
| Entity Central Index Key | 0001006281 |
| Amendment Flag | false |
