Voting items 0000466805_3 R1.0.1.18 The Board of Directors recommends you vote FOR the following: 1. To elect the following three nominees to the Board of Directors as Class II directors, terms to expire in 2023.Nominees01) Douglas Fisher, M.D. 02) Jeffrey Cossman, M.D. 03) Richard Sandberg The Board of Directors recommends you vote FOR proposals 2, 3, 4 and 5. 2 To approve, for purposes of complying with applicable Nasdaq Listing Rules, the potential issuance and sale of more than 20% of the Company's common stock pursuant to the Company's purchase agreement with Lincoln Park Capital Fund, LLC (LPC) pursuant to which LPC has agreed to purchase from us, from time to time, up to $10,000,000 of our common stock. To approve, for purposes of complying with applicable Nasdaq Listing Rules, the potential issuance of more than 20% of the Company's common stock which may be issued by the Company to certain investors in connection with an amendment agreement (the March 2020 Amendment) amending the terms of that certain 8% Senior Secured Convertible Promissory Notes issued to the investors on April 16, 2019 and May 14, 2019.To approve an amendment and restatement of the Company's 2017 Stock Option and Incentive Plan (the 2017 Plan) to (i) increase the aggregate number of shares authorized for issuance under the 2017 Plan by 250,000 shares from 913,586 shares to 1,163,586 shares; (ii) increase the maximum number of shares that may be granted in the form of stock options or stock appreciation rights to any one individual in any one calendar year and the maximum number of shares underlying any award intended to qualify as performance-based compensation to any one individual in any performance cycle, in each case to 250,000 shares of common stock; (iii) amend the evergreen provision, pursuant to which the aggregate number of shares authorized for issuance under the 2017 Plan will be automatically increased each year beginning on January 1, 2021 by 8% of the number of shares of common stock issued and outstanding on the immediately preceding December 31, or such lesser number of shares determined by our Board of Directors or Compensation Committee (the 2017 Plan Amendment Proposal); 5 To ratify the appointment of Marcum LLP as our independent registered public accounting firm for the year ending December 31, 2020. NOTE: To transact such other business as may properly come before the Annual Meeting or any adjournment or postponement thereof.