Dynavax Technologies (DVAX) 10-Q 7 Aug 17 2017 Q2 Quarterly report Financial data

Document and Entity Information

Document and Entity Information - shares	6 Months Ended
	Jun. 30, 2017	Aug. 02, 2017
Document And Entity Information [Abstract]
Document Type	10-Q
Amendment Flag	false
Document Period End Date	Jun. 30, 2017
Document Fiscal Year Focus	2,017
Document Fiscal Period Focus	Q2
Trading Symbol	DVAX
Entity Registrant Name	DYNAVAX TECHNOLOGIES CORP
Entity Central Index Key	1,029,142
Current Fiscal Year End Date	--12-31
Entity Filer Category	Accelerated Filer
Entity Common Stock, Shares Outstanding		54,747,656

Condensed Consolidated Balance

Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Jun. 30, 2017	Dec. 31, 2016
Current assets:
Cash and cash equivalents	$ 37,675	$ 24,289
Marketable securities available-for-sale	89,286	57,126
Accounts and other receivables	810	1,342
Prepaid expenses and other current assets	4,434	6,842
Total current assets	132,205	89,599
Property and equipment, net	16,751	17,174
Goodwill	2,140	1,971
Restricted cash	619	602
Other assets	253	334
Total assets	151,968	109,680
Current liabilities:
Accounts payable	681	3,796
Accrued research and development	3,223	5,048
Accrued liabilities	7,184	11,192
Total current liabilities	11,088	20,036
Other long-term liabilities	353	443
Total liabilities	11,441	20,479
Commitments and contingencies (Note 4)
Stockholders’ equity:
Preferred stock: $0.001 par value; 5,000 shares authorized at June 30, 2017 and December 31, 2016; no shares issued and outstanding at June 30, 2017 and December 31, 2016
Common stock: $0.001 par value; 139,000 and 69,500 shares authorized at June 30, 2017 and December 31, 2016, respectively; 54,748 and 38,599 shares issued and outstanding at June 30, 2017 and December 31, 2016, respectively	55	39
Additional paid-in capital	1,000,177	904,957
Accumulated other comprehensive loss	(1,929)	(3,624)
Accumulated deficit	(857,776)	(812,171)
Total stockholders’ equity	140,527	89,201
Total liabilities and stockholders’ equity	$ 151,968	$ 109,680

Condensed Consolidated Balance3

Condensed Consolidated Balance Sheets (Parenthetical) - $ / shares	Jun. 30, 2017	Dec. 31, 2016
Statement Of Financial Position [Abstract]
Preferred stock, par value	$ 0.001	$ 0.001
Preferred stock, shares authorized	5,000,000	5,000,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Common stock, par value	$ 0.001	$ 0.001
Common stock, shares authorized	139,000,000	69,500,000
Common stock, shares issued	54,748,000	38,599,000
Common stock, shares outstanding	54,747,656	38,599,000

Condensed Consolidated Statemen

Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Revenues:
Collaboration revenue		$ 1,683		$ 2,578
Grant revenue	$ 105	88	$ 253	127
Service and license revenue		876		884
Total revenues	105	2,647	253	3,589
Operating expenses:
Research and development	14,814	22,750	31,159	42,817
General and administrative	5,612	9,151	12,084	17,320
Restructuring			2,783
Total operating expenses	20,426	31,901	46,026	60,137
Loss from operations	(20,321)	(29,254)	(45,773)	(56,548)
Other income (expense):
Interest income	235	220	380	445
Other income (expense), net	(232)	48	(212)	94
Net loss	$ (20,318)	$ (28,986)	$ (45,605)	$ (56,009)
Basic and diluted net loss per share	$ (0.41)	$ (0.75)	$ (1)	$ (1.46)
Weighted average shares used to compute basic and diluted net loss per share	49,700	38,496	45,787	38,491

Condensed Consolidated Stateme5

Condensed Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Statement Of Income And Comprehensive Income [Abstract]
Net loss	$ (20,318)	$ (28,986)	$ (45,605)	$ (56,009)
Other comprehensive income:
Unrealized (loss) gain on marketable securities available-for-sale	(16)	(41)	(45)	68
Cumulative foreign currency translation adjustments	1,437	(383)	1,740	303
Total other comprehensive income (loss)	1,421	(424)	1,695	371
Total comprehensive loss	$ (18,897)	$ (29,410)	$ (43,910)	$ (55,638)

Condensed Consolidated Stateme6

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016
Operating activities
Net loss	$ (45,605)	$ (56,009)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	1,674	946
Gain on disposal of property and equipment	(24)
Accretion of discounts and amortization of premiums on marketable securities	(35)	123
Reversal of deferred rent upon lease amendment	(209)
Cash-settled portion of stock-based compensation expense		602
Stock compensation expense	7,184	6,368
Changes in operating assets and liabilities:
Accounts and other receivables	532	(470)
Prepaid expenses and other current assets	(1,642)	204
Other assets	81	(115)
Accounts payable	(2,934)	1,604
Accrued liabilities and other long term liabilities	(1,664)	(3,160)
Deferred revenues		(2,654)
Net cash used in operating activities	(42,642)	(52,561)
Investing activities
Purchases of marketable securities	(93,045)	(98,108)
Proceeds from maturities of marketable securities	60,875	135,170
Purchases of property and equipment, net	(242)	(4,916)
Net cash (used in) provided by investing activities	(32,412)	32,146
Financing activities
Proceeds from issuance of common stock, net	88,200
(Tax withholding) proceeds from exercise of stock options and restricted stock awards, net	(303)	99
Proceeds from Employee Stock Purchase Plan	155	261
Net cash provided by financing activities	88,052	360
Effect of exchange rate changes on cash and cash equivalents	388	30
Net increase (decrease) in cash and cash equivalents	13,386	(20,025)
Cash and cash equivalents at beginning of period	24,289	44,812
Cash and cash equivalents at end of period	37,675	24,787
Supplemental disclosure of cash flow information
Accrual for litigation settlement and insurance recovery (Note 4)		4,050
Release of accrual for litigation settlement and insurance recovery (Note 4)	4,050
Non-cash investing and financing activities:
Disposal of fully depreciated property and equipment		1,158
Net change in unrealized (loss) gain on marketable securities	$ (45)	$ 68

Organization and Summary of Sig

Organization and Summary of Significant Accounting Policies	6 Months Ended
	Jun. 30, 2017
Organization Consolidation And Presentation Of Financial Statements [Abstract]
Organization and Summary of Significant Accounting Policies	1. Organization and Summary of Significant Accounting Policies Dynavax Technologies Corporation (“we,” “our,” “us,” “Dynavax” or the “Company”), is a clinical-stage immunotherapy company focused on leveraging the power of the body’s innate and adaptive immune response through toll-like receptor (“TLR”) stimulation. Our current product candidates are being investigated for use in multiple cancer indications, as a vaccine for the prevention of hepatitis B and as a disease modifying therapy for asthma. We were incorporated in California in August 1996 under the name Double Helix Corporation, and we changed our name to Dynavax Technologies Corporation in September 1996. We reincorporated in Delaware in 2000. Basis of Presentation Our accompanying unaudited condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (“GAAP”) for interim financial information and pursuant to the instructions to Form 10-Q and Article 10 of Regulation S-X. In our opinion, these unaudited condensed consolidated financial statements include all adjustments, consisting of normal recurring adjustments, which we consider necessary to present fairly our financial position and the results of our operations and cash flows. As permitted under those rules, certain footnotes or other financial information that are normally required by GAAP have been condensed or omitted. Interim-period results are not necessarily indicative of results of operations or cash flows to be expected for a full-year period or any other interim-period. The condensed consolidated balance sheet at December 31, 2016 has been derived from audited financial statements at that date, but excludes disclosures required by GAAP for complete financial statements. The unaudited condensed consolidated financial statements and these notes should be read in conjunction with our Annual Report on Form 10-K for the year ended December 31, 2016, as filed with the Securities and Exchange Commission (the “SEC”). The unaudited condensed consolidated financial statements include the accounts of Dynavax and our wholly-owned subsidiary, Dynavax GmbH. All significant intercompany accounts and transactions among these entities have been eliminated from the condensed consolidated financial statements. We operate in one business segment: the discovery and development of biopharmaceutical products. Liquidity and Financial Condition As of June 30, 2017, we had cash, cash equivalents and marketable securities of $127.0 million. During the six months ended June 30, 2017, we received $88.2 million in net proceeds from our We have incurred significant operating losses and negative cash flows from operations since our inception. In January 2017, we implemented organizational restructuring and cost reduction plans to align around our immuno-oncology business while allowing us to advance HEPLISAV-B through the U.S. Food and Drug Administration (“FDA”) review and approval process. To achieve these cost reductions, we suspended manufacturing activities, commercial preparations and other long term investment related to HEPLISAV-B and reduced our global workforce by approximately 40 percent. We expect to continue to spend substantial funds in connection with the development and manufacturing of our product candidates, particularly SD-101 and DV281, our lead investigational cancer immunotherapeutic product candidates, human clinical trials for our other product candidates and additional applications and advancement of our technology. In order to continue ongoing development activities of our product candidates and to support commercialization of HEPLISAV-B, if approved, we will need additional funding or a partnership in support of HEPLISAV-B. This may occur through strategic alliance and licensing arrangements and/or future public or private debt and equity financings. Sufficient funding may not be available, or if available, may be on terms that significantly dilute or otherwise adversely affect the rights of existing stockholders. If adequate funds are not available in the future, we may need to delay, reduce the scope of or put on hold one or more development programs while we seek strategic alternatives, which could have an adverse impact on our ability to achieve our intended business objectives. Our ability to raise additional capital in the equity and debt markets is dependent on a number of factors, including, but not limited to, the market demand for our common stock, which itself is subject to a number of development and business risks and uncertainties, as well as the uncertainty that we would be able to raise such additional capital at a price or on terms that are favorable to us. Use of Estimates The preparation of financial statements in conformity with GAAP requires management to make informed estimates and assumptions that affect the amounts reported in the condensed consolidated financial statements and accompanying notes. Management’s estimates are based on historical information available as of the date of the condensed consolidated financial statements and various other assumptions we believe are reasonable under the circumstances. Actual results could differ materially from these estimates. Summary of Significant Accounting Policies There have been no material changes in our significant accounting policies during the six months ended June 30, 2017, as compared with those disclosed in our Annual Report on Form 10-K for the year ended December 31, 2016. Revenue Recognition Our revenues consist of amounts earned from collaborations, grants and fees from services and licenses. We enter into license and manufacturing agreements and collaborative research and development arrangements with pharmaceutical and biotechnology partners that may involve multiple deliverables. Our arrangements may include one or more of the following elements: upfront license payments, cost reimbursement for the performance of research and development activities, milestone payments, other contingent payments, contract manufacturing service fees, royalties and license fees. Each deliverable in the arrangement is evaluated to determine whether it meets the criteria to be accounted for as a separate unit of accounting or whether it should be combined with other deliverables. In order to account for the multiple-element arrangements, we identify the deliverables included within the arrangement and evaluate which deliverables represent separate units of accounting. Analyzing the arrangement to identify deliverables requires the use of judgment, and each deliverable may be an obligation to deliver services, a right or license to use an asset, or another performance obligation. We recognize revenue when there is persuasive evidence that an arrangement exists, delivery has occurred or services have been rendered, the price is fixed or determinable and collectability is reasonably assured. Non-refundable upfront fees received for license and collaborative agreements and other payments under collaboration agreements where we have continuing performance obligations related to the payments are deferred and recognized over our estimated performance period. Revenue is recognized on a ratable basis, unless we determine that another method is more appropriate, through the date at which our performance obligations are completed. Management makes its best estimate of the period over which we expect to fulfill our performance obligations, which may include clinical development activities. Given the uncertainties of research and development collaborations, significant judgment is required to determine the duration of the performance period. We recognize revenues for costs that are reimbursed under collaborative agreements as the related research and development costs are incurred. Contingent consideration received for the achievement of a substantive milestone is recognized in its entirety in the period in which the milestone is achieved. A milestone is defined as an event having all of the following characteristics: (i) there is substantive uncertainty at the date the arrangement is entered into that the event will be achieved, (ii) the event can only be achieved based in whole or in part on either the entity’s performance or a specific outcome resulting from the entity’s performance and (iii) if achieved, the event would result in additional payments being due to the entity. Our license and collaboration agreements with our partners provide for payments to be paid to us upon the achievement of milestones. Given the challenges inherent in developing biologic products, there is substantial uncertainty whether any such milestones will be achieved at the time we entered into these agreements. In addition, we evaluate whether milestones meet the criteria to be considered substantive. The conditions include: (i) work is contingent on either of the following: (a) the vendor’s performance to achieve the milestone or (b) the enhancement of the value of the deliverable item or items as a result of a specific outcome resulting from the vendor’s performance to achieve the milestone; (ii) it relates solely to past performance and (iii) it is reasonable relative to all the deliverable and payment terms within the arrangement. As a result of our analysis, we may consider our development milestones to be substantive. Milestone payments that are contingent upon the achievement of substantive at-risk performance criteria are recognized in full upon achievement of those milestone events in accordance with the terms of the agreement. All revenue recognized to date under our collaborative agreements has been nonrefundable. Our license and collaboration agreements with certain partners also provide for contingent payments based solely upon the performance of our partner. We expect to recognize the contingent payments as revenue upon receipt, provided that all other revenue recognition criteria have been satisfied. Revenues from manufacturing services are recognized upon meeting the criteria for substantial performance and acceptance by the customer. Revenue from royalty payments is contingent on future sales activities by our licensees. Royalty revenue is recognized when all revenue recognition criteria have been satisfied. Revenue from government and private agency grants is recognized as the related research expenses are incurred and to the extent that funding is approved. Research and Development Expenses and Accruals Research and development expenses include personnel and facility-related expenses, outside contracted services including clinical trial costs, manufacturing and process development costs, research costs and other consulting services and non-cash stock-based compensation. Research and development costs are expensed as incurred. Amounts due under contracts with third parties may be either fixed fee or fee for service, and may include upfront payments, monthly payments and payments upon the completion of milestones or receipt of deliverables. Non-refundable advance payments under agreements are capitalized and expensed as the related goods are delivered or services are performed. We contract with third parties to perform various clinical trial activities in the on-going development of potential products. The financial terms of these agreements are subject to negotiation, vary from contract to contract and may result in uneven payment flows to our vendors. Payments under the contracts depend on factors such as the achievement of certain events, successful enrollment of patients, and completion of portions of the clinical trial or similar conditions. Our accrual for clinical trials is based on estimates of the services received and efforts expended pursuant to contracts with clinical trial centers and clinical research organizations. We may terminate these contracts upon written notice and we are generally only liable for actual effort expended by the organizations to the date of termination, although in certain instances we may be further responsible for termination fees and penalties. We estimate our research and development expenses and the related accrual as of each balance sheet date based on the facts and circumstances known to us at that time. There have been no material adjustments to the prior period accrued estimates for clinical trial activities through June 30, 2017. Restructuring Restructuring costs are comprised of severance costs related to workforce reductions. We recognize restructuring charges when the liability is incurred. Employee termination benefits are accrued at the date management has committed to a plan of termination and employees have been notified of their termination dates and expected severance payments. Recent Accounting Pronouncements Accounting Standards Update 2014-09 In May 2014, the Financial Accounting Standards Board (“FASB”) issued guidance codified in ASC 606, Revenue Recognition, Revenue from Contracts with Customers, which amends the guidance in former ASC 605, Revenue Recognition, which provides a single comprehensive model for entities to use in accounting for revenue arising from contracts with customers and will supersede most current revenue recognition guidance. In July 2015, the FASB deferred the effective date for annual reporting periods beginning after December 15, 2017 (including interim periods within those periods) , with early application permitted . The FASB issued supplemental adoption guidance and clarification to ASU 2014-09 in March 2016, April 2016 and May 2016 within ASU 2016-08 "Revenue From Contracts With Customers: Principal vs. Agent Considerations," ASU 2016-10 "Revenue From Contracts with Customers: Identifying Performance Obligations and Licensing," and ASU 2016-12 "Revenue from Contracts with Customers: Narrow-Scope Improvements and Practical Expedients," respectively. We are currently evaluating the impact (if any) this guidance will have on our consolidated financial statements. with a cumulative catch-up adjustment to the opening balance sheet of retained earnings at the effective date, during the first quarter of 2018. Based on preliminary assessment, the adoption of this guidance is not expected to materially impact the Company’s revenue recognition as there are no collaboration agreements where we have significant contractual obligations. We will reevaluate the impact of this guidance as we enter into new revenue arrangements and will continue to review variable consideration, potential disclosures, and the method of adoption in order to complete the evaluation of the impact on the consolidated financial statements. In addition, we will continue to monitor additional changes, modifications, clarifications or interpretations undertaken by the FASB, which may impact the current conclusions. Accounting Standards Update 2016-02 In February 2016, the FASB issued ASU No. 2016-02, Leases Accounting Standards Update 2016-18 In November 2016, the FASB issued ASU 2016-18, Statement of Cash Flows (Topic 230): Restricted Cash (a consensus of the FASB Emerging Issues Task Force). Accounting Standards Update 2017-04 In January 2017, the FASB issued ASU 2017-04, Intangibles – Goodwill and other (Topic 350), which simplifies the test for goodwill impairment by eliminating a previously required step. We will adopt the standard effective January 1, 2020. The adoption is not expected to have a material impact on our consolidated financial statements. Accounting Standards Update 2017-09 In May 2017, the FASB issued ASU 2017-09, Compensation – Stock Compensation (Topic 718): Scope of Modification Accounting. The ASU provides guidance about which changes to the terms or conditions of a share-based payment award require an entity to apply modification accounting in Topic 718. The ASU is effective for annual periods beginning after December 15, 2017 with early adoption permitted. The adoption of this standard is not expected to have a material impact on our consolidated financial statements.

Fair Value Measurements

Fair Value Measurements	6 Months Ended
	Jun. 30, 2017
Fair Value Disclosures [Abstract]
Fair Value Measurements	2. Fair Value Measurements We measure fair value as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value must maximize the use of observable inputs and minimize the use of unobservable inputs. The accounting standard describes a fair value hierarchy based on three levels of inputs, of which the first two are considered observable and the last unobservable, that may be used to measure fair value which are the following: • Level 1—Observable inputs, such as quoted prices in active markets for identical assets or liabilities; • Level 2—Inputs other than Level 1 that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities, quoted prices in markets that are not active or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities; and • Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities; therefore, requiring an entity to develop its own valuation techniques and assumptions. The carrying amounts of cash equivalents, accounts and other receivables, accounts payable and accrued liabilities are considered reasonable estimates of their respective fair value because of their short-term nature. Recurring Fair Value Measurements The following table represents the fair value hierarchy for our financial assets (cash equivalents and marketable securities) measured at fair value on a recurring basis (in thousands): Level 1 Level 2 Level 3 Total June 30, 2017 Money market funds $ 18,215 $ - $ - $ 18,215 U.S. Treasuries - 6,779 - 6,779 U.S. government agency securities - 43,373 - 43,373 Corporate debt securities - 56,362 - 56,362 Total $ 18,215 $ 106,514 $ - $ 124,729 Level 1 Level 2 Level 3 Total December 31, 2016 Money market funds $ 18,981 $ - $ - $ 18,981 U.S. Treasuries - 3,499 - 3,499 U.S. government agency securities - 30,437 - 30,437 Corporate debt securities - 24,941 - 24,941 Total $ 18,981 $ 58,877 $ - $ 77,858 Money market funds are highly liquid investments and are actively traded. The pricing information on these investment instruments is readily available and can be independently validated as of the measurement date. This approach results in the classification of these securities as Level 1 of the fair value hierarchy. U.S. Treasuries, U.S. Government agency securities and corporate debt securities are measured at fair value using Level 2 inputs. We review trading activity and pricing for these investments as of each measurement date. When sufficient quoted pricing for identical securities is not available, we use market pricing and other observable market inputs for similar securities obtained from various third party data providers. These inputs represent quoted prices for similar assets in active markets or these inputs have been derived from observable market data. This approach results in the classification of these securities as Level 2 of the fair value hierarchy. There were no transfers between Level 1 and Level 2 during the six months ended June 30, 2017.

Cash, Cash Equivalents and Mark

Cash, Cash Equivalents and Marketable Securities	6 Months Ended
	Jun. 30, 2017
Cash Cash Equivalents And Short Term Investments [Abstract]
Cash, Cash Equivalents and Marketable Securities	3. Cash, cash equivalents and marketable securities Cash, cash equivalents and marketable securities consist of the following (in thousands): Amortized Cost Unrealized Gains Unrealized Losses Estimated Fair Value June 30, 2017 Cash and cash equivalents: Cash $ 2,233 $ - $ - $ 2,233 Money market funds 18,215 - - 18,215 U.S. government agency securities 4,496 - - 4,496 Corporate debt securities 12,731 - - 12,731 Total cash and cash equivalents 37,675 - - 37,675 Marketable securities available-for-sale: U.S. Treasuries 6,788 - (9 ) 6,779 U.S. government agency securities 38,902 - (26 ) 38,876 Corporate debt securities 43,638 1 (8 ) 43,631 Total marketable securities available-for-sale 89,328 1 (43 ) 89,286 Total cash, cash equivalents and marketable securities $ 127,003 $ 1 $ (43 ) $ 126,961 December 31, 2016 Cash and cash equivalents: Cash $ 3,557 $ - $ - $ 3,557 Money market funds 18,981 - - 18,981 U.S. government agency securities 1,751 - - 1,751 Total cash and cash equivalents 24,289 - - 24,289 Marketable securities available-for-sale: U.S. Treasuries 3,499 - - 3,499 U.S. government agency securities 28,685 3 (2 ) 28,686 Corporate debt securities 24,938 5 (2 ) 24,941 Total marketable securities available-for-sale 57,122 8 (4 ) 57,126 Total cash, cash equivalents and marketable securities $ 81,411 $ 8 $ (4 ) $ 81,415 The maturities of our marketable securities available-for-sale are as follows (in thousands): June 30, 2017 Amortized Cost Estimated Fair Value Mature in one year or less $ 89,328 $ 89,286 Mature after one year through two years - - $ 89,328 $ 89,286 There were no realized gains or losses from the sale of marketable securities during the six months ended June 30, 2017 and 2016. We have classified our entire investment portfolio as available-for-sale and available for use in current operations and accordingly have classified all investments as short-term. Available-for-sale securities are carried at fair value based on inputs that are observable, either directly or indirectly, such as quoted market prices for similar securities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the securities, with unrealized gains and losses included in accumulated other comprehensive income (loss) in stockholders’ equity. Realized gains and losses and declines in value, if any, judged to be other than temporary on available-for-sale securities are included in interest income or expense. The cost of securities sold is based on the specific identification method. Management assesses whether declines in the fair value of investment securities are other than temporary. In determining whether a decline is other than temporary, management considers the following factors: • Whether the investment has been in a continuous realized loss position for over 12 months; • the duration to maturity of our investments; • our intention and ability to hold the investment to maturity and if it is not more likely than not that we will be required to sell the investment before recovery of the amortized cost bases; • the credit rating, financial condition and near-term prospects of the issuer; and • the type of investments made. To date, there have been no declines in fair value that have been identified as other than temporary.

Commitments and Contingencies

Commitments and Contingencies	6 Months Ended
	Jun. 30, 2017
Commitments And Contingencies Disclosure [Abstract]
Commitments and Contingencies	4. Commitments and Contingencies We lease our facilities in Berkeley, California (“Berkeley Lease”) and Düsseldorf, Germany (“Düsseldorf Lease”) under operating leases that expire in December 2025 and March 2023, respectively. In May 2017, we amended the Berkeley Lease to extend the term of the lease to expire in December 2025 and to terminate the lease of an adjacent building. The early termination of the adjacent building’s lease did not result in a termination fee as the lease rate under the amended Berkeley Lease was not above market rates. In addition, as a result of the early termination, we reversed the deferred rent liability of $0.2 million against rent expense during the quarter ended June 30, 2017. The amended Berkeley Lease provides for periods of escalating rent. The total cash payments over the life of the Berkeley Lease and Dusseldorf Lease are divided by the total number of months in the lease period and the average rent is charged to expense each month during the lease period. Total net rent expense related to our operating leases for the three month periods ended June 30, 2017 and 2016, was $0.4 million and $0.6 million, respectively. Total net rent expense related to our operating leases for the six month periods ended June 30, 2017 and 2016 was $1.0 million and $1.1 million, respectively. Deferred rent was $0.4 million and $0.3 million as of June 30, 2017 and December 31, 2016, respectively. Future minimum payments under the non-cancelable portion of our operating leases at June 30, 2017, are as follows (in thousands): Years ending December 31, 2017 (remaining) $ 1,069 2018 2,332 2019 2,535 2020 2,597 2021 2,526 Thereafter 9,109 Total $ 20,168 In addition to the non-cancelable commitments included above, we have entered into contractual arrangements that obligate us to make payments to the contractual counterparties upon the occurrence of future events. In addition, in the normal course of operations, we have entered into license and other agreements and intend to continue to seek additional rights relating to compounds or technologies in connection with our discovery, manufacturing and development programs. Under the terms of the agreements, we may be required to pay future up-front fees, milestones and royalties on net sales of products originating from the licensed technologies, if any, or other payments contingent upon the occurrence of future events that cannot reasonably be estimated. We rely on and have entered into agreements with research institutions, contract research organizations and clinical investigators as well as clinical and commercial material manufacturers. These agreements are terminable by us upon written notice. Generally, we are liable only for actual effort expended by the organizations at any point in time during the contract through the notice period. From time to time, we may be involved in claims, suits, and proceedings arising from the ordinary course of our business, including actions with respect to intellectual property claims, commercial claims, and other matters. Such claims, suits, and proceedings are inherently uncertain and their results cannot be predicted with certainty. Regardless of the outcome, such legal proceedings can have an adverse impact on us because of legal costs, diversion of management resources, and other factors. In addition, it is possible that a resolution of one or more such proceedings could result in substantial damages, fines, penalties or orders requiring a change in our business practices, which could in the future materially and adversely affect our financial position, financial statements, results of operations, or cash flows in a particular period. On September 7, 2016, we entered into a Stipulation of Settlement to settle the case entitled In re Dynavax Technologies Securities Litigation filed in 2013. The settlement, which was approved by the U.S. District Court for the Northern District of California on February 6, 2017, provided for a payment of $4.1 million by us and results in a dismissal and release of all claims against all defendants, including us. The settlement was paid by our insurers in February 2017. The $4.1 million accrued liability and corresponding $4.1 million prepaid expense and other current asset reflected in our consolidated balance sheets as of December 31, 2016 were released during the first quarter of 2017. In February 2017, we tentatively agreed to a settlement for derivative complaints filed in 2013, all of which will be paid by our insurers. We recorded an accrual of $0.9 million reflected in accrued liabilities in the consolidated balance sheets as of December 31, 2016 and do not expect any significant additional charges related to this matter. In addition, we record anticipated recoveries under existing insurance contracts when recovery is assured. We recorded a current asset in the amount of $0.9 million reflected in prepaid expenses and other current assets in the consolidated balance sheets as of December 31, 2016. Amounts recorded for contingencies can result from a complex series of judgments about future events and uncertainties and can rely heavily on estimates and assumptions.

Collaborative Research and Deve

Collaborative Research and Development Agreements	6 Months Ended
	Jun. 30, 2017
Research And Development [Abstract]
Collaborative Research and Development Agreements	5. Collaborative Research and Development Agreements AstraZeneca Pursuant to a research collaboration and license agreement with AstraZeneca AB (“AstraZeneca”), as amended, we discovered and performed initial clinical development of AZD1419, a TLR9 agonist product candidate for the treatment of asthma. Under the amended agreement we received non-refundable payments of $3.0 million and $5.4 million in 2011 and in 2014, respectively. These payments were deferred and recognized over the estimated period of performance at the time of payment, as subsequently revised. We have also received payments for development work of $3.0 million, $6.0 million and $8.0 million, in 2011, 2012 and 2014, respectively, which were deferred and recognized as research and development expenses were incurred. In January 2016, we amended our agreement with AstraZeneca whereby AstraZeneca will conduct the Phase 2a safety and efficacy trial of AZD1419 in patients with asthma that originally was to be conducted by Dynavax. In June 2016, all of our remaining contractual obligations under our agreement with AstraZeneca were completed. As no further performance obligations remain, we revised the estimated period of performance of development work to June 2016 from September 2016, and recognized remaining deferred payments as revenue as of June 30, 2016. The revision of the performance period led to the recognition of an additional $0.8 million in collaboration revenue during 2016. In November 2016, AstraZeneca initiated the Phase 2a trial of AZD1419 in asthma patients. Upon AstraZeneca’s initiation of the Phase 2a trial, we earned a milestone payment of $7.2 million, which was offset against the $7.4 million in unused development funding previously advanced by AstraZeneca. We recognized the $7.2 million milestone as revenue during the fourth quarter of 2016. The remaining balance of unused development funding, net of the $7.2 million milestone payment, was $0.2 million which was paid during the first quarter of 2017. No liability related to unused development funding remains on the accompanying condensed consolidated balance sheet as of June 30, 2017. Under the terms of the agreement, as amended, we are eligible to receive up to approximately $100 million in additional milestone payments, based on the achievement of certain development and regulatory objectives. Additionally, upon commercialization of AZD1419, we are eligible to receive tiered royalties ranging from the mid to high single-digits based on product sales of any products originating from the collaboration. We have the option to co-promote in the United States products arising from the collaboration, if any. AstraZeneca has the right to sublicense its rights upon our prior consent. The following table summarizes the revenues earned under our agreement with AstraZeneca, included as collaboration revenue in our consolidated statements of operations (in thousands): As of June 30, 2017 and December 31, 2016, no deferred revenue from the initial payment, subsequent payment or development funding payments remained. Three Months Ended Six Months Ended June 30, June 30, 2017 2016 2017 2016 Initial payment $ - $ 347 $ - $ 521 Subsequent payment - 1,302 - 1,953 Performance of research activities - 34 - 104 Total $ - $ 1,683 $ - $ 2,578 Absent early termination, the agreement will expire when all of AstraZeneca’s payment obligations expire. AstraZeneca has the right to terminate the agreement at any time upon prior written notice and either party may terminate the agreement early upon written notice if the other party commits an uncured material breach of the agreement.

Net Loss Per Share

Net Loss Per Share	6 Months Ended
	Jun. 30, 2017
Earnings Per Share [Abstract]
Net Loss Per Share	6. Net Loss Per Share Basic net loss per share is calculated by dividing the net loss by the weighted-average number of common shares outstanding during the period. Diluted net loss per share is computed by dividing the net loss by the weighted-average number of common shares outstanding during the period and giving effect to all potentially dilutive common shares using the treasury-stock method. For purposes of this calculation, outstanding options and stock awards are considered to be potentially dilutive common shares and are only included in the calculation of diluted net loss per share when their effect is dilutive. Stock options and stock awards totaling approximately 6,310,000 and 4,510,000 shares of common stock as of June 30, 2017 and 2016, respectively, were excluded from the calculation of diluted net loss per share for the three and six months ended June 30, 2017 and 2016, because the effect of their inclusion would have been anti-dilutive. For periods in which we have a net loss and no instruments are determined to be dilutive, such as the three and six months ended June 30, 2017 and 2016, basic and diluted net loss per share are the same.

Common Stock

Common Stock	6 Months Ended
	Jun. 30, 2017
Preferred Stock Common Stock And Warrants [Abstract]
Common Stock	7. Common Stock Common Stock Outstanding As of June 30, 2017, there were 54,747,656 shares of our common stock outstanding. On November 12, 2015, we entered into the 2015 ATM Agreement with Cowen and Company, LLC (“Cowen”) we received net cash proceeds of $88.2 million ur common stock

Equity Plans and Stock-Based Co

Equity Plans and Stock-Based Compensation	6 Months Ended
	Jun. 30, 2017
Share Based Compensation [Abstract]
Equity Plans and Stock-Based Compensation	8. Equity Plans and Stock-Based Compensation Option activity under our stock-based compensation plans during the six months ended June 30, 2017 was as follows (in thousands except per share amounts): Shares Underlying Outstanding Options (in thousands) Weighted-Average Exercise Price Per Share Weighted-Average Remaining Contractual Term (years) Aggregate Intrinsic Value (in thousands) Balance at December 31, 2016 3,975 $ 21.38 Options granted 279 6.08 Options exercised - - Options cancelled: Options forfeited (unvested) (310 ) 18.24 Options cancelled (vested) (193 ) 29.32 Balance at June 30, 2017 3,751 20.09 6.09 $ 1,136 Vested and expected to vest at June 30, 2017 3,741 20.10 6.09 $ 1,136 Exercisable at June 30, 2017 2,290 22.34 5.57 $ 151 In June 2017, stockholders of the Company approved a proposal to increase the aggregate number of shares of common stock authorized for issuance under the 2011 Equity Incentive Plan, as amended, by 1,600,000 shares. Restricted stock unit activity under our stock-based compensation plans during the six months ended June 30, 2017 was as follows (in thousands except per share amounts): Number of Shares (In thousands) Weighted-Average Grant-Date Fair Value Non-vested as of December 31, 2016 699 $ 12.12 Granted 2,124 4.76 Vested (171 ) 18.62 Forfeited or expired (93 ) 12.25 Non-vested as of June 30, 2017 2,559 $ 5.58 The aggregate intrinsic value of the restricted stock units outstanding as of June 30, 2017, based on our stock price on that date, was $24.7 million. Fair value of restricted stock units is determined at the date of grant using our closing stock price. As of June 30, 2017, approximately 110,000 shares underlying stock options and restricted stock units awards with performance-based vesting criteria were outstanding. Vesting criteria for these performance-based awards were not probable as of June 30, 2017. Under our stock-based compensation plans, option awards generally vest over a three or four-year period contingent upon continuous service, and expire seven to ten years from the date of grant (or earlier upon termination of continuous service). The fair value-based measurement of each option is estimated on the date of grant using the Black-Scholes option valuation model. The fair value-based measurements and weighted-average assumptions used in the calculations of these measurements are as follows: Stock Options Stock Options Employee Stock Purchase Plan Three Months Ended Six Months Ended Six Months Ended June 30, June 30, June 30, 2017 2016 2017 2016 2017 2016 Weighted-average fair value $ 3.90 $ 10.25 $ 4.12 $ 9.79 $ 2.37 $ 8.18 Risk-free interest rate 1.8 % 1.5 % 1.9 % 1.4 % 0.9 % 0.6 % Expected life (in years) 4.5 5.4 4.5 5.0 1.2 1.2 Volatility 0.9 0.7 0.9 0.7 1.0 0.6 We recognized stock-based compensation expense of $3.4 million and $3.1 The components of stock-based compensation expense were (in thousands): Three Months Ended Six Months Ended June 30, June 30, 2017 2016 2017 2016 Research and development $ 1,771 $ 1,336 $ 3,734 $ 2,851 General and administrative 1,592 1,788 3,450 3,517 Total $ 3,363 $ 3,124 $ 7,184 $ 6,368 As of June 30, 2017, the total unrecognized compensation cost related to non-vested equity awards including all awards with time-based vesting amounted to $25.3 million, which is expected to be recognized over the remaining weighted-average vesting period of 1.9 years. Additionally, as of June 30, 2017, the total unrecognized compensation cost related to equity awards with performance-based vesting criteria not deemed probable of vesting amounted to $0.6 million. Employee Stock Purchase Plan The 2014 Employee Stock Purchase Plan, as amended, (the “Purchase Plan”) provides for the purchase of common stock by eligible employees and became effective on May 28, 2014. The purchase price per share is the lesser of (i) 85% of the fair market value of the common stock on the commencement of the offer period (generally, the sixteenth day in February or August) or (ii) 85% of the fair market value of the common stock on the exercise date, which is the last day of a purchase period (generally, the fifteenth day in February or August). As of June 30, 2017, employees have acquired 90,156 shares of our common stock under the Purchase Plan and 137,885 shares of our common stock remained available for future purchases under the Purchase Plan.

Restructuring

Restructuring	6 Months Ended
	Jun. 30, 2017
Restructuring And Related Activities [Abstract]
Restructuring	9. Restructuring In January 2017, we implemented organizational restructuring and cost reduction plans to align around our immuno-oncology business while allowing us to advance HEPLISAV-B through the FDA review and approval process. To achieve these cost reductions, we suspended manufacturing activities, commercial preparations and other long term investment related to HEPLISAV-B and reduced our global workforce by approximately 40 percent. In the first quarter of 2017 we recorded charges of $2.8 million related to severance, other termination benefits and outplacement services. There were no additional charges during the three months ended June 30, 2017. Of that amount, we paid $2.5 million during the first half of 2017 and expect to pay approximately $0.3 million in the third quarter of 2017. The outstanding restructuring liabilities are included in accrued liabilities on the condensed consolidated balance sheets. As of June 30, 2017, the components of the liabilities were as follows (in thousands): Employee Severance and Other Benefits Restructuring charges $ 2,783 Cash payments (2,523 ) Balance at June 30, 2017 $ 260

Organization and Summary of S16

Organization and Summary of Significant Accounting Policies (Policies)	6 Months Ended
	Jun. 30, 2017
Organization Consolidation And Presentation Of Financial Statements [Abstract]
Basis of Presentation	Basis of Presentation Our accompanying unaudited condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (“GAAP”) for interim financial information and pursuant to the instructions to Form 10-Q and Article 10 of Regulation S-X. In our opinion, these unaudited condensed consolidated financial statements include all adjustments, consisting of normal recurring adjustments, which we consider necessary to present fairly our financial position and the results of our operations and cash flows. As permitted under those rules, certain footnotes or other financial information that are normally required by GAAP have been condensed or omitted. Interim-period results are not necessarily indicative of results of operations or cash flows to be expected for a full-year period or any other interim-period. The condensed consolidated balance sheet at December 31, 2016 has been derived from audited financial statements at that date, but excludes disclosures required by GAAP for complete financial statements. The unaudited condensed consolidated financial statements and these notes should be read in conjunction with our Annual Report on Form 10-K for the year ended December 31, 2016, as filed with the Securities and Exchange Commission (the “SEC”). The unaudited condensed consolidated financial statements include the accounts of Dynavax and our wholly-owned subsidiary, Dynavax GmbH. All significant intercompany accounts and transactions among these entities have been eliminated from the condensed consolidated financial statements. We operate in one business segment: the discovery and development of biopharmaceutical products.
Liquidity and Financial Condition	Liquidity and Financial Condition As of June 30, 2017, we had cash, cash equivalents and marketable securities of $127.0 million. During the six months ended June 30, 2017, we received $88.2 million in net proceeds from our We have incurred significant operating losses and negative cash flows from operations since our inception. In January 2017, we implemented organizational restructuring and cost reduction plans to align around our immuno-oncology business while allowing us to advance HEPLISAV-B through the U.S. Food and Drug Administration (“FDA”) review and approval process. To achieve these cost reductions, we suspended manufacturing activities, commercial preparations and other long term investment related to HEPLISAV-B and reduced our global workforce by approximately 40 percent. We expect to continue to spend substantial funds in connection with the development and manufacturing of our product candidates, particularly SD-101 and DV281, our lead investigational cancer immunotherapeutic product candidates, human clinical trials for our other product candidates and additional applications and advancement of our technology. In order to continue ongoing development activities of our product candidates and to support commercialization of HEPLISAV-B, if approved, we will need additional funding or a partnership in support of HEPLISAV-B. This may occur through strategic alliance and licensing arrangements and/or future public or private debt and equity financings. Sufficient funding may not be available, or if available, may be on terms that significantly dilute or otherwise adversely affect the rights of existing stockholders. If adequate funds are not available in the future, we may need to delay, reduce the scope of or put on hold one or more development programs while we seek strategic alternatives, which could have an adverse impact on our ability to achieve our intended business objectives. Our ability to raise additional capital in the equity and debt markets is dependent on a number of factors, including, but not limited to, the market demand for our common stock, which itself is subject to a number of development and business risks and uncertainties, as well as the uncertainty that we would be able to raise such additional capital at a price or on terms that are favorable to us.
Use of Estimates	Use of Estimates The preparation of financial statements in conformity with GAAP requires management to make informed estimates and assumptions that affect the amounts reported in the condensed consolidated financial statements and accompanying notes. Management’s estimates are based on historical information available as of the date of the condensed consolidated financial statements and various other assumptions we believe are reasonable under the circumstances. Actual results could differ materially from these estimates.
Summary of Significant Accounting Policies	Summary of Significant Accounting Policies There have been no material changes in our significant accounting policies during the six months ended June 30, 2017, as compared with those disclosed in our Annual Report on Form 10-K for the year ended December 31, 2016.
Revenue Recognition	Revenue Recognition Our revenues consist of amounts earned from collaborations, grants and fees from services and licenses. We enter into license and manufacturing agreements and collaborative research and development arrangements with pharmaceutical and biotechnology partners that may involve multiple deliverables. Our arrangements may include one or more of the following elements: upfront license payments, cost reimbursement for the performance of research and development activities, milestone payments, other contingent payments, contract manufacturing service fees, royalties and license fees. Each deliverable in the arrangement is evaluated to determine whether it meets the criteria to be accounted for as a separate unit of accounting or whether it should be combined with other deliverables. In order to account for the multiple-element arrangements, we identify the deliverables included within the arrangement and evaluate which deliverables represent separate units of accounting. Analyzing the arrangement to identify deliverables requires the use of judgment, and each deliverable may be an obligation to deliver services, a right or license to use an asset, or another performance obligation. We recognize revenue when there is persuasive evidence that an arrangement exists, delivery has occurred or services have been rendered, the price is fixed or determinable and collectability is reasonably assured. Non-refundable upfront fees received for license and collaborative agreements and other payments under collaboration agreements where we have continuing performance obligations related to the payments are deferred and recognized over our estimated performance period. Revenue is recognized on a ratable basis, unless we determine that another method is more appropriate, through the date at which our performance obligations are completed. Management makes its best estimate of the period over which we expect to fulfill our performance obligations, which may include clinical development activities. Given the uncertainties of research and development collaborations, significant judgment is required to determine the duration of the performance period. We recognize revenues for costs that are reimbursed under collaborative agreements as the related research and development costs are incurred. Contingent consideration received for the achievement of a substantive milestone is recognized in its entirety in the period in which the milestone is achieved. A milestone is defined as an event having all of the following characteristics: (i) there is substantive uncertainty at the date the arrangement is entered into that the event will be achieved, (ii) the event can only be achieved based in whole or in part on either the entity’s performance or a specific outcome resulting from the entity’s performance and (iii) if achieved, the event would result in additional payments being due to the entity. Our license and collaboration agreements with our partners provide for payments to be paid to us upon the achievement of milestones. Given the challenges inherent in developing biologic products, there is substantial uncertainty whether any such milestones will be achieved at the time we entered into these agreements. In addition, we evaluate whether milestones meet the criteria to be considered substantive. The conditions include: (i) work is contingent on either of the following: (a) the vendor’s performance to achieve the milestone or (b) the enhancement of the value of the deliverable item or items as a result of a specific outcome resulting from the vendor’s performance to achieve the milestone; (ii) it relates solely to past performance and (iii) it is reasonable relative to all the deliverable and payment terms within the arrangement. As a result of our analysis, we may consider our development milestones to be substantive. Milestone payments that are contingent upon the achievement of substantive at-risk performance criteria are recognized in full upon achievement of those milestone events in accordance with the terms of the agreement. All revenue recognized to date under our collaborative agreements has been nonrefundable. Our license and collaboration agreements with certain partners also provide for contingent payments based solely upon the performance of our partner. We expect to recognize the contingent payments as revenue upon receipt, provided that all other revenue recognition criteria have been satisfied. Revenues from manufacturing services are recognized upon meeting the criteria for substantial performance and acceptance by the customer. Revenue from royalty payments is contingent on future sales activities by our licensees. Royalty revenue is recognized when all revenue recognition criteria have been satisfied. Revenue from government and private agency grants is recognized as the related research expenses are incurred and to the extent that funding is approved.
Research and Development Expenses and Accruals	Research and Development Expenses and Accruals Research and development expenses include personnel and facility-related expenses, outside contracted services including clinical trial costs, manufacturing and process development costs, research costs and other consulting services and non-cash stock-based compensation. Research and development costs are expensed as incurred. Amounts due under contracts with third parties may be either fixed fee or fee for service, and may include upfront payments, monthly payments and payments upon the completion of milestones or receipt of deliverables. Non-refundable advance payments under agreements are capitalized and expensed as the related goods are delivered or services are performed. We contract with third parties to perform various clinical trial activities in the on-going development of potential products. The financial terms of these agreements are subject to negotiation, vary from contract to contract and may result in uneven payment flows to our vendors. Payments under the contracts depend on factors such as the achievement of certain events, successful enrollment of patients, and completion of portions of the clinical trial or similar conditions. Our accrual for clinical trials is based on estimates of the services received and efforts expended pursuant to contracts with clinical trial centers and clinical research organizations. We may terminate these contracts upon written notice and we are generally only liable for actual effort expended by the organizations to the date of termination, although in certain instances we may be further responsible for termination fees and penalties. We estimate our research and development expenses and the related accrual as of each balance sheet date based on the facts and circumstances known to us at that time. There have been no material adjustments to the prior period accrued estimates for clinical trial activities through June 30, 2017.
Restructuring	Restructuring Restructuring costs are comprised of severance costs related to workforce reductions. We recognize restructuring charges when the liability is incurred. Employee termination benefits are accrued at the date management has committed to a plan of termination and employees have been notified of their termination dates and expected severance payments.
Recent Accounting Pronouncements	Recent Accounting Pronouncements Accounting Standards Update 2014-09 In May 2014, the Financial Accounting Standards Board (“FASB”) issued guidance codified in ASC 606, Revenue Recognition, Revenue from Contracts with Customers, which amends the guidance in former ASC 605, Revenue Recognition, which provides a single comprehensive model for entities to use in accounting for revenue arising from contracts with customers and will supersede most current revenue recognition guidance. In July 2015, the FASB deferred the effective date for annual reporting periods beginning after December 15, 2017 (including interim periods within those periods) , with early application permitted . The FASB issued supplemental adoption guidance and clarification to ASU 2014-09 in March 2016, April 2016 and May 2016 within ASU 2016-08 "Revenue From Contracts With Customers: Principal vs. Agent Considerations," ASU 2016-10 "Revenue From Contracts with Customers: Identifying Performance Obligations and Licensing," and ASU 2016-12 "Revenue from Contracts with Customers: Narrow-Scope Improvements and Practical Expedients," respectively. We are currently evaluating the impact (if any) this guidance will have on our consolidated financial statements. with a cumulative catch-up adjustment to the opening balance sheet of retained earnings at the effective date, during the first quarter of 2018. Based on preliminary assessment, the adoption of this guidance is not expected to materially impact the Company’s revenue recognition as there are no collaboration agreements where we have significant contractual obligations. We will reevaluate the impact of this guidance as we enter into new revenue arrangements and will continue to review variable consideration, potential disclosures, and the method of adoption in order to complete the evaluation of the impact on the consolidated financial statements. In addition, we will continue to monitor additional changes, modifications, clarifications or interpretations undertaken by the FASB, which may impact the current conclusions. Accounting Standards Update 2016-02 In February 2016, the FASB issued ASU No. 2016-02, Leases Accounting Standards Update 2016-18 In November 2016, the FASB issued ASU 2016-18, Statement of Cash Flows (Topic 230): Restricted Cash (a consensus of the FASB Emerging Issues Task Force). Accounting Standards Update 2017-04 In January 2017, the FASB issued ASU 2017-04, Intangibles – Goodwill and other (Topic 350), which simplifies the test for goodwill impairment by eliminating a previously required step. We will adopt the standard effective January 1, 2020. The adoption is not expected to have a material impact on our consolidated financial statements. Accounting Standards Update 2017-09 In May 2017, the FASB issued ASU 2017-09, Compensation – Stock Compensation (Topic 718): Scope of Modification Accounting. The ASU provides guidance about which changes to the terms or conditions of a share-based payment award require an entity to apply modification accounting in Topic 718. The ASU is effective for annual periods beginning after December 15, 2017 with early adoption permitted. The adoption of this standard is not expected to have a material impact on our consolidated financial statements.

Fair Value Measurements (Tables

Fair Value Measurements (Tables)	6 Months Ended
	Jun. 30, 2017
Fair Value Disclosures [Abstract]
Fair Value Hierarchy for Financial Assets Measured at Fair Value on Recurring Basis	The following table represents the fair value hierarchy for our financial assets (cash equivalents and marketable securities) measured at fair value on a recurring basis (in thousands): Level 1 Level 2 Level 3 Total June 30, 2017 Money market funds $ 18,215 $ - $ - $ 18,215 U.S. Treasuries - 6,779 - 6,779 U.S. government agency securities - 43,373 - 43,373 Corporate debt securities - 56,362 - 56,362 Total $ 18,215 $ 106,514 $ - $ 124,729 Level 1 Level 2 Level 3 Total December 31, 2016 Money market funds $ 18,981 $ - $ - $ 18,981 U.S. Treasuries - 3,499 - 3,499 U.S. government agency securities - 30,437 - 30,437 Corporate debt securities - 24,941 - 24,941 Total $ 18,981 $ 58,877 $ - $ 77,858

Cash, Cash Equivalents and Ma18

Cash, Cash Equivalents and Marketable Securities (Tables)	6 Months Ended
	Jun. 30, 2017
Cash Cash Equivalents And Short Term Investments [Abstract]
Summary of Cash, Cash Equivalents and Marketable Securities	Cash, cash equivalents and marketable securities consist of the following (in thousands): Amortized Cost Unrealized Gains Unrealized Losses Estimated Fair Value June 30, 2017 Cash and cash equivalents: Cash $ 2,233 $ - $ - $ 2,233 Money market funds 18,215 - - 18,215 U.S. government agency securities 4,496 - - 4,496 Corporate debt securities 12,731 - - 12,731 Total cash and cash equivalents 37,675 - - 37,675 Marketable securities available-for-sale: U.S. Treasuries 6,788 - (9 ) 6,779 U.S. government agency securities 38,902 - (26 ) 38,876 Corporate debt securities 43,638 1 (8 ) 43,631 Total marketable securities available-for-sale 89,328 1 (43 ) 89,286 Total cash, cash equivalents and marketable securities $ 127,003 $ 1 $ (43 ) $ 126,961 December 31, 2016 Cash and cash equivalents: Cash $ 3,557 $ - $ - $ 3,557 Money market funds 18,981 - - 18,981 U.S. government agency securities 1,751 - - 1,751 Total cash and cash equivalents 24,289 - - 24,289 Marketable securities available-for-sale: U.S. Treasuries 3,499 - - 3,499 U.S. government agency securities 28,685 3 (2 ) 28,686 Corporate debt securities 24,938 5 (2 ) 24,941 Total marketable securities available-for-sale 57,122 8 (4 ) 57,126 Total cash, cash equivalents and marketable securities $ 81,411 $ 8 $ (4 ) $ 81,415
Maturities of Marketable Securities Available-for-Sale	The maturities of our marketable securities available-for-sale are as follows (in thousands): June 30, 2017 Amortized Cost Estimated Fair Value Mature in one year or less $ 89,328 $ 89,286 Mature after one year through two years - - $ 89,328 $ 89,286

Commitments and Contingencies (

Commitments and Contingencies (Tables)	6 Months Ended
	Jun. 30, 2017
Commitments And Contingencies Disclosure [Abstract]
Future Minimum Payments Under Non-Cancelable Portion of Operating Leases	Future minimum payments under the non-cancelable portion of our operating leases at June 30, 2017, are as follows (in thousands): Years ending December 31, 2017 (remaining) $ 1,069 2018 2,332 2019 2,535 2020 2,597 2021 2,526 Thereafter 9,109 Total $ 20,168

Collaborative Research and De20

Collaborative Research and Development Agreements (Tables)	6 Months Ended
	Jun. 30, 2017
Astra Zeneca
Summary of Revenue Recognized under Various Agreements	The following table summarizes the revenues earned under our agreement with AstraZeneca, included as collaboration revenue in our consolidated statements of operations (in thousands): Three Months Ended Six Months Ended June 30, June 30, 2017 2016 2017 2016 Initial payment $ - $ 347 $ - $ 521 Subsequent payment - 1,302 - 1,953 Performance of research activities - 34 - 104 Total $ - $ 1,683 $ - $ 2,578

Equity Plans and Stock-Based 21

Equity Plans and Stock-Based Compensation (Tables)	6 Months Ended
	Jun. 30, 2017
Share Based Compensation [Abstract]
Option Activity under Stock-Based Compensation Plans	Option activity under our stock-based compensation plans during the six months ended June 30, 2017 was as follows (in thousands except per share amounts): Shares Underlying Outstanding Options (in thousands) Weighted-Average Exercise Price Per Share Weighted-Average Remaining Contractual Term (years) Aggregate Intrinsic Value (in thousands) Balance at December 31, 2016 3,975 $ 21.38 Options granted 279 6.08 Options exercised - - Options cancelled: Options forfeited (unvested) (310 ) 18.24 Options cancelled (vested) (193 ) 29.32 Balance at June 30, 2017 3,751 20.09 6.09 $ 1,136 Vested and expected to vest at June 30, 2017 3,741 20.10 6.09 $ 1,136 Exercisable at June 30, 2017 2,290 22.34 5.57 $ 151
Summary of Restricted Stock Units Activity	Restricted stock unit activity under our stock-based compensation plans during the six months ended June 30, 2017 was as follows (in thousands except per share amounts): Number of Shares (In thousands) Weighted-Average Grant-Date Fair Value Non-vested as of December 31, 2016 699 $ 12.12 Granted 2,124 4.76 Vested (171 ) 18.62 Forfeited or expired (93 ) 12.25 Non-vested as of June 30, 2017 2,559 $ 5.58
Fair Value-Based Measurements and Weighted-Average Assumptions	The fair value-based measurements and weighted-average assumptions used in the calculations of these measurements are as follows: Stock Options Stock Options Employee Stock Purchase Plan Three Months Ended Six Months Ended Six Months Ended June 30, June 30, June 30, 2017 2016 2017 2016 2017 2016 Weighted-average fair value $ 3.90 $ 10.25 $ 4.12 $ 9.79 $ 2.37 $ 8.18 Risk-free interest rate 1.8 % 1.5 % 1.9 % 1.4 % 0.9 % 0.6 % Expected life (in years) 4.5 5.4 4.5 5.0 1.2 1.2 Volatility 0.9 0.7 0.9 0.7 1.0 0.6
Stock-Based Compensation Expense	The components of stock-based compensation expense were (in thousands): Three Months Ended Six Months Ended June 30, June 30, 2017 2016 2017 2016 Research and development $ 1,771 $ 1,336 $ 3,734 $ 2,851 General and administrative 1,592 1,788 3,450 3,517 Total $ 3,363 $ 3,124 $ 7,184 $ 6,368

Restructuring (Tables)

Restructuring (Tables)	6 Months Ended
	Jun. 30, 2017
Restructuring And Related Activities [Abstract]
Schedule of Components of Restructuring Liabilities	The outstanding restructuring liabilities are included in accrued liabilities on the condensed consolidated balance sheets. As of June 30, 2017, the components of the liabilities were as follows (in thousands): Employee Severance and Other Benefits Restructuring charges $ 2,783 Cash payments (2,523 ) Balance at June 30, 2017 $ 260

Organization and Summary of S23

Organization and Summary of Significant Accounting Policies - Additional Information (Detail) $ in Thousands	1 Months Ended	6 Months Ended
	Jan. 31, 2017	Jun. 30, 2017USD ($)Segment	Jun. 30, 2016USD ($)
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Number of operating segment | Segment		1
Cash, cash equivalents and marketable securities		$ 127,000
Proceeds from issuance of common stock, net		88,200
Cash used in operating activities		42,642	$ 52,561
Percentage of reduction in global workforce	40.00%
Cowen
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]
Proceeds from issuance of common stock, net		$ 88,200

Fair Value Hierarchy for Financ

Fair Value Hierarchy for Financial Assets Measured at Fair Value on Recurring Basis (Detail) - Fair Value, Measurements, Recurring - USD ($) $ in Thousands	Jun. 30, 2017	Dec. 31, 2016
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets	$ 124,729	$ 77,858
Money Market Funds
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets	18,215	18,981
U.S. Treasuries
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets	6,779	3,499
U.S. Government Agency Securities
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets	43,373	30,437
Corporate Debt Securities
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets	56,362	24,941
Fair Value, Inputs, Level 1
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets	18,215	18,981
Fair Value, Inputs, Level 1 | Money Market Funds
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets	18,215	18,981
Fair Value, Inputs, Level 2
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets	106,514	58,877
Fair Value, Inputs, Level 2 | U.S. Treasuries
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets	6,779	3,499
Fair Value, Inputs, Level 2 | U.S. Government Agency Securities
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets	43,373	30,437
Fair Value, Inputs, Level 2 | Corporate Debt Securities
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Assets	$ 56,362	$ 24,941

Fair Value Measurements - Addit

Fair Value Measurements - Additional Information (Detail)	Jun. 30, 2017USD ($)
Fair Value Disclosures [Abstract]
Transfers from level 1 to level 2	$ 0
Transfers from level 2 to level 1	$ 0

Summary of Cash, Cash Equivalen

Summary of Cash, Cash Equivalents and Marketable Securities (Detail) - USD ($) $ in Thousands	Jun. 30, 2017	Dec. 31, 2016
Cash Cash Equivalents And Marketable Securities [Line Items]
Amortized Cost	$ 127,003	$ 81,411
Unrealized Gains	1	8
Unrealized Losses	(43)	(4)
Estimated Fair Value	126,961	81,415
Cash and Cash Equivalents
Cash Cash Equivalents And Marketable Securities [Line Items]
Amortized Cost	37,675	24,289
Estimated Fair Value	37,675	24,289
Marketable Securities Available-for-Sale
Cash Cash Equivalents And Marketable Securities [Line Items]
Amortized Cost	89,328	57,122
Unrealized Gains	1	8
Unrealized Losses	(43)	(4)
Estimated Fair Value	89,286	57,126
Cash | Cash and Cash Equivalents
Cash Cash Equivalents And Marketable Securities [Line Items]
Amortized Cost	2,233	3,557
Estimated Fair Value	2,233	3,557
Money Market Funds | Cash and Cash Equivalents
Cash Cash Equivalents And Marketable Securities [Line Items]
Amortized Cost	18,215	18,981
Estimated Fair Value	18,215	18,981
U.S. Government Agency Securities | Cash and Cash Equivalents
Cash Cash Equivalents And Marketable Securities [Line Items]
Amortized Cost	4,496	1,751
Estimated Fair Value	4,496	1,751
U.S. Government Agency Securities | Marketable Securities Available-for-Sale
Cash Cash Equivalents And Marketable Securities [Line Items]
Amortized Cost	38,902	28,685
Unrealized Gains		3
Unrealized Losses	(26)	(2)
Estimated Fair Value	38,876	28,686
Corporate Debt Securities | Cash and Cash Equivalents
Cash Cash Equivalents And Marketable Securities [Line Items]
Amortized Cost	12,731
Estimated Fair Value	12,731
Corporate Debt Securities | Marketable Securities Available-for-Sale
Cash Cash Equivalents And Marketable Securities [Line Items]
Amortized Cost	43,638	24,938
Unrealized Gains	1	5
Unrealized Losses	(8)	(2)
Estimated Fair Value	43,631	24,941
U.S. Treasuries | Marketable Securities Available-for-Sale
Cash Cash Equivalents And Marketable Securities [Line Items]
Amortized Cost	6,788	3,499
Unrealized Losses	(9)
Estimated Fair Value	$ 6,779	$ 3,499

Maturities of Marketable Securi

Maturities of Marketable Securities Available-for-Sale (Detail) $ in Thousands	Jun. 30, 2017USD ($)
Amortized Cost
Mature in one year or less	$ 89,328
Mature after one year through two years	0
Total amortized cost	89,328
Estimated Fair Value
Mature in one year or less	89,286
Mature after one year through two years	0
Total estimated fair value	$ 89,286

Cash, Cash Equivalents and Ma28

Cash, Cash Equivalents and Marketable Securities - Additional Information (Detail) - USD ($)	6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016
Investments Debt And Equity Securities [Abstract]
Realized gains or losses from the sale of marketable securities	$ 0	$ 0

Commitments and Contingencies -

Commitments and Contingencies - Additional Information (Detail) - USD ($) $ in Thousands	Sep. 07, 2016	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016	Dec. 31, 2016
Loss Contingencies [Line Items]
Reversal of deferred rent liability		$ 200		$ 209
Rent expense, net		400	$ 600	1,000	$ 1,100
Deferred rent		$ 400		$ 400		$ 300
Litigation settlement agreement date				September 7, 2016
Dynavax Technologies Securities Litigation
Loss Contingencies [Line Items]
Litigation amount payable	$ 4,100
Dynavax Technologies Securities Litigation | Accrued Liabilities
Loss Contingencies [Line Items]
Estimated loss accrual on litigation						4,100
Dynavax Technologies Securities Litigation | Prepaid Expenses and Other Current Assets
Loss Contingencies [Line Items]
Anticipated recovery on litigation						4,100
Derivative Complaints | Accrued Liabilities
Loss Contingencies [Line Items]
Estimated loss accrual on litigation						900
Derivative Complaints | Prepaid Expenses and Other Current Assets
Loss Contingencies [Line Items]
Anticipated recovery on litigation						$ 900
Berkeley, California (the "Berkeley Lease")
Loss Contingencies [Line Items]
Operating leases expiration date				2025-12
Dusseldorf, Germany (the "Dusseldorf Lease")
Loss Contingencies [Line Items]
Operating leases expiration date				2023-03

Future Minimum Payments Under N

Future Minimum Payments Under Non-Cancelable Portion of Operating Leases (Detail) $ in Thousands	Jun. 30, 2017USD ($)
Commitments And Contingencies Disclosure [Abstract]
2017 (remaining)	$ 1,069
2,018	2,332
2,019	2,535
2,020	2,597
2,021	2,526
Thereafter	9,109
Total	$ 20,168

Collaborative Research and De31

Collaborative Research and Development Agreements - Additional Information (Detail) - USD ($)	1 Months Ended	3 Months Ended			6 Months Ended		12 Months Ended
	Nov. 30, 2016	Mar. 31, 2017	Dec. 31, 2016	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016	Dec. 31, 2016	Dec. 31, 2014	Dec. 31, 2012	Dec. 31, 2011
Deferred Revenue Arrangement [Line Items]
Liability related to unused development funding			$ 11,192,000		$ 7,184,000		$ 11,192,000
Maximum
Deferred Revenue Arrangement [Line Items]
Additional revenue recognized					100,000,000
Astra Zeneca
Deferred Revenue Arrangement [Line Items]
Collaboration Revenue								$ 5,400,000		$ 3,000,000
Payments received for development work								$ 8,000,000	$ 6,000,000	$ 3,000,000
Additional collaboration revenue							800,000
Milestone payments earned	$ 7,200,000
Unused development funding advanced by AstraZeneca	$ 7,400,000
Milestone revenue recognition			7,200,000	$ 34,000		$ 104,000
Unused development funding paid		$ 200,000
Liability related to unused development funding					0
Deferred revenue			$ 0		$ 0		$ 0

Summary of Revenue Recognized u

Summary of Revenue Recognized under Various Agreements (Detail) - USD ($) $ in Thousands	3 Months Ended			6 Months Ended
	Jun. 30, 2017	Dec. 31, 2016	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Product Information [Line Items]
Total revenues	$ 105		$ 2,647	$ 253	$ 3,589
Astra Zeneca
Product Information [Line Items]
Initial payment			347		521
Subsequent payment			1,302		1,953
Performance of research activities		$ 7,200	34		104
Total revenues			$ 1,683		$ 2,578

Net Loss Per Share - Additional

Net Loss Per Share - Additional Information (Detail) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Dilutive securities, effect on basic earnings per share	$ 0	$ 0	$ 0	$ 0
Stock Options and Stock Awards
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Outstanding securities excluded from the calculation of diluted net loss per share			6,310,000	4,510,000

Common Stock - Additional Infor

Common Stock - Additional Information (Detail) - USD ($)	Nov. 12, 2015	Jun. 30, 2017	Dec. 31, 2016
Class Of Stock [Line Items]
Common stock, shares outstanding		54,747,656	38,599,000
Proceeds from issuance of common stock, net		$ 88,200,000
Agreement Termination period		2017-06
Cowen
Class Of Stock [Line Items]
Proceeds from issuance of common stock, net		$ 88,200,000
Issuance of common stock (in shares)		15,997,202
Maximum | Cowen
Class Of Stock [Line Items]
Common stock sales agreement aggregate sales proceeds	$ 90,000,000

Option Activity under Stock-Bas

Option Activity under Stock-Based Compensation Plans (Detail) $ / shares in Units, shares in Thousands, $ in Thousands	6 Months Ended
	Jun. 30, 2017USD ($)$ / sharesshares
Shares Underlying Outstanding Options
Beginning balance | shares	3,975
Options granted | shares	279
Ending balance | shares	3,751
Vested and expected to vest at June 30, 2017 | shares	3,741
Exercisable at June 30, 2017 | shares	2,290
Weighted-Average Exercise Price Per Share
Beginning balance | $ / shares	$ 21.38
Options granted | $ / shares	6.08
Ending balance | $ / shares	20.09
Vested and expected to vest at June 30, 2017 | $ / shares	20.10
Exercisable at June 30, 2017 | $ / shares	$ 22.34
Weighted-Average Remaining Contractual Term (years)
Balance at June 30, 2017	6 years 1 month 2 days
Vested and expected to vest at June 30, 2017	6 years 1 month 2 days
Exercisable at June 30, 2017	5 years 6 months 25 days
Aggregate Intrinsic Value
Balance at June 30, 2017 | $	$ 1,136
Vested and expected to vest at June 30, 2017 | $	1,136
Exercisable at June 30, 2017 | $	$ 151
Unvested
Shares Underlying Outstanding Options
Options cancelled | shares	(310)
Weighted-Average Exercise Price Per Share
Options cancelled | $ / shares	$ 18.24
Vested
Shares Underlying Outstanding Options
Options cancelled | shares	(193)
Weighted-Average Exercise Price Per Share
Options cancelled | $ / shares	$ 29.32

Equity Plans and Stock-Based 36

Equity Plans and Stock-Based Compensation - Additional Information (Detail) - USD ($) $ in Thousands	May 28, 2014	Jun. 30, 2017	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock-based compensation expense			$ 3,363	$ 3,124	$ 7,184	$ 6,368
Restricted Stock Units (RSUs)
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Aggregate intrinsic value		$ 24,700	24,700		$ 24,700
Performance Based Vesting Condition
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Options and restricted stock units outstanding					110,000
Maximum | Employee Stock Option
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Options vesting period					4 years
Expiration period					10 years
Minimum | Employee Stock Option
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Options vesting period					3 years
Expiration period					7 years
2011 Equity Incentive Plan | Maximum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Increase in the aggregate number of shares of common stock authorized for issuance		1,600,000
Time Based Vesting Schedule
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Total unrecognized compensation cost related to non-vested equity awards		$ 25,300	25,300		$ 25,300
Total unrecognized compensation cost, weighted-average vesting period					1 year 10 months 24 days
Performance Based Vesting Schedule
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Total unrecognized compensation cost related to non-vested equity awards		$ 600	$ 600		$ 600
2014 Employee Stock Purchase Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares issued to employees					90,156
Shares remaining available for future purchases		137,885	137,885		137,885
2014 Employee Stock Purchase Plan | The commencement of the offer period (generally, the sixteenth day in February or August)
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Purchase price per share as percentage of fair market value of common stock	85.00%
2014 Employee Stock Purchase Plan | The exercise date, which is the last day of a purchase period (generally, the fifteenth day in February or August)
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Purchase price per share as percentage of fair market value of common stock	85.00%

Summary of Restricted Stock Uni

Summary of Restricted Stock Units Activity (Detail) - Restricted Stock Units (RSUs) shares in Thousands	6 Months Ended
	Jun. 30, 2017$ / sharesshares
Number of Shares
Non-vested, Beginning Balance | shares	699
Granted | shares	2,124
Vested | shares	(171)
Forfeited or expired | shares	(93)
Non-vested, Ending Balance | shares	2,559
Weighted-Average Grant-Date Fair Value
Non-vested, Beginning Balance | $ / shares	$ 12.12
Granted | $ / shares	4.76
Vested | $ / shares	18.62
Forfeited or expired | $ / shares	12.25
Non-vested, Ending Balance | $ / shares	$ 5.58

Fair Value-Based Measurements a

Fair Value-Based Measurements and Weighted-Average Assumptions (Detail) - $ / shares	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Employee Stock Purchase Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Weighted-average fair value			$ 2.37	$ 8.18
Risk-free interest rate			0.90%	0.60%
Expected life (in years)			1 year 2 months 12 days	1 year 2 months 12 days
Volatility			1.00%	0.60%
Stock Options
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Weighted-average fair value	$ 3.90	$ 10.25	$ 4.12	$ 9.79
Risk-free interest rate	1.80%	1.50%	1.90%	1.40%
Expected life (in years)	4 years 6 months	5 years 4 months 24 days	4 years 6 months	5 years
Volatility	0.90%	0.70%	0.90%	0.70%

Stock-Based Compensation Expens

Stock-Based Compensation Expense (Detail) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Deferred Compensation Arrangement With Individual Share Based Payments [Line Items]
Stock-based compensation expense	$ 3,363	$ 3,124	$ 7,184	$ 6,368
Research and Development
Deferred Compensation Arrangement With Individual Share Based Payments [Line Items]
Stock-based compensation expense	1,771	1,336	3,734	2,851
General and Administrative
Deferred Compensation Arrangement With Individual Share Based Payments [Line Items]
Stock-based compensation expense	$ 1,592	$ 1,788	$ 3,450	$ 3,517

Restructuring - Additional Info

Restructuring - Additional Information (Detail) - USD ($)	1 Months Ended	3 Months Ended			6 Months Ended
	Jan. 31, 2017	Sep. 30, 2017	Jun. 30, 2017	Mar. 31, 2017	Jun. 30, 2017
Restructuring Cost And Reserve [Line Items]
Percentage of reduction in global workforce	40.00%
Restructuring					$ 2,783,000
Employee Severance and Other Benefits
Restructuring Cost And Reserve [Line Items]
Restructuring			$ 0	$ 2,800,000	2,783,000
Cash payments					$ 2,523,000
Scenario, Forecast | Employee Severance and Other Benefits
Restructuring Cost And Reserve [Line Items]
Cash payments		$ 300,000

Restructuring - Schedule of Com

Restructuring - Schedule of Components of Restructuring Liabilities (Detail) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Mar. 31, 2017	Jun. 30, 2017
Restructuring Cost And Reserve [Line Items]
Restructuring			$ 2,783,000
Employee Severance and Other Benefits
Restructuring Cost And Reserve [Line Items]
Restructuring	$ 0	$ 2,800,000	2,783,000
Cash payments			(2,523,000)
Balance at June 30, 2017	$ 260,000		$ 260,000