Orbimed Advisors 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ABBOTT LABS	COM	002824100	68,810	822,400	SH		DFND	1	194,000	0	628,400
ACADIA PHARMACEUTICALS INC	COM	004225108	3,460	96,143	SH		SOLE		0	0	96,143
ADAPTIMMUNE THERAPEUTICS PLC	SPONDS ADR	00653A107	2,039	1,350,655	SH		SOLE		1,350,655	0	0
ADVERUM BIOTECHNOLOGIES INC	COM	00773U108	21,871	4,012,969	SH		DFND	1	341,300	0	3,671,669
AEGLEA BIOTHERAPEUTICS INC	COM	00773J103	22,036	2,865,524	SH		SOLE		2,865,524	0	0
AERPIO PHARMACEUTICALS INC	COM	00810B105	3,531	5,193,946	SH		SOLE		5,193,946	0	0
ALCON INC	ORD SHS	H01301128	20,493	351,380	SH		DFND	1	125,800	0	225,580
ALDER BIOPHARMACEUTICALS INC	COM	014339105	6,601	350,000	SH	Put	DFND	1	66,500	0	283,500
ALECTOR INC	COM	014442107	180,716	12,532,329	SH		DFND	1	12,240,829	0	291,500
ALEXION PHARMACEUTICALS INC	COM	015351109	162,902	1,663,285	SH		DFND	1	270,000	0	1,393,285
ALPINE IMMUNE SCIENCES INC	COM	02083G100	14,537	3,670,955	SH		SOLE		3,670,955	0	0
AMARIN CORP PLC	SPONS ADR NEW	023111206	3,352	221,100	SH		SOLE		0	0	221,100
AMGEN INC	COM	031162100	23,628	122,100	SH		SOLE		0	0	122,100
ANTHEM INC	COM	036752103	61,129	254,600	SH		DFND	1	39,000	0	215,600
APELLIS PHARMACEUTICALS INC	COM	03753U106	15,029	623,859	SH		SOLE		0	0	623,859
ARENA PHARMACEUTICALS INC	COM NEW	040047607	5,035	110,000	SH		SOLE		0	0	110,000
ARGENX SE	SPONSORED ADR	04016X101	35,373	310,400	SH		SOLE		0	0	310,400
ARQULE INC	COM	04269E107	26,538	3,701,273	SH		DFND	1	261,200	0	3,440,073
ARVINAS INC	COM	04335A105	45,153	2,095,283	SH		DFND	1	1,517,183	0	578,100
ASCENDIS PHARMA A S	SPONSORED ADR	04351P101	358,231	3,719,173	SH		DFND	1	3,397,673	0	321,500
ATHENEX INC	COM	04685N103	40,253	3,308,920	SH		SOLE		0	0	3,308,920
AUDENTES THERAPEUTICS INC	COM	05070R104	44,609	1,588,069	SH		SOLE		1,588,069	0	0
AURINIA PHARMACEUTICALS INC	COM	05156V102	18,856	3,531,002	SH		SOLE		0	0	3,531,002
AVEDRO INC	COM	05355N109	96,251	4,240,128	SH		SOLE		4,240,128	0	0
AVROBIO INC	COM	05455M100	8,058	570,700	SH		SOLE		0	0	570,700
BAUSCH HEALTH COS INC	COM	071734107	72,374	3,312,300	SH		DFND	1	675,000	0	2,637,300
BELLUS HEALTH INC NEW	COM NEW	07987C204	45,129	7,025,832	SH		DFND	1	4,943,416	0	2,082,416
BIOGEN INC	COM	09062X103	8,428	36,200	SH		SOLE		0	0	36,200
BIOLINERX LTD	SPONSORED ADS	09071M205	183	69,240	SH		SOLE		69,240	0	0
BOSTON SCIENTIFIC CORP	COM	101137107	214,383	5,268,700	SH		DFND	1	1,017,800	0	4,250,900
CEL SCI CORP	COM PAR NEW	150837607	1,118	125,000	SH	Put	DFND	1	24,000	0	101,000
CIGNA CORP NEW	COM	125523100	44,262	291,600	SH		DFND	1	73,000	0	218,600
CONSTELLATION PHARMCETICLS I	COM	210373106	5,400	835,842	SH		SOLE		835,842	0	0
CORVUS PHARMACEUTICALS INC	COM	221015100	20,370	6,767,584	SH		SOLE		6,767,584	0	0
CRINETICS PHARMACEUTICALS IN	COM	22663K107	30,671	2,039,282	SH		SOLE		2,039,282	0	0
CRISPR THERAPEUTICS AG	NAMEN AKT	H17182108	21,167	516,400	SH		DFND	1	27,400	0	489,000
CTI BIOPHARMA CORP	COM	12648L601	4,185	5,000,000	SH		SOLE		5,000,000	0	0
CURIS INC	COM NEW	231269200	2,781	1,241,494	SH		SOLE		0	0	1,241,494
DECIPHERA PHARMACEUTICALS IN	COM	24344T101	83,512	2,460,571	SH		DFND	1	384,800	0	2,075,771
DEXCOM INC	COM	252131107	57,308	384,000	SH		DFND	1	61,000	0	323,000
EDWARDS LIFESCIENCES CORP	COM	28176E108	111,670	507,800	SH		DFND	1	77,000	0	430,800
EHEALTH INC	COM	28238P109	6,679	100,000	SH	Call	DFND	1	19,000	0	81,000
EHEALTH INC	COM	28238P109	74,632	1,117,414	SH		DFND	1	124,800	0	992,614
ESSA PHARMA INC	COM NEW	29668H708	4,960	1,471,853	SH		SOLE		1,471,853	0	0
EXELIXIS INC	COM	30161Q104	69,200	3,912,900	SH		DFND	1	555,200	0	3,357,700
FOAMIX PHARMACEUTICALS LTD	SHS	M46135105	14,558	4,788,896	SH		SOLE		0	0	4,788,896
GILEAD SCIENCES INC	COM	375558103	20,668	326,100	SH		SOLE		0	0	326,100
HARPOON THERAPEUTICS INC	COM	41358P106	33,418	2,446,409	SH		DFND	1	1,360,704	0	1,085,705
HEALTH CATALYST INC	COM	42225T107	5,682	179,598	SH		SOLE		179,598	0	0
HUMANA INC	COM	444859102	46,481	181,800	SH		DFND	1	32,000	0	149,800
INSMED INC	COM PAR $.01	457669307	9,919	562,300	SH		SOLE		0	0	562,300
INSPIRE MED SYS INC	COM	457730109	89,760	1,471,000	SH		SOLE		1,471,000	0	0
INTELLIA THERAPEUTICS INC	COM	45826J105	4,373	327,600	SH		SOLE		327,600	0	0
INTERCEPT PHARMACEUTICALS IN	COM	45845P108	2,137	32,200	SH		SOLE		0	0	32,200
INTUITIVE SURGICAL INC	COM NEW	46120E602	111,010	205,600	SH		DFND	1	32,000	0	173,600
IOVANCE BIOTHERAPEUTICS INC	COM	462260100	100,980	5,548,326	SH		DFND	1	1,337,800	0	4,210,526
IQVIA HLDGS INC	COM	46266C105	26,142	175,000	SH		SOLE		0	0	175,000
ISHARES TR	NASDAQ BIOTECH	464287556	19,900	200,000	SH	Put	DFND	1	38,000	0	162,000
KALA PHARMACEUTICALS INC	COM	483119103	13,119	3,447,840	SH		SOLE		3,447,840	0	0
KALVISTA PHARMACEUTICALS INC	COM	483497103	449	38,733	SH		SOLE		0	0	38,733
KARYOPHARM THERAPEUTICS INC	COM	48576U106	10,254	1,065,900	SH		SOLE		0	0	1,065,900
KRYSTAL BIOTECH INC	COM	501147102	20,903	601,950	SH		SOLE		0	0	601,950
LOGICBIO THERAPEUTICS INC	COM	54142F102	69,906	6,466,783	SH		SOLE		6,466,783	0	0
MEDIGUS LTD	SPONSORED ADS	58471G300	26	15,000	SH		SOLE		15,000	0	0
MEIRAGTX HOLDINGS PLC	COM	G59665102	53,418	3,349,060	SH		SOLE		0	0	3,349,060
MENLO THERAPEUTICS INC	COM	586858102	2,968	662,600	SH		SOLE		0	0	662,600
MERCK & CO INC	COM	58933Y105	164,496	1,954,100	SH		DFND	1	290,000	0	1,664,100
MERSANA THERAPEUTICS INC	COM	59045L106	2,988	1,891,119	SH		SOLE		0	0	1,891,119
MIRATI THERAPEUTICS INC	COM	60468T105	41,693	535,143	SH		DFND	1	65,400	0	469,743
MYOKARDIA INC	COM	62857M105	40,835	783,032	SH		DFND	1	140,400	0	642,632
NABRIVA THERAPEUTICS PLC	SHS	G63637105	9,289	4,644,600	SH		SOLE		4,644,600	0	0
NATERA INC	COM	632307104	98,404	3,000,128	SH		DFND	1	978,786	0	2,021,342
NEUROCRINE BIOSCIENCES INC	COM	64125C109	141,939	1,575,170	SH		DFND	1	235,170	0	1,340,000
NEXTCURE INC	COM	65343E108	83,635	2,711,013	SH		SOLE		2,711,013	0	0
NOVO-NORDISK A S	ADR	670100205	17,061	330,000	SH		SOLE		0	0	330,000
NOVUS THERAPEUTICS INC	COM	67011N105	1,974	3,183,314	SH		SOLE		3,183,314	0	0
OBSEVA SA	COM	H5861P103	21,704	2,605,531	SH		SOLE		2,605,531	0	0
PERSONALIS INC	COM	71535D106	7,100	483,842	SH		SOLE		0	0	483,842
PREVAIL THERAPEUTICS INC	COM	74140Y101	169,740	13,822,463	SH		SOLE		13,822,463	0	0
PRINCIPIA BIOPHARMA INC	COM	74257L108	45,345	1,605,713	SH		SOLE		1,605,713	0	0
PROTHENA CORP PLC	SHS	G72800108	23,693	3,022,117	SH		DFND	1	613,800	0	2,408,317
PTC THERAPEUTICS INC	COM	69366J200	66,250	1,958,900	SH		DFND	1	302,600	0	1,656,300
PUMA BIOTECHNOLOGY INC	COM	74587V107	6,853	636,600	SH		SOLE		0	0	636,600
PUMA BIOTECHNOLOGY INC	COM	74587V107	1,615	150,000	SH	Call	DFND	1	28,500	0	121,500
RA PHARMACEUTICALS INC	COM	74933V108	8,914	376,894	SH		SOLE		0	0	376,894
REATA PHARMACEUTICALS INC	CL A	75615P103	12,044	150,000	SH	Put	DFND	1	28,500	0	121,500
REGENERON PHARMACEUTICALS	COM	75886F107	63,275	228,100	SH		DFND	1	54,000	0	174,100
RESTORBIO INC	COM	76133L103	42,701	4,830,387	SH		SOLE		4,830,387	0	0
RUBIUS THERAPEUTICS INC	COM	78116T103	785	100,000	SH	Put	DFND	1	39,000	0	61,000
SAREPTA THERAPEUTICS INC	COM	803607100	63,069	837,349	SH		DFND	1	134,800	0	702,549
SAREPTA THERAPEUTICS INC	COM	803607100	3,766	50,000	SH	Call	DFND	1	9,500	0	40,500
SCPHARMACEUTICALS INC	COM	810648105	20,016	3,409,865	SH		SOLE		3,409,865	0	0
SELECTA BIOSCIENCES INC	COM	816212104	5,038	2,879,064	SH		SOLE		2,879,064	0	0
SI BONE INC	COM	825704109	7,457	422,000	SH		SOLE		422,000	0	0
SINOVAC BIOTECH LTD	SHS	P8696W104	16,611	2,839,500	SH		SOLE		0	0	2,839,500
SPARK THERAPEUTICS INC	COM	84652J103	23,750	244,900	SH		DFND	1	38,500	0	206,400
SPERO THERAPEUTICS INC	COM	84833T103	1,492	140,709	SH		SOLE		0	0	140,709
SPRINGWORKS THERAPEUTICS INC	COM	85205L107	160,569	7,406,307	SH		SOLE		7,406,307	0	0
SYNDAX PHARMACEUTICALS INC	COM	87164F105	1,584	212,000	SH		SOLE		212,000	0	0
SYNLOGIC INC	COM	87166L100	4,649	2,029,996	SH		SOLE		2,029,996	0	0
SYNTHORX INC	COM	87167A103	86,497	5,316,355	SH		SOLE		5,316,355	0	0
TAKEDA PHARMACEUTICAL CO LTD	SPONSORED ADS	874060205	12,900	750,000	SH		DFND	1	172,000	0	578,000
TANDEM DIABETES CARE INC	COM NEW	875372203	39,186	664,390	SH		DFND	1	134,200	0	530,190
THERMO FISHER SCIENTIFIC INC	COM	883556102	102,498	351,900	SH		DFND	1	68,000	0	283,900
TRICIDA INC	COM	89610F101	343,098	11,114,280	SH		SOLE		11,114,280	0	0
TURNING POINT THERAPEUTICS I	COM	90041T108	103,224	2,745,327	SH		DFND	1	2,027,550	0	717,777
ULTRAGENYX PHARMACEUTICAL IN	COM	90400D108	35,692	834,313	SH		DFND	1	136,100	0	698,213
UNIQURE NV	SHS	N90064101	33,047	839,600	SH		DFND	1	137,300	0	702,300
VERONA PHARMA PLC	SPONSORED ADS	925050106	5,714	1,250,396	SH		SOLE		1,250,396	0	0
VERRICA PHARMACEUTICALS INC	COM	92511W108	21,841	1,479,733	SH		SOLE		1,479,733	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	143,397	846,400	SH		DFND	1	113,100	0	733,300
WRIGHT MED GROUP N V	ORD SHS	N96617118	79,162	3,837,250	SH		DFND	1	745,000	0	3,092,250
X4 PHARMACEUTICALS INC	COM	98420X103	11,903	936,493	SH		SOLE		936,493	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	5,720	634,812	SH		SOLE		634,812	0	0
XTANT MED HLDGS INC	COM NEW	98420P308	26,148	9,207,012	SH		SOLE		9,207,012	0	0
ZAI LAB LTD	ADR	98887Q104	16,628	514,000	SH		SOLE		514,000	0	0