Deerfield Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ACCELERON PHARMA INC	COM	00434H108	24,955	145,000	SH		DFND	1	145,000	0	0
ACUTUS MED INC	COM	005111109	23,412	2,648,386	SH		DFND	1	2,648,386	0	0
ADAPTHEALTH CORP	COMMON STOCK	00653Q102	188,737	8,103,792	SH		DFND	1	8,103,792	0	0
AERIE PHARMACEUTICALS INC	NOTE 1.500%10/0	00771VAB4	143,842	157,390,000	PRN		DFND	1	157,390,000	0	0
AERIE PHARMACEUTICALS INC	COM	00771V108	33,938	2,977,020	SH		DFND	1	2,977,020	0	0
AEROVATE THERAPEUTICS INC	COM	008064107	14,986	714,285	SH		DFND	1	714,285	0	0
ALECTOR INC	COM	014442107	24,079	1,055,192	SH		DFND	1	1,055,192	0	0
ALPHATEC HLDGS INC	COM NEW	02081G201	43,821	3,594,829	SH		DFND	1	3,594,829	0	0
AMERICAN WELL CORP	CL A	03044L105	9,029	991,115	SH		DFND	1	991,115	0	0
ANNEXON INC	COM	03589W102	10,867	583,913	SH		DFND	1	583,913	0	0
APELLIS PHARMACEUTICALS INC	NOTE 3.500% 9/1	03753UAB2	35,498	28,825,000	PRN		DFND	1	28,825,000	0	0
APRIA INC	COM	03836A101	52,668	1,417,700	SH		DFND	1	1,417,700	0	0
AURINIA PHARMACEUTICALS INC	COM	05156V102	9,412	425,300	SH	Put	DFND	1	425,300	0	0
AVEANNA HEALTHCARE HLDGS INC	COM	05356F105	8,124	1,013,007	SH		DFND	1	1,013,007	0	0
BENEFITFOCUS INC	NOTE 1.250%12/1	08180DAB2	6,135	6,500,000	PRN		DFND	1	6,500,000	0	0
BIOATLA INC	COM	09077B104	13,669	464,300	SH		DFND	1	464,300	0	0
BIOCRYST PHARMACEUTICALS INC	COM	09058V103	3,372	234,643	SH		DFND	1	234,643	0	0
BIODELIVERY SCIENCES INTL IN	COM	09060J106	33,106	9,170,699	SH		DFND	1	9,170,699	0	0
BLACK DIAMOND THERAPEUTICS I	COM	09203E105	6,431	760,128	SH		DFND	1	760,128	0	0
BLUEPRINT MEDICINES CORP	COM	09627Y109	19,056	185,354	SH		DFND	1	185,354	0	0
BRIDGEBIO PHARMA INC	NOTE 2.500% 3/1	10806XAB8	110,499	80,000,000	PRN		DFND	1	80,000,000	0	0
BROOKDALE SR LIVING INC	COM	112463104	33,093	5,252,800	SH		DFND	1	5,252,800	0	0
BUTTERFLY NETWORK INC	*W EXP 02/12/202	124155110	2,017	733,333	SH		DFND	1	733,333	0	0
CABALETTA BIO INC	COM	12674W109	5,645	464,252	SH		DFND	1	464,252	0	0
CAREMAX INC	COM CL A	14171W103	162,083	16,778,750	SH		DFND	1	16,778,750	0	0
CAREMAX INC	*W EXP 06/08/202	14171W111	1,900	672,000	SH		DFND	1	672,000	0	0
CENTENE CORP DEL	COM	15135B101	62,547	1,003,800	SH		DFND	1	1,003,800	0	0
COGENT BIOSCIENCES INC	COM	19240Q201	13,464	1,601,000	SH		DFND	1	1,601,000	0	0
CUE HEALTH INC	COM	229790100	9,435	798,867	SH		DFND	1	798,867	0	0
CULLINAN ONCOLOGY INC	COM	230031106	23,563	1,044,000	SH		DFND	1	1,044,000	0	0
CVRX INC	COM	126638105	6,843	413,747	SH		DFND	1	413,747	0	0
CYTOKINETICS INC	COM NEW	23282W605	54,924	1,536,758	SH		DFND	1	1,536,758	0	0
DA32 LIFE SCNCE TEC ACQSTN C	CLASS A COM	23312M106	15,728	1,600,000	SH		DFND	1	1,600,000	0	0
DAY ONE BIOPHARMACEUTICALS I	COM	23954D109	40,596	1,710,730	SH		DFND	1	1,710,730	0	0
DECIPHERA PHARMACEUTICALS IN	COM	24344T101	27,694	815,000	SH		DFND	1	815,000	0	0
DEFINITIVE HEALTHCARE CORP	CLASS A COM	24477E103	10,708	250,000	SH		DFND	1	250,000	0	0
DELCATH SYS INC	COM NEW	24661P807	5,220	500,000	SH		DFND	1	500,000	0	0
DFP HEALTHCARE ACQUISITNS CO	COM CL A	23343Q100	49,700	5,000,000	SH		DFND	1	5,000,000	0	0
DFP HEALTHCARE ACQUISITNS CO	*W EXP 03/31/202	23343Q118	2,013	1,250,000	SH		DFND	1	1,250,000	0	0
EDGEWISE THERAPEUTICS INC	COM	28036F105	65,290	3,933,137	SH		DFND	1	3,933,137	0	0
ENVISTA HOLDINGS CORPORATION	NOTE 2.375% 6/0	29415FAB0	109,205	52,500,000	PRN		DFND	1	52,500,000	0	0
ERASCA INC	COM	29479A108	16,693	786,660	SH		DFND	1	786,660	0	0
EUCRATES BIOMEDICAL ACQU COR	UNIT 10/23/2027	G3141W114	9,950	1,000,000	SH		DFND	1	1,000,000	0	0
FATE THERAPEUTICS INC	COM	31189P102	21,456	362,000	SH		DFND	1	362,000	0	0
GH RESEARCH PLC	ORDINARY SHARES	G3855L106	8,943	405,416	SH		DFND	1	405,416	0	0
GLAUKOS CORP	NOTE 2.750% 6/1	377322AB8	129,642	108,000,000	PRN		DFND	1	108,000,000	0	0
GLAUKOS CORP	COM	377322102	29,817	619,000	SH		DFND	1	619,000	0	0
GRAPHITE BIO INC	COM	38870X104	14,854	906,308	SH		DFND	1	906,308	0	0
GRAYBUG VISION INC	COM SHS	38942Q103	17,535	5,281,713	SH		DFND	1	5,281,713	0	0
HEALTH CATALYST INC	NOTE 2.500% 4/1	42225TAB3	26,292	15,000,000	PRN		DFND	1	15,000,000	0	0
IGNYTE ACQUISITION CORP	*W EXP 01/05/202	45175H114	232	362,500	SH		DFND	1	362,500	0	0
IGNYTE ACQUISITION CORP	COM	45175H106	7,098	725,000	SH		DFND	1	725,000	0	0
INOZYME PHARMA INC	COM	45790W108	27,176	2,344,786	SH		DFND	1	2,344,786	0	0
INSMED INC	NOTE 1.750% 1/1	457669AA7	51,712	50,000,000	PRN		DFND	1	50,000,000	0	0
INSMED INC	NOTE 0.750% 6/0	457669AB5	55,120	50,000,000	PRN		DFND	1	50,000,000	0	0
INSTIL BIO INC	COM	45783C101	19,944	1,115,739	SH		DFND	1	1,115,739	0	0
INSULET CORP	NOTE 0.00375 9/0	45784PAK7	80,407	57,581,000	PRN		DFND	1	57,581,000	0	0
INTERCEPT PHARMACEUTICALS IN	NOTE 3.250% 7/0	45845PAA6	52,121	57,791,000	PRN		DFND	1	57,791,000	0	0
INVITAE CORP	NOTE 2.000% 9/0	46185LAB9	199,645	163,385,000	PRN		DFND	1	163,385,000	0	0
IRHYTHM TECHNOLOGIES INC	COM	450056106	3,529	60,271	SH		DFND	1	60,271	0	0
ITAMAR MED LTD	SPONSORED ADS	465437101	20,993	694,667	SH		DFND	1	694,667	0	0
IVERIC BIO INC	COM	46583P102	78,987	4,863,725	SH		DFND	1	4,863,725	0	0
KALVISTA PHARMACEUTICALS INC	COM	483497103	37,754	2,163,554	SH		DFND	1	2,163,554	0	0
KINNATE BIOPHARMA INC	COM	49705R105	23,676	1,028,508	SH		DFND	1	1,028,508	0	0
KURA ONCOLOGY INC	COM	50127T109	43,368	2,315,417	SH		DFND	1	2,315,417	0	0
LARIMAR THERAPEUTICS INC	COM	517125100	67,223	5,830,249	SH		DFND	1	5,830,249	0	0
LEAP THERAPEUTICS INC	COM	52187K101	16,040	4,000,000	SH		DFND	1	4,000,000	0	0
MEDAVAIL HOLDINGS INC	COM	58406B103	3,336	1,142,552	SH		DFND	1	1,142,552	0	0
MEDTECH ACQUISITION CORP	COM CL A	58507N105	9,930	999,999	SH		DFND	1	999,999	0	0
MEDTECH ACQUISITION CORP	*W EXP 12/22/202	58507N113	273	333,333	SH		DFND	1	333,333	0	0
MERIDIAN BIOSCIENCE INC	COM	589584101	39,694	2,063,083	SH		DFND	1	2,063,083	0	0
METACRINE INC	COM	59101E103	952	277,469	SH		DFND	1	277,469	0	0
MIRUM PHARMACEUTICALS INC	COM	604749101	65,396	3,282,912	SH		DFND	1	3,282,912	0	0
MOLINA HEALTHCARE INC	COM	60855R100	62,883	231,776	SH		DFND	1	231,776	0	0
MONTES ARCHIMEDES ACQUISITIO	*W EXP 99/99/999	612657114	1,490	1,000,000	SH		DFND	1	1,000,000	0	0
MONTES ARCHIMEDES ACQUISITIO	COM CL A	612657106	18,700	2,000,000	SH		DFND	1	2,000,000	0	0
NATERA INC	NOTE 2.250% 5/0	632307AB0	135,236	45,000,000	PRN		DFND	1	45,000,000	0	0
NATERA INC	NOTE 2.250% 5/0	670002AB0	43,056	25,000,000	PRN		DFND	1	25,000,000	0	0
NEOGENOMICS INC	NOTE 0.250% 1/1	64049MAB6	2,514	2,500,000	PRN		DFND	1	2,500,000	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	109,569	1,142,415	SH		DFND	1	1,142,415	0	0
NEVRO CORP NOTE	2.750% 4/0	64157FAC7	34,876	26,000,000	PRN		DFND	1	26,000,000	0	0
NUVASIVE INC	NOTE 0.00375 3/1	670704AJ4	54,110	55,800,000	PRN		DFND	1	55,800,000	0	0
NUVASIVE INC	NOTE 0.01 6/0	670704AL9	98,794	96,966,000	PRN		DFND	1	96,966,000	0	0
NUVATION BIO INC	COM CL A	67080N101	35,558	3,577,233	SH		DFND	1	3,577,233	0	0
NUVATION BIO INC	*W EXP 07/07/202	67080N119	427	166,666	SH		DFND	1	166,666	0	0
NUVALENT INC	COM	670703107	436,140	19,341,024	SH		DFND	1	19,341,024	0	0
NYXOAH S A	SHS	B6S7WD106	8,797	300,800	SH		DFND	1	300,800	0	0
OLEMA PHARMACEUTICALS INC	COM	68062P106	7,474	271,191	SH		DFND	1	271,191	0	0
ONCORUS INC	COM	68236R103	29,411	3,148,977	SH		DFND	1	3,148,977	0	0
ORCHARD THERAPEUTICS PLC	ADS	68570P101	15,984	6,949,416	SH		DFND	1	6,949,416	0	0
ORGANOGENESIS HLDGS INC	COM	68621F102	106,267	7,462,543	SH		DFND	1	7,462,543	0	0
ORION ACQUISITION CORP	*W EXP 02/19/202	68626A116	80	125,000	SH		DFND	1	125,000	0	0
ORION ACQUISITION CORP	COM CL A	68626A108	4,850	500,000	SH		DFND	1	500,000	0	0
OUTSET MED INC	COM	690145107	19,807	400,622	SH		DFND	1	400,622	0	0
PACIRA BIOSCIENCES INC	COM	695127100	54,165	967,236	SH		DFND	1	967,236	0	0
PACIRA BIOSCIENCES INC	NOTE 0.750% 8/0	695127AF7	87,723	81,600,000	PRN		DFND	1	81,600,000	0	0
PHARVARIS N V	COM	N69605108	28,518	1,608,471	SH		DFND	1	1,608,471	0	0
PMV PHARMACEUTICALS INC	COM	69353Y103	23,959	804,000	SH		DFND	1	804,000	0	0
PRIVIA HEALTH GROUP INC	COM	74276R102	7,068	300,000	SH		DFND	1	300,000	0	0
PROFOUND MED CORP	COM NEW	74319B502	19,000	1,297,797	SH		DFND	1	1,297,797	0	0
PROTAGONIST THERAPEUTICS INC	COM	74366E102	24,702	1,394,000	SH		DFND	1	1,394,000	0	0
PTC THERAPEUTICS INC NOTE	0.03 8/1	69366JAB7	15,061	14,527,000	PRN		DFND	1	14,527,000	0	0
PULMONX CORP	COM	745848101	73,035	2,029,887	SH		DFND	1	2,029,887	0	0
QUANTUM SI INC	COM CL A	74765K105	11,676	1,400,000	SH		DFND	1	1,400,000	0	0
QUANTUM SI INC	*W EXP 06/10/202	74765K113	677	333,333	SH		DFND	1	333,333	0	0
RENEO PHARMACEUTICALS INC	COM	75974E103	6,327	849,300	SH		DFND	1	849,300	0	0
REVOLUTION HEALTHCAR AQ CORP	CLASS A COM	76155Y108	9,710	1,000,000	SH		DFND	1	1,000,000	0	0
REVOLUTION HEALTHCAR AQ CORP	*W EXP 12/31/202	76155Y116	186	200,000	SH		DFND	1	200,000	0	0
REVOLUTION MEDICINES INC	COM	76155X100	43,073	1,565,712	SH		DFND	1	1,565,712	0	0
RHYTHM PHARMACEUTICALS INC	COM	76243J105	25,985	1,989,625	SH		DFND	1	1,989,625	0	0
RXSIGHT INC	COM	78349D107	11,403	900,000	SH		DFND	1	900,000	0	0
SARISSA CAPITAL ACQUISITN CO	UNIT 10/23/2027	G7823W128	9,876	1,000,000	SH		DFND	1	1,000,000	0	0
SEMA4 HOLDINGS CORP	COM CL A	81663L101	105,110	13,848,488	SH		DFND	1	13,848,488	0	0
SENIOR CONNECT ACQUISITN COR	*W EXP 12/31/202	81723H116	355	500,000	SH		DFND	1	500,000	0	0
SENIOR CONNECT ACQUISITN COR	COM CL A	81723H108	9,770	1,000,000	SH		DFND	1	1,000,000	0	0
SILK RD MED INC	COM	82710M100	54,494	990,251	SH		DFND	1	990,251	0	0
SINGULAR GENOMICS SYSTEMS IN	COM	82933R100	101,963	9,112,019	SH		DFND	1	9,112,019	0	0
SOMALOGIC INC	*W EXP 03/01/202	83444K113	414	120,000	SH		DFND	1	120,000	0	0
SPRINGWORKS THERAPEUTICS INC	COM	85205L107	32,397	510,673	SH		DFND	1	510,673	0	0
SPRUCE BIOSCIENCES INC	COM	85209E109	13,222	2,200,000	SH		DFND	1	2,200,000	0	0
SURROZEN INC	*W EXP 08/01/203	86889P117	190	166,666	SH		DFND	1	166,666	0	0
TABULA RASA HEALTHCARE INC	NOTE 1.750% 2/1	873379AA9	37,450	45,000,000	PRN		DFND	1	45,000,000	0	0
TALKSPACE INC	COM	87427V103	2,738	750,000	SH		DFND	1	750,000	0	0
TERNS PHARMACEUTICALS INC	COM	880881107	24,445	2,345,959	SH		DFND	1	2,345,959	0	0
TURMERIC ACQUISITION CORP	UNIT 10/08/2025	G9127T116	7,448	750,000	SH		DFND	1	750,000	0	0
TURNING POINT THERAPEUTICS I	COM	90041T108	5,570	83,846	SH		DFND	1	83,846	0	0
TYRA BIOSCIENCES INC	COM	90240B106	10,994	625,000	SH		DFND	1	625,000	0	0
VIATRIS INC	COM	92556V106	255,065	18,824,000	SH		DFND	1	18,824,000	0	0
VINCERX PHARMA INC	COM NEW	92731L106	22,303	1,379,310	SH		DFND	1	1,379,310	0	0
WAVE LIFE SCIENCES LTD	SHS	Y95308105	15,750	3,214,340	SH		DFND	1	3,214,340	0	0
WEREWOLF THERAPEUTICS INC	COM	95075A107	30,078	1,752,787	SH		DFND	1	1,752,787	0	0
WINDTREE THERAPEUTICS INC	COM	97382D303	42	20,148	SH		DFND	1	20,148	0	0
XERIS PHARMACEUTICALS INC	NOTE 5.000% 7/1	98422LAA5	18,864	18,000,000	PRN		DFND	1	18,000,000	0	0