ELECTION OF DIRECTORS (Item 1 on the Proxy Card) The Board is nominating for re-election the following current directors: Dr. Candace Kendle, Philip E. Beekman, Christopher C. Bergen, Dr. G. Steven Geis, Dr. Donald C. Harrison, Dr. Timothy E. Johnson, Dr. Frederick A. Russ and Robert C. Simpson. Dr. Geis, Dr. Johnson and Dr. Russ were appointed to the Board in November 2002. All directors elected at the Annual Meeting will be elected to hold office until the next Annual Meeting or until their successors are elected and qualified. Proxies will be voted in favor of election of the nominees named herein unless authority to vote is withheld. If any of the nominees should become unable to accept election or declines to serve, neither of which the Board anticipates, it is intended, in the absence of contrary direction, that the proxies will be voted for the balance of those named above and for substitute nominees as the Board may designate. The proxies will in no event be voted for a greater number of nominees than eight. The eight nominees receiving the highest number of votes will be elected. The Board of Directors recommends a vote “FOR” the election of each of the nominees for Director. Information About Nominees Candace Kendle, Pharm.D., 56, co-founded the Company in 1981 and has served as Chief Executive Officer since its incorporation. She has been Chairman of the Board since 1991. From 1979 through 1981, Dr. Kendle served as Clinical Associate Professor of Pediatrics at The University of Pennsylvania School of Medicine; Clinical Assistant Professor at Philadelphia College of Pharmacy and Sciences; and Director, Department of Pharmacy, The Children’s Hospital of Philadelphia. She has published more than 15 scientific articles. Dr. Kendle serves as a director of H. J. Heinz Company, a food products manufacturer; the Isabella Venture Fund, a venture capital fund which focuses on women-owned businesses; and UMD, Inc., a medical device company. She is the wife of Christopher C. Bergen, President and Chief Operating Officer of the Company. Philip E. Beekman, 71, was elected a director of the Company in January 1997. Mr. Beekman is the President of Owl Hollow Enterprises, a consulting and investment company. Prior to July 1994, Mr. Beekman served as Chairman of the Board and Chief Executive Officer of Hook-SupeRx, Inc. Mr. Beekman is a director of the National Association of Chain Drug Stores; General Chemical Group Inc., a supplier of soda ash and other chemicals; Linens ’N Things, a retail chain of home furnishings; the Ladies Professional Golf Association; the National Organization on Disability; Procurenet Inc., a company engaged in procuring products via electronic and other media for other companies; and Panavision Inc., a manufacturer of cameras for the movie/television industry. Christopher C. Bergen, 52, co-founded the Company in 1981 and since its incorporation has served as a director and its President and Chief Operating Officer. From 1977 to 1981, Mr. Bergen served in various capacities at The Children’s Hospital of Philadelphia, most recently as Associate Vice President. He is the husband of Candace Kendle, Chairman and Chief Executive Officer of the Company. G. Steven Geis, Ph.D., M.D., 51, was appointed a director of the Company in November 2002. Now retired, Dr. Geis served in a number of management and senior management positions with Pharmacia & Upjohn Company from 1985 to July 2002, including most recently Group Vice President: Arthritis, Cardiovascular and Oncology Clinical Development from March 2001 to July 2002 and Vice President: Arthritis Clinical Development from August 1998 through March 2001. Dr. Geis has authored or co-authored numerous journal articles covering several therapeutic areas. Donald C. Harrison, M.D., 69, was appointed a director of the Company in November 2001. Now retired, Dr. Harrison served as the Senior Vice President and Provost for Health Affairs at University of Cincinnati from 1986 through 2002 and also served as the Chief Executive Officer of the University of |