Adynxx (ADYX) 8-K Alliqua Announces Transaction with Celgene

Exhibit 99.3

Investor Presentation

November 2013Ticker: ALQA

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This presentation contains forward-looking statements. Forward-looking statements are generally
identifiable by the use of words like "may," "will," "should," "could," "expect," "anticipate," "estimate,"
"believe," "intend," or "project" or the negative of these words or other variations on these words or
comparable terminology. The reader is cautioned not to put undue reliance on these forward-looking
statements, as these statements are subject to numerous factors and uncertainties outside of our control
that can make such statements untrue, including, but not limited to, inadequate capital, adverse economic
conditions, intense competition, lack of meaningful research results, entry of new competitors and
products, adverse federal, state and local government regulation, termination of contracts or agreements,
technological obsolescence of our products, technical problems with our research and products, price
increases for supplies and components, inability to carry out research, development and commercialization
plans, loss or retirement of key executives and research scientists and other specific risks. We currently
have no commercial products intended to diagnose, treat, prevent or cure any disease. The statements
contained in this presentation regarding our ongoing research and development and the results attained by
us to-date have not been evaluated by the Food and Drug Administration. There can be no assurance that
further research and development, and/or whether clinical trial results, if any, will validate and support the
results of our preliminary research and studies. Further, there can be no assurance that the necessary
regulatory approvals will be obtained or that we will be able to develop new products on the basis of our
technologies. In addition, other factors that could cause actual results to differ materially are discussed in
our Annual Report on Form 10-K/A filed with the SEC on May 16, 2013 and our most recent Form 10-Q
filings with the SEC. Investors and security holders are urged to read these documents free of charge on the
SEC's web site at www.sec.gov. We undertake no obligation to publicly update or revise our forward-
looking statements as a result of new information, future events or otherwise.

Forward-Looking Statement Disclaimer

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About Alliqua Biomedical

Alliqua Biomedical, Inc. (OTCQB: ALQA) is an advanced wound
management and drug delivery company that strives to deliver superior
outcomes to patients, providers, and partners through its platform
technologies and unique, proprietary wound care products.

CORE BUSINESS UNITS

Advanced Wound Management

A growing suite of proven
technologies for wound care practitioners that
seek to address the full spectrum of patient
needs.

Supported by a world class sales
organization that markets and distributes
Alliqua's exclusive products.

Transdermal / Topical Drug Delivery

Developing a platform to deliver
pharmaceutical ingredients through the skin.

Custom Hydrogel Manufacturing

Custom hydrogels for the OEM market
with a focus on medical applications.

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Growth Strategy

Beginning in February 2013, Alliqua has been pursuing a growth strategy
that leverages the knowledge and experience of CEO Dave Johnson and
Chairman Dr. Jerry Zeldis.

STRATEGIC INITIATIVES NOW UNDERWAY

§Building a world class sales organization to market and distribute Alliqua's
proprietary products while making the company attractive to partners and
licensors seeking to penetrate the highly fragmented wound care space.

§Assembling a suite of advanced wound care products that are superior, FDA
approved, reimbursed, and can address the spectrum of needs facing the wound
care practitioner.

§The ability to offer practitioners multiple wound management solutions
makes Alliqua’s sales organization more efficient and effective.

§Developing topical and transdermal drug delivery capabilities using Alliqua’s
hydrogel manufacturing capabilities.

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BACKGROUND IN BRIEF

1998Aquamed - A private OEM Hydrogel Manufacturer

2010Investor Acquires Aquamed, Takes Public, and Renames

2012FDA Clearance - SilverSeal® and Hydress®

2013New Leadership - Led by David Johnson and Jerry Zeldis

2013New Focus - Wound Management and Drug Delivery

2013New Wound Care Technologies - Partnerships with Celgene and Sorbion

ANTICPATED FUTURE MILESTONES

2014Uplist - to a National Exchange

2014Add Technologies - Expand Wound Management Product Portfolio

2014Expand Selling Organization and Distribution Network - Grow Revenues

2014Pursue Drug Delivery - Accelerate Commercialization

Corporate History

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New Senior Management

In 2013, Alliqua introduced new leadership comprised of healthcare and
life sciences industry veterans.

DAVID JOHNSON, CEO OF ALLIQUA

Former CEO of ConvaTec where he grew revenues to $1.7B and
oversaw its sale for $4.1B. Senior positions at Zimmer, Fisher
Scientific, and Baxter Corporation. 32 years in medical devices
and 25 years leading companies.

DR. JERRY ZELDIS, CHAIRMAN OF ALLIQUA

Chief Medical Officer of Celgene Corporation since 1997.
Celgene’s market cap grew from $100M to $55B during this
period. CEO of Celgene Global Health where he creates new
therapeutics for diseases of the developing world.

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New Senior Management Cont.

PHILLIP FORMAN

VP CLINICAL

AFFAIRS

GREGORY ROBB

VP OPERATIONS

JAMES SAPIRSTEIN
CEO, THERAPEUTICS

DIVISION

BRAD BARTON

CHIEF OPERATING

OFFICER

LORI TONER

CHIEF MARKETING

OFFICER

BRIAN POSNER

CHIEF FINANCIAL

OFFICER

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Key Corporate Milestones

ACHIEVED UNDER NEW MANAGEMENT

üWorld-class team in place with deep domain experience in the field of advanced wound
care.

ü$17M raised in 2013; led by Board and Management, Celgene, and new investors.

üStrategic partnership with Celgene whereby Alliqua received the exclusive rights to two
Celgene Cellular Therapeutics advanced wound care products, Biovance® and ECM.

üStrategic partnership with Sorbion whereby Alliqua acquired the exclusive Americas’
distribution rights to Sorbion Sana Gentle® and Sorbion Sachet S®.

üCompleted SilverSeal® Clinical Study demonstrating a reduction of incision
complications, including infection and scarring, in foot and ankle surgery patients.

üEarly validation of topical and transdermal drug delivery technology in porcine study
examining lidocaine delivery.

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Advanced

Wound Care

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Advanced Wound Care Market Opportunity

The global market for advanced wound care products was $6.0B+ in
2011 with approximately 60% of sales in the U.S.

MARKETSEGMENTS

Source: Worldwide Wound Management Market, Size and Growth to 2021 by Segment, MedMarket Diligence.

CHRONIC WOUNDS

§Diabetic Ulcers

§Venus Stasis Ulcers

§Pressure Ulcers

ACUTE WOUNDS

§Surgical Wounds

§Trauma

§Burns

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Advanced Wound Management Vision

Acquire a suite of technological solutions to enable wound care
practitioners to deal with the challenges of acute and chronic wounds.

EXPAND PRODUCT PORTFOLIO AND DRIVE SALES

§Integrate multiple technologies into Alliqua’s offering through licensing
agreements, distribution agreements, and acquisitions.

§Build a world-class sales force of knowledgeable, professional, and
committed individuals with a background in wound care.

§Extensive selling model including direct and independent agents.

§Extensive channel reach through network of distributors.

§Attractive compensation for sales specialists.

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Advanced Wound Management Vision Cont.

Expand the wound care portfolio through business development.

PRODUCTS	ACUTE WOUNDS					CHRONIC WOUNDS
Current Products	Cosmetic	Surgical	Skin Tears	Trauma (Other)	Burns	Pressure Ulcers	Diabetic Ulcers	Venous Leg Ulcers	Arterial Ulcers
SilverSeal®	X	X	X	X	X	X	X		X
Hydress®			X		X	X			X
Sorbion Sana		X		X	X	X	X	X	X
Planned Product Introductions
Biovance® (Q2 2014)	X	X		X	X	X	X	X	X
Extracellular Matrix (~Q2 2015)	X	X		X	X	X	X	X	X
Q1 2014 (Partner Prospect)	X	X		X	X	X	X	X	X

Dry to Low Draining WoundsModerate to HighRisk of InfectionRecalcitrant

Hydress® / SilverSeal®Sorbion Sache / SanaSilverSeal®Biovance® / ECM

PRODUCT FIT

Anticipated New Products

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Advanced Wound Care Product Portfolio

Our suite of differentiated products enhance a clinician’s ability to
effectively and efficiently manage a variety of wound indications.

Extracellular Matrix®

Biovance®

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Advanced Wound Care Product Portfolio Cont.

HYDRESS®AND SILVERSEAL®

§SilverSeal® Clinical Study demonstrated a reduction
in infection and scarring in foot and ankle surgery
patients as compared to standard petroleum-based
dressings.

§FDA clearance with Medicare reimbursement.

§Controls the volume of wound fluid; absorbs wound
exudate (up to 2x its own weight).

§SilverSeal® offers broad spectrum antimicrobial
activity.

§Made at Alliqua’s Langhorne, PA manufacturing
facility; low COGS with high margins.

Hydress® and SilverSeal® leverage Alliqua’s core hydrogel
manufacturing capabilities.

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Advanced Wound Care Product Portfolio Cont.

SORBION SACHET S® AND SANA®

§510k approved with Medicare reimbursement.

§Hydroactive wound dressing for the management of
moderately to heavily exuding wounds.

§Designed for wounds with a heterogeneous
production of exudate during granulation.

§Ideal dressing for patients with contact sensitivities.

§Expanded sales and distribution infrastructure opens
up a $500M opportunity in the wound management
space.

In September 2013, Alliqua became the exclusive distributor of sorbion-
branded products in the Americas.

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Extracellular Matrix®

Biovance®

Advanced Wound Care Product Portfolio Cont.

CELGENE BIOVANCE® AND ECM®

§Biovance® is a collagen-based decellularized and
dehydrated biologic wound covering produced from human
amniotic membrane.

§Biovance® is indicated for the management of non-infected
partial- and full-thickness wounds.

§Biovance® is ready for commercial use and a Q2 2014
launch is anticipated.

§ECM is a suite of advanced wound management products
made from extracellular matrix derived from the human
placenta.

§Alliqua anticipates a Q2 2015 launch of ECM, pending
regulatory approvals.

In November 2013, Alliqua acquired the exclusive right to develop and
market Celgene’s Biovance® and Extracellular Matrix (“ECM”).

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Advanced Wound Care Milestones

ACHIEVED UNDER NEW MANAGEMENT

üCompleted a SilverSeal® Clinical Study demonstrating a reduction of incision
complications, including infection and scarring, in foot and ankle surgery patients
(May 2013).

üSecured strategic wholesale distributor relationships with Team Distribution
International, World Health Industries, and McKesson Medical-Surgical, Medline,
O&M, Cardinal, and PSS (2013).

üAssembled sales and marketing team with more than 50 independent agents and
three direct sales reps (2013).

üAdded to the Wound Care Portfolio with key partnerships and acquisitions.

§Strategic partnerships with sorbion GmbH & Co. KG that made Alliqua the
exclusive sales agent of sorbion products in the Americas (Sept 2013).

§Strategic partnerships with Celgene Cellular Therapeutics bringing two
novel advanced wound care technologies, Biovance® and Extracellular
Matrix (Nov 2013).

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Media Excitement Surrounding Alliqua

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Topical / Transdermal

Drug Delivery

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Topical and Transdermal Drug Delivery

Alliqua is using its hydrogel technology platform to deliver active
pharmaceutical ingredients, initially lidocaine, through the skin.

DRUG DELIVERY OVERVIEW

§Alliqua plans to develop lidocaine hydrogel patches for the treatment of localized acute
pain, including post-operative pain, back pain, as well as pain associated with sports
injuries and arthritis.

§Beyond lidocaine, Alliqua plans to explore transdermal delivery of dermatologic,
oncologic, antibiotic, and neurologic products.

§Key advantages of Alliqua’s delivery platform include:

§Patient comfort (94% water with less potential for skin irritation).

§Stability of form and composition.

§Purity and reproducibility.

§Compatibility with various active ingredients.

§High product margins.

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Topical and Transdermal Drug Delivery Cont.

The global transdermal and topical drug delivery market was valued at
$21.5B in 2010 and is expected to grow to $31.5B by 2015.

Sources: FDA Orange Book; UBM Canon Data Products, September 2011

MARKET OVERVIEW

§Transdermal drug delivery accounts for
more than 12% of the global drug
delivery market.

§The annual U.S. market for transdermal
patches is estimated at $3B+.

§Today there are more than 20 types of
transdermal drug delivery patches
available; substantial unmet need still
exist in the area of pain management
and women's health.

Cumulative number of transdermal drugs approved by the
FDA.

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Lidocaine Patch

In October 2013, Alliqua completed a proof-of-principle study designed
to examine the use of hydrogel technology as a topical drug delivery
vehicle for lidocaine.

LIDOCAINE STUDY OUTCOME

§Safety and tolerability of Alliqua's lidocaine hydrogel patches were explored in
an animal model.

§Alliqua’s investigational lidocaine transdermal patch compared favorably to the
Lidoderm® patch currently on the market.

§Alliqua's patch was able to deliver in a pig slightly higher amounts of lidocaine
than Lidoderm® and reached maximum delivery within a comparable period.

§Further development could result in Alliqua creating a generic version of the
Lidoderm® patch or providing better drug delivery resulting in 505 (b)(2)
approval.

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Lidocaine Patch Cont.

Lidocaine patches are a large and growing market with over $1.4B in
annual sales.

MARKET OPPORTUNITY

§In 1999, Lidoderm was approved by FDA.In September 2013, Actavis
introduced a competing generic (early release negotiated with Endo
Pharmaceuticals) product at 87% of the branded price.

§Lidocaine patches are indicated for the treatment of post-herpetic neuralgia
(PHN), also called post-shingles pain.

§PHN is the most common complication of herpes zoster (shingles), a
condition that affects 1.1M individuals annually in the U.S.

§Approximately 13% of shingles sufferers over 60 years experience PHN.

§An aging population is expected to drive demand for the product.

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Custom Hydrogel

Manufacturing

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Custom Hydrogel Manufacturing

Alliqua serves as a contract
manufacturer, supplying its hydrogels to
third parties who incorporate them into
their own products.

Alliqua’s Langhorne, PA facility.

ADDRESSABLE SEGMENTS

§Transdermal and topical delivery of
prescription and OTC Drugs.

§Proof-of-Concept established in
Lidocaine.

§Moist wound and burn dressings.

§Components of medical devices.

§Cosmetic applications.

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Proprietary Hydrogel Technology Platform

The hydrogel technology platform provides Alliqua with key competitive
advantages.

PROPRIETARY TECHNOLOGIES

§Proprietary Mixing: Alliqua is able to manufacture hydrogel feed mixes with far
greater homogeneity than those of its competition. This manufacturing
advantage is critical for transdermal drug delivery.

§Proprietary Cross-Linking: Alliqua cross-links its hydrogels using an electron
beam accelerator. The creation of longer chains of the polymer in the gel
increases its molecular integrity, giving the gel characteristics that make it useful
in a variety of products.

§Proprietary Coating: Thickness controls are critical to the performance of
medical electrodes, transdermal delivery patches, and cosmetic patches.

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Manufacturing and Development Facility

Alliqua operates a 16,000 square foot manufacturing facility in
Langhorne, PA. The facility features an Industrial Electron Accelerator,
or RDI Accelerator; this RDI Accelerator has been extensively
customized to meet Alliqua’s needs.

COMPETITIVE BARRIERS

§Alliqua developed, acquired and sells applications that require tight tolerances
and/or incorporate active ingredients. Barriers to entry for competitors include:

§Costs of acquiring an electron beam ($7M - $10M).

§Time required to install the beam of 2 - 3 years.

§Trade and process secrets.

§Portfolio of intellectual property.

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Ticker: ALQA

Alliqua, Inc.

info@alliqua.com

2150 Cabot Blvd West

Langhorne, PA 19047

(215) 702-8550

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