Oracle Investment Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ACCELERATE DIAGNOSTICS INC	COM	00430H102	30,436	3,776,121	SH		SOLE		3,776,121	0	0
AGENUS INC	COM NEW	00847G705	50,363	9,173,582	SH		SOLE		9,173,582	0	0
AMARIN CORP PLC	SPONS ADR NEW	023111206	3,729	851,335	SH		SOLE		851,335	0	0
ANTARES PHARMA INC	COM	036642106	8,284	1,900,000	SH		SOLE		1,900,000	0	0
ASPIRA WOMENS HEALTH INC	COM	04537Y109	48,597	8,647,094	SH		SOLE		8,647,094	0	0
BIOCRYST PHARMACEUTICALS INC	COM	09058V103	30,367	1,920,733	SH		SOLE		1,920,733	0	0
BIODESIX INC	COM	09075X108	3,111	235,511	SH		SOLE		235,511	0	0
BIOGEN INC	COM	09062X103	835	2,412	SH		SOLE		2,412	0	0
BIOHAVEN PHARMACTL HLDG CO L	COM	G11196105	202,174	2,082,555	SH		SOLE		2,082,555	0	0
BIOHAVEN PHARMACTL HLDG CO L	COM	G11196105	1,820	248,200	SH	Put	SOLE		248,200	0	0
CAPRICOR THERAPEUTICS INC	COM NEW	14070B309	5,983	1,166,249	SH		SOLE		1,166,249	0	0
CODIAK BIOSCIENCES INC	COM	192010106	12,576	678,700	SH		SOLE		678,700	0	0
CONTRAFECT CORP	COM NEW	212326300	7,431	1,688,902	SH		SOLE		1,688,902	0	0
DERMTECH INC	COM	24984K105	27,265	655,877	SH		SOLE		655,877	0	0
FORIAN INC	COM	34630N106	10,915	868,342	SH		SOLE		868,342	0	0
IMMUTEP LTD	SPONSORED ADS	45257L108	3,870	1,000,000	SH		SOLE		1,000,000	0	0
MOTUS GI HLDGS INC	COM	62014P108	3,845	3,697,551	SH		SOLE		3,697,551	0	0
OPKO HEALTH INC	COM	68375N103	51,917	12,819,073	SH		SOLE		12,819,073	0	0
OPKO HEALTH INC	COM	68375N103	334	667,800	SH	Put	SOLE		667,800	0	0
PACIFIC BIOSCIENCES CALIF IN	COM	69404D108	48,054	1,374,159	SH		SOLE		1,374,159	0	0
QUIDEL CORP	COM	74838J101	107,250	837,109	SH		SOLE		837,109	0	0
SELECT MED HLDGS CORP	COM	81619Q105	3,744	88,589	SH		SOLE		88,589	0	0
SOLENO THERAPEUTICS INC	COM NEW	834203200	2,430	2,132,000	SH		SOLE		2,132,000	0	0
SPDR SER TR	S&P BIOTECH	78464A870	10,317	76,200	SH		SOLE		76,200	0	0
SPDR SER TR	S&P BIOTECH	78464A870	3,898	825,000	SH	Put	SOLE		825,000	0	0
VERTEX ENERGY INC	COM	92534K107	1,191	90,000	SH		SOLE		90,000	0	0
VIR BIOTECHNOLOGY INC	COM	92764N102	33,355	705,486	SH		SOLE		705,486	0	0
VIR BIOTECHNOLOGY INC	COM	92764N102	1,313	196,700	SH	Put	SOLE		196,700	0	0
Y-MABS THERAPEUTICS INC	COM	984241109	10,162	300,642	SH		SOLE		300,642	0	0