Deerfield Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ACUTUS MED INC	COM	005111109	3,681	2,648,386	SH		DFND	1	2,648,386	0	0
ADAPTHEALTH CORP	COMMON STOCK	00653Q102	186,751	11,650,072	SH		DFND	1	11,650,072	0	0
AERIE PHARMACEUTICALS INC	NOTE 1.500%10/0	00771VAB4	141,877	157,390,000	PRN		DFND	1	157,390,000	0	0
AERIE PHARMACEUTICALS INC	COM	00771V108	42,725	4,695,020	SH		DFND	1	4,695,020	0	0
ALECTOR INC	COM	014442107	15,036	1,055,192	SH		DFND	1	1,055,192	0	0
ALPHATEC HLDGS INC	COM NEW	02081G201	41,341	3,594,829	SH		DFND	1	3,594,829	0	0
AMERICAN WELL CORP	CL A	03044L105	1,647	391,115	SH		DFND	1	391,115	0	0
AN2 THERAPEUTICS INC	COM	037326105	8,803	584,136	SH		DFND	1	584,136	0	0
ANNEXON INC	COM	03589W102	1,594	583,913	SH		DFND	1	583,913	0	0
APELLIS PHARMACEUTICALS INC	NOTE 3.500% 9/1	03753UAB2	81,724	51,885,000	PRN		DFND	1	51,885,000	0	0
APOLLO ENDOSURGERY INC	COM	03767D108	10,588	1,750,000	SH		DFND	1	1,750,000	0	0
BELLUS HEALTH INC NEW	COM NEW	07987C204	25,269	3,672,808	SH		DFND	1	3,672,808	0	0
BENEFITFOCUS INC	NOTE 1.250%12/1	08180DAB2	6,311	6,500,000	SH		DFND	1	6,500,000	0	0
BIOATLA INC	COM	09077B104	1,445	289,002	SH		DFND	1	289,002	0	0
BIOCRYST PHARMACEUTICALS INC	COM	09058V103	16,455	1,012,000	SH		DFND	1	1,012,000	0	0
BRIDGEBIO PHARMA INC	NOTE 2.500% 3/1	10806XAB8	47,402	80,000,000	PRN		DFND	1	80,000,000	0	0
BROOKDALE SR LIVING INC	COM	112463104	37,922	5,379,000	SH		DFND	1	5,379,000	0	0
BUTTERFLY NETWORK INC	*W EXP 02/12/202	124155110	748	733,333	SH		DFND	1	733,333	0	0
CABALETTA BIO INC	COM	12674W109	942	464,252	SH		DFND	1	464,252	0	0
CAREMAX INC	COM CL A	14171W103	121,813	15,861,090	SH		DFND	1	15,861,090	0	0
CAREMAX INC	*W EXP 06/08/202	14171W111	1,277	672,000	SH		DFND	1	672,000	0	0
CENTENE CORP DEL	COM	15135B101	46,624	553,800	SH		DFND	1	553,800	0	0
COGENT BIOSCIENCES INC	COM	19240Q201	11,991	1,601,000	SH		DFND	1	1,601,000	0	0
CULLINAN ONCOLOGY INC	COM	230031106	3,932	375,585	SH		DFND	1	375,585	0	0
CYTOKINETICS INC	COM NEW	23282W605	35,069	952,703	SH		DFND	1	952,703	0	0
DA32 LIFE SCNCE TEC ACQSTN C	CLASS A COM	23312M106	15,544	1,600,000	SH		DFND	1	1,600,000	0	0
DAY ONE BIOPHARMACEUTICALS I	COM	23954D109	20,698	2,086,449	SH		DFND	1	2,086,449	0	0
DECIPHERA PHARMACEUTICALS IN	COM	24344T101	51,731	5,580,456	SH		DFND	1	5,580,456	0	0
DELCATH SYS INC	COM NEW	24661P807	3,200	500,000	SH		DFND	1	500,000	0	0
EDGEWISE THERAPEUTICS INC	COM	28036F105	38,151	3,933,137	SH		DFND	1	3,933,137	0	0
ENVISTA HOLDINGS CORPORATION	NOTE 2.375% 6/0	29415FAB0	123,924	52,500,000	PRN		DFND	1	52,500,000	0	0
EUCRATES BIOMEDICAL ACQU COR	*W EXP 10/23/202	G3141W122	62	333,333	SH		DFND	1	333,333	0	0
EUCRATES BIOMEDICAL ACQU COR	UNIT 10/23/2027	G3141W114	0	1	SH		DFND	1	1	0	0
EUCRATES BIOMEDICAL ACQU COR	SHS	G3141W106	9,840	999,999	SH		DFND	1	999,999	0	0
EVOLUS INC	COM	30052C107	13,792	1,229,234	SH		DFND	1	1,229,234	0	0
FOGHORN THERAPEUTICS INC	COM	344174107	3,638	238,865	SH		DFND	1	238,865	0	0
GILEAD SCIENCES INC	COM	375558103	45,508	765,489	SH		DFND	1	765,489	0	0
GLAUKOS CORP	NOTE 2.750% 6/1	377322AB8	358,786	269,897,000	PRN		DFND	1	269,897,000	0	0
GLAUKOS CORP	COM	377322102	21,365	369,514	SH		DFND	1	369,514	0	0
GLAUKOS CORP	COM	377322102	2,613	45,200	SH	Call	DFND	1	45,200	0	0
GOODRX HLDGS INC	COM CL A	38246G108	18,926	979,106	SH		DFND	1	979,106	0	0
GRAYBUG VISION INC	COM SHS	38942Q103	6,497	5,281,713	SH		DFND	1	5,281,713	0	0
HEALTH CATALYST INC	NOTE 2.500% 4/1	42225TAB3	17,171	15,000,000	PRN		DFND	1	15,000,000	0	0
HORIZON THERAPEUTICS PUB L	SHS	G46188101	48,923	465,000	SH		DFND	1	465,000	0	0
IGNYTE ACQUISITION CORP	*W EXP 01/05/202	45175H114	132	362,500	SH		DFND	1	362,500	0	0
IGNYTE ACQUISITION CORP	COM	45175H106	7,134	725,000	SH		DFND	1	725,000	0	0
IMMUNOGEN INC	COM	45253H101	16,520	3,470,675	SH		DFND	1	3,470,675	0	0
INOZYME PHARMA INC	COM	45790W108	9,590	2,344,786	SH		DFND	1	2,344,786	0	0
INSMED INC	NOTE 1.750% 1/1	457669AA7	74,929	75,000,000	PRN		DFND	1	75,000,000	0	0
INSMED INC	COM PAR $.01	457669307	7,157	304,572	SH		DFND	1	304,572	0	0
INSULET CORP	NOTE 0.375% 9/0	45784PAK7	76,232	57,581,000	PRN		DFND	1	57,581,000	0	0
INTERCEPT PHARMACEUTICALS IN	NOTE 3.250% 7/0	45845PAA6	52,992	57,791,000	PRN		DFND	1	57,791,000	0	0
INVITAE CORP	NOTE 2.000% 9/0	46185LAB9	169,769	206,873,000	PRN		DFND	1	206,873,000	0	0
IVERIC BIO INC	COM	46583P102	82,332	4,891,996	SH		DFND	1	4,891,996	0	0
KALVISTA PHARMACEUTICALS INC	COM	483497103	12,241	830,472	SH		DFND	1	830,472	0	0
KINNATE BIOPHARMA INC	COM	49705R105	11,097	985,568	SH		DFND	1	985,568	0	0
KURA ONCOLOGY INC	COM	50127T109	71,015	4,416,361	SH		DFND	1	4,416,361	0	0
LARIMAR THERAPEUTICS INC	COM	517125100	23,613	5,830,249	SH		DFND	1	5,830,249	0	0
MEDAVAIL HOLDINGS INC	COM	58406B103	1,110	1,142,552	SH		DFND	1	1,142,552	0	0
MEDTECH ACQUISITION CORP	UNIT 12/18/2025	58507N204	0	1	SH		DFND	1	1	0	0
MEDTECH ACQUISITION CORP	COM CL A	58507N105	9,800	999,999	SH		DFND	1	999,999	0	0
MEDTECH ACQUISITION CORP	*W EXP 12/22/202	58507N113	85	333,333	SH		DFND	1	333,333	0	0
MERUS N V	COM	N5749R100	11,554	437,000	SH		DFND	1	437,000	0	0
MIRATI THERAPEUTICS INC	COM	60468T105	22,199	270,000	SH		DFND	1	270,000	0	0
MIRUM PHARMACEUTICALS INC	COM	604749101	72,290	3,282,912	SH		DFND	1	3,282,912	0	0
MOLINA HEALTHCARE INC	COM	60855R100	45,031	134,989	SH		DFND	1	134,989	0	0
NATERA INC	NOTE 2.250% 5/0	632307AB0	120,177	90,638,000	PRN		DFND	1	90,638,000	0	0
NEOGENOMICS INC	NOTE 0.250% 1/1	64049MAB6	1,666	2,500,000	PRN		DFND	1	2,500,000	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	155,419	1,657,800	SH		DFND	1	1,657,800	0	0
NEVRO CORP	NOTE 2.750% 4/0	64157FAC7	65,368	61,000,000	PRN		DFND	1	61,000,000	0	0
NOVAVAX INC	NOTE 3.750% 2/0	670002AB0	26,777	25,000,000	PRN		DFND	1	25,000,000	0	0
NUVALENT INC	COM	670703107	268,647	19,341,024	SH		DFND	1	19,341,024	0	0
NUVASIVE INC	NOTE 0.375% 3/1	670704AJ4	76,133	80,000,000	PRN		DFND	1	80,000,000	0	0
NUVASIVE INC	NOTE 1.000% 6/0	670704AL9	96,433	96,966,000	PRN		DFND	1	96,966,000	0	0
NUVATION BIO INC	COM CL A	67080N101	18,816	3,577,233	SH		DFND	1	3,577,233	0	0
NUVATION BIO INC	*W EXP 07/07/202	67080N119	135	166,666	SH		DFND	1	166,666	0	0
NYXOAH S A	SHS	B6S7WD106	8,714	455,262	SH		DFND	1	455,262	0	0
THE ONCOLOGY INSTITUTE INC	*W EXP 11/15/202	68236X118	1,438	1,250,000	SH		DFND	1	1,250,000	0	0
THE ONCOLOGY INSTITUTE INC	COM	68236X100	32,137	3,296,107	SH		DFND	1	3,296,107	0	0
ONCORUS INC	COM	68236R103	5,605	3,148,977	SH		DFND	1	3,148,977	0	0
1LIFE HEALTHCARE INC	NOTE 3.000% 6/1	68269GAB3	34,716	40,000,000	PRN		DFND	1	40,000,000	0	0
ORCHARD THERAPEUTICS PLC	ADS	68570P101	4,948	6,949,416	SH		DFND	1	6,949,416	0	0
ORGANOGENESIS HLDGS INC	COM	68621F102	64,441	8,456,876	SH		DFND	1	8,456,876	0	0
ORION ACQUISITION CORP	*W EXP 02/19/202	68626A116	39	125,000	SH		DFND	1	125,000	0	0
ORION ACQUISITION CORP	COM CL A	68626A108	4,885	500,000	SH		DFND	1	500,000	0	0
OAK STR HEALTH INC	NOTE 3/1	67181AAB3	14,316	18,000,000	PRN		DFND	1	18,000,000	0	0
OUTSET MED INC	COM	690145107	18,188	400,622	SH		DFND	1	400,622	0	0
PACIRA BIOSCIENCES INC	NOTE 0.750% 8/0	695127AF7	100,908	81,600,000	PRN		DFND	1	81,600,000	0	0
PHARVARIS N V	COM	N69605108	28,600	1,577,078	SH		DFND	1	1,577,078	0	0
PMV PHARMACEUTICALS INC	COM	69353Y103	10	470	SH		DFND	1	470	0	0
PROFOUND MED CORP	COM NEW	74319B502	15,424	1,713,797	SH		DFND	1	1,713,797	0	0
PTC THERAPEUTICS INC	NOTE 3.000% 8/1	69366JAB7	15,076	14,527,000	PRN		DFND	1	14,527,000	0	0
PULMONX CORP	COM	745848101	91,681	3,695,341	SH		DFND	1	3,695,341	0	0
QUANTUM SI INC	COM CL A	74765K105	6,552	1,400,000	SH		DFND	1	1,400,000	0	0
QUANTUM SI INC	*W EXP 06/10/202	74765K113	383	333,333	SH		DFND	1	333,333	0	0
REVOLUTION HEALTHCAR AQ CORP	CLASS A COM	76155Y108	9,810	1,000,000	SH		DFND	1	1,000,000	0	0
REVOLUTION HEALTHCAR AQ CORP	*W EXP 12/31/202	76155Y116	90	200,000	SH		DFND	1	200,000	0	0
REVOLUTION MEDICINES INC	COM	76155X100	22,744	891,587	SH		DFND	1	891,587	0	0
RHYTHM PHARMACEUTICALS INC	COM	76243J105	3,352	291,005	SH		DFND	1	291,005	0	0
ROIVANT SCIENCES LTD	*W EXP 09/30/202	G76279119	880	1,000,000	SH		DFND	1	1,000,000	0	0
SAREPTA THERAPEUTICS INC	DBCV 1.500%11/1	803607AB6	116,124	88,657,000	SH		DFND	1	88,657,000	0	0
SARISSA CAPITAL ACQUISITN CO	UNIT 10/23/2027	G7823W128	0	1	SH		DFND	1	1	0	0
SARISSA CAPITAL ACQUISITN CO	CL A	G7823W102	9,900	999,999	SH		DFND	1	999,999	0	0
SARISSA CAPITAL ACQUISITN CO	*W EXP 10/23/202	G7823W110	120	333,333	SH		DFND	1	333,333	0	0
SEMA4 HOLDINGS CORP	COM CL A	81663L101	42,515	13,848,488	SH		DFND	1	13,848,488	0	0
SENIOR CONNECT ACQUISITN COR	*W EXP 12/31/202	81723H116	90	500,000	SH		DFND	1	500,000	0	0
SENIOR CONNECT ACQUISITN COR	COM CL A	81723H108	9,820	1,000,000	SH		DFND	1	1,000,000	0	0
SILK RD MED INC	COM	82710M100	88,927	2,153,712	SH		DFND	1	2,153,712	0	0
SINGULAR GENOMICS SYSTEMS IN	COM	82933R100	41,722	6,612,019	SH		DFND	1	6,612,019	0	0
SOMALOGIC INC	*W EXP 08/31/202	83444K113	257	120,000	SH		DFND	1	120,000	0	0
SPRINGWORKS THERAPEUTICS INC	COM	85205L107	14,109	249,988	SH		DFND	1	249,988	0	0
SURROZEN INC	*W EXP 08/01/203	86889P117	42	166,666	SH		DFND	1	166,666	0	0
TABULA RASA HEALTHCARE INC	NOTE 1.750% 2/1	873379AA9	79,740	107,816,000	PRN		DFND	1	107,816,000	0	0
TERNS PHARMACEUTICALS INC	COM	880881107	6,967	2,345,959	SH		DFND	1	2,345,959	0	0
TURMERIC ACQUISITION CORP	*W EXP 10/08/202	G9127T124	82	250,000	SH		DFND	1	250,000	0	0
TURMERIC ACQUISITION CORP	CL A	G9127T108	7,388	750,000	SH		DFND	1	750,000	0	0
VIATRIS INC	COM	92556V106	224,930	20,673,700	SH		DFND	1	20,673,700	0	0
VINCERX PHARMA INC	COM NEW	92731L106	5,517	1,379,310	SH		DFND	1	1,379,310	0	0
WEREWOLF THERAPEUTICS INC	COM	95075A107	4,216	958,125	SH		DFND	1	958,125	0	0
WINDTREE THERAPEUTICS INC	COM	97382D303	23	20,148	SH		DFND	1	20,148	0	0
XERIS BIOPHARMA HOLDINGS INC	NOTE 5.000% 7/1	98422LAA5	21,095	18,000,000	PRN		DFND	1	18,000,000	0	0
XILIO THERAPEUTICS INC	COM	98422T100	14,696	2,078,692	SH		DFND	1	2,078,692	0	0