Pernix Therapeutics 10-Q 2010 Q3 Quarterly report

Exhibit 32.1

CERTIFICATION UNDER SECTION 906

OF THE SARBANES-OXLEY ACT OF 2002

Pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, each of the undersigned certifies that this periodic report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and that information contained in this periodic report fairly presents, in all material respects, the financial condition and results of operations of Pernix Therapeutics Holdings, Inc. for the periods covered by this periodic report.

Date: November 12, 2010	/s/ Cooper C. Collins
	Cooper C. Collins
	Chief Executive Officer and President
Date: November 12, 2010	/s/ Tracy S. Clifford
	Tracy S. Clifford
	Chief Financial Officer and Secretary