Deerfield Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ABEONA THERAPEUTICS INC	COM NEW	00289Y206	2,452,173	869,565	SH		DFND	1	869,565	0	0
ACCOLADE INC	NOTE 0.500% 4/0	00437EAB8	96,642,410	122,598,000	PRN		DFND	1	122,598,000	0	0
ACUTUS MED INC	COM	005111109	1,999,357	2,651,667	SH		DFND	1	2,651,667	0	0
ADAPTHEALTH CORP	COMMON STOCK	00653Q102	131,694,781	10,594,914	SH		DFND	1	10,594,914	0	0
ALECTOR INC	COM	014442107	6,531,638	1,055,192	SH		DFND	1	1,055,192	0	0
ALPHATEC HLDGS INC	COM NEW	02081G201	16,329,940	1,046,791	SH		DFND	1	1,046,791	0	0
AMEDISYS INC	COM	023436108	109,087,815	1,483,179	SH		DFND	1	1,483,179	0	0
AMYLYX PHARMACEUTICALS INC	COM	03237H101	58,220,330	1,984,333	SH		DFND	1	1,984,333	0	0
ANAPTYSBIO INC	COM	032724106	13,338,880	613,000	SH		DFND	1	613,000	0	0
ANNEXON INC	COM	03589W102	2,248,065	583,913	SH		DFND	1	583,913	0	0
APELLIS PHARMACEUTICALS INC	NOTE 3.500% 9/1	03753UAB2	95,989,624	51,793,000	PRN		DFND	1	51,793,000	0	0
ARS PHARMACEUTICALS INC	COM	82835W108	72,117,305	11,077,927	SH		DFND	1	11,077,927	0	0
BELLUS HEALTH INC NEW	COM NEW	07987C204	25,783,200	3,581,000	SH		DFND	1	3,581,000	0	0
BIOCRYST PHARMACEUTICALS INC	COM	09058V103	23,060,100	2,765,000	SH		DFND	1	2,765,000	0	0
BLUEBIRD BIO INC	COM	09609G100	6,916,500	2,175,000	SH		DFND	1	2,175,000	0	0
BROOKDALE SR LIVING INC	COM	112463104	48,397,839	16,406,047	SH		DFND	1	16,406,047	0	0
BROOKDALE SR LIVING INC	NOTE 2.000%10/1	112463AC8	104,789,706	145,955,000	PRN		DFND	1	145,955,000	0	0
BUTTERFLY NETWORK INC	*W EXP 02/12/202	124155110	195,140	733,333	SH		DFND	1	733,333	0	0
CABALETTA BIO INC	COM	12674W109	3,839,364	464,252	SH		DFND	1	464,252	0	0
CAREMAX INC	COM CL A	14171W103	42,349,110	15,861,090	SH		DFND	1	15,861,090	0	0
CAREMAX INC	*W EXP 06/08/202	14171W111	323,770	672,000	SH		DFND	1	672,000	0	0
CASTLE BIOSCIENCES INC	COM	14843C105	6,182,907	272,135	SH		DFND	1	272,135	0	0
CATALYST PHARMACEUTICALS INC	COM	14888U101	171,687,541	10,355,099	SH		DFND	1	10,355,099	0	0
CENTENE CORP DEL	COM	15135B101	67,950,750	1,075,000	SH		DFND	1	1,075,000	0	0
COGENT BIOSCIENCES INC	COM	19240Q201	32,006,863	2,966,345	SH		DFND	1	2,966,345	0	0
DA32 LIFE SCNCE TEC ACQSTN C	CLASS A COM	23312M106	16,192,000	1,600,000	SH		DFND	1	1,600,000	0	0
DECIPHERA PHARMACEUTICALS IN	COM	24344T101	80,627,957	5,218,638	SH		DFND	1	5,218,638	0	0
DENALI THERAPEUTICS INC	COM	24823R105	13,708,547	594,989	SH		DFND	1	594,989	0	0
DOCGO INC	COM	256086109	26,460,350	3,059,000	SH		DFND	1	3,059,000	0	0
EDGEWISE THERAPEUTICS INC	COM	28036F105	26,234,024	3,933,137	SH		DFND	1	3,933,137	0	0
ENHABIT INC	COM	29332G102	47,276,557	3,398,746	SH		DFND	1	3,398,746	0	0
EUCRATES BIOMEDICAL ACQU COR	UNIT 10/23/2027	G3141W114	10	1	SH		DFND	1	1	0	0
EUCRATES BIOMEDICAL ACQU COR	*W EXP 10/23/202	G3141W122	13,500	333,333	SH		DFND	1	333,333	0	0
EVOLUS INC	COM	30052C107	30,193,740	3,569,000	SH		DFND	1	3,569,000	0	0
FOGHORN THERAPEUTICS INC	COM	344174107	4,820,655	777,525	SH		DFND	1	777,525	0	0
FUSION PHARMACEUTICALS INC	COM	36118A100	10,642,710	2,823,000	SH		DFND	1	2,823,000	0	0
GENEDX HOLDINGS CORP	COM CL A	81663L101	20,875,117	57,192,101	SH		DFND	1	57,192,101	0	0
GLAUKOS CORP	NOTE 2.750% 6/1	377322AB8	336,238,478	271,752,000	PRN		DFND	1	271,752,000	0	0
GUARDANT HEALTH INC	NOTE 11/1	40131MAB5	59,608,534	89,036,000	PRN		DFND	1	89,036,000	0	0
GUARDANT HEALTH INC	COM	40131M109	18,259,737	778,999	SH		DFND	1	778,999	0	0
HEALTH CATALYST INC	NOTE 2.500% 4/1	42225TAB3	27,186,090	30,000,000	PRN		DFND	1	30,000,000	0	0
HILLEVAX INC	COM	43157M102	46,840,896	2,833,690	SH		DFND	1	2,833,690	0	0
IDEAYA BIOSCIENCES INC	COM	45166A102	23,940,012	1,743,628	SH		DFND	1	1,743,628	0	0
INSMED INC	COM PAR $.01	457669307	11,228,209	658,546	SH		DFND	1	658,546	0	0
INSMED INC	NOTE 1.750% 1/1	457669AA7	94,378,258	103,200,000	PRN		DFND	1	103,200,000	0	0
INTERCEPT PHARMACEUTICALS IN	NOTE 3.250% 7/0	45845PAA6	57,036,596	57,791,000	PRN		DFND	1	57,791,000	0	0
INTERCEPT PHARMACEUTICALS IN	NOTE 3.500% 2/1	45845PAC2	101,202,725	98,354,000	PRN		DFND	1	98,354,000	0	0
INTRA-CELLULAR THERAPIES INC	COM	46116X101	39,746,100	734,000	SH		DFND	1	734,000	0	0
INVITAE CORP	NOTE 2.000% 9/0	46185LAB9	14,146,090	15,711,000	PRN		DFND	1	15,711,000	0	0
INVITAE CORP	COM	46185L103	12,520,854	9,274,707	SH		DFND	1	9,274,707	0	0
IONIS PHARMACEUTICALS INC	NOTE 4/0	462222AD2	116,871,183	127,800,000	PRN		DFND	1	127,800,000	0	0
IOVANCE BIOTHERAPEUTICS INC	COM	462260100	11,191,119	1,831,607	SH		DFND	1	1,831,607	0	0
IVERIC BIO INC	COM	46583P102	36,606,383	1,504,578	SH		DFND	1	1,504,578	0	0
KRYSTAL BIOTECH INC	COM	501147102	24,974,637	311,949	SH		DFND	1	311,949	0	0
KURA ONCOLOGY INC	COM	50127T109	29,144,090	2,383,000	SH		DFND	1	2,383,000	0	0
LARIMAR THERAPEUTICS INC	COM	517125100	76,744,347	16,941,357	SH		DFND	1	16,941,357	0	0
LIVONGO HEALTH INC	NOTE 0.875% 6/0	539183AA1	44,427,400	50,000,000	PRN		DFND	1	50,000,000	0	0
MEDAVAIL HOLDINGS INC	COM	58406B103	239,777	836,626	SH		DFND	1	836,626	0	0
MEDTECH ACQUISITION CORP	UNIT 12/18/2025	58507N204	10	1	SH		DFND	1	1	0	0
MEDTECH ACQUISITION CORP	*W EXP 12/22/202	58507N113	20,467	333,333	SH		DFND	1	333,333	0	0
MERUS N V	COM	N5749R100	43,800,059	2,380,438	SH		DFND	1	2,380,438	0	0
MINERALYS THERAPEUTICS INC	COM	603170101	11,416,469	729,021	SH		DFND	1	729,021	0	0
MIRUM PHARMACEUTICALS INC	COM	604749101	48,816,687	2,032,335	SH		DFND	1	2,032,335	0	0
NANOSTRING TECHNOLOGIES INC	NOTE 2.625% 3/0	63009RAD1	58,045,159	70,204,000	PRN		DFND	1	70,204,000	0	0
NATERA INC	NOTE 2.250% 5/0	632307AB0	164,112,922	101,042,000	PRN		DFND	1	101,042,000	0	0
NEOGENOMICS INC	NOTE 1.250% 5/0	64049MAA8	6,035,757	6,500,000	PRN		DFND	1	6,500,000	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	176,599,951	1,744,714	SH		DFND	1	1,744,714	0	0
NEWAMSTERDAM PHARMA COMPANY	*W EXP 11/22/202	N62509117	170,728	92,787	SH		DFND	1	92,787	0	0
NEWAMSTERDAM PHARMA COMPANY	ORDINARY SHARES	N62509109	33,623,687	2,535,723	SH		DFND	1	2,535,723	0	0
NUVALENT INC	COM	670703107	521,565,816	19,991,024	SH		DFND	1	19,991,024	0	0
NUVATION BIO INC	COM CL A	67080N101	9,719,068	5,854,860	SH		DFND	1	5,854,860	0	0
NUVATION BIO INC	*W EXP 07/07/202	67080N119	20,000	166,666	SH		DFND	1	166,666	0	0
NYXOAH S A	SHS	B6S7WD106	3,400,807	455,262	SH		DFND	1	455,262	0	0
OAK STR HEALTH INC	NOTE 3/1	67181AAB3	15,185,063	15,403,000	PRN		DFND	1	15,403,000	0	0
ORCHARD THERAPEUTICS PLC	SPON ADS NEW	68570P200	1,697,828	316,169	SH		DFND	1	316,169	0	0
OWENS & MINOR INC NEW	COM	690732102	56,271,470	3,867,455	SH		DFND	1	3,867,455	0	0
PACIFIC BIOSCIENCES CALIF IN	COM	69404D108	7,527,000	650,000	SH		DFND	1	650,000	0	0
PACIRA BIOSCIENCES INC	NOTE 0.750% 8/0	695127AF7	75,026,712	81,600,000	PRN		DFND	1	81,600,000	0	0
PRIME MEDICINE INC	COM	74168J101	10,889,362	885,314	SH		DFND	1	885,314	0	0
PTC THERAPEUTICS INC	NOTE 1.500% 9/1	69366JAD3	36,310,720	32,000,000	PRN		DFND	1	32,000,000	0	0
PULMONX CORP	COM	745848101	26,862,231	2,402,704	SH		DFND	1	2,402,704	0	0
QUANTUM SI INC	*W EXP 06/10/202	74765K113	50,000	333,333	SH		DFND	1	333,333	0	0
RAIN ONCOLOGY INC	COM	75082Q105	1,987,415	227,393	SH		DFND	1	227,393	0	0
REVOLUTION MEDICINES INC	COM	76155X100	17,972,103	829,737	SH		DFND	1	829,737	0	0
ROIVANT SCIENCES LTD	*W EXP 09/30/202	G76279119	1,459,800	1,000,000	SH		DFND	1	1,000,000	0	0
ROIVANT SCIENCES LTD	SHS	G76279101	12,915,000	1,750,000	SH		DFND	1	1,750,000	0	0
SENIOR CONNECT ACQUISITN COR	*W EXP 12/31/202	81723H116	19,550	500,000	SH		DFND	1	500,000	0	0
SIENTRA INC	COM	82621J204	15,400	10,000	SH		DFND	1	10,000	0	0
SILK RD MED INC	COM	82710M100	67,524,293	1,725,640	SH		DFND	1	1,725,640	0	0
SINGULAR GENOMICS SYSTEMS IN	COM	82933R100	7,805,554	6,450,871	SH		DFND	1	6,450,871	0	0
SOMALOGIC INC	*W EXP 08/31/202	83444K113	36,000	120,000	SH		DFND	1	120,000	0	0
SPRINGWORKS THERAPEUTICS INC	COM	85205L107	40,652,443	1,579,349	SH		DFND	1	1,579,349	0	0
STRUCTURE THERAPEUTICS INC	SPONSORED ADS	86366E106	8,921,250	375,000	SH		DFND	1	375,000	0	0
SURROZEN INC	*W EXP 08/01/203	86889P117	16,667	166,666	SH		DFND	1	166,666	0	0
TABULA RASA HEALTHCARE INC	NOTE 1.750% 2/1	873379AA9	117,283,260	144,516,000	PRN		DFND	1	144,516,000	0	0
TARSUS PHARMACEUTICALS INC	COM	87650L103	14,531,322	1,156,032	SH		DFND	1	1,156,032	0	0
TERNS PHARMACEUTICALS INC	COM	880881107	24,383,545	2,059,421	SH		DFND	1	2,059,421	0	0
THE ONCOLOGY INSTITUTE INC	COM	68236X100	2,277,779	3,360,052	SH		DFND	1	3,360,052	0	0
THE ONCOLOGY INSTITUTE INC	*W EXP 11/15/202	68236X118	81,375	1,250,000	SH		DFND	1	1,250,000	0	0
VAXCYTE INC	COM	92243G108	11,056,600	295,000	SH		DFND	1	295,000	0	0
VENTYX BIOSCIENCES INC	COM	92332V107	20,669,500	617,000	SH		DFND	1	617,000	0	0
VERA THERAPEUTICS INC	CL A	92337R101	10,088,000	1,300,000	SH		DFND	1	1,300,000	0	0
VIATRIS INC	COM	92556V106	162,924,291	16,935,997	SH		DFND	1	16,935,997	0	0
VIGIL NEUROSCIENCE INC	COM	92673K108	20,089,178	2,052,010	SH		DFND	1	2,052,010	0	0
VIKING THERAPEUTICS INC	COM	92686J106	18,731,250	1,125,000	SH		DFND	1	1,125,000	0	0
XERIS BIOPHARMA HOLDINGS INC	NOTE 5.000% 7/1	98422LAA5	17,348,832	18,000,000	PRN		DFND	1	18,000,000	0	0