License Agreements (Details) - USD ($) | | | | | | | | | | | | | | 1 Months Ended | 3 Months Ended | 12 Months Ended |
Jan. 11, 2023 | Dec. 22, 2022 | Jul. 22, 2022 | Apr. 11, 2022 | Jan. 03, 2022 | Jan. 02, 2022 | Nov. 24, 2021 | May 24, 2021 | Jan. 28, 2021 | Jan. 02, 2021 | Jan. 02, 2020 | Feb. 15, 2019 | Sep. 21, 2016 | Jul. 31, 2022 | Apr. 30, 2022 | Jan. 31, 2022 | Dec. 31, 2021 | Nov. 30, 2021 | Feb. 29, 2020 | Jun. 30, 2022 | Mar. 31, 2019 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2019 |
Business Combination, Separately Recognized Transactions [Line Items] | | | | | | | | | | | | | | | | | | | | | | | | |
Stock Issued During Period, Shares, New Issues | | 500,000 | 500,000 | | | | | 22,258,066 | 17,530,488 | | | | | | | | | | | | | 350,000 | | |
Research and development expense - Vyera repurchase | | | | | | | | | | | | | | | | | | | | | | $ 500,000 | | |
Research and development | | | | | | | | | | | | | | | | | | | | | | 58,620,000 | $ 46,649,000 | |
Non refundable Cash Payment | | | | | | | | | | | | | | | | | | | | | | 1,200,000 | | |
Issuance of common stock, net of issuance costs | $ 1,000,000 | | | | | | | $ 64,500,000 | $ 33,500,000 | | | | | | | | | | | | | | 97,957,000 | |
Other Accrued Liabilities, Current | | | | | | | | | | | | | | | | | $ 25,000 | | | | | 89,000 | $ 25,000 | |
Total aggregate | | | | | | | | | | | | | | | | | | | | | | $ 239,000,000 | | |
Assetsfrom Vyera Pharmaceuticals [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Business Combination, Separately Recognized Transactions [Line Items] | | | | | | | | | | | | | | | | | | | | | | | | |
Business Combination, Separately Recognized Transactions, Description | | | | | | | | | | | | | | | | | | | | | | On April 8, 2022, Seelos Corporation (“STI”), a wholly-owned subsidiary of the Company, and Vyera, entered into an amendment (the “Amendment”) to the Asset Purchase Agreement by and between STI and Vyera, dated March 6, 2018 (as amended by a first amendment thereto entered into on May 18, 2018, a second amendment thereto entered into on December 31, 2018, a third amendment thereto entered into on October 15, 2019 and a fourth amendment thereto entered into on February 15, 2021, the “Vyera Purchase Agreement”). Pursuant to the Vyera Purchase Agreement, STI acquired the assets and liabilities of Vyera related to a product candidate currently referred to as SLS-002 (intranasal ketamine) (the “Vyera Assets”) and agreed, among other things, to make certain development and commercialization milestone payments and royalty payments related to the Vyera Assets (the “Milestone and Royalty Payment Obligations”) and further agreed that in the event that the Company sold, directly or indirectly, all or substantially all of the Vyera Assets to a third party, then the Company would pay Vyera an amount equal to 4% of the net proceeds actually received by the Company as an upfront payment in such sale (the “Change of Control Payment Obligation” | | |
Stock Issued During Period, Shares, New Issues | | | | 500,000 | | | | | | | | | | 500,000 | 500,000 | | | | | | | | | |
Research and development | | | | | | | | | | | | | | | | | | | | $ 5,800,000 | | | | |
Aggregate purchase price | | | $ 1,200,000 | | | | | | | | | | | | | | | | | | | | | |
Cash payment | | | | | | | | | | | | | | | $ 4,000,000 | | | | | | | $ 4,000,000 | | |
License agreement description | | | | | | | | | | | | | | | | | | | | | | On April 8, 2022, Seelos Corporation (“STI”), a wholly-owned subsidiary of the Company, and Vyera, entered into an amendment (the “Amendment”) to the Asset Purchase Agreement by and between STI and Vyera, dated March 6, 2018 (as amended by a first amendment thereto entered into on May 18, 2018, a second amendment thereto entered into on December 31, 2018, a third amendment thereto entered into on October 15, 2019 and a fourth amendment thereto entered into on February 15, 2021, the “Vyera Purchase Agreement”). Pursuant to the Vyera Purchase Agreement, STI acquired the assets and liabilities of Vyera related to a product candidate currently referred to as SLS-002 (intranasal ketamine) (the “Vyera Assets”) and agreed, among other things, to make certain development and commercialization milestone payments and royalty payments related to the Vyera Assets (the “Milestone and Royalty Payment Obligations”) and further agreed that in the event that the Company sold, directly or indirectly, all or substantially all of the Vyera Assets to a third party, then the Company would pay Vyera an amount equal to 4% of the net proceeds actually received by the Company as an upfront payment in such sale (the “Change of Control Payment Obligation” | | |
Issuance of common stock, net of issuance costs | | | | | | | | | | | | | | $ 800,000 | | | | | | | | | | |
Other Accrued Liabilities, Current | | | | | | | | | | | | | | | | | | | | | | $ 1,000,000 | | |
Cash Payments Agreedtoin Amendment to the Asset Purchase Agreement | | | | | | | | | | | | | | | | | | | | | | 4,000,000 | | |
Licensefrom Ligand Pharmaceuticals [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Business Combination, Separately Recognized Transactions [Line Items] | | | | | | | | | | | | | | | | | | | | | | | | |
Business Combination, Separately Recognized Transactions, Description | | | | | | | | | | | | | On September 21, 2016, the Company entered into a License Agreement (the “License Agreement”) with Ligand Pharmaceuticals Incorporated (“Ligand”), Neurogen Corporation and CyDex Pharmaceuticals, Inc. (collectively, the “Licensors”), pursuant to which, among other things, the Licensors granted to the Company an exclusive, perpetual, irrevocable, worldwide, royalty-bearing, nontransferable right and license under (i) patents related to a product known as Aplindore, which is now known as SLS-006, acetaminophen (as it may have been or may be modified for use in a product to be administered by any method in any form including, without limitation injection and intravenously, the sole active pharmaceutical ingredient of which is acetaminophen), which is now known as SLS-012, an H3 receptor antagonist, which is now known as SLS-010, and either or both of the Licensors’ two proprietary CRTh2 antagonists, which are now known collectively as SLS-008 (collectively, the “Licensed Products”), and (ii) copyrights, trade secrets, moral rights and all other intellectual and proprietary rights related thereto. The Company is obligated to use commercially reasonable efforts to (a) develop the Licensed Products, (b) obtain regulatory approval for the Licensed Products in the European Union (either in its entirety or including at least one of France, Germany or, if at the time the United Kingdom is a member of the European Union, the United Kingdom), the United Kingdom, if at the time the United Kingdom is not a member of the European Union, Japan or the People’s Republic of China (each, a “Major Market”) or the United States, and (c) commercialize the Licensed Products in each country where regulatory approval is obtained. The Company has the exclusive right and sole responsibility and decision-making authority to research and develop any Licensed Products and to conduct all clinical trials and non-clinical studies the Company believes appropriate to obtain regulatory approvals for commercialization of the Licensed Products. The Company also has the exclusive right and sole responsibility and decision-making authority to commercialize any of the Licensed Products. | | | | | | | | | | | |
Stock Issued During Period, Shares, New Issues | | | | | | | | | | | | | | | | | | | | | 801,253 | | | |
Research and development expense - Vyera repurchase | | | | | | | | | | | | | | | | | | | | | $ 2,200,000 | | | |
Contingent non-refundable regulatory milestone payment upon submission of an application | | | | | | | | | | | | | | | | | | | | | | 750,000 | | |
Contingent non-refundable regulatory milestone payment upon FDA approval of an application for a particular Licensed Product | | | | | | | | | | | | | | | | | | | | | | 1,125,000 | | |
Contingent non-refundable regulatory milestone payment upon FDA approval of an application for a particular Licensed Product | | | | | | | | | | | | | | | | | | | | | | 350,000 | | |
contingent non-refundable regulatory milestone payment in connection with aplindore upon regulatory approval In major market for such particular licensed product | | | | | | | | | | | | | | | | | | | | | | 100,000 | | |
Contingent Nonrefundable Regulatory Milestone Payment In Connection With Aplindore Upon Fda Approval Of Application For Such Particular Licensed Product | | | | | | | | | | | | | | | | | | | | | | 3,000,000 | | |
Contingent Nonrefundable Commercial Milestone Payments In Connection With Achievement Of 1.0 Billion Of Cumulative Worldwide Net Sales Of Licensed Products Based Upon Aplindore | | | | | | | | | | | | | | | | | | | | | | 10,000,000 | | |
Contingent Nonrefundable Commercial Milestone Payments In Connection With Achievement Of 1.0 Billion Of Cumulative Worldwide Net Sales Of Licensed Products Based Upon H3 Receptor Antagonist | | | | | | | | | | | | | | | | | | | | | | 10,000,000 | | |
Contingent Nonrefundable Commercial Milestone Payments In Connection With Achievement Of 1.0 Billion Of Cumulative Worldwide Net Sales Of Licensed Products Based Upon Acetaminophen | | | | | | | | | | | | | | | | | | | | | | 10,000,000 | | |
Contingent Nonrefundable Commercial Milestone Payments In Connection With Achievement Of 1.0 Billion Of Cumulative Worldwide Net Sales Of Licensed Products Based Upon Crth2Antagonists | | | | | | | | | | | | | | | | | | | | | | 10,000,000 | | |
Contingent Nonrefundable Commercial Milestone Payments In Connection With Achievement of 2.0 billion of cumulative world wide net sales of licensed products based upon aplindore | | | | | | | | | | | | | | | | | | | | | | 20,000,000 | | |
Contingent Nonrefundable Commercial Milestone Payments In Connection With Achievement Of 2.0 Billion Of Cumulative Worldwide Net Sales Of Licensed Products Based Upon Acetaminophen | | | | | | | | | | | | | | | | | | | | | | 20,000,000 | | |
Contingent Nonrefundable Commercial Milestone Payments In Connection With Achievement Of 2.0 Billion Of Cumulative Worldwide Net Sales Of Licensed Products Based Upon Crth2 Antagonists | | | | | | | | | | | | | | | | | | | | | | 20,000,000 | | |
Contingent non-refundable commercial milestone payments in connection with the achievement of $2.0 billion of cumulative worldwide net sales of Licensed Products based upon an H3 receptor antagonist | | | | | | | | | | | | | | | | | | | | | | 20,000,000 | | |
Contingent nonrefundable regulatory milestone payment in connection with aplindore. | | | | | | | | | | | | | | | | | | | | | | 125,000 | | |
Milestone payments accrued | | | | | | | | | | | | | | | | | | | | | | 0 | | |
License agreement description | | | | | | | | | | | | | On September 21, 2016, the Company entered into a License Agreement (the “License Agreement”) with Ligand Pharmaceuticals Incorporated (“Ligand”), Neurogen Corporation and CyDex Pharmaceuticals, Inc. (collectively, the “Licensors”), pursuant to which, among other things, the Licensors granted to the Company an exclusive, perpetual, irrevocable, worldwide, royalty-bearing, nontransferable right and license under (i) patents related to a product known as Aplindore, which is now known as SLS-006, acetaminophen (as it may have been or may be modified for use in a product to be administered by any method in any form including, without limitation injection and intravenously, the sole active pharmaceutical ingredient of which is acetaminophen), which is now known as SLS-012, an H3 receptor antagonist, which is now known as SLS-010, and either or both of the Licensors’ two proprietary CRTh2 antagonists, which are now known collectively as SLS-008 (collectively, the “Licensed Products”), and (ii) copyrights, trade secrets, moral rights and all other intellectual and proprietary rights related thereto. The Company is obligated to use commercially reasonable efforts to (a) develop the Licensed Products, (b) obtain regulatory approval for the Licensed Products in the European Union (either in its entirety or including at least one of France, Germany or, if at the time the United Kingdom is a member of the European Union, the United Kingdom), the United Kingdom, if at the time the United Kingdom is not a member of the European Union, Japan or the People’s Republic of China (each, a “Major Market”) or the United States, and (c) commercialize the Licensed Products in each country where regulatory approval is obtained. The Company has the exclusive right and sole responsibility and decision-making authority to research and develop any Licensed Products and to conduct all clinical trials and non-clinical studies the Company believes appropriate to obtain regulatory approvals for commercialization of the Licensed Products. The Company also has the exclusive right and sole responsibility and decision-making authority to commercialize any of the Licensed Products. | | | | | | | | | | | |
Asset Acquisition, Contingent Consideration, Liability, Current | | | | | | | | | | | | | | | | | | | | | | $ 0 | | |
Weg License Agreement [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Business Combination, Separately Recognized Transactions [Line Items] | | | | | | | | | | | | | | | | | | | | | | | | |
Business Combination, Separately Recognized Transactions, Description | | | | | | | | | | | | | | | | | | | | | | On August 29, 2019, the Company entered into an amended and restated exclusive license agreement with Stuart Weg, M.D. (the “Weg License Agreement”), pursuant to which the Company was granted an exclusive worldwide license to certain intellectual property and regulatory materials related to SLS-002. Under the terms of the Weg License Agreement, the Company paid an upfront license fee of $75,000 upon execution of the agreement. The Company agreed to pay additional consideration to Dr. Weg as follows: (i) $0.1 million on January 2, 2020, (ii) $0.125 million on January 2, 2021, and (iii) in the event the FDA has not approved an NDA for a product containing ketamine in any dosage on or before December 31, 2021, $0.2 million on January 2, 2022. The Company paid the required $0.1 million on January 2, 2020, $0.125 million on January 2, 2021, and $0.2 million on January 3, 2022. As further consideration, the Company agreed to pay Dr. Weg certain milestone payments consisting of (i) $0.1 million and shares of common stock equal to $0.15 million divided by the closing sales price of the Company’s common stock upon the issuance of the first patent directed to an anxiety indication, (ii) $0.5 million after the locking of the database and unblinding the data for the statistically significant readout of a Phase III trial of an intranasal racemic ketamine product that has been conducted for the submission under an NDA or equivalent seeking regulatory approval in the United States, the United Kingdom, France, Germany, Italy, Spain, China or Japan, or seeking regulatory approval from the EMA in the EU, for such product (the “Milestone Product”), (iii) $3.0 million upon FDA approval of an NDA for the Milestone Product, (iv) $2.0 million upon regulatory approval by the EMA for the Milestone Product, (v) $1.5 million upon regulatory approval in Japan for the Milestone Product; provided, however, that the maximum amount to be paid by the Company under milestones (i)-(v) will be $6.6 million. The Company will also pay to Dr. Weg a royalty percentage equal to 2.25% on the sale of each product containing ketamine in any dosage. | | |
Non refundable Cash Payment | | | | | | $ 200,000 | | | | $ 125,000 | $ 100,000 | | | | | | | | | | | | | |
Milestone payments accrued | | | | | | | | | | | | | | | | | | | | | | $ 0 | | |
Contingent nonrefundable milestone share value of common stock payment upon issuance of first patent directed to anxiety indication | | | | | $ 150,000 | | | | | | | | | | | | | | | | | | | |
License agreement description | | | | | | | | | | | | | | | | | | | | | | On August 29, 2019, the Company entered into an amended and restated exclusive license agreement with Stuart Weg, M.D. (the “Weg License Agreement”), pursuant to which the Company was granted an exclusive worldwide license to certain intellectual property and regulatory materials related to SLS-002. Under the terms of the Weg License Agreement, the Company paid an upfront license fee of $75,000 upon execution of the agreement. The Company agreed to pay additional consideration to Dr. Weg as follows: (i) $0.1 million on January 2, 2020, (ii) $0.125 million on January 2, 2021, and (iii) in the event the FDA has not approved an NDA for a product containing ketamine in any dosage on or before December 31, 2021, $0.2 million on January 2, 2022. The Company paid the required $0.1 million on January 2, 2020, $0.125 million on January 2, 2021, and $0.2 million on January 3, 2022. As further consideration, the Company agreed to pay Dr. Weg certain milestone payments consisting of (i) $0.1 million and shares of common stock equal to $0.15 million divided by the closing sales price of the Company’s common stock upon the issuance of the first patent directed to an anxiety indication, (ii) $0.5 million after the locking of the database and unblinding the data for the statistically significant readout of a Phase III trial of an intranasal racemic ketamine product that has been conducted for the submission under an NDA or equivalent seeking regulatory approval in the United States, the United Kingdom, France, Germany, Italy, Spain, China or Japan, or seeking regulatory approval from the EMA in the EU, for such product (the “Milestone Product”), (iii) $3.0 million upon FDA approval of an NDA for the Milestone Product, (iv) $2.0 million upon regulatory approval by the EMA for the Milestone Product, (v) $1.5 million upon regulatory approval in Japan for the Milestone Product; provided, however, that the maximum amount to be paid by the Company under milestones (i)-(v) will be $6.6 million. The Company will also pay to Dr. Weg a royalty percentage equal to 2.25% on the sale of each product containing ketamine in any dosage. | | |
Non-refundable cash payment | | | | | 200,000 | | | | | | | | | | | | | | | | | | | |
Asset Acquisition, Contingent Consideration, Liability, Current | | | | | | | | | | | | | | | | | | | | | | $ 0 | | |
Contingent nonrefundable milestone payment upon fda approval of nda for milestone product. | | | | | | | | | | | | | | | | | | | | | | 3,000,000 | | |
Contingent nonrefundable milestone payment | | | | | $ 100,000 | | | | | | | | | | | | | | | | | | | |
Contingent nonrefundable milestone payment after locking of database | | | | | | | | | | | | | | | | | | | | | | 500,000 | | |
Contingent nonrefundable milestone payment upon regulatory approval by ema for milestone product | | | | | | | | | | | | | | | | | | | | | | 2,000,000 | | |
Contingent nonrefundable milestone payment upon regulatory approval in japan for milestone product | | | | | | | | | | | | | | | | | | | | | | 1,500,000 | | |
Maximum amount to be paid under milestones | | | | | | | | | | | | | | | | | | | | | | $ 6,600,000 | | |
Percentage of royalty payments | | | | | | | | | | | | | | | | | | | | | | 2.25% | | |
Assets from Bioblast Pharma [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Business Combination, Separately Recognized Transactions [Line Items] | | | | | | | | | | | | | | | | | | | | | | | | |
Research and development | | | | | | | | | | | | | | | | | | | | | | | | $ 3,500,000 |
Milestone payments accrued | | | | | | | | | | | | | | | | | | | | | | $ 0 | | |
Non-refundable cash payment | | | | | | | | | | | | $ 1,500,000 | | | | | | | $ 2,000,000 | | | | | |
Asset Acquisition, Contingent Consideration, Liability, Current | | | | | | | | | | | | | | | | | | | | | | $ 0 | | |
Percentage of royalty payments | | | | | | | | | | | | 1% | | | | | | | | | | | | |
Contingent additional milestone consideration | | | | | | | | | | | | $ 8,500,000 | | | | | | | | | | | | |
Future grant revenue contingent | | | | | | | | | | | | $ 1,500,000 | | | | | | | | | | | | |
U C Regents License Agreement [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Business Combination, Separately Recognized Transactions [Line Items] | | | | | | | | | | | | | | | | | | | | | | | | |
Business Combination, Separately Recognized Transactions, Description | | | | | | | | | | | | | | | | | | | | | | On March 7, 2019, the Company entered into an exclusive license agreement (the “UC Regents License Agreement”) with The Regents of the University of California (“The UC Regents”) pursuant to which the Company was granted an exclusive license to intellectual property owned by The UC Regents pertaining to a technology that was created by researchers at the University of California, Los Angeles (“UCLA”). Such technology relates to a family of rationally-designed peptide inhibitors that target the aggregation of alpha-synuclein (“α-synuclein”). The Company plans to study this initial approach in PD and will further evaluate the potential clinical approach in other disorders affecting the central nervous system (“CNS”). This program is now known as SLS-007. Upon entry into the UC Regents License Agreement, the Company paid to The UC Regents $0.1 million and recognized a $0.1 million charge to research and development expense during the year ended December 31, 2019. Under the terms of the UC Regents License Agreement, the Company agreed to pay additional consideration upon the achievement of certain milestones in the future, as follows: (i) within 90 days following the dosing of the first patient in a Phase I clinical trial, the Company will pay $50,000; (ii) within 90 days following dosing of the first patient in a Phase II clinical trial, the Company will pay $0.1 million; (iii) within 90 days following dosing of the first patient in a Phase III clinical trial, the Company will pay $0.3 million; (iv) within 90 days following the first commercial sales in the U.S., the Company will pay $1.0 million; (v) within 90 days following the first commercial sales in any European market, the Company will pay $1.0 million; and (vi) within 90 days following $250 million in cumulative worldwide net sales of a licensed product, the Company will pay $2.5 million. The Company is also obligated to pay a single digit royalty on sales of the product, if any. In addition, if the Company fails to achieve certain milestones within a specified timeframe, The UC Regents may terminate the agreement or reduce the Company’s license to a nonexclusive license. | | |
Research and development | | | | | | | | | | | | | | | | | | | | | | | | 100,000 |
Contingent Milestone Payment Within Ninety Days Following Completion Of Dosing Of First Patient In Phase I Clinical Trial | | | | | | | | | | | | | | | | | | | | | | $ 50,000 | | |
Contingent Milestone Payment Within Ninety Days Following Dosing Of First Patient In Phase Ii Clinical Trial | | | | | | | | | | | | | | | | | | | | | | 100,000 | | |
Contingent Milestone Payment Within Ninety Days Following First Commercial Sales In Any European Market | | | | | | | | | | | | | | | | | | | | | | 1,000,000 | | |
Contingent milestone payment within 90 Days following 250 million in cumulative world wide net sales of licensed product | | | | | | | | | | | | | | | | | | | | | | 2,500,000 | | |
Contingent Nonrefundable Commercial Milestone Payments In Connection With Achievement Of 1.0 Billion Of Cumulative Worldwide Net Sales Of Licensed Products Based Upon Aplindore | | | | | | | | | | | | | | | | | | | | | | 125,000 | | |
Milestone payments accrued | | | | | | | | | | | | | | | | | | | | | | $ 0 | | |
License agreement description | | | | | | | | | | | | | | | | | | | | | | On March 7, 2019, the Company entered into an exclusive license agreement (the “UC Regents License Agreement”) with The Regents of the University of California (“The UC Regents”) pursuant to which the Company was granted an exclusive license to intellectual property owned by The UC Regents pertaining to a technology that was created by researchers at the University of California, Los Angeles (“UCLA”). Such technology relates to a family of rationally-designed peptide inhibitors that target the aggregation of alpha-synuclein (“α-synuclein”). The Company plans to study this initial approach in PD and will further evaluate the potential clinical approach in other disorders affecting the central nervous system (“CNS”). This program is now known as SLS-007. Upon entry into the UC Regents License Agreement, the Company paid to The UC Regents $0.1 million and recognized a $0.1 million charge to research and development expense during the year ended December 31, 2019. Under the terms of the UC Regents License Agreement, the Company agreed to pay additional consideration upon the achievement of certain milestones in the future, as follows: (i) within 90 days following the dosing of the first patient in a Phase I clinical trial, the Company will pay $50,000; (ii) within 90 days following dosing of the first patient in a Phase II clinical trial, the Company will pay $0.1 million; (iii) within 90 days following dosing of the first patient in a Phase III clinical trial, the Company will pay $0.3 million; (iv) within 90 days following the first commercial sales in the U.S., the Company will pay $1.0 million; (v) within 90 days following the first commercial sales in any European market, the Company will pay $1.0 million; and (vi) within 90 days following $250 million in cumulative worldwide net sales of a licensed product, the Company will pay $2.5 million. The Company is also obligated to pay a single digit royalty on sales of the product, if any. In addition, if the Company fails to achieve certain milestones within a specified timeframe, The UC Regents may terminate the agreement or reduce the Company’s license to a nonexclusive license. | | |
Non-refundable cash payment | | | | | | | | | | | | | | | | | | | | | | | | 100,000 |
Asset Acquisition, Contingent Consideration, Liability, Current | | | | | | | | | | | | | | | | | | | | | | $ 0 | | |
Duke License Agreement [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Business Combination, Separately Recognized Transactions [Line Items] | | | | | | | | | | | | | | | | | | | | | | | | |
Business Combination, Separately Recognized Transactions, Description | | | | | | | | | | | | | | | | | | | | | | On June 27, 2019, the Company entered into an exclusive license agreement (the “Duke License Agreement”) with Duke University pursuant to which the Company was granted an exclusive license to a gene therapy program targeting the regulation of the SNCA gene, which encodes α-synuclein expression. The Company plans to study this initial approach in PD and will further evaluate the potential clinical approach in other disorders affecting the CNS. This program is now known as SLS-004. Upon entry into the Duke License Agreement, the Company paid to Duke University $0.1 million and recognized $0.1 million charge to research and development expense during the year ended December 31, 2019. The Company agreed to pay additional consideration to Duke University upon the achievement of certain milestones in the future, as follows: (i) within 30 days following filing of an IND following the completion of preclinical studies including comprehensive validation of the platform, the Company will pay $0.1 million; (ii) within 30 days following dosing of the first patient in a Phase I clinical trial, the Company will pay $0.2 million; (iii) within 30 days following dosing of the first patient in a Phase II clinical trial, the Company will pay $0.5 million; (iv) within 30 days following dosing of the first patient in a Phase III clinical trial, the Company will pay $1.0 million; and (v) within 30 days following an NDA approval, the Company will pay $2.0 million. The Company is also obligated to pay a single digit royalty on sales of the product, if any. In addition, if the Company fails to achieve certain milestones within a specified timeframe, Duke University may terminate the agreement. | | |
Research and development | | | | | | | | | | | | | | | | | | | | | | | | 100,000 |
Contingent Milestone Payment Within Thirty Days Following Filing Of Ind Following Completion Of Preclinical Studies Including Comprehensive Validation Of Platform | | | | | | | | | | | | | | | | | | | | | | $ 100,000 | | |
Contingent Milestone Payment Within Thirty Days Following Dosing Of First Patient In Phase Clinical Trial | | | | | | | | | | | | | | | | | | | | | | 200,000 | | |
Contingent Milestone Payment Within Thirty Days Following Nda Approval | | | | | | | | | | | | | | | | | | | | | | 2,000,000 | | |
Contingent milestone payment within 30days following dosing Of first patient phase Iii clinical trial. | | | | | | | | | | | | | | | | | | | | | | 1,000,000 | | |
Contingent milestone payment within 30 days following dosing Of first patient In phase Ii clinical trial | | | | | | | | | | | | | | | | | | | | | | 500,000 | | |
Milestone payments accrued | | | | | | | | | | | | | | | | | | | | | | $ 0 | | |
License agreement description | | | | | | | | | | | | | | | | | | | | | | On June 27, 2019, the Company entered into an exclusive license agreement (the “Duke License Agreement”) with Duke University pursuant to which the Company was granted an exclusive license to a gene therapy program targeting the regulation of the SNCA gene, which encodes α-synuclein expression. The Company plans to study this initial approach in PD and will further evaluate the potential clinical approach in other disorders affecting the CNS. This program is now known as SLS-004. Upon entry into the Duke License Agreement, the Company paid to Duke University $0.1 million and recognized $0.1 million charge to research and development expense during the year ended December 31, 2019. The Company agreed to pay additional consideration to Duke University upon the achievement of certain milestones in the future, as follows: (i) within 30 days following filing of an IND following the completion of preclinical studies including comprehensive validation of the platform, the Company will pay $0.1 million; (ii) within 30 days following dosing of the first patient in a Phase I clinical trial, the Company will pay $0.2 million; (iii) within 30 days following dosing of the first patient in a Phase II clinical trial, the Company will pay $0.5 million; (iv) within 30 days following dosing of the first patient in a Phase III clinical trial, the Company will pay $1.0 million; and (v) within 30 days following an NDA approval, the Company will pay $2.0 million. The Company is also obligated to pay a single digit royalty on sales of the product, if any. In addition, if the Company fails to achieve certain milestones within a specified timeframe, Duke University may terminate the agreement. | | |
Non-refundable cash payment | | | | | | | | | | | | | | | | | | | | | | | | $ 100,000 |
Asset Acquisition, Contingent Consideration, Liability, Current | | | | | | | | | | | | | | | | | | | | | | $ 0 | | |
I X License Agreement [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Business Combination, Separately Recognized Transactions [Line Items] | | | | | | | | | | | | | | | | | | | | | | | | |
Business Combination, Separately Recognized Transactions, Description | | | | | | | | | | | | | | | | | | On November 24, 2021, the Company entered into an exclusive license agreement (the “iX License Agreement”) with iXBEL and the iXBEL Stock Purchase Agreement. Pursuant to the iX License Agreement, among other things, iXBEL granted the Company an exclusive, sublicensable, perpetual, worldwide (excluding certain jurisdictions identified in the iX License Agreement) and irrevocable right and license to certain of iXBEL’s licensed patents, know-how, and technological information, including access to iXBEL’s research, development and manufacturing capabilities, to enable the further development, manufacture, promotion and commercialization of WafermineTM and certain other existing and to be developed iXBEL wafer-based delivery technologies, in all cases for sublingual administration of ketamine. In addition, iXBEL will supply the Company with sufficient product for the potential treatment of 400 patients, with further supplied amounts to be determined by the parties. The Company granted iXBEL an exclusive license to exploit technology developed under the iX License Agreement outside of the licensed territory and to undertake limited, non-exclusive research and development activities in the territory. The Company further agreed not to undertake certain activities with respect to products competitive with those licensed under the iX License Agreement during the term of the iX License Agreement. | | | | | | |
Research and development | | | | | | | $ 9,000,000 | | | | | | | | | | | $ 9,000,000 | | | | | | |
Milestone payments accrued | | | | | | | | | | | | | | | | | | | | | | 0 | | |
License agreement description | | | | | | | | | | | | | | | | | | On November 24, 2021, the Company entered into an exclusive license agreement (the “iX License Agreement”) with iXBEL and the iXBEL Stock Purchase Agreement. Pursuant to the iX License Agreement, among other things, iXBEL granted the Company an exclusive, sublicensable, perpetual, worldwide (excluding certain jurisdictions identified in the iX License Agreement) and irrevocable right and license to certain of iXBEL’s licensed patents, know-how, and technological information, including access to iXBEL’s research, development and manufacturing capabilities, to enable the further development, manufacture, promotion and commercialization of WafermineTM and certain other existing and to be developed iXBEL wafer-based delivery technologies, in all cases for sublingual administration of ketamine. In addition, iXBEL will supply the Company with sufficient product for the potential treatment of 400 patients, with further supplied amounts to be determined by the parties. The Company granted iXBEL an exclusive license to exploit technology developed under the iX License Agreement outside of the licensed territory and to undertake limited, non-exclusive research and development activities in the territory. The Company further agreed not to undertake certain activities with respect to products competitive with those licensed under the iX License Agreement during the term of the iX License Agreement. | | | | | | |
Non-refundable cash payment | | | | | | | 3,500,000 | | | | | | | | | $ 1,200,000 | 1,200,000 | $ 3,500,000 | | | | | | |
Shortfall amount | | | | | | | $ 800,000 | | | | | | | | | | $ 1,200,000 | | | | | | | |
Issuance of common stock for license acquired, shares | | | | | | | 2,570,266 | | | | | | | | | | | 2,570,266 | | | | | | |
Asset Acquisition, Contingent Consideration, Liability, Current | | | | | | | | | | | | | | | | | | | | | | $ 0 | | |