Deerfield Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ACCELERON PHARMA INC	COM	00434H108	27,545	219,500	SH		DFND	1	219,500	0	0
ACHILLES THERAPEUTICS PLC	SPONSORED ADS	00449L102	2,951	301,431	SH		DFND	1	301,431	0	0
ACUTUS MED INC	COM	005111109	73,724	4,341,799	SH		DFND	1	4,341,799	0	0
ADAPTHEALTH CORP	COM CL A	00653Q102	201,567	7,353,792	SH		DFND	1	7,353,792	0	0
ADVERUM BIOTECHNOLOGIES INC	COM	00773U108	9,895	2,827,000	SH		DFND	1	2,827,000	0	0
AERIE PHARMACEUTICALS INC	NOTE 1.500%10/0	00771VAB4	156,612	157,390,000	PRN		DFND	1	157,390,000	0	0
AERIE PHARMACEUTICALS INC	COM	00771V108	13,223	825,937	SH		DFND	1	825,937	0	0
AEROVATE THERAPEUTICS INC	COM	008064107	16,307	714,285	SH		DFND	1	714,285	0	0
AGILON HEALTH INC	COM	00857U107	12,171	300,000	SH		DFND	1	300,000	0	0
ALECTOR INC	COM	014442107	21,980	1,055,192	SH		DFND	1	1,055,192	0	0
ALPHATEC HLDGS INC	COM NEW	02081G201	52,125	3,402,384	SH		DFND	1	3,402,384	0	0
AMERICAN WELL CORP	CL A	03044L105	12,468	991,115	SH		DFND	1	991,115	0	0
AMICUS THERAPEUTICS INC	COM	03152W109	28,356	2,941,492	SH		DFND	1	2,941,492	0	0
ANNEXON INC	COM	03589W102	13,144	583,913	SH		DFND	1	583,913	0	0
APELLIS PHARMACEUTICALS INC	NOTE 3.500% 9/1	03753UAB2	77,769	41,825,000	PRN		DFND	1	41,825,000	0	0
APRIA INC	COM	03836A101	44,041	1,572,892	SH		DFND	1	1,572,892	0	0
ARDELYX INC	COM	039697107	28,892	3,811,554	SH		DFND	1	3,811,554	0	0
AVEANNA HEALTHCARE HLDGS INC	COM	05356F105	24,740	2,000,000	SH		DFND	1	2,000,000	0	0
AVIDITY BIOSCIENCES INC	COM	05370A108	13,841	560,132	SH		DFND	1	560,132	0	0
BENEFITFOCUS INC	NOTE 1.250%12/1	08180DAB2	6,130	6,500,000	PRN		DFND	1	6,500,000	0	0
BIOATLA INC	COM	09077B104	10,399	245,381	SH		DFND	1	245,381	0	0
BIOCRYST PHARMACEUTICALS INC	COM	09058V103	44,821	2,835,000	SH		DFND	1	2,835,000	0	0
BIODELIVERY SCIENCES INTL IN	COM	09060J106	34,117	9,530,000	SH		DFND	1	9,530,000	0	0
BIOMEA FUSION INC	COM	09077A106	3,878	248,447	SH		DFND	1	248,447	0	0
BIOVENTUS INC	COM CL A	09075A108	13,703	778,567	SH		DFND	1	778,567	0	0
BLACK DIAMOND THERAPEUTICS I	COM	09203E105	12,770	1,047,599	SH		DFND	1	1,047,599	0	0
BLUEBIRD BIO INC	COM	09609G100	15,360	480,300	SH		DFND	1	480,300	0	0
BLUEPRINT MEDICINES CORP	COM	09627Y109	24,783	281,754	SH		DFND	1	281,754	0	0
BRIDGEBIO PHARMA INC	NOTE 2.500% 3/1	10806XAB8	131,241	80,000,000	PRN		DFND	1	80,000,000	0	0
BRIGHT HEALTH GROUP INC	COM	10920V107	24,024	1,400,000	SH		DFND	1	1,400,000	0	0
BROOKDALE SR LIVING INC	COM	112463104	26,054	3,298,000	SH		DFND	1	3,298,000	0	0
BUTTERFLY NETWORK INC	*W EXP 02/12/202	124155110	3,542	733,333	SH		DFND	1	733,333	0	0
CABALETTA BIO INC	COM	12674W109	3,993	464,252	SH		DFND	1	464,252	0	0
CAREMAX INC	COM CL A	14171W103	216,446	16,778,750	SH		DFND	1	16,778,750	0	0
CAREMAX INC	*W EXP 06/08/202	14171W111	3,172	672,000	SH		DFND	1	672,000	0	0
CENTENE CORP DEL	COM	15135B101	72,565	995,000	SH		DFND	1	995,000	0	0
CEREVEL THERAPEUTICS HLDNG I	*W EXP 06/09/202	15678U102	2,398	166,666	SH		DFND	1	166,666	0	0
CHIMERIX INC	COM	16934W106	14,530	1,816,221	SH		DFND	1	1,816,221	0	0
CLOVIS ONCOLOGY INC	NOTE 2.500% 9/1	189464AB6	47,809	49,064,000	PRN		DFND	1	49,064,000	0	0
CM LIFE SCIENCES II INC	UNIT 02/25/2028	125842203	8,070	600,000	SH		DFND	1	600,000	0	0
COGENT BIOSCIENCES INC	COM	19240Q201	12,984	1,601,000	SH		DFND	1	1,601,000	0	0
CONSONANCE HFW ACQUISITION C	UNIT 99/99/9999	G2445M129	5,200	500,000	SH		DFND	1	500,000	0	0
CONSTELLATION PHARMCETICLS I	COM	210373106	54,128	1,601,427	SH		DFND	1	1,601,427	0	0
CONVEY HLDG PARENT INC	COM	21258C108	12,518	1,100,000	SH		DFND	1	1,100,000	0	0
CULLINAN ONCOLOGY INC	COM	230031106	26,883	1,044,000	SH		DFND	1	1,044,000	0	0
CVRX INC	COM	126638105	11,200	400,000	SH		DFND	1	400,000	0	0
CYTOKINETICS INC	COM NEW	23282W605	24,502	1,238,083	SH		DFND	1	1,238,083	0	0
DAY ONE BIOPHARMACEUTICALS I	COM	23954D109	18,648	818,980	SH		DFND	1	818,980	0	0
DECIPHERA PHARMACEUTICALS IN	COM	24344T101	49,188	1,343,560	SH		DFND	1	1,343,560	0	0
DELCATH SYS INC	COM NEW	24661P807	6,305	500,000	SH		DFND	1	500,000	0	0
DFP HEALTHCARE ACQUISITNS CO	COM CL A	23343Q100	49,750	5,000,000	SH		DFND	1	5,000,000	0	0
DFP HEALTHCARE ACQUISITNS CO	*W EXP 03/31/202	23343Q118	2,163	1,250,000	SH		DFND	1	1,250,000	0	0
DYNE THERAPEUTICS INC	COM	26818M108	16,558	787,000	SH		DFND	1	787,000	0	0
EDGEWISE THERAPEUTICS INC	COM	28036F105	83,894	3,933,137	SH		DFND	1	3,933,137	0	0
ENVISTA HOLDINGS CORPORATION	NOTE 2.375% 6/0	29415FAB0	112,018	52,500,000	PRN		DFND	1	52,500,000	0	0
EUCRATES BIOMEDICAL ACQU COR	UNIT 10/23/2027	G3141W114	10,200	1,000,000	SH		DFND	1	1,000,000	0	0
FATE THERAPEUTICS INC	COM	31189P102	26,384	304,000	SH		DFND	1	304,000	0	0
GALAPAGOS NV	SPON ADR	36315X101	45,261	657,005	SH		DFND	1	657,005	0	0
GH RESEARCH PLC	ORDINARY SHARES	G3855L106	12,069	555,416	SH		DFND	1	555,416	0	0
GLAUKOS CORP	NOTE 2.750% 6/1	377322AB8	153,534	90,000,000	PRN		DFND	1	90,000,000	0	0
GRAPHITE BIO INC	COM	38870X104	27,851	906,308	SH		DFND	1	906,308	0	0
GRAYBUG VISION INC	COM SHS	38942Q103	28,680	5,281,713	SH		DFND	1	5,281,713	0	0
HEALTH CATALYST INC	NOTE 2.500% 4/1	42225TAB3	28,740	15,000,000	PRN		DFND	1	15,000,000	0	0
IGNYTE ACQUISITION CORP	UNIT 01/05/2026	45175H205	7,265	725,000	SH		DFND	1	725,000	0	0
IMMUNOCORE HLDGS PLC	ADS	45258D105	14,096	360,966	SH		DFND	1	360,966	0	0
INOZYME PHARMA INC	COM	45790W108	37,130	2,178,985	SH		DFND	1	2,178,985	0	0
INSMED INC	NOTE 1.750% 1/1	457669AA7	52,525	50,000,000	PRN		DFND	1	50,000,000	0	0
INSMED INC	COM PAR $.01	457669307	5,692	200,000	SH		DFND	1	200,000	0	0
INSMED INC	NOTE 0.750% 6/0	457669AB5	55,522	50,000,000	PRN		DFND	1	50,000,000	0	0
INSTIL BIO INC	COM	45783C101	21,556	1,115,739	SH		DFND	1	1,115,739	0	0
INSULET CORP	NOTE 0.375% 9/0	45784PAK7	78,182	57,581,000	PRN		DFND	1	57,581,000	0	0
INTERCEPT PHARMACEUTICALS IN	NOTE 3.250% 7/0	45845PAA6	51,920	57,791,000	PRN		DFND	1	57,791,000	0	0
INTERSECT ENT INC	COM	46071F103	4,366	255,456	SH		DFND	1	255,456	0	0
INVITAE CORP	NOTE 2.000% 9/0	46185LAB9	221,666	163,385,000	PRN		DFND	1	163,385,000	0	0
ITAMAR MED LTD	SPONSORED ADS	465437101	28,114	1,193,803	SH		DFND	1	1,193,803	0	0
IVERIC BIO INC	COM	46583P102	36,392	5,767,409	SH		DFND	1	5,767,409	0	0
JANUX THERAPEUTICS INC	COM	47103J105	17,465	700,000	SH		DFND	1	700,000	0	0
KALVISTA PHARMACEUTICALS INC	COM	483497103	51,839	2,163,554	SH		DFND	1	2,163,554	0	0
KINNATE BIOPHARMA INC	COM	49705R105	23,746	1,020,000	SH		DFND	1	1,020,000	0	0
KURA ONCOLOGY INC	COM	50127T109	37,405	1,794,000	SH		DFND	1	1,794,000	0	0
LARIMAR THERAPEUTICS INC	COM	517125100	57,253	5,830,249	SH		DFND	1	5,830,249	0	0
LIFESTANCE HEALTH GROUP INC	COM	53228F101	11,144	400,000	SH		DFND	1	400,000	0	0
LUMOS PHARMA INC	COM	55028X109	331	33,117	SH		DFND	1	33,117	0	0
MEDAVAIL HOLDINGS INC	COM	58406B103	13,996	1,142,552	SH		DFND	1	1,142,552	0	0
MEDTECH ACQUISITION CORP	UNIT 12/18/2025	58507N204	10,020	1,000,000	SH		DFND	1	1,000,000	0	0
MERIDIAN BIOSCIENCE INC	COM	589584101	31,590	1,424,274	SH		DFND	1	1,424,274	0	0
METACRINE INC	COM	59101E103	1,054	277,469	SH		DFND	1	277,469	0	0
MIRUM PHARMACEUTICALS INC	COM	604749101	59,632	3,448,912	SH		DFND	1	3,448,912	0	0
MOLINA HEALTHCARE INC	COM	60855R100	58,653	231,776	SH		DFND	1	231,776	0	0
MONTE ROSA THERAPEUTICS INC	COM	61225M102	7,945	350,000	SH		DFND	1	350,000	0	0
MONTES ARCHIMEDES ACQUISITIO	UNIT 09/30/2025	612657205	21,320	2,000,000	SH		DFND	1	2,000,000	0	0
NATERA INC	NOTE 2.250% 5/0	632307AB0	136,309	45,000,000	PRN		DFND	1	45,000,000	0	0
NEOGENOMICS INC	NOTE 0.250% 1/1	64049MAB6	2,452	2,500,000	PRN		DFND	1	2,500,000	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	70,557	725,000	SH		DFND	1	725,000	0	0
NEVRO CORP	NOTE 2.750% 4/0	64157FAC7	20,863	12,000,000	PRN		DFND	1	12,000,000	0	0
NOVAVAX INC	NOTE 3.750% 2/0	670002AB0	44,647	25,000,000	PRN		DFND	1	25,000,000	0	0
NUVASIVE INC	NOTE 0.375% 3/1	670704AJ4	39,639	40,000,000	PRN		DFND	1	40,000,000	0	0
NUVASIVE INC	NOTE 1.000% 6/0	670704AL9	101,298	96,966,000	PRN		DFND	1	96,966,000	0	0
NUVATION BIO INC	COM CL A	67080N101	33,304	3,577,233	SH		DFND	1	3,577,233	0	0
NUVATION BIO INC	*W EXP 07/07/202	67080N119	433	166,666	SH		DFND	1	166,666	0	0
OLEMA PHARMACEUTICALS INC	COM	68062P106	7,588	271,191	SH		DFND	1	271,191	0	0
ONCORUS INC	COM	68236R103	43,456	3,148,977	SH		DFND	1	3,148,977	0	0
ORCHARD THERAPEUTICS PLC	ADS	68570P101	30,508	6,949,416	SH		DFND	1	6,949,416	0	0
ORGANOGENESIS HLDGS INC	COM	68621F102	120,032	7,222,127	SH		DFND	1	7,222,127	0	0
ORION ACQUISITION CORP	UNIT 02/19/2026	68626A207	4,960	500,000	SH		DFND	1	500,000	0	0
OUTSET MED INC	COM	690145107	20,023	400,622	SH		DFND	1	400,622	0	0
OWENS & MINOR INC NEW	COM	690732102	42,182	996,500	SH		DFND	1	996,500	0	0
PACIRA BIOSCIENCES INC	COM	695127100	69,600	1,147,000	SH		DFND	1	1,147,000	0	0
PHARVARIS N V	COM	N69605108	19,240	1,032,757	SH		DFND	1	1,032,757	0	0
PMV PHARMACEUTICALS INC	COM	69353Y103	27,465	804,000	SH		DFND	1	804,000	0	0
PRIVIA HEALTH GROUP INC	COM	74276R102	13,311	300,000	SH		DFND	1	300,000	0	0
PROFOUND MED CORP	COM NEW	74319B502	21,232	1,297,797	SH		DFND	1	1,297,797	0	0
PROTAGONIST THERAPEUTICS INC	COM	74366E102	61,162	1,362,790	SH		DFND	1	1,362,790	0	0
PTC THERAPEUTICS INC	NOTE 3.000% 8/1	69366JAB7	15,558	14,527,000	PRN		DFND	1	14,527,000	0	0
PULMONX CORP	COM	745848101	79,455	1,800,887	SH		DFND	1	1,800,887	0	0
PUMA BIOTECHNOLOGY INC	COM	74587V107	34,607	3,769,795	SH		DFND	1	3,769,795	0	0
QUANTUM SI INC	COM CL A	74765K105	17,164	1,400,000	SH		DFND	1	1,400,000	0	0
QUANTUM SI INC	*W EXP 06/10/202	74765K113	1,253	333,333	SH		DFND	1	333,333	0	0
QUIDEL CORP	COM	74838J101	52,429	409,219	SH		DFND	1	409,219	0	0
REATA PHARMACEUTICALS INC	CL A	75615P103	42,459	300,000	SH		DFND	1	300,000	0	0
RENEO PHARMACEUTICALS INC	COM	75974E103	7,924	849,300	SH		DFND	1	849,300	0	0
REVOLUTION HEALTHCAR AQ CORP	UNIT 03/18/20266	76155Y207	10,080	1,000,000	SH		DFND	1	1,000,000	0	0
REVOLUTION MEDICINES INC	COM	76155X100	49,696	1,565,712	SH		DFND	1	1,565,712	0	0
RHYTHM PHARMACEUTICALS INC	COM	76243J105	38,957	1,989,625	SH		DFND	1	1,989,625	0	0
SARISSA CAPITAL ACQUISITN CO	UNIT 10/23/2027	G7823W128	10,420	1,000,000	SH		DFND	1	1,000,000	0	0
SENIOR CONNECT ACQUISITN COR	UNIT 12/09/2023	81723H207	10,120	1,000,000	SH		DFND	1	1,000,000	0	0
SILK RD MED INC	COM	82710M100	54,490	1,138,525	SH		DFND	1	1,138,525	0	0
SINGULAR GENOMICS SYSTEMS IN	COM	82933R100	250,398	9,112,019	SH		DFND	1	9,112,019	0	0
SPRINGWORKS THERAPEUTICS INC	COM	85205L107	46,032	558,574	SH		DFND	1	558,574	0	0
SPRUCE BIOSCIENCES INC	COM	85209E109	22,946	2,046,958	SH		DFND	1	2,046,958	0	0
STEREOTAXIS INC	COM NEW	85916J409	17,767	1,843,000	SH		DFND	1	1,843,000	0	0
TABULA RASA HEALTHCARE INC	NOTE 1.750% 2/1	873379AA9	45,640	45,000,000	PRN		DFND	1	45,000,000	0	0
TALKSPACE INC	COM	87427V103	6,233	750,000	SH		DFND	1	750,000	0	0
TERNS PHARMACEUTICALS INC	COM	880881107	28,761	2,345,959	SH		DFND	1	2,345,959	0	0
TURMERIC ACQUISITION CORP	UNIT 10/08/2025	G9127T116	7,545	750,000	SH		DFND	1	750,000	0	0
TURNING POINT THERAPEUTICS I	COM	90041T108	6,542	83,846	SH		DFND	1	83,846	0	0
VIATRIS INC	COM	92556V106	268,995	18,824,000	SH		DFND	1	18,824,000	0	0
WAVE LIFE SCIENCES LTD	SHS	Y95308105	32,162	4,829,069	SH		DFND	1	4,829,069	0	0
WEREWOLF THERAPEUTICS INC	COM	95075A107	44,521	2,552,787	SH		DFND	1	2,552,787	0	0
WINDTREE THERAPEUTICS INC	COM	97382D303	46	20,148	SH		DFND	1	20,148	0	0
XERIS PHARMACEUTICALS INC	NOTE 5.000% 7/1	98422LAA5	28,545	18,000,000	PRN		DFND	1	18,000,000	0	0
XERIS PHARMACEUTICALS INC	COM	98422L107	26,672	6,553,398	SH		DFND	1	6,553,398	0	0
ZIMMER BIOMET HOLDINGS INC	COM	98956P102	54,357	338,000	SH		DFND	1	338,000	0	0