Deerfield Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
1LIFE HEALTHCARE INC	NOTE 3.000% 6/1	68269GAB3	40,222	48,599,000	PRN		DFND	1	48,599,000	0	0
89BIO INC	COM	282559103	1,630	506,100	SH		DFND	1	506,100	0	0
ACCOLADE INC	NOTE 0.500% 4/0	00437EAB8	59,134	92,624,000	PRN		DFND	1	92,624,000	0	0
ACUTUS MED INC	COM	005111109	2,966	2,648,386	SH		DFND	1	2,648,386	0	0
ADAPTHEALTH CORP	COMMON STOCK	00653Q102	201,160	11,150,797	SH		DFND	1	11,150,797	0	0
AERIE PHARMACEUTICALS INC	NOTE 1.500%10/0	00771VAB4	133,036	157,390,000	PRN		DFND	1	157,390,000	0	0
AERIE PHARMACEUTICALS INC	COM	00771V108	35,213	4,695,020	SH		DFND	1	4,695,020	0	0
ALECTOR INC	COM	014442107	10,721	1,055,192	SH		DFND	1	1,055,192	0	0
ALPHATEC HLDGS INC	COM NEW	02081G201	15,830	2,420,547	SH		DFND	1	2,420,547	0	0
AMEDISYS INC	COM	023436108	20,919	199,000	SH		DFND	1	199,000	0	0
AN2 THERAPEUTICS INC	COM	037326105	5,553	716,538	SH		DFND	1	716,538	0	0
ANAPTYSBIO INC	COM	032724106	15,672	772,000	SH		DFND	1	772,000	0	0
ANNEXON INC	COM	03589W102	2,201	583,913	SH		DFND	1	583,913	0	0
APELLIS PHARMACEUTICALS INC	NOTE 3.500% 9/1	03753UAB2	76,456	51,885,000	PRN		DFND	1	51,885,000	0	0
APOLLO ENDOSURGERY INC	COM	03767D108	6,388	1,750,000	SH		DFND	1	1,750,000	0	0
BELLUS HEALTH INC NEW	COM NEW	07987C204	22,851	2,473,000	SH		DFND	1	2,473,000	0	0
BENEFITFOCUS INC	NOTE 1.250%12/1	08180DAB2	5,907	6,500,000	PRN		DFND	1	6,500,000	0	0
BIOGEN INC	COM	09062X103	101,970	500,000	SH	Call	DFND	1	500,000	0	0
BROOKDALE SR LIVING INC	COM	112463104	39,010	8,592,461	SH		DFND	1	8,592,461	0	0
BUTTERFLY NETWORK INC	*W EXP 02/12/202	124155110	296	733,333	SH		DFND	1	733,333	0	0
CABALETTA BIO INC	COM	12674W109	492	464,252	SH		DFND	1	464,252	0	0
CAREMAX INC	COM CL A	14171W103	57,576	15,861,090	SH		DFND	1	15,861,090	0	0
CAREMAX INC	*W EXP 06/08/202	14171W111	484	672,000	SH		DFND	1	672,000	0	0
CENTENE CORP DEL	COM	15135B101	48,972	578,800	SH		DFND	1	578,800	0	0
COGENT BIOSCIENCES INC	COM	19240Q201	53,009	5,876,805	SH		DFND	1	5,876,805	0	0
CYTOKINETICS INC	COM NEW	23282W605	45,589	1,160,315	SH		DFND	1	1,160,315	0	0
DA32 LIFE SCNCE TEC ACQSTN C	CLASS A COM	23312M106	15,504	1,600,000	SH		DFND	1	1,600,000	0	0
DAY ONE BIOPHARMACEUTICALS I	COM	23954D109	62,867	3,512,123	SH		DFND	1	3,512,123	0	0
DECIPHERA PHARMACEUTICALS IN	COM	24344T101	82,200	6,250,964	SH		DFND	1	6,250,964	0	0
DELCATH SYS INC	COM NEW	24661P807	1,995	500,000	SH		DFND	1	500,000	0	0
DYNAVAX TECHNOLOGIES CORP	NOTE 2.500% 5/1	268158AD4	44,735	30,000,000	PRN		DFND	1	30,000,000	0	0
EDGEWISE THERAPEUTICS INC	COM	28036F105	31,308	3,933,137	SH		DFND	1	3,933,137	0	0
ENVISTA HOLDINGS CORPORATION	NOTE 2.375% 6/0	29415FAB0	100,380	52,500,000	PRN		DFND	1	52,500,000	0	0
EUCRATES BIOMEDICAL ACQU COR	*W EXP 10/23/202	G3141W122	22	333,333	SH		DFND	1	333,333	0	0
EUCRATES BIOMEDICAL ACQU COR	UNIT 10/23/2027	G3141W114	0	1	SH		DFND	1	1	0	0
EUCRATES BIOMEDICAL ACQU COR	SHS	G3141W106	9,900	999,999	SH		DFND	1	999,999	0	0
EVOLUS INC	COM	30052C107	42,140	3,632,751	SH		DFND	1	3,632,751	0	0
FOGHORN THERAPEUTICS INC	COM	344174107	10,574	777,525	SH		DFND	1	777,525	0	0
GUARDANT HEALTH INC	NOTE 11/1	40131MAB5	56,684	89,036,000	PRN		DFND	1	89,036,000	0	0
GILEAD SCIENCES INC	COM	375558103	95,969	1,552,639	SH		DFND	1	1,552,639	0	0
GLAUKOS CORP	NOTE 2.750% 6/1	377322AB8	324,465	271,752,000	PRN		DFND	1	271,752,000	0	0
GLAUKOS CORP	COM	377322102	47,215	1,039,514	SH		DFND	1	1,039,514	0	0
GRAYBUG VISION INC	COM SHS	38942Q103	5,757	5,281,713	SH		DFND	1	5,281,713	0	0
HEALTH CATALYST INC	NOTE 2.500% 4/1	42225TAB3	13,452	15,000,000	PRN		DFND	1	15,000,000	0	0
HILLEVAX INC	COM	43157M102	28,614	2,617,948	SH		DFND	1	2,617,948	0	0
HORIZON THERAPEUTICS PUB L	SHS	G46188101	24,965	313,000	SH		DFND	1	313,000	0	0
IGNYTE ACQUISITION CORP	*W EXP 01/05/202	45175H114	76	362,500	SH		DFND	1	362,500	0	0
IGNYTE ACQUISITION CORP	COM	45175H106	7,149	725,000	SH		DFND	1	725,000	0	0
IMMUNOGEN INC	COM	45253H101	67,592	15,020,490	SH		DFND	1	15,020,490	0	0
INOZYME PHARMA INC	COM	45790W108	12,862	2,696,372	SH		DFND	1	2,696,372	0	0
INSMED INC	NOTE 1.750% 1/1	457669AA7	70,460	75,000,000	PRN		DFND	1	75,000,000	0	0
INSMED INC	COM PAR $.01	457669307	18,941	960,484	SH		DFND	1	960,484	0	0
INSULET CORP	NOTE 0.375% 9/0	45784PAK7	66,018	57,581,000	PRN		DFND	1	57,581,000	0	0
INTERCEPT PHARMACEUTICALS IN	NOTE 3.250% 7/0	45845PAA6	56,158	57,791,000	PRN		DFND	1	57,791,000	0	0
INVITAE CORP	NOTE 2.000% 9/0	46185LAB9	163,025	206,873,000	PRN		DFND	1	206,873,000	0	0
IONIS PHARMACEUTICALS INC	NOTE 4/0	462222AD2	116,991	127,800,000	PRN		DFND	1	127,800,000	0	0
IVERIC BIO INC	COM	46583P102	50,159	5,214,000	SH		DFND	1	5,214,000	0	0
KEZAR LIFE SCIENCES INC	COM	49372L100	11,735	1,419,000	SH		DFND	1	1,419,000	0	0
KINNATE BIOPHARMA INC	COM	49705R105	3,153	250,000	SH		DFND	1	250,000	0	0
KURA ONCOLOGY INC	COM	50127T109	48,153	2,627,000	SH		DFND	1	2,627,000	0	0
LARIMAR THERAPEUTICS INC	COM	517125100	11,427	5,830,249	SH		DFND	1	5,830,249	0	0
LIVONGO HEALTH INC	NOTE 0.875% 6/0	539183AA1	42,380	50,000,000	PRN		DFND	1	50,000,000	0	0
MEDAVAIL HOLDINGS INC	COM	58406B103	1,280	836,626	SH		DFND	1	836,626	0	0
MEDTECH ACQUISITION CORP	UNIT 12/18/2025	58507N204	0	1	SH		DFND	1	1	0	0
MEDTECH ACQUISITION CORP	COM CL A	58507N105	9,845	999,999	SH		DFND	1	999,999	0	0
MEDTECH ACQUISITION CORP	*W EXP 12/22/202	58507N113	28	333,333	SH		DFND	1	333,333	0	0
MERUS N V	COM	N5749R100	44,961	1,985,924	SH		DFND	1	1,985,924	0	0
MIRUM PHARMACEUTICALS INC	COM	604749101	63,137	3,244,434	SH		DFND	1	3,244,434	0	0
MOLINA HEALTHCARE INC	COM	60855R100	46,695	167,000	SH		DFND	1	167,000	0	0
NATERA INC	NOTE 2.250% 5/0	632307AB0	111,924	90,638,000	PRN		DFND	1	90,638,000	0	0
NEOGENOMICS INC	NOTE 1.250% 5/0	64049MAA8	5,443	6,500,000	PRN		DFND	1	6,500,000	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	196,199	2,012,714	SH		DFND	1	2,012,714	0	0
NEVRO CORP	NOTE 2.750% 4/0	64157FAC7	57,724	61,000,000	PRN		DFND	1	61,000,000	0	0
NKARTA INC	COM	65487U108	7,392	600,000	SH		DFND	1	600,000	0	0
NOVAVAX INC	NOTE 3.750% 2/0	670002AB0	24,855	25,000,000	PRN		DFND	1	25,000,000	0	0
NUVALENT INC	COM	670703107	262,264	19,341,024	SH		DFND	1	19,341,024	0	0
NUVASIVE INC	NOTE 0.375% 3/1	670704AJ4	71,655	80,000,000	PRN		DFND	1	80,000,000	0	0
NUVASIVE INC	NOTE 1.000% 6/0	670704AL9	93,615	96,966,000	PRN		DFND	1	96,966,000	0	0
NUVATION BIO INC	*W EXP 07/07/202	67080N119	47	166,666	SH		DFND	1	166,666	0	0
NYXOAH S A	SHS	B6S7WD106	4,188	455,262	SH		DFND	1	455,262	0	0
ONCORUS INC	COM	68236R103	3,968	3,148,977	SH		DFND	1	3,148,977	0	0
THE ONCOLOGY INSTITUTE INC	*W EXP 11/15/202	68236X118	625	1,250,000	SH		DFND	1	1,250,000	0	0
THE ONCOLOGY INSTITUTE INC	COM	68236X100	17,118	3,383,099	SH		DFND	1	3,383,099	0	0
ORCHARD THERAPEUTICS PLC	ADS	68570P101	4,060	6,949,416	SH		DFND	1	6,949,416	0	0
ORGANOGENESIS HLDGS INC	COM	68621F102	21,705	4,447,740	SH		DFND	1	4,447,740	0	0
ORION ACQUISITION CORP	*W EXP 02/19/202	68626A116	11	125,000	SH		DFND	1	125,000	0	0
ORION ACQUISITION CORP	COM CL A	68626A108	4,900	500,000	SH		DFND	1	500,000	0	0
OAK STR HEALTH INC	NOTE 3/1	67181AAB3	48,551	68,000,000	SH		DFND	1	68,000,000	0	0
OUTSET MED INC	COM	690145107	5,953	400,622	SH		DFND	1	400,622	0	0
PACIRA BIOSCIENCES INC	COM	695127100	17,024	292,000	SH		DFND	1	292,000	0	0
PACIRA BIOSCIENCES INC	NOTE 0.750% 8/0	695127AF7	84,967	81,600,000	PRN		DFND	1	81,600,000	0	0
PEPGEN INC	COM	713317105	9,470	953,626	SH		DFND	1	953,626	0	0
PHARVARIS N V	COM	N69605108	26,307	1,190,343	SH		DFND	1	1,190,343	0	0
PHREESIA INC	COM	71944F106	21,436	857,115	SH		DFND	1	857,115	0	0
PROFOUND MED CORP	COM NEW	74319B502	12,494	1,713,797	SH		DFND	1	1,713,797	0	0
PTC THERAPEUTICS INC	NOTE 3.000% 8/1	69366JAB7	25,518	25,417,000	PRN		DFND	1	25,417,000	0	0
PTC THERAPEUTICS INC	NOTE 1.500% 9/1	69366JAD3	33,439	32,000,000	PRN		DFND	1	32,000,000	0	0
PULMONX CORP	COM	745848101	51,018	3,465,901	SH		DFND	1	3,465,901	0	0
QUANTUM SI INC	COM CL A	74765K105	3,248	1,400,000	SH		DFND	1	1,400,000	0	0
QUANTUM SI INC	*W EXP 06/10/202	74765K113	188	333,333	SH		DFND	1	333,333	0	0
REVOLUTION HEALTHCAR AQ CORP	CLASS A COM	76155Y108	9,770	1,000,000	SH		DFND	1	1,000,000	0	0
REVOLUTION HEALTHCAR AQ CORP	*W EXP 12/31/202	76155Y116	49	200,000	SH		DFND	1	200,000	0	0
REVOLUTION MEDICINES INC	COM	76155X100	17,377	891,587	SH		DFND	1	891,587	0	0
RHYTHM PHARMACEUTICALS INC	COM	76243J105	1,208	291,005	SH		DFND	1	291,005	0	0
ROIVANT SCIENCES LTD	*W EXP 09/30/202	G76279119	600	1,000,000	SH		DFND	1	1,000,000	0	0
SARISSA CAPITAL ACQUISITN CO	UNIT 10/23/2027	G7823W128	0	1	SH		DFND	1	1	0	0
SARISSA CAPITAL ACQUISITN CO	CL A	G7823W102	9,890	999,999	SH		DFND	1	999,999	0	0
SARISSA CAPITAL ACQUISITN CO	*W EXP 10/23/202	G7823W110	33	333,333	SH		DFND	1	333,333	0	0
SEMA4 HOLDINGS CORP	COM CL A	81663L101	23,749	18,848,488	SH		DFND	1	18,848,488	0	0
SENIOR CONNECT ACQUISITN COR	*W EXP 12/31/202	81723H116	35	500,000	SH		DFND	1	500,000	0	0
SENIOR CONNECT ACQUISITN COR	COM CL A	81723H108	9,840	1,000,000	SH		DFND	1	1,000,000	0	0
SILK RD MED INC	COM	82710M100	97,412	2,676,891	SH		DFND	1	2,676,891	0	0
SINGULAR GENOMICS SYSTEMS IN	COM	82933R100	24,205	6,336,330	SH		DFND	1	6,336,330	0	0
SOMALOGIC INC	*W EXP 08/31/202	83444K113	91	120,000	SH		DFND	1	120,000	0	0
SAREPTA THERAPEUTICS INC	DBCV 1.500%11/1	803607AB6	111,766	88,657,000	SH		DFND	1	88,657,000	0	0
SURROZEN INC	*W EXP 08/01/203	86889P117	32	166,666	SH		DFND	1	166,666	0	0
SYNDAX PHARMACEUTICALS INC	COM	87164F105	21,378	1,111,111	SH		DFND	1	1,111,111	0	0
TABULA RASA HEALTHCARE INC	NOTE 1.750% 2/1	873379AA9	97,174	144,516,000	PRN		DFND	1	144,516,000	0	0
TARSUS PHARMACEUTICALS INC	COM	87650L103	19,334	1,324,214	SH		DFND	1	1,324,214	0	0
TG THERAPEUTICS INC	COM	88322Q108	11,379	2,677,500	SH		DFND	1	2,677,500	0	0
TURMERIC ACQUISITION CORP	*W EXP 10/08/202	G9127T124	19	250,000	SH		DFND	1	250,000	0	0
TURMERIC ACQUISITION CORP	CL A	G9127T108	7,448	750,000	SH		DFND	1	750,000	0	0
VIATRIS INC	COM	92556V106	216,454	20,673,700	SH		DFND	1	20,673,700	0	0
WEREWOLF THERAPEUTICS INC	COM	95075A107	3,919	958,125	SH		DFND	1	958,125	0	0
WINDTREE THERAPEUTICS INC	COM	97382D303	8	20,148	SH		DFND	1	20,148	0	0
XERIS BIOPHARMA HOLDINGS INC	NOTE 5.000% 7/1	98422LAA5	17,607	18,000,000	PRN		DFND	1	18,000,000	0	0
XILIO THERAPEUTICS INC	COM	98422T100	6,070	2,078,692	SH		DFND	1	2,078,692	0	0