Paratek Pharmaceuticals S-1 IPO registration

Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the use in this Registration Statement on Form S-1 of Paratek Pharmaceuticals, Inc. of our report dated August 10, 2012 relating to the financial statements of Paratek Pharmaceuticals, Inc., which appears in such Registration Statement. We also consent to the reference to us under the heading “Experts” in such Registration Statement.

/s/ PricewaterhouseCoopers LLP

Boston, MA

September 27, 2012