Orbimed Advisors 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ABBOTT LABS	COM	002824100	78,886	938,000	SH		DFND	1	337,000	0	601,000
ABBVIE INC	COM	00287Y109	14,544	200,000	SH	Call	DFND	1	44,500	0	155,500
ACADIA PHARMACEUTICALS INC	COM	004225108	2,724	101,900	SH		SOLE		0	0	101,900
ADAPTIMMUNE THERAPEUTICS PLC	SPONDS ADR	00653A107	5,430	1,350,655	SH		SOLE		1,350,655	0	0
ADAPTIVE BIOTECHNOLOGIES COR	COM	00650F109	5,796	120,000	SH		DFND	1	23,900	0	96,100
ADVERUM BIOTECHNOLOGIES INC	COM	00773U108	23,307	1,960,200	SH		SOLE		0	0	1,960,200
AEGLEA BIOTHERAPEUTICS INC	COM	00773J103	14,834	2,165,524	SH		SOLE		2,165,524	0	0
AERPIO PHARMACEUTICALS INC	COM	00810B105	4,726	5,193,946	SH		SOLE		5,193,946	0	0
AGILENT TECHNOLOGIES INC	COM	00846U101	66,695	893,200	SH		DFND	1	304,700	0	588,500
ALCON INC	ORD SHS	H01301128	21,682	351,380	SH		DFND	1	125,800	0	225,580
ALECTOR INC	COM	014442107	250,464	13,182,329	SH		DFND	1	12,890,829	0	291,500
ALEXION PHARMACEUTICALS INC	COM	015351109	252,279	1,926,085	SH		DFND	1	398,400	0	1,527,685
ALPINE IMMUNE SCIENCES INC	COM	02083G100	15,455	3,670,955	SH		SOLE		3,670,955	0	0
AMARIN CORP PLC	SPONS ADR NEW	023111206	13,914	717,600	SH		DFND	1	56,500	0	661,100
AMGEN INC	COM	031162100	22,501	122,100	SH		SOLE		0	0	122,100
AMICUS THERAPEUTICS INC	COM	03152W109	6,468	518,309	SH		SOLE		0	0	518,309
ANTHEM INC	COM	036752103	102,047	361,600	SH		DFND	1	110,800	0	250,800
APELLIS PHARMACEUTICALS INC	COM	03753U106	46,213	1,823,700	SH		SOLE		0	0	1,823,700
APELLIS PHARMACEUTICALS INC	COM	03753U106	1,901	75,000	SH	Call	DFND	1	17,000	0	58,000
ARENA PHARMACEUTICALS INC	COM NEW	040047607	6,449	110,000	SH		SOLE		0	0	110,000
ARGENX SE	SPONSORED ADR	04016X101	43,946	310,400	SH		SOLE		0	0	310,400
ARQULE INC	COM	04269E107	11,010	1,000,000	SH		SOLE		0	0	1,000,000
ARVINAS INC	COM	04335A105	58,907	2,678,810	SH		DFND	1	1,916,310	0	762,500
ASCENDIS PHARMA A S	SPONSORED ADR	04351P101	442,944	3,846,673	SH		DFND	1	3,397,673	0	449,000
ASSEMBLY BIOSCIENCES INC	COM	045396108	7,063	523,600	SH		SOLE		0	0	523,600
ATHENEX INC	COM	04685N103	76,035	3,840,130	SH		SOLE		0	0	3,840,130
AUDENTES THERAPEUTICS INC	COM	05070R104	64,857	1,713,069	SH		SOLE		1,713,069	0	0
AURINIA PHARMACEUTICALS INC	COM	05156V102	23,234	3,531,002	SH		SOLE		0	0	3,531,002
AVEDRO INC	COM	05355N109	83,276	4,240,128	SH		SOLE		4,240,128	0	0
AVROBIO INC	COM	05455M100	1,724	106,000	SH		SOLE		0	0	106,000
BAUSCH HEALTH COS INC	COM	071734107	94,340	3,740,700	SH		DFND	1	873,400	0	2,867,300
BIOGEN INC	COM	09062X103	20,510	87,700	SH		SOLE		0	0	87,700
BIOLINERX LTD	SPONSORED ADS	09071M106	379	1,038,600	SH		SOLE		1,038,600	0	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	6,424	75,000	SH		DFND	1	17,000	0	58,000
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	6,424	75,000	SH	Put	DFND	1	17,500	0	57,500
BOSTON SCIENTIFIC CORP	COM	101137107	290,222	6,752,500	SH		DFND	1	1,682,300	0	5,070,200
BRISTOL MYERS SQUIBB CO	COM	110122108	61,005	1,345,200	SH		DFND	1	307,000	0	1,038,200
BRISTOL MYERS SQUIBB CO	COM	110122108	22,675	500,000	SH	Call	DFND	1	112,500	0	387,500
CAREDX INC	COM	14167L103	29,785	827,600	SH		DFND	1	189,700	0	637,900
CIGNA CORP NEW	COM	125523100	39,797	252,600	SH		DFND	1	91,000	0	161,600
CLOVIS ONCOLOGY INC	COM	189464100	28,450	1,913,234	SH		DFND	1	332,200	0	1,581,034
CONSTELLATION PHARMCETICLS I	COM	210373106	10,264	835,842	SH		SOLE		835,842	0	0
CORVUS PHARMACEUTICALS INC	COM	221015100	24,556	6,565,685	SH		SOLE		6,565,685	0	0
CRINETICS PHARMACEUTICALS IN	COM	22663K107	50,982	2,039,282	SH		SOLE		2,039,282	0	0
CTI BIOPHARMA CORP	COM	12648L601	4,297	5,000,000	SH		SOLE		5,000,000	0	0
DECIPHERA PHARMACEUTICALS IN	COM	24344T101	81,590	3,618,171	SH		DFND	1	548,800	0	3,069,371
DEXCOM INC	COM	252131107	39,393	262,900	SH		DFND	1	59,700	0	203,200
DYNAVAX TECHNOLOGIES CORP	COM NEW	268158201	2,328	583,500	SH		SOLE		0	0	583,500
EDWARDS LIFESCIENCES CORP	COM	28176E108	132,089	715,000	SH		DFND	1	163,800	0	551,200
EHEALTH INC	COM	28238P109	78,335	909,814	SH		DFND	1	103,000	0	806,814
ENDO INTL PLC	SHS	G30401106	25,402	6,165,464	SH		DFND	1	1,125,200	0	5,040,264
EXELIXIS INC	COM	30161Q104	83,619	3,912,900	SH		DFND	1	555,200	0	3,357,700
FLEXION THERAPEUTICS INC	COM	33938J106	1,106	89,919	SH		SOLE		0	0	89,919
FOAMIX PHARMACEUTICALS LTD	SHS	M46135105	12,365	5,195,330	SH		SOLE		0	0	5,195,330
GENFIT S A	ADS	372279109	22,231	1,125,607	SH		DFND	1	265,290	0	860,317
GILEAD SCIENCES INC	COM	375558103	27,132	401,600	SH		SOLE		0	0	401,600
GILEAD SCIENCES INC	COM	375558103	6,756	100,000	SH	Call	DFND	1	22,500	0	77,500
HARPOON THERAPEUTICS INC	COM	41358P106	31,803	2,446,409	SH		DFND	1	1,360,704	0	1,085,705
ILLUMINA INC	COM	452327109	51,615	140,200	SH		DFND	1	25,600	0	114,600
IMMUNOMEDICS INC	COM	452907108	11,348	818,200	SH		DFND	1	183,500	0	634,700
INSPIRE MED SYS INC	COM	457730109	89,216	1,471,000	SH		SOLE		1,471,000	0	0
INTELLIA THERAPEUTICS INC	COM	45826J105	5,363	327,600	SH		SOLE		327,600	0	0
INTUITIVE SURGICAL INC	COM NEW	46120E602	110,313	210,300	SH		DFND	1	51,400	0	158,900
IOVANCE BIOTHERAPEUTICS INC	COM	462260100	136,045	5,548,326	SH		DFND	1	1,337,800	0	4,210,526
KALA PHARMACEUTICALS INC	COM	483119103	21,997	3,447,840	SH		SOLE		3,447,840	0	0
KARYOPHARM THERAPEUTICS INC	COM	48576U106	18,859	3,148,475	SH		SOLE		0	0	3,148,475
KRYSTAL BIOTECH INC	COM	501147102	25,854	642,006	SH		SOLE		0	0	642,006
LOGICBIO THERAPEUTICS INC	COM	54142F102	84,068	6,466,783	SH		SOLE		6,466,783	0	0
MARINUS PHARMACEUTICALS INC	COM	56854Q101	1,652	398,101	SH		SOLE		398,101	0	0
MEDICINES CO	COM	584688105	5,526	151,515	SH		SOLE		0	0	151,515
MEDIGUS LTD	SPONSORED ADS	58471G300	37	15,000	SH		SOLE		15,000	0	0
MEIRAGTX HOLDINGS PLC	COM	G59665102	69,537	2,586,951	SH		SOLE		0	0	2,586,951
MENLO THERAPEUTICS INC	COM	586858102	4,035	673,700	SH		SOLE		0	0	673,700
MERCK & CO INC	COM	58933Y105	215,503	2,570,100	SH		DFND	1	723,400	0	1,846,700
MERSANA THERAPEUTICS INC	COM	59045L106	7,659	1,891,119	SH		SOLE		0	0	1,891,119
MYLAN N V	SHS EURO	N59465109	26,148	1,373,305	SH		DFND	1	310,700	0	1,062,605
MYOKARDIA INC	COM	62857M105	47,899	955,300	SH		DFND	1	176,600	0	778,700
NABRIVA THERAPEUTICS PLC	SHS	G63637105	11,286	4,644,600	SH		SOLE		4,644,600	0	0
NATERA INC	COM	632307104	88,927	3,224,328	SH		DFND	1	978,786	0	2,245,542
NEUROCRINE BIOSCIENCES INC	COM	64125C109	154,777	1,833,200	SH		DFND	1	322,500	0	1,510,700
NEXTCURE INC	COM	65343E108	40,611	2,711,013	SH		SOLE		2,711,013	0	0
NOVO-NORDISK A S	ADR	670100205	16,843	330,000	SH		SOLE		0	0	330,000
NOVUS THERAPEUTICS INC	COM	67011N105	3,215	3,183,314	SH		SOLE		3,183,314	0	0
NUVECTRA CORP	COM	67075N108	1,173	350,000	SH		SOLE		0	0	350,000
OBSEVA SA	COM	H5861P103	29,469	2,605,531	SH		SOLE		2,605,531	0	0
PERSONALIS INC	COM	71535D106	8,145	300,000	SH		SOLE		0	0	300,000
PFIZER INC	COM	717081103	10,830	250,000	SH	Put	DFND	1	56,500	0	193,500
PREVAIL THERAPEUTICS INC	COM	74140Y101	182,457	13,822,463	SH		SOLE		13,822,463	0	0
PRINCIPIA BIOPHARMA INC	COM	74257L108	53,294	1,605,713	SH		SOLE		1,605,713	0	0
PROQR THRAPEUTICS N V	SHS EURO	N71542109	12,581	1,382,502	SH		DFND	1	235,002	0	1,147,500
PROTHENA CORP PLC	SHS	G72800108	32,400	3,065,278	SH		DFND	1	613,800	0	2,451,478
PTC THERAPEUTICS INC	COM	69366J200	94,037	2,089,700	SH		DFND	1	330,400	0	1,759,300
PUMA BIOTECHNOLOGY INC	COM	74587V107	7,934	624,249	SH		DFND	1	121,100	0	503,149
REALM THERAPEUTICS PLC	SPONSORED ADS	75606L103	2,870	1,021,484	SH		SOLE		1,021,484	0	0
REATA PHARMACEUTICALS INC	CL A	75615P103	9,435	100,000	SH	Put	DFND	1	22,000	0	78,000
REGENERON PHARMACEUTICALS	COM	75886F107	67,545	215,800	SH		DFND	1	54,000	0	161,800
RESTORBIO INC	COM	76133L103	49,270	4,830,387	SH		SOLE		4,830,387	0	0
RHYTHM PHARMACEUTICALS INC	COM	76243J105	17,321	787,300	SH		SOLE		787,300	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	125,875	828,400	SH		DFND	1	129,400	0	699,000
SCPHARMACEUTICALS INC	COM	810648105	10,877	3,409,865	SH		SOLE		3,409,865	0	0
SELECTA BIOSCIENCES INC	COM	816212104	5,154	2,879,064	SH		SOLE		2,879,064	0	0
SI BONE INC	COM	825704109	20,042	985,368	SH		SOLE		985,368	0	0
SINOVAC BIOTECH LTD	SHS	P8696W104	16,611	2,839,500	SH		SOLE		0	0	2,839,500
SPARK THERAPEUTICS INC	COM	84652J103	22,513	219,900	SH		DFND	1	33,800	0	186,100
SPDR S&P 500 ETF TR	TR UNIT	78462F103	29,300	100,000	SH	Put	DFND	1	22,500	0	77,500
SPERO THERAPEUTICS INC	COM	84833T103	5,841	507,471	SH		SOLE		0	0	507,471
STOKE THERAPEUTICS INC	COM	86150R107	3,792	130,000	SH		SOLE		0	0	130,000
STRYKER CORP	COM	863667101	11,101	54,000	SH		SOLE		54,000	0	0
SYNDAX PHARMACEUTICALS INC	COM	87164F105	1,974	212,000	SH		SOLE		212,000	0	0
SYNLOGIC INC	COM	87166L100	18,473	2,029,996	SH		SOLE		2,029,996	0	0
SYNTHORX INC	COM	87167A103	71,824	5,316,355	SH		SOLE		5,316,355	0	0
TAKEDA PHARMACEUTICAL CO LTD	SPONSORED ADS	874060205	13,275	750,000	SH		DFND	1	172,000	0	578,000
TAKEDA PHARMACEUTICAL CO LTD	SPONSORED ADS	874060205	17,700	1,000,000	SH	Call	DFND	1	70,000	0	930,000
TANDEM DIABETES CARE INC	COM NEW	875372203	36,827	570,790	SH		DFND	1	134,200	0	436,590
THERMO FISHER SCIENTIFIC INC	COM	883556102	135,915	462,800	SH		DFND	1	123,900	0	338,900
TRICIDA INC	COM	89610F101	438,569	11,114,280	SH		SOLE		11,114,280	0	0
TURNING POINT THERAPEUTICS I	COM	90041T108	104,499	2,567,550	SH		DFND	1	2,027,550	0	540,000
ULTRAGENYX PHARMACEUTICAL IN	COM	90400D108	5,055	79,607	SH		DFND	1	7,100	0	72,507
UNIQURE NV	SHS	N90064101	70,163	897,800	SH		DFND	1	182,300	0	715,500
VERONA PHARMA PLC	SPONSORED ADS	925050106	6,377	1,250,396	SH		SOLE		1,250,396	0	0
VERRICA PHARMACEUTICALS INC	COM	92511W108	17,194	1,479,733	SH		SOLE		1,479,733	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	178,484	973,300	SH		DFND	1	156,900	0	816,400
VIEWRAY INC	COM	92672L107	45,363	5,149,019	SH		SOLE		5,149,019	0	0
WRIGHT MED GROUP N V	ORD SHS	N96617118	124,880	4,187,799	SH		DFND	1	967,749	0	3,220,050
X4 PHARMACEUTICALS INC	COM	98420X103	14,047	936,493	SH		SOLE		936,493	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	6,259	634,812	SH		SOLE		634,812	0	0
XTANT MED HLDGS INC	COM NEW	98420P308	27,621	9,207,012	SH		SOLE		9,207,012	0	0
ZAI LAB LTD	ADR	98887Q104	40,763	1,169,000	SH		SOLE		1,169,000	0	0