Exhibit 31.1
CERTIFICATE OF CHIEF EXECUTIVE OFFICER
I, Paolo Pucci, certify that:
| 1. | I have reviewed this annual report on Form 10-K/A of ArQule, Inc.; |
| 2. | Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report; |
Date: April 10, 2012
| | /s/ Paolo Pucci |
| | Chief Executive Officer |
