Deerfield Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
1LIFE HEALTHCARE INC	NOTE 3.000% 6/1	68269GAB3	39,377	40,599,000	PRN		DFND	1	40,599,000	0	0
ACCOLADE INC	NOTE 0.500% 4/0	00437EAB8	79,078	105,000,000	PRN		DFND	1	105,000,000	0	0
ACUTUS MED INC	COM	005111109	2,333	2,651,667	SH		DFND	1	2,651,667	0	0
ADAPTHEALTH CORP	COMMON STOCK	00653Q102	154,438	8,223,536	SH		DFND	1	8,223,536	0	0
ADC THERAPEUTICS SA	SHS	H0036K147	11,521	2,390,297	SH		DFND	1	2,390,297	0	0
AERIE PHARMACEUTICALS INC	NOTE 1.500%10/0	00771VAB4	170,826	174,372,000	PRN		DFND	1	174,372,000	0	0
AERIE PHARMACEUTICALS INC	COM	00771V108	73,456	4,855,005	SH		DFND	1	4,855,005	0	0
ALECTOR INC	COM	014442107	9,982	1,055,192	SH		DFND	1	1,055,192	0	0
ALPHATEC HLDGS INC	COM NEW	02081G201	22,137	2,532,792	SH		DFND	1	2,532,792	0	0
ALPHATEC HLDGS INC	NOTE 0.750% 8/0	02081GAB8	81,430	100,000,000	PRN		DFND	1	100,000,000	0	0
AMEDISYS INC	COM	023436108	34,822	359,765	SH		DFND	1	359,765	0	0
AN2 THERAPEUTICS INC	COM	037326105	12,453	716,538	SH		DFND	1	716,538	0	0
ANAPTYSBIO INC	COM	032724106	37,413	1,466,600	SH		DFND	1	1,466,600	0	0
ANNEXON INC	COM	03589W102	3,609	583,913	SH		DFND	1	583,913	0	0
APELLIS PHARMACEUTICALS INC	NOTE 3.500% 9/1	03753UAB2	99,115	51,885,000	PRN		DFND	1	51,885,000	0	0
APOLLO ENDOSURGERY INC	COM	03767D108	9,643	1,750,000	SH		DFND	1	1,750,000	0	0
BELLUS HEALTH INC NEW	COM NEW	07987C204	32,535	3,081,000	SH		DFND	1	3,081,000	0	0
BIOGEN INC	COM	09062X103	88,110	330,000	SH		DFND	1	330,000	0	0
BROOKDALE SR LIVING INC	COM	112463104	37,117	8,692,561	SH		DFND	1	8,692,561	0	0
BUTTERFLY NETWORK INC	*W EXP 02/12/202	124155110	616	733,333	SH		DFND	1	733,333	0	0
CABALETTA BIO INC	COM	12674W109	302	464,252	SH		DFND	1	464,252	0	0
CAREMAX INC	COM CL A	14171W103	112,455	15,861,090	SH		DFND	1	15,861,090	0	0
CAREMAX INC	*W EXP 06/08/202	14171W111	1,263	672,000	SH		DFND	1	672,000	0	0
CATALYST PHARMACEUTICALS INC	COM	14888U101	62,816	4,896,000	SH		DFND	1	4,896,000	0	0
CENTENE CORP DEL	COM	15135B101	36,104	464,000	SH		DFND	1	464,000	0	0
COGENT BIOSCIENCES INC	COM	19240Q201	44,258	2,966,345	SH		DFND	1	2,966,345	0	0
CYTOKINETICS INC	COM NEW	23282W605	39,395	813,112	SH		DFND	1	813,112	0	0
DA32 LIFE SCNCE TEC ACQSTN C	CLASS A COM	23312M106	15,568	1,600,000	SH		DFND	1	1,600,000	0	0
DAY ONE BIOPHARMACEUTICALS I	COM	23954D109	20,671	1,032,000	SH		DFND	1	1,032,000	0	0
DECIPHERA PHARMACEUTICALS IN	COM	24344T101	46,093	2,491,490	SH		DFND	1	2,491,490	0	0
DELCATH SYS INC	COM NEW	24661P807	1,555	486,068	SH		DFND	1	486,068	0	0
EDGEWISE THERAPEUTICS INC	COM	28036F105	38,702	3,933,137	SH		DFND	1	3,933,137	0	0
ENHABIT INC	COM	29332G102	20,418	1,454,279	SH		DFND	1	1,454,279	0	0
EUCRATES BIOMEDICAL ACQU COR	*W EXP 10/23/202	G3141W122	13	333,333	SH		DFND	1	333,333	0	0
EUCRATES BIOMEDICAL ACQU COR	UNIT 10/23/2027	G3141W114	0	1	SH		DFND	1	1	0	0
EUCRATES BIOMEDICAL ACQUISIT	SHS	G3141W106	10,020	999,999	SH		DFND	1	999,999	0	0
EVOLUS INC	COM	30052C107	43,390	5,390,103	SH		DFND	1	5,390,103	0	0
FOGHORN THERAPEUTICS INC	COM	344174107	6,671	777,525	SH		DFND	1	777,525	0	0
GILEAD SCIENCES INC	COM	375558103	94,851	1,537,539	SH		DFND	1	1,537,539	0	0
GLAUKOS CORP	NOTE 2.750% 6/1	377322AB8	355,849	271,752,000	PRN		DFND	1	271,752,000	0	0
GLAUKOS CORP	COM	377322102	0	0	SH		DFND	1	0	0	0
GRAYBUG VISION INC	COMMON	38942Q103	4,967	5,281,713	SH		DFND	1	5,281,713	0	0
GUARDANT HEALTH INC	NOTE 11/1	40131MAB5	65,033	89,036,000	PRN		DFND	1	89,036,000	0	0
HEALTH CATALYST INC	NOTE 2.500% 4/1	42225TAB3	25,533	30,000,000	PRN		DFND	1	30,000,000	0	0
HILLEVAX INC	COM	43157M102	45,344	2,653,231	SH		DFND	1	2,653,231	0	0
IDEAYA BIOSCIENCES INC	COM	45166A102	26,015	1,743,628	SH		DFND	1	1,743,628	0	0
IGNYTE ACQUISITION CORP	*W EXP 01/05/202	45175H114	45	362,500	SH		DFND	1	362,500	0	0
IGNYTE ACQUISITION CORP	COM	45175H106	7,236	725,000	SH		DFND	1	725,000	0	0
IMMUNOGEN INC	COM	45253H101	65,678	13,740,205	SH		DFND	1	13,740,205	0	0
INOZYME PHARMA INC	COM	45790W108	5,602	2,090,436	SH		DFND	1	2,090,436	0	0
INSMED INC	NOTE 1.750% 1/1	457669AA7	73,212	75,000,000	PRN		DFND	1	75,000,000	0	0
INSMED INC	COM PAR $.01	457669307	20,689	960,484	SH		DFND	1	960,484	0	0
INTERCEPT PHARMACEUTICALS IN	NOTE 3.500% 2/1	45845PAC2	81,098	78,500,000	PRN		DFND	1	78,500,000	0	0
INTERCEPT PHARMACEUTICALS IN	NOTE 3.250% 7/0	45845PAA6	56,098	57,791,000	PRN		DFND	1	57,791,000	0	0
INVITAE CORP	NOTE 2.000% 9/0	46185LAB9	162,218	206,873,000	PRN		DFND	1	206,873,000	0	0
IONIS PHARMACEUTICALS INC	NOTE 4/0	462222AD2	128,518	127,800,000	PRN		DFND	1	127,800,000	0	0
IVERIC BIO INC	COM	46583P102	76,139	4,244,098	SH		DFND	1	4,244,098	0	0
IVERIC BIO INC	COM	46583P102	8,073	450,000	SH	Call	DFND	1	450,000	0	0
IVERIC BIO INC	COM	46583P102	9,867	550,000	SH	Call	DFND	1	550,000	0	0
KINNATE BIOPHARMA INC	COM	49705R105	2,988	250,000	SH		DFND	1	250,000	0	0
KRYSTAL BIOTECH INC	COM	501147102	12,198	175,000	SH		DFND	1	175,000	0	0
KURA ONCOLOGY INC	COM	50127T109	30,313	2,219,128	SH		DFND	1	2,219,128	0	0
LARIMAR THERAPEUTICS INC	COM	517125100	54,212	16,941,357	SH		DFND	1	16,941,357	0	0
MEDAVAIL HOLDINGS INC	COM	58406B103	649	836,626	SH		DFND	1	836,626	0	0
MEDTECH ACQUISITION CORP	UNIT 12/18/2025	58507N204	0	1	SH		DFND	1	1	0	0
MEDTECH ACQUISITION CORP	COM CL A	58507N105	9,930	999,999	SH		DFND	1	999,999	0	0
MEDTECH ACQUISITION CORP	*W EXP 12/22/202	58507N113	20	333,333	SH		DFND	1	333,333	0	0
MERUS N V	COM	N5749R100	50,507	2,521,553	SH		DFND	1	2,521,553	0	0
MIRUM PHARMACEUTICALS INC	COM	604749101	42,699	2,032,335	SH		DFND	1	2,032,335	0	0
MOLINA HEALTHCARE INC	COM	60855R100	24,738	75,000	SH		DFND	1	75,000	0	0
NANOSTRING TECHNOLOGIES INC	NOTE 2.625% 3/0	63009RAD1	48,669	57,604,000	PRN		DFND	1	57,604,000	0	0
NATERA INC	NOTE 2.250% 5/0	632307AB0	51,398	37,638,000	PRN		DFND	1	37,638,000	0	0
NEOGENOMICS INC	NOTE 1.250% 5/0	64049MAA8	5,571	6,500,000	PRN		DFND	1	6,500,000	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	160,665	1,512,714	SH		DFND	1	1,512,714	0	0
NEVRO CORP	NOTE 2.750% 4/0	64157FAC7	39,609	42,000,000	PRN		DFND	1	42,000,000	0	0
NOVAVAX INC	NOTE 3.750% 2/0	670002AB0	24,388	25,000,000	PRN		DFND	1	25,000,000	0	0
NUVALENT INC	COM	670703107	375,990	19,341,024	SH		DFND	1	19,341,024	0	0
NUVASIVE INC	NOTE 1.000% 6/0	670704AL9	93,716	96,966,000	PRN		DFND	1	96,966,000	0	0
NUVATION BIO INC	*W EXP 07/07/202	67080N119	33	166,666	SH		DFND	1	166,666	0	0
NUVATION BIO INC	COM CL A	67080N101	550	245,360	SH		DFND	1	245,360	0	0
NYXOAH S A	SHS	B6S7WD106	2,868	455,262	SH		DFND	1	455,262	0	0
OAK STR HEALTH INC	NOTE 3/1	67181AAB3	52,497	68,000,000	SH		DFND	1	68,000,000	0	0
ONCORUS INC	COM	68236R103	2,677	3,148,977	SH		DFND	1	3,148,977	0	0
ORCHARD THERAPEUTICS PLC	SPON ADS	68570P101	3,475	6,949,416	SH		DFND	1	6,949,416	0	0
ORION ACQUISITION CORP	*W EXP 02/19/202	68626A116	7	125,000	SH		DFND	1	125,000	0	0
ORION ACQUISITION CORP	COM CL A	68626A108	4,923	500,000	SH		DFND	1	500,000	0	0
PACIFIC BIOSCIENCES CALIF IN	COM	69404D108	11,732	2,021,000	SH		DFND	1	2,021,000	0	0
PACIRA BIOSCIENCES INC	COM	695127100	15,531	292,000	SH		DFND	1	292,000	0	0
PACIRA BIOSCIENCES INC	NOTE 0.750% 8/0	695127AF7	80,771	81,600,000	PRN		DFND	1	81,600,000	0	0
PEPGEN INC	COM	713317105	6,767	745,293	SH		DFND	1	745,293	0	0
PHARVARIS N V	COM	N69605108	8,472	1,104,552	SH		DFND	1	1,104,552	0	0
PHATHOM PHARMACEUTICALS INC	COM	71722W107	26,757	2,414,897	SH		DFND	1	2,414,897	0	0
PHREESIA INC	COM	71944F106	34,602	1,358,000	SH		DFND	1	1,358,000	0	0
POINT BIOPHARMA GLOBAL INC	COM	730541109	7,730	1,000,000	SH		DFND	1	1,000,000	0	0
PROFOUND MED CORP	COM NEW	74319B502	2,959	732,543	SH		DFND	1	732,543	0	0
PTC THERAPEUTICS INC	NOTE 1.500% 9/1	69366JAD3	37,558	32,000,000	PRN		DFND	1	32,000,000	0	0
PULMONX CORP	COM	745848101	61,990	3,720,901	SH		DFND	1	3,720,901	0	0
QUANTUM SI INC	COM CL A	74765K105	3,850	1,400,000	SH		DFND	1	1,400,000	0	0
QUANTUM SI INC	*W EXP 06/10/202	74765K113	177	333,333	SH		DFND	1	333,333	0	0
REVOLUTION HEALTHCAR AQ CORP	CLASS A COM	76155Y108	9,820	1,000,000	SH		DFND	1	1,000,000	0	0
REVOLUTION HEALTHCAR AQ CORP	*W EXP 12/31/202	76155Y116	9	200,000	SH		DFND	1	200,000	0	0
REVOLUTION MEDICINES INC	COM	76155X100	57,022	2,891,587	SH		DFND	1	2,891,587	0	0
ROCKET PHARMACEUTICALS INC	COM	77313F106	13,885	870,000	SH		DFND	1	870,000	0	0
ROIVANT SCIENCES LTD	*W EXP 09/30/202	G76279119	390	1,000,000	SH		DFND	1	1,000,000	0	0
SAREPTA THERAPEUTICS INC	DBCV 1.500%11/1	803607AB6	148,264	88,657,000	PRN		DFND	1	88,657,000	0	0
SARISSA CAPITAL ACQUISITN CO	UNIT 10/23/2027	G7823W128	0	1	SH		DFND	1	1	0	0
SARISSA CAPITAL ACQUISITN CO	CL A	G7823W102	10,000	999,999	SH		DFND	1	999,999	0	0
SARISSA CAPITAL ACQUISITN CO	*W EXP 10/23/202	G7823W110	7	333,333	SH		DFND	1	333,333	0	0
SEMA4 HOLDINGS CORP	COM CL A	81663L101	14,894	16,973,488	SH		DFND	1	16,973,488	0	0
SENIOR CONNECT ACQUISITN COR	*W EXP 12/31/202	81723H116	10	500,000	SH		DFND	1	500,000	0	0
SENIOR CONNECT ACQUISITN COR	COM CL A	81723H108	9,945	1,000,000	SH		DFND	1	1,000,000	0	0
SILK RD MED INC	COM	82710M100	114,092	2,535,369	SH		DFND	1	2,535,369	0	0
SINGULAR GENOMICS SYSTEMS IN	COM	82933R100	17,695	7,078,019	SH		DFND	1	7,078,019	0	0
SOMALOGIC INC	*W EXP 08/31/202	83444K113	53	120,000	SH		DFND	1	120,000	0	0
SPRINGWORKS THERAPEUTICS INC	COM	85205L107	23,309	816,994	SH		DFND	1	816,994	0	0
SURROZEN INC	*W EXP 08/01/203	86889P117	31	166,666	SH		DFND	1	166,666	0	0
TABULA RASA HEALTHCARE INC	NOTE 1.750% 2/1	873379AA9	115,533	144,516,000	PRN		DFND	1	144,516,000	0	0
TARSUS PHARMACEUTICALS INC	COM	87650L103	22,671	1,324,214	SH		DFND	1	1,324,214	0	0
LIVONGO HEALTH INC	NOTE 0.875% 6/0	539183AA1	41,977	50,000,000	PRN		DFND	1	50,000,000	0	0
TERNS PHARMACEUTICALS INC	COM	880881107	10,955	1,860,000	SH		DFND	1	1,860,000	0	0
TG THERAPEUTICS INC	COM	88322Q108	15,851	2,677,500	SH		DFND	1	2,677,500	0	0
THE ONCOLOGY INSTITUTE INC	*W EXP 11/15/202	68236X118	691	1,250,000	SH		DFND	1	1,250,000	0	0
THE ONCOLOGY INSTITUTE INC	COM	68236X100	15,557	3,360,052	SH		DFND	1	3,360,052	0	0
TURMERIC ACQUISITION CORP	*W EXP 10/08/202	G9127T124	7	250,000	SH		DFND	1	250,000	0	0
TURMERIC ACQUISITION CORP	CL A	G9127T108	7,500	750,000	SH		DFND	1	750,000	0	0
VERICEL CORP	COM	92346J108	11,251	484,947	SH		DFND	1	484,947	0	0
VERVE THERAPEUTICS INC	COM	92539P101	25,763	750,000	SH		DFND	1	750,000	0	0
VIATRIS INC	COM	92556V106	90,940	10,673,700	SH		DFND	1	10,673,700	0	0
VIGIL NEUROSCIENCE INC	COM	92673K108	17,951	2,054,794	SH		DFND	1	2,054,794	0	0
WEREWOLF THERAPEUTICS INC	COM	95075A107	4,321	958,125	SH		DFND	1	958,125	0	0
WINDTREE THERAPEUTICS INC	COM	97382D303	6	20,148	SH		DFND	1	20,148	0	0
XERIS BIOPHARMA HOLDINGS INC	NOTE 5.000% 7/1	98422LAA5	17,384	18,000,000	PRN		DFND	1	18,000,000	0	0