The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
111 INC | ADS | 68247Q102 | 6,084 | 450,000 | SH | DFND | 1,2,3,4,5 | 450,000 | 0 | 0 | |
AC IMMUNE SA | SHS | H00263105 | 6,000 | 750,000 | SH | DFND | 1,2,3,4,5 | 750,000 | 0 | 0 | |
ACCELERATE DIAGNOSTICS INC | COM | 00430H102 | 11,475 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
ACCELERATE DIAGNOSTICS INC | COM | 00430H102 | 11,475 | 500,000 | SH | Call | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 |
ACCELERON PHARMA INC | COM | 00434H108 | 57,230 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
ADURO BIOTECH INC | COM | 00739L101 | 4,043 | 550,000 | SH | DFND | 1,2,3,4,5 | 550,000 | 0 | 0 | |
ADVERUM BIOTECHNOLOGIES INC | COM | 00773U108 | 2,420 | 400,000 | SH | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 | |
AERPIO PHARMACEUTICALS INC | COM | 00810B105 | 4,815 | 1,558,400 | SH | DFND | 1,2,3,4,5 | 1,558,400 | 0 | 0 | |
AGENUS INC | COM NEW | 00847G705 | 5,885 | 2,750,000 | SH | DFND | 1,2,3,4,5 | 2,750,000 | 0 | 0 | |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 23,136 | 300,000 | SH | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 | |
AKEBIA THERAPEUTICS INC | COM | 00972D105 | 4,194 | 475,000 | SH | DFND | 1,2,3,4,5 | 475,000 | 0 | 0 | |
ALBIREO PHARMA INC | COM | 01345P106 | 16,480 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
ALIBABA GROUP HLDG LTD | SPONSORED ADS | 01609W102 | 10,709 | 65,000 | SH | DFND | 1,2,3,4,5 | 65,000 | 0 | 0 | |
ALIBABA GROUP HLDG LTD | SPONSORED ADS | 01609W102 | 16,476 | 100,000 | SH | Call | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 52,512 | 600,000 | SH | DFND | 1,2,3,4,5 | 600,000 | 0 | 0 | |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 8,752 | 100,000 | SH | Call | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 |
AMERICAN AIRLS GROUP INC | COM | 02376R102 | 12,399 | 300,000 | SH | Call | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 |
AMICUS THERAPEUTICS INC | COM | 03152W109 | 48,360 | 4,000,000 | SH | DFND | 1,2,3,4,5 | 4,000,000 | 0 | 0 | |
AMICUS THERAPEUTICS INC | COM | 03152W109 | 12,090 | 1,000,000 | SH | Call | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 |
ANAPTYSBIO INC | COM | 032724106 | 29,931 | 300,000 | SH | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 | |
ARCUS BIOSCIENCES INC | COM | 03969F109 | 4,182 | 300,000 | SH | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 | |
ARGENX SE | SPONSORED ADR | 04016X101 | 14,030 | 185,000 | SH | DFND | 1,2,3,4,5 | 185,000 | 0 | 0 | |
ARRAY BIOPHARMA INC | COM | 04269X105 | 28,880 | 1,900,000 | SH | DFND | 1,2,3,4,5 | 1,900,000 | 0 | 0 | |
ATARA BIOTHERAPEUTICS INC | COM | 046513107 | 41,350 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
ATYR PHARMA INC | COM | 002120103 | 406 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
AUDENTES THERAPEUTICS INC | COM | 05070R104 | 9,898 | 250,000 | SH | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 | |
AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 15,335 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
AVROBIO INC | COM | 05455M100 | 5,187 | 100,000 | SH | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 | |
BANK AMER CORP | COM | 060505104 | 132,570 | 4,500,000 | SH | Call | DFND | 1,2,3,4,5 | 4,500,000 | 0 | 0 |
BEIGENE LTD | SPONSORED ADR | 07725L102 | 103,332 | 600,000 | SH | DFND | 1,2,3,4,5 | 600,000 | 0 | 0 | |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 19,394 | 200,000 | SH | Call | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 |
BLUEBIRD BIO INC | COM | 09609G100 | 25,550 | 175,000 | SH | DFND | 1,2,3,4,5 | 175,000 | 0 | 0 | |
BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 39,030 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
BRISTOL MYERS SQUIBB CO | COM | 110122108 | 46,560 | 750,000 | SH | Call | DFND | 1,2,3,4,5 | 750,000 | 0 | 0 |
CELGENE CORP | COM | 151020104 | 67,118 | 750,000 | SH | Call | DFND | 1,2,3,4,5 | 750,000 | 0 | 0 |
CHIMERIX INC | COM | 16934W106 | 3,890 | 1,000,000 | SH | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 | |
CITIGROUP INC | COM NEW | 172967424 | 17,935 | 250,000 | SH | Call | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 |
CLEMENTIA PHARMACEUTICALS IN | COM | 185575107 | 7,716 | 692,000 | SH | DFND | 1,2,3,4,5 | 692,000 | 0 | 0 | |
CONATUS PHARMACEUTICALS INC | COM | 20600T108 | 2,900 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | 5,730 | 200,000 | SH | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 | |
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 4,435 | 100,000 | SH | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 | |
CYMABAY THERAPEUTICS INC | COM | 23257D103 | 8,864 | 800,000 | SH | DFND | 1,2,3,4,5 | 800,000 | 0 | 0 | |
DENALI THERAPEUTICS INC | COM | 24823R105 | 10,870 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
DICERNA PHARMACEUTICALS INC | COM | 253031108 | 6,486 | 425,000 | SH | DFND | 1,2,3,4,5 | 425,000 | 0 | 0 | |
ELANCO ANIMAL HEALTH INC | COM | 28414H103 | 3,489 | 100,000 | SH | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 | |
FATE THERAPEUTICS INC | COM | 31189P102 | 35,675 | 2,190,000 | SH | DFND | 1,2,3,4,5 | 2,190,000 | 0 | 0 | |
FIBROGEN INC | COM | 31572Q808 | 15,188 | 250,000 | SH | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 | |
FLEX LTD | ORD | Y2573F102 | 3,280 | 250,000 | SH | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 | |
FREEPORT-MCMORAN INC | CL B | 35671D857 | 13,920 | 1,000,000 | SH | Call | DFND | 1,2,3,4,5 | 1,000,000 | 0 | 0 |
GENERAL MTRS CO | COM | 37045V100 | 101,010 | 3,000,000 | SH | Call | DFND | 1,2,3,4,5 | 3,000,000 | 0 | 0 |
GOLDMAN SACHS GROUP INC | COM | 38141G104 | 235,452 | 1,050,000 | SH | Call | DFND | 1,2,3,4,5 | 1,050,000 | 0 | 0 |
GRITSTONE ONCOLOGY INC | COM | 39868T105 | 2,848 | 200,000 | SH | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 | |
HOMOLOGY MEDICINES INC | COM | 438083107 | 2,286 | 100,000 | SH | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 | |
INFLARX NV | COM | N44821101 | 17,160 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
INTELLIA THERAPEUTICS INC | COM | 45826J105 | 2,576 | 90,000 | SH | DFND | 1,2,3,4,5 | 90,000 | 0 | 0 | |
IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 7,875 | 700,000 | SH | DFND | 1,2,3,4,5 | 700,000 | 0 | 0 | |
IRONWOOD PHARMACEUTICALS INC | COM CL A | 46333X108 | 2,040 | 110,532 | SH | DFND | 1,2,3,4 | 110,532 | 0 | 0 | |
KRYSTAL BIOTECH INC | COM | 501147102 | 2,637 | 150,000 | SH | DFND | 1,2,3,4,5 | 150,000 | 0 | 0 | |
LA JOLLA PHARMACEUTICAL CO | COM PAR $.0001 2 | 503459604 | 4,026 | 200,000 | SH | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 | |
LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 37,518 | 3,516,214 | SH | DFND | 1,2,3,4,5 | 3,516,214 | 0 | 0 | |
LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 605,252 | 56,724,650 | SH | DFND | 1,2,3,4 | 56,724,650 | 0 | 0 | |
LOGMEIN INC | COM | 54142L109 | 5,792 | 65,000 | SH | DFND | 1,2,3,4,5 | 65,000 | 0 | 0 | |
MADRIGAL PHARMACEUTICALS INC | COM | 558868105 | 10,707 | 50,000 | SH | DFND | 1,2,3,4,5 | 50,000 | 0 | 0 | |
MAGENTA THERAPEUTICS INC | COM | 55910K108 | 2,402 | 200,000 | SH | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 | |
MARINUS PHARMACEUTICALS INC | COM | 56854Q101 | 5,000 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
MEDICINES CO | COM | 584688105 | 11,964 | 400,000 | SH | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 | |
MEDICINES CO | COM | 584688105 | 17,946 | 600,000 | SH | Call | DFND | 1,2,3,4,5 | 600,000 | 0 | 0 |
MICRON TECHNOLOGY INC | COM | 595112103 | 18,092 | 400,000 | SH | Call | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 |
MIRAGEN THERAPEUTICS INC | COM | 60463E103 | 2,790 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
MORGAN STANLEY | COM NEW | 617446448 | 93,140 | 2,000,000 | SH | Call | DFND | 1,2,3,4,5 | 2,000,000 | 0 | 0 |
NEKTAR THERAPEUTICS | COM | 640268108 | 48,768 | 800,000 | SH | DFND | 1,2,3,4,5 | 800,000 | 0 | 0 | |
NEKTAR THERAPEUTICS | COM | 640268108 | 12,192 | 200,000 | SH | Call | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 |
NIO INC | SPON ADS | 62914V106 | 10,470 | 1,500,000 | SH | DFND | 1,2,3,4,5 | 1,500,000 | 0 | 0 | |
NOVAVAX INC | COM | 670002104 | 940 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
NOVELION THERAPEUTICS INC | COM NEW | 67001K202 | 759 | 256,400 | SH | DFND | 1,2,3,4,5 | 256,400 | 0 | 0 | |
ONCOCYTE CORPORATION | COM | 68235C107 | 375 | 150,000 | SH | DFND | 1,2,3,4,5 | 150,000 | 0 | 0 | |
PROQR THRAPEUTICS N V | SHS EURO | N71542109 | 25,155 | 1,300,000 | SH | DFND | 1,2,3,4,5 | 1,300,000 | 0 | 0 | |
REGENXBIO INC | COM | 75901B107 | 11,325 | 150,000 | SH | DFND | 1,2,3,4,5 | 150,000 | 0 | 0 | |
REPLIMUNE GROUP INC | COM | 76029N106 | 7,245 | 450,000 | SH | DFND | 1,2,3,4,5 | 450,000 | 0 | 0 | |
RESTORBIO INC | COM | 76133L103 | 7,570 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 9,848 | 400,000 | SH | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 | |
RUBIUS THERAPEUTICS INC | COM | 78116T103 | 12,600 | 525,000 | SH | DFND | 1,2,3,4,5 | 525,000 | 0 | 0 | |
RUBIUS THERAPEUTICS, INC. | COM | 78116T103 | 57,211 | 2,383,791 | SH | DFND | 1,2,3,4 | 2,383,791 | 0 | 0 | |
SAGE THERAPEUTICS INC | COM | 78667J108 | 14,125 | 100,000 | SH | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 | |
SANGAMO THERAPEUTICS INC | COM | 800677106 | 5,085 | 300,000 | SH | DFND | 1,2,3,4,5 | 300,000 | 0 | 0 | |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 11,588 | 450,000 | SH | DFND | 1,2,3,4,5 | 450,000 | 0 | 0 | |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 50,111 | 1,946,040 | SH | DFND | 1,2,3,4 | 1,946,040 | 0 | 0 | |
SELECTA BIOSCIENCES INC | COM | 816212104 | 8,732 | 561,540 | SH | DFND | 1,2,3,4,5 | 561,540 | 0 | 0 | |
SOLID BIOSCIENCES INC | COM | 83422E105 | 10,616 | 225,000 | SH | DFND | 1,2,3,4,5 | 225,000 | 0 | 0 | |
SPDR SERIES TRUST | S&P BIOTECH | 78464A870 | 19,174 | 200,000 | SH | Call | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 |
SPERO THERAPEUTICS INC | COM | 84833T103 | 6,306 | 600,000 | SH | DFND | 1,2,3,4,5 | 600,000 | 0 | 0 | |
STEMLINE THERAPEUTICS INC | COM | 85858C107 | 6,640 | 400,000 | SH | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 | |
SYNLOGIC INC | COM | 87166L100 | 2,842 | 200,000 | SH | DFND | 1,2,3,4,5 | 200,000 | 0 | 0 | |
TESARO INC | COM | 881569107 | 31,208 | 800,000 | SH | DFND | 1,2,3,4,5 | 800,000 | 0 | 0 | |
TESARO INC | COM | 881569107 | 19,505 | 500,000 | SH | Call | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 |
TG THERAPEUTICS INC | COM | 88322Q108 | 2,240 | 400,000 | SH | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 | |
TRANSLATE BIO INC | COM | 89374L104 | 6,000 | 600,000 | SH | DFND | 1,2,3,4,5 | 600,000 | 0 | 0 | |
TRICIDA INC | COM | 89610F101 | 3,055 | 100,000 | SH | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 | |
TRILLIUM THERAPEUTICS INC | COM NEW | 89620X506 | 870 | 150,000 | SH | DFND | 1,2,3,4,5 | 150,000 | 0 | 0 | |
UNITY BIOTECHNOLOGY INC | COM | 91381U101 | 815 | 50,000 | SH | DFND | 1,2,3,4,5 | 50,000 | 0 | 0 | |
WEIGHT WATCHERS INTL INC NEW | COM | 948626106 | 1,066,769 | 14,818,300 | SH | DFND | 1,2,3,4 | 14,818,300 | 0 | 0 | |
WELLS FARGO CO NEW | COM | 949746101 | 78,840 | 1,500,000 | SH | Call | DFND | 1,2,3,4,5 | 1,500,000 | 0 | 0 |
WYNN RESORTS LTD | COM | 983134107 | 12,706 | 100,000 | SH | Call | DFND | 1,2,3,4,5 | 100,000 | 0 | 0 |
XENCOR INC | COM | 98401F105 | 19,485 | 500,000 | SH | DFND | 1,2,3,4,5 | 500,000 | 0 | 0 | |
XENON PHARMACEUTICALS INC | COM | 98420N105 | 3,300 | 250,000 | SH | DFND | 1,2,3,4,5 | 250,000 | 0 | 0 | |
Y MABS THERAPEUTICS INC | COM | 984241109 | 3,984 | 150,000 | SH | DFND | 1,2,3,4,5 | 150,000 | 0 | 0 | |
ZAFGEN INC | COM | 98885E103 | 9,352 | 800,000 | SH | DFND | 1,2,3,4,5 | 800,000 | 0 | 0 | |
ZOGENIX INC | COM NEW | 98978L204 | 19,840 | 400,000 | SH | DFND | 1,2,3,4,5 | 400,000 | 0 | 0 |