Orbimed Advisors 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ABBOTT LABS	COM	002824100	24,036	394,100	SH		DFND	1	250,000	0	144,100
ACADIA PHARMACEUTICALS INC	COM	004225108	65,392	4,282,400	SH		DFND	1	764,300	0	3,518,100
ADAMAS PHARMACEUTICALS INC	COM	00548A106	2,583	100,000	SH	Call	DFND	1	23,500	0	76,500
ADAPTIMMUNE THERAPEUTICS PLC	SPONDS ADR	00653A107	7,912	666,593	SH		SOLE		666,593	0	0
AEGERION PHARMACEUTICALS INC	NOTE 2.000% 8/1	00767EAB8	9,718	15,000,000	PRN		DFND	1	3,098,000	0	11,902,000
AEGLEA BIOTHERAPEUTICS INC	COM	00773J103	19,737	1,865,524	SH		SOLE		1,865,524	0	0
AERIE PHARMACEUTICALS INC	COM	00771V108	127,271	1,884,100	SH		DFND	1	303,200	0	1,580,900
AERPIO PHARMACEUTICALS INC	COM	00810B105	21,555	5,193,946	SH		SOLE		5,193,946	0	0
AFFIMED N V	COM	N01045108	539	326,650	SH		SOLE		326,650	0	0
AGILENT TECHNOLOGIES INC	COM	00846U101	116,575	1,885,100	SH		DFND	1	322,400	0	1,562,700
AKORN INC	COM	009728106	3,318	200,000	SH	Call	DFND	1	47,000	0	153,000
ALEXION PHARMACEUTICALS INC	COM	015351109	387,919	3,124,603	SH		DFND	1	584,700	0	2,539,903
ALEXION PHARMACEUTICALS INC	COM	015351109	8,691	70,000	SH	Call	DFND	1	16,500	0	53,500
ALIMERA SCIENCES INC	COM	016259103	245	250,000	SH		DFND	1	25,000	0	225,000
ALKERMES PLC	SHS	G01767105	5,968	145,000	SH		SOLE		0	0	145,000
ALLERGAN PLC	SHS	G0177J108	214,436	1,286,205	SH		DFND	1	347,431	0	938,774
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	124,685	1,265,966	SH		DFND	1	237,300	0	1,028,666
ALPINE IMMUNE SCIENCES INC	COM	02083G100	24,970	3,298,516	SH		SOLE		3,298,516	0	0
AMEDISYS INC	COM	023436108	14,622	171,100	SH		SOLE		0	0	171,100
AMGEN INC	COM	031162100	22,908	124,100	SH		SOLE		0	0	124,100
AMICUS THERAPEUTICS INC	COM	03152W109	110,472	7,072,500	SH		DFND	1	1,320,215	0	5,752,285
ANTHEM INC	COM	036752103	126,584	531,800	SH		DFND	1	127,000	0	404,800
ARGENX SE	SPONSORED ADR	04016X101	49,658	599,300	SH		SOLE		0	0	599,300
ARRAY BIOPHARMA INC	COM	04269X105	82,237	4,900,900	SH		DFND	1	871,600	0	4,029,300
ARSANIS INC	COM	042873109	6,784	1,868,966	SH		SOLE		1,868,966	0	0
ASCENDIS PHARMA A S	SPONSORED ADR	04351P101	293,572	4,413,291	SH		DFND	1	3,763,291	0	650,000
ASSEMBLY BIOSCIENCES INC	COM	045396108	28,277	721,166	SH		SOLE		0	0	721,166
ATHENEX INC	COM	04685N103	8,024	430,000	SH		SOLE		0	0	430,000
AUDENTES THERAPEUTICS INC	COM	05070R104	99,919	2,615,000	SH		SOLE		2,615,000	0	0
AURINIA PHARMACEUTICALS INC	COM	05156V102	943	167,419	SH		SOLE		0	0	167,419
AVROBIO INC	COM	05455M100	7,140	250,000	SH		SOLE		0	0	250,000
BEIGENE LTD	SPONSORED ADR	07725L102	40,185	261,400	SH		DFND	1	55,200	0	206,200
BIOGEN INC	COM	09062X103	338,971	1,167,900	SH		DFND	1	209,800	0	958,100
BIOLINERX LTD	SPONSORED ADR	09071M106	924	1,038,600	SH		SOLE		1,038,600	0	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	6,594	70,000	SH	Call	DFND	1	16,500	0	53,500
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	7,206	76,500	SH		SOLE		0	0	76,500
BIOMARIN PHARMACEUTICAL INC	NOTE 0.750%10/1	09061GAE1	532	500,000	PRN		SOLE		0	0	500,000
BIOMARIN PHARMACEUTICAL INC	NOTE 1.500%10/1	09061GAF8	592	500,000	PRN		SOLE		0	0	500,000
BLUEBIRD BIO INC	COM	09609G100	76,623	488,200	SH		DFND	1	88,400	0	399,800
BOSTON SCIENTIFIC CORP	COM	101137107	313,093	9,574,695	SH		DFND	1	1,864,500	0	7,710,195
BRISTOL MYERS SQUIBB CO	COM	110122108	131,726	2,380,300	SH		DFND	1	505,300	0	1,875,000
CELGENE CORP	COM	151020104	204,161	2,570,650	SH		DFND	1	446,800	0	2,123,850
CIGNA CORPORATION	COM	125509109	36,505	214,800	SH		DFND	1	82,200	0	132,600
CLEMENTIA PHARMACEUTICALS IN	COM	185575107	137,196	10,425,225	SH		SOLE		10,425,225	0	0
CLOVIS ONCOLOGY INC	COM	189464100	105,985	2,330,870	SH		DFND	1	514,800	0	1,816,070
CLOVIS ONCOLOGY INC	COM	189464100	4,547	100,000	SH	Call	DFND	1	23,500	0	76,500
COHERUS BIOSCIENCES INC	COM	19249H103	20,727	1,480,482	SH		SOLE		0	0	1,480,482
CORVUS PHARMACEUTICALS INC	COM	221015100	65,524	5,967,584	SH		SOLE		5,967,584	0	0
CRISPR THERAPEUTICS AG	NAMEN AKT	H17182108	29,157	496,200	SH		DFND	1	106,100	0	390,100
CTI BIOPHARMA CORP	COM NEW	12648L601	24,900	5,000,000	SH		SOLE		5,000,000	0	0
DAVITA INC	COM	23918K108	117,312	1,689,400	SH		DFND	1	375,000	0	1,314,400
DBV TECHNOLOGIES S A	SPONSORED ADR	23306J101	7,922	410,700	SH		SOLE		0	0	410,700
DECIPHERA PHARMACEUTICALS IN	COM	24344T101	78,924	2,005,700	SH		DFND	1	287,000	0	1,718,700
DENTSPLY SIRONA INC	COM	24906P109	104,763	2,393,500	SH		DFND	1	590,200	0	1,803,300
DERMIRA INC	COM	24983L104	9,491	1,031,596	SH		SOLE		0	0	1,031,596
EDWARDS LIFESCIENCES CORP	COM	28176E108	126,777	870,900	SH		DFND	1	170,500	0	700,400
EHEALTH INC	COM	28238P109	40,547	1,834,700	SH		SOLE		0	0	1,834,700
ELECTROCORE INC	COM	28531P103	6,568	397,826	SH		DFND	1	198,913	0	198,913
EXELIXIS INC	COM	30161Q104	36,179	1,681,200	SH		DFND	1	329,400	0	1,351,800
FLUIDIGM CORP DEL	COM	34385P108	9,439	1,583,700	SH		DFND	1	59,600	0	1,524,100
FLUIDIGM CORP DEL	NOTE 2.750% 2/0	34385PAA6	8,093	10,000,000	PRN		SOLE		0	0	10,000,000
FOAMIX PHARMACEUTICALS LTD	SHS	M46135105	20,240	4,040,000	SH		SOLE		0	0	4,040,000
GALAPAGOS NV	SPON ADR	36315X101	44,891	486,990	SH		DFND	1	68,500	0	418,490
GILEAD SCIENCES INC	COM	375558103	25,828	364,600	SH		SOLE		0	0	364,600
GLOBAL BLOOD THERAPEUTICS IN	COM	37890U108	20,217	447,275	SH		DFND	1	60,300	0	386,975
GW PHARMACEUTICALS PLC	ADS	36197T103	2,930	21,000	SH		SOLE		0	0	21,000
HCA HEALTHCARE INC	COM	40412C101	24,347	237,300	SH		DFND	1	76,000	0	161,300
HERON THERAPEUTICS INC	COM	427746102	51,092	1,315,100	SH		SOLE		0	0	1,315,100
HUMANA INC	COM	444859102	21,608	72,600	SH		DFND	1	31,300	0	41,300
ILLUMINA INC	COM	452327109	79,458	284,500	SH		DFND	1	70,600	0	213,900
IMMUNOGEN INC	COM	45253H101	28,259	2,904,270	SH		DFND	1	424,000	0	2,480,270
IMMUNOMEDICS INC	COM	452907108	117,038	4,944,573	SH		DFND	1	1,184,203	0	3,760,370
INCYTE CORP	COM	45337C102	29,346	438,000	SH		DFND	1	93,400	0	344,600
INOTEK PHARMACEUTICALS CORP	NOTE 5.750% 8/0	45780VAB8	7,214	7,000,000	PRN		SOLE		0	0	7,000,000
INSMED INC	COM PAR $.01	457669307	69,245	2,927,891	SH		DFND	1	494,900	0	2,432,991
INSMED INC	NOTE 1.750% 1/1	457669AA7	24,253	26,500,000	PRN		DFND	1	7,456,000	0	19,044,000
INSPIRE MED SYS INC	COM	457730109	87,161	2,444,221	SH		SOLE		2,444,221	0	0
INSYS THERAPEUTICS INC NEW	COM NEW	45824V209	25,424	3,511,544	SH		DFND	1	708,500	0	2,803,044
INTELLIA THERAPEUTICS INC	COM	45826J105	23,967	876,000	SH		SOLE		876,000	0	0
INTUITIVE SURGICAL INC	COM NEW	46120E602	52,872	110,500	SH		DFND	1	48,000	0	62,500
INVITAE CORP	COM	46185L103	11,159	1,518,197	SH		SOLE		1,518,197	0	0
IOVANCE BIOTHERAPEUTICS INC	COM	462260100	71,019	5,548,326	SH		DFND	1	1,337,800	0	4,210,526
IRONWOOD PHARMACEUTICALS INC	COM CL A	46333X108	56,007	2,929,250	SH		DFND	1	667,500	0	2,261,750
IRONWOOD PHARMACEUTICALS INC	COM CL A	46333X108	2,868	150,000	SH	Call	DFND	1	34,500	0	115,500
JAZZ PHARMACEUTICALS PLC	SHS USD	G50871105	179,209	1,040,100	SH		DFND	1	234,300	0	805,800
JOHNSON & JOHNSON	COM	478160104	91,733	756,000	SH		DFND	1	551,000	0	205,000
K2M GROUP HLDGS INC	COM	48273J107	18,972	843,205	SH		DFND	1	195,700	0	647,505
KALA PHARMACEUTICALS INC	COM	483119103	47,339	3,447,840	SH		SOLE		3,447,840	0	0
LIFEPOINT HEALTH INC	COM	53219L109	25,044	513,200	SH		DFND	1	120,900	0	392,300
LOXO ONCOLOGY INC	COM	548862101	93,332	538,000	SH		SOLE		538,000	0	0
MAGELLAN HEALTH INC	COM NEW	559079207	24,120	251,383	SH		DFND	1	54,900	0	196,483
MARINUS PHARMACEUTICALS INC	COM	56854Q101	4,013	567,600	SH		SOLE		567,600	0	0
MEDIGUS LTD	SPONSORD ADR NEW	58471G201	74	60,000	SH		SOLE		60,000	0	0
MEDNAX INC	COM	58502B106	37,333	862,600	SH		DFND	1	295,300	0	567,300
MERCK & CO INC	COM	58933Y105	284,076	4,680,000	SH		DFND	1	1,157,800	0	3,522,200
MYLAN N V	SHS EURO	N59465109	133,819	3,702,800	SH		DFND	1	739,400	0	2,963,400
NABRIVA THERAPEUTICS PLC	SHS	G63637105	13,640	3,919,600	SH		SOLE		3,919,600	0	0
NATERA INC	COM	632307104	18,520	984,086	SH		SOLE		984,086	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	13,537	137,800	SH		SOLE		0	0	137,800
NEURONETICS INC	COM	64131A105	3,992	150,000	SH		DFND	1	51,400	0	98,600
NEVRO CORP	COM	64157F103	100,618	1,260,091	SH		DFND	1	267,900	0	992,191
NOVO-NORDISK A S	ADR	670100205	15,220	330,000	SH		SOLE		0	0	330,000
NOVUS THERAPEUTICS INC	COM	67011N105	17,760	2,537,110	SH		SOLE		2,537,110	0	0
OBSEVA SA	COM	H5861P103	39,448	2,605,531	SH		SOLE		2,605,531	0	0
ORTHOPEDIATRICS CORP	COM	68752L100	3,647	136,900	SH		SOLE		0	0	136,900
PFIZER INC	COM	717081103	35,627	982,000	SH		SOLE		982,000	0	0
PIERIS PHARMACEUTICALS INC	COM	720795103	15,920	3,140,000	SH		SOLE		3,140,000	0	0
PROQR THRAPEUTICS N V	SHS EURO	N71542109	9,512	1,302,955	SH		DFND	1	85,783	0	1,217,172
PUMA BIOTECHNOLOGY INC	COM	74587V107	161,650	2,732,881	SH		DFND	1	542,246	0	2,190,635
RADIUS HEALTH INC	COM NEW	750469207	22,483	762,900	SH		DFND	1	59,700	0	703,200
RECRO PHARMA INC	COM	75629F109	539	107,357	SH		SOLE		107,357	0	0
REDHILL BIOPHARMA LTD	SPONSORED ADS	757468103	4,819	564,900	SH		SOLE		564,900	0	0
REGENERON PHARMACEUTICALS	COM	75886F107	128,509	372,500	SH		DFND	1	73,200	0	299,300
RESTORBIO INC	COM	76133L103	44,198	4,830,387	SH		SOLE		4,830,387	0	0
RHYTHM PHARMACEUTICALS INC	COM	76243J105	64,552	2,065,000	SH		SOLE		2,065,000	0	0
ROCKET PHARMACEUTICALS INC	COM	77313F106	15,213	775,000	SH		SOLE		0	0	775,000
SAREPTA THERAPEUTICS INC	COM	803607100	59,825	452,600	SH		DFND	1	94,300	0	358,300
SCPHARMACEUTICALS INC	COM	810648105	19,300	3,409,865	SH		SOLE		3,409,865	0	0
SELECT MED HLDGS CORP	COM	81619Q105	92,097	5,074,200	SH		DFND	1	1,248,800	0	3,825,400
SELECTA BIOSCIENCES INC	COM	816212104	24,417	1,842,797	SH		SOLE		1,842,797	0	0
SHIRE PLC	SPONSORED ADR	82481R106	60,195	356,608	SH		DFND	1	102,600	0	254,008
SIERRA ONCOLOGY INC	COM	82640U107	3,751	1,267,104	SH		SOLE		1,267,104	0	0
SINOVAC BIOTECH LTD	SHS	P8696W104	21,183	2,839,500	SH		SOLE		0	0	2,839,500
STEADYMED LTD	SHS	M84920103	19,108	4,246,196	SH		SOLE		4,246,196	0	0
STRYKER CORP	COM	863667101	24,215	143,400	SH		DFND	1	62,400	0	81,000
SYNDAX PHARMACEUTICALS INC	COM	87164F105	3,068	437,000	SH		SOLE		437,000	0	0
SYNLOGIC INC	COM	87166L100	19,955	2,029,996	SH		SOLE		2,029,996	0	0
TANDEM DIABETES CARE INC	COM NEW	875372203	37,192	1,689,000	SH		DFND	1	286,000	0	1,403,000
TELEFLEX INC	COM	879369106	51,067	190,400	SH		DFND	1	35,700	0	154,700
TENET HEALTHCARE CORP	COM NEW	88033G407	12,518	372,900	SH		DFND	1	87,800	0	285,100
TESARO INC	COM	881569107	2,992	67,281	SH		DFND	1	17,934	0	49,347
THERMO FISHER SCIENTIFIC INC	COM	883556102	120,866	583,500	SH		DFND	1	102,500	0	481,000
TRICIDA INC	COM	89610F101	325,589	10,889,280	SH		SOLE		10,889,280	0	0
TRIPLE-S MGMT CORP	CL B	896749108	11,359	290,800	SH		SOLE		0	0	290,800
ULTRAGENYX PHARMACEUTICAL IN	COM	90400D108	5,197	67,605	SH		DFND	1	11,700	0	55,905
UNITEDHEALTH GROUP INC	COM	91324P102	30,250	123,300	SH		DFND	1	53,100	0	70,200
UNIVERSAL HLTH SVCS INC	CL B	913903100	51,630	463,300	SH		DFND	1	103,900	0	359,400
VERONA PHARMA PLC	SPONSORED ADS	925050106	17,080	1,250,396	SH		SOLE		1,250,396	0	0
VERRICA PHARMACEUTICALS INC	COM	92511W108	29,195	1,479,733	SH		SOLE		1,479,733	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	304,670	1,792,600	SH		DFND	1	276,700	0	1,515,900
VERTEX PHARMACEUTICALS INC	COM	92532F100	29,743	175,000	SH	Call	DFND	1	41,500	0	133,500
VIEWRAY INC	COM	92672L107	65,453	9,458,567	SH		SOLE		9,458,567	0	0
WRIGHT MED GROUP N V	ORD SHS 0.03 PAR	N96617118	164,136	6,322,668	SH		DFND	1	1,049,359	0	5,273,309
WRIGHT MED GROUP N V	RIGHT 03/01/2019	N96617126	11,196	8,746,583	SH		SOLE		0	0	8,746,583
XENON PHARMACEUTICALS INC	COM	98420N105	5,840	634,812	SH		SOLE		634,812	0	0
XTANT MED HLDGS INC	COM NEW	98420P308	51,099	9,207,012	SH		SOLE		9,207,012	0	0
ZAI LAB LTD	ADR	98887Q104	37,456	1,611,000	SH		SOLE		1,611,000	0	0