Medivation 10-Q 2013 Q2 Quarterly report

Exhibit 12.1

Medivation, Inc.

Computation of Ratio of Earnings to Fixed Charges

(Unaudited)

(in thousands)

	Six  Months Ended June  30, 2013			Years Ended December 31,
				2012			2011			2010			2009			2008
Earnings
Net loss before income taxes	$	(32,003	)	$	(41,250	)	$	(43,172	)	$	(32,465	)	$	(46,481	)	$	(62,470	)
Fixed charges		11,037			16,985			933			733			933			200
Earnings, as defined	$	(20,966	)	$	(24,265	)	$	(42,239	)	$	(31,732	)	$	(45,548	)	$	(62,270	)
Fixed Charges
Interest expense	$	3,396		$	5,322		$	—		$	—		$	—		$	—
Amortization of debt discount and issuance costs		6,474			9,663			—			—			—			—
Interest component of rentals (1)		1,167			2,000			933			733			933			200
Total	$	11,037		$	16,985		$	933		$	733		$	933		$	200
Deficiency in earnings to cover fixed charges	$	32,003		$	41,250		$	43,172		$	32,465		$	46,481		$	62,470
Ratio of earnings to fixed charges			*			*			*			*			*			*

(1) Represents the estimated portion of operating lease rental expense that is considered by us to be a reasonable representation of interest.

* Because of the deficiency in earnings to cover fixed charges, the ratio information is not applicable.