Deerfield Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
4D MOLECULAR THERAPEUTICS IN	COM	35104E100	6,507	150,000	SH		DFND	1	150,000	0	0
ACCELERON PHARMA INC	COM	00434H108	29,766	219,500	SH		DFND	1	219,500	0	0
ACHILLES THERAPEUTICS PLC	SPONSORED ADS	00449L102	13,240	800,000	SH		DFND	1	800,000	0	0
ACUTUS MED INC	COM	005111109	58,050	4,341,799	SH		DFND	1	4,341,799	0	0
ADAPTHEALTH CORP	COM CL A	00653Q102	83,735	2,277,871	SH		DFND	1	2,277,871	0	0
ADVERUM BIOTECHNOLOGIES INC	COM	00773U108	23,708	2,404,439	SH		DFND	1	2,404,439	0	0
AERIE PHARMACEUTICALS INC	NOTE 1.500%10/0	00771VAB4	154,446	149,600,000	PRN		DFND	1	149,600,000	0	0
AERIE PHARMACEUTICALS INC	COM	00771V108	8,832	494,216	SH		DFND	1	494,216	0	0
ALECTOR INC	COM	014442107	21,252	1,055,192	SH		DFND	1	1,055,192	0	0
ALEXION PHARMACEUTICALS INC	COM	015351109	88,573	579,248	SH		DFND	1	579,248	0	0
ALPHATEC HLDGS INC	COM NEW	02081G201	50,558	3,201,916	SH		DFND	1	3,201,916	0	0
AMERICAN WELL CORP	CL A	03044L105	17,216	991,115	SH		DFND	1	991,115	0	0
AMICUS THERAPEUTICS INC	COM	03152W109	26,661	2,698,497	SH		DFND	1	2,698,497	0	0
ANNEXON INC	COM	03589W102	16,256	583,913	SH		DFND	1	583,913	0	0
APELLIS PHARMACEUTICALS INC	NOTE 3.500% 9/1	03753UAB2	30,574	21,825,000	PRN		DFND	1	21,825,000	0	0
APRIA INC	COM	03836A101	33,516	1,200,000	SH		DFND	1	1,200,000	0	0
ARDELYX INC	COM	039697107	16,957	2,561,554	SH		DFND	1	2,561,554	0	0
AUTOLUS THERAPEUTICS PLC	SPON ADS	05280R100	12,279	2,142,857	SH		DFND	1	2,142,857	0	0
AVIDITY BIOSCIENCES INC	COM	05370A108	9,901	453,973	SH		DFND	1	453,973	0	0
BENEFITFOCUS INC	NOTE 1.250%12/1	08180DAB2	5,936	6,500,000	PRN		DFND	1	6,500,000	0	0
BIOATLA INC	COM	09077B104	10,444	205,422	SH		DFND	1	205,422	0	0
BIOCRYST PHARMACEUTICALS	COM	09058V103	26,497	2,605,380	SH		DFND	1	2,605,380	0	0
BIODELIVERY SCIENCES INTL IN	COM	09060J106	37,262	9,530,000	SH		DFND	1	9,530,000	0	0
BIOGEN INC	COM	09062X103	86,723	310,000	SH		DFND	1	310,000	0	0
BIOVENTUS INC	COM CL A	09075A108	14,623	957,000	SH		DFND	1	957,000	0	0
BLACK DIAMOND THERAPEUTICS I	COM	09203E105	25,415	1,047,599	SH		DFND	1	1,047,599	0	0
BLUEBIRD BIO INC	COM	09609G100	14,481	480,300	SH		DFND	1	480,300	0	0
BLUEPRINT MEDICINES CORP	COM	09627Y109	20,321	209,000	SH		DFND	1	209,000	0	0
BOLT BIOTHERAPEUTICS INC	COM	097702104	11,519	350,000	SH		DFND	1	350,000	0	0
BOSTON SCIENTIFIC CORP	COM	101137107	110,423	2,857,000	SH		DFND	1	2,857,000	0	0
BRIDGEBIO PHARMA INC	NOTE 2.500% 3/1	10806XAB8	131,952	80,000,000	PRN		DFND	1	80,000,000	0	0
BROOKDALE SR LIVING INC	COM	112463104	45,320	7,490,845	SH		DFND	1	7,490,845	0	0
BUTTERFLY NETWORK INC	*W EXP 05/27/202	124155110	4,730	733,333	SH		DFND	1	733,333	0	0
CABALETTA BIO INC	COM	12674W109	5,153	464,252	SH		DFND	1	464,252	0	0
CENTENE CORP DEL	COM	15135B101	126,901	1,985,619	SH		DFND	1	1,985,619	0	0
CEREVEL THERAPEUTICS HLDNG I	*W EXP 06/09/202	15678U102	718	166,666	SH		DFND	1	166,666	0	0
CERTARA INC	COM	15687V109	16,380	600,000	SH		DFND	1	600,000	0	0
CHIMERIX INC	COM	16934W106	17,508	1,816,221	SH		DFND	1	1,816,221	0	0
CLOVIS ONCOLOGY INC	NOTE 2.500% 9/1	189464AB6	46,323	49,064,000	PRN		DFND	1	49,064,000	0	0
CM LIFE SCIENCES II INC	UNIT 02/25/2028	125842203	7,680	600,000	SH		DFND	1	600,000	0	0
COGENT BIOSCIENCES INC	COM	19240Q201	8,780	1,000,000	SH		DFND	1	1,000,000	0	0
CONSONANCE HFW ACQUISITION C	UNIT 99/99/9999	G2445M129	4,880	500,000	SH		DFND	1	500,000	0	0
CONSTELLATION PHARMCETICLS I	COM	210373106	39,973	1,708,957	SH		DFND	1	1,708,957	0	0
CYTOKINETICS INC	COM NEW	23282W605	59,569	2,561,000	SH		DFND	1	2,561,000	0	0
DECIPHERA PHARMACEUTICALS IN	COM	24344T101	23,702	528,585	SH		DFND	1	528,585	0	0
DEERFIELD HEALTHCARE TECH AC	COM CL A	244413100	82,158	6,778,750	SH		DFND	1	6,778,750	0	0
DEERFIELD HEALTHCARE TECH AC	*W EXP 07/16/202	244413118	1,552	672,000	SH		DFND	1	672,000	0	0
DELCATH SYS INC	COM NEW	24661P807	6,210	500,000	SH		DFND	1	500,000	0	0
DFP HEALTHCARE ACQUISITNS CO	COM CL A	23343Q100	104,182	10,460,000	SH		DFND	1	10,460,000	0	0
DFP HEALTHCARE ACQUISITNS CO	*W EXP 03/31/202	23343Q118	1,688	1,250,000	SH		DFND	1	1,250,000	0	0
DYNE THERAPEUTICS INC	COM	26818M108	10,654	686,000	SH		DFND	1	686,000	0	0
EDGEWISE THERAPEUTICS INC	COM	28036F105	127,827	3,933,137	SH		DFND	1	3,933,137	0	0
EUCRATES BIOMEDICAL ACQU COR	UNIT 10/23/2027	G3141W114	10,012	1,000,000	SH		DFND	1	1,000,000	0	0
FATE THERAPEUTICS INC	COM	31189P102	25,065	304,000	SH		DFND	1	304,000	0	0
GENERATION BIO CO	COM	37148K100	25,551	897,779	SH		DFND	1	897,779	0	0
GRACELL BIOTECHNOLOGIES INC	SPONSORED ADS	38406L103	6,160	400,000	SH		DFND	1	400,000	0	0
GRAYBUG VISION INC	COM SHS	38942Q103	29,314	5,281,713	SH		DFND	1	5,281,713	0	0
HIGHCAPE CAP ACQUISITION COR	UNIT 09/30/2027	42984L204	12,920	1,000,000	SH		DFND	1	1,000,000	0	0
HILL ROM HLDGS INC	COM	431475102	30,920	279,870	SH		DFND	1	279,870	0	0
IGNYTE ACQUISITION CORP	UNIT 01/05/2026	45175H205	7,265	725,000	SH		DFND	1	725,000	0	0
IMARA INC	COM	45249V107	671	79,465	SH		DFND	1	79,465	0	0
IMMUNOCORE HLDGS PLC	ADS	45258D105	7,318	171,908	SH		DFND	1	171,908	0	0
INNOVAGE HLDG CORP	COM	45784A104	7,737	300,000	SH		DFND	1	300,000	0	0
INOZYME PHARMA INC	COM	45790W108	38,887	1,964,000	SH		DFND	1	1,964,000	0	0
INSMED INC	NOTE 1.750% 1/1	457669AA7	67,986	61,000,000	PRN		DFND	1	61,000,000	0	0
INSTIL BIO INC	COM	45783C101	27,983	1,115,739	SH		DFND	1	1,115,739	0	0
INSULET CORP	NOTE 0.375% 9/0	45784PAK7	76,117	57,581,000	PRN		DFND	1	57,581,000	0	0
INTERCEPT PHARMACEUTICALS IN	NOTE 3.250% 7/0	45845PAA6	47,537	57,791,000	PRN		DFND	1	57,791,000	0	0
INTERSECT ENT INC	COM	46071F103	5,334	255,456	SH		DFND	1	255,456	0	0
ITAMAR MED LTD	SPONSORED ADS	465437101	28,592	1,193,803	SH		DFND	1	1,193,803	0	0
IVERIC BIO INC	COM	46583P102	35,643	5,767,409	SH		DFND	1	5,767,409	0	0
KALVISTA PHARMACEUTICALS INC	COM	483497103	26,204	1,020,005	SH		DFND	1	1,020,005	0	0
KINNATE BIOPHARMA INC	COM	49705R105	10,750	345,000	SH		DFND	1	345,000	0	0
LANDOS BIOPHARMA INC	COM	515069102	4,334	450,000	SH		DFND	1	450,000	0	0
LARIMAR THERAPEUTICS INC	COM	517125100	75,162	5,144,539	SH		DFND	1	5,144,539	0	0
LUMOS PHARMA INC	COM	55028X109	4,365	373,117	SH		DFND	1	373,117	0	0
MEDAVAIL HOLDINGS INC	COM	58406B103	15,996	1,142,552	SH		DFND	1	1,142,552	0	0
MEDTECH ACQUISITION CORP	UNIT 12/18/2025	58507N204	10,050	1,000,000	SH		DFND	1	1,000,000	0	0
MERIDIAN BIOSCIENCE INC	COM	589584101	23,343	889,269	SH		DFND	1	889,269	0	0
METACRINE INC	COM	59101E103	1,720	277,469	SH		DFND	1	277,469	0	0
MIRUM PHARMACEUTICALS INC	COM	604749101	68,357	3,448,912	SH		DFND	1	3,448,912	0	0
MOLINA HEALTHCARE INC	COM	60855R100	54,180	231,776	SH		DFND	1	231,776	0	0
MONTES ARCHIMEDES ACQUISITIO	UNIT 09/30/2025	612657205	20,400	2,000,000	PRN		DFND	1	2,000,000	0	0
NEOGENOMICS INC	NOTE 0.250% 1/1	64049MAB6	2,524	2,500,000	PRN		DFND	1	2,500,000	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	70,506	725,000	SH		DFND	1	725,000	0	0
NEURONETICS INC	COM	64131A105	11,368	919,000	SH		DFND	1	919,000	0	0
NEVRO CORP	NOTE 1.750% 6/0	64157FAA1	168,437	115,776,000	PRN		DFND	1	115,776,000	0	0
NEVRO CORP	NOTE 2.750% 4/0	64157FAC7	18,208	12,000,000	PRN		DFND	1	12,000,000	0	0
NOVAVAX INC	NOTE 3.750% 2/0	670002AB0	41,054	25,000,000	PRN		DFND	1	25,000,000	0	0
NUVASIVE INC	NOTE 0.375% 3/1	670704AJ4	40,857	40,000,000	PRN		DFND	1	40,000,000	0	0
NUVATION BIO INC	COM CL A	67080N101	31,350	3,000,000	SH		DFND	1	3,000,000	0	0
NUVATION BIO INC	*W EXP 07/07/202	67080N119	445	166,666	SH		DFND	1	166,666	0	0
INVITAE CORP	NOTE 2.000% 9/0	46185LAB9	245,760	163,385,000	PRN		DFND	1	163,385,000	0	0
OLEMA PHARMACEUTICALS INC	COM	68062P106	8,998	271,191	SH		DFND	1	271,191	0	0
ONCORUS INC	COM	68236R103	43,834	3,148,977	SH		DFND	1	3,148,977	0	0
ORCHARD THERAPEUTICS PLC	ADS	68570P101	50,453	6,949,416	SH		DFND	1	6,949,416	0	0
ORGANOGENESIS HLDGS INC	COM	68621F102	54,581	2,995,638	SH		DFND	1	2,995,638	0	0
ORION ACQUISITION CORP	UNIT 02/19/2026	68626A207	5,000	500,000	SH		DFND	1	500,000	0	0
ORTHO CLINICAL DIAGNOSTICS H	ORD SHS	G6829J107	45,400	2,352,941	SH		DFND	1	2,352,941	0	0
OWENS & MINOR INC NEW	COM	690732102	58,227	1,549,000	SH		DFND	1	1,549,000	0	0
PACIFIC BIOSCIENCES CALIF IN	COM	69404D108	15,589	468,000	SH		DFND	1	468,000	0	0
PACIRA BIOSCIENCES INC	COM	695127100	81,653	1,164,973	SH		DFND	1	1,164,973	0	0
PETCO HEALTH & WELLNESS CO I	COM	71601V105	11,080	500,000	SH		DFND	1	500,000	0	0
PHARVARIS N V	COM	N69605108	28,897	1,032,757	SH		DFND	1	1,032,757	0	0
PMV PHARMACEUTICALS INC	COM	69353Y103	13,935	423,680	SH		DFND	1	423,680	0	0
PROFOUND MED CORP	COM NEW	74319B502	26,138	1,297,797	SH		DFND	1	1,297,797	0	0
PROTAGONIST THERAPEUTICS INC	COM	74366E102	32,603	1,258,790	SH		DFND	1	1,258,790	0	0
PTC THERAPEUTICS INC	NOTE 3.000% 8/1	69366JAB7	16,688	14,527,000	PRN		DFND	1	14,527,000	0	0
PULMONX CORP	COM	745848101	42,860	937,032	SH		DFND	1	937,032	0	0
PUMA BIOTECHNOLOGY INC	COM	74587V107	36,642	3,769,795	SH		DFND	1	3,769,795	0	0
REATA PHARMACEUTICALS INC	CL A	75615P103	41,874	420,000	SH		DFND	1	420,000	0	0
REVOLUTION HEALTHCAR AQ CORP	UNIT 03/18/20266	76155Y207	10,054	1,000,000	SH		DFND	1	1,000,000	0	0
REVOLUTION MEDICINES INC	COM	76155X100	65,916	1,436,712	SH		DFND	1	1,436,712	0	0
RHYTHM PHARMACEUTICALS INC	COM	76243J105	42,319	1,989,625	SH		DFND	1	1,989,625	0	0
RUBIUS THERAPEUTICS INC	COM	78116T103	14,575	550,000	SH		DFND	1	550,000	0	0
SARISSA CAPITAL ACQUISITN CO	UNIT 10/23/2027	G7823W128	10,830	1,000,000	SH		DFND	1	1,000,000	0	0
SENIOR CONNECT ACQUISITN COR	UNIT 12/09/2023	81723H207	10,010	1,000,000	SH		DFND	1	1,000,000	0	0
SENSEI BIOTHERAPEUTICS INC	COM	81728A108	5,449	375,000	SH		DFND	1	375,000	0	0
SIGNIFY HEALTH INC	CL A COM	82671G100	11,704	400,000	SH		DFND	1	400,000	0	0
SILK RD MED INC	COM	82710M100	24,745	488,545	SH		DFND	1	488,545	0	0
SOTERA HEALTH CO	COM	83601L102	27,731	1,111,000	SH		DFND	1	1,111,000	0	0
SPRINGWORKS THERAPEUTICS INC	COM	85205L107	41,094	558,574	SH		DFND	1	558,574	0	0
STRYKER CORPORATION	COM	863667101	14,371	59,000	SH		DFND	1	59,000	0	0
TABULA RASA HEALTHCARE INC	NOTE 1.750% 2/1	873379AA9	44,718	45,000,000	PRN		DFND	1	45,000,000	0	0
TERNS PHARMACEUTICALS INC	COM	880881107	51,611	2,345,959	SH		DFND	1	2,345,959	0	0
TURMERIC ACQUISITION CORP	UNIT 10/08/2025	G9127T116	7,500	750,000	SH		DFND	1	750,000	0	0
TURNING POINT THERAPEUTICS I	COM	90041T108	7,931	83,846	SH		DFND	1	83,846	0	0
VIATRIS INC	COM	92556V106	240,619	17,224,000	SH		DFND	1	17,224,000	0	0
WAVE LIFE SCIENCES LTD	SHS	Y95308105	19,652	3,502,970	SH		DFND	1	3,502,970	0	0
WINDTREE THERAPEUTICS INC	COM	97382D303	49	20,148	SH		DFND	1	20,148	0	0
XERIS PHARMACEUTICALS INC	NOTE 5.000% 7/1	98422LAA5	30,417	18,000,000	PRN		DFND	1	18,000,000	0	0
XERIS PHARMACEUTICALS INC	COM	98422L107	29,556	6,553,398	SH		DFND	1	6,553,398	0	0
ZIMMER BIOMET HOLDINGS INC	COM	98956P102	57,149	357,000	SH		DFND	1	357,000	0	0