Medivation 10-Q 2014 Q3 Quarterly report

Exhibit 12.1

Medivation, Inc.

Computation of Ratio of Earnings to Fixed Charges

(Unaudited)

(in thousands, except ratios)

	Nine Months Ended September 30, 2014		Years Ended December 31,
			2013			2012			2011			2010			2009
Earnings
Income (loss) before income taxes	$	122,218	$	(42,498	)	$	(41,250	)	$	(43,172	)	$	(32,465	)	$	(46,481	)
Add: Fixed charges		18,912		21,982			16,985			933			733			933
Earnings, as defined	$	141,130	$	(20,516	)	$	(24,265	)	$	(42,239	)	$	(31,732	)	$	(45,548	)
Fixed Charges
Interest expense	$	5,094	$	6,793		$	5,322		$	—		$	—		$	—
Capitalized interest		945		—			—			—			—			—
Amortization of debt discount and issuance costs		11,007		13,456			9,663			—			—			—
Interest component of rentals (1)		1,867		1,733			2,000			933			733			933
Total	$	18,913	$	21,982		$	16,985		$	933		$	733		$	933
Earnings (deficiency in earnings) to cover fixed charges	$	122,217	$	(42,498	)	$	(41,250	)	$	(43,172	)	$	(32,465	)	$	(46,481	)
Ratio of earnings to fixed charges		7.46			*			*			*			*			*

(1) Represents the estimated portion of operating lease rental expense that is considered by us to be a reasonable representation of interest.

* Because of the deficiency in earnings to cover fixed charges, the ratio information is not applicable.