Orbimed Advisors 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
89BIO INC	COM	282559103	105,277	4,004,442	SH		SOLE		4,004,442	0	0
ABBOTT LABS	COM	002824100	62,114	715,100	SH		DFND	1	194,000	0	521,100
ACADIA PHARMACEUTICALS INC	COM	004225108	4,113	96,143	SH		SOLE		0	0	96,143
ACCELERON PHARMA INC	COM	00434H108	5,700	107,500	SH		SOLE		0	0	107,500
ADAPTIMMUNE THERAPEUTICS PLC	SPONDS ADR	00653A107	1,621	1,350,655	SH		SOLE		1,350,655	0	0
ADVERUM BIOTECHNOLOGIES INC	COM	00773U108	50,022	4,342,190	SH		DFND	1	398,100	0	3,944,090
AEGLEA BIOTHERAPEUTICS INC	COM	00773J103	21,893	2,865,524	SH		SOLE		2,865,524	0	0
AERPIO PHARMACEUTICALS INC	COM	00810B105	3,238	5,193,946	SH		SOLE		5,193,946	0	0
ALCON INC	ORD SHS	H01301128	19,925	351,380	SH		DFND	1	125,800	0	225,580
ALECTOR INC	COM	014442107	189,322	10,987,944	SH		DFND	1	10,930,344	0	57,600
ALEXION PHARMACEUTICALS INC	COM	015351109	179,809	1,662,585	SH		DFND	1	285,200	0	1,377,385
ALPINE IMMUNE SCIENCES INC	COM	02083G100	14,096	3,670,955	SH		SOLE		3,670,955	0	0
AMARIN CORP PLC	SPONS ADR NEW	023111206	5,351	249,600	SH		SOLE		0	0	249,600
AMGEN INC	COM	031162100	29,435	122,100	SH		SOLE		0	0	122,100
ANAPTYSBIO INC	COM	032724106	6,107	375,800	SH		DFND	1	35,200	0	340,600
ANTHEM INC	COM	036752103	32,196	106,600	SH		DFND	1	19,000	0	87,600
APPLIED THERAPEUTICS INC	COM	03828A101	26,930	987,186	SH		DFND	1	137,932	0	849,254
APTINYX INC	COM	03836N103	489	143,000	SH		SOLE		143,000	0	0
APTOSE BIOSCIENCES INC	COM NEW	03835T200	6,521	1,150,000	SH		DFND	1	283,000	0	867,000
ARENA PHARMACEUTICALS INC	COM NEW	040047607	4,996	110,000	SH		SOLE		0	0	110,000
ARGENX SE	SPONSORED ADR	04016X101	41,141	256,300	SH		SOLE		0	0	256,300
ARQULE INC	COM	04269E107	99,800	5,000,000	SH		DFND	1	584,600	0	4,415,400
ARVINAS INC	COM	04335A105	78,022	1,898,800	SH		DFND	1	910,000	0	988,800
ASCENDIS PHARMA A S	SPONSORED ADR	04351P101	465,092	3,343,100	SH		DFND	1	3,056,000	0	287,100
ASTRAZENECA PLC	SPONSORED ADR	046353108	3,470	69,600	SH		SOLE		69,600	0	0
ATHENEX INC	COM	04685N103	42,332	2,772,221	SH		SOLE		0	0	2,772,221
ATRICURE INC	COM	04963C209	5,482	168,621	SH		DFND	1	27,000	0	141,621
AURINIA PHARMACEUTICALS INC	COM	05156V102	47,519	2,345,447	SH		SOLE		0	0	2,345,447
AVANTOR INC	COM	05352A100	18,382	1,012,800	SH		DFND	1	133,700	0	879,100
AVROBIO INC	COM	05455M100	12,777	634,700	SH		DFND	1	64,000	0	570,700
BAUSCH HEALTH COS INC	COM	071734107	95,238	3,183,100	SH		DFND	1	675,000	0	2,508,100
BELLUS HEALTH INC NEW	COM NEW	07987C204	53,137	7,025,832	SH		DFND	1	4,943,416	0	2,082,416
BIOGEN INC	COM	09062X103	19,139	64,500	SH		SOLE		0	0	64,500
BIOLINERX LTD	SPONSORED ADS	09071M205	156	69,240	SH		SOLE		69,240	0	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	2,934	34,700	SH		SOLE		0	0	34,700
BIOMX INC	COM	09090D103	22,406	2,313,489	SH		SOLE		2,313,489	0	0
BOSTON SCIENTIFIC CORP	COM	101137107	211,394	4,674,800	SH		DFND	1	888,500	0	3,786,300
BRISTOL MYERS SQUIBB CO	COM	110122108	109,123	1,700,000	SH		DFND	1	290,500	0	1,409,500
BRISTOL MYERS SQUIBB CO	RIGHT 99/99/9999	110122157	1,054	350,000	SH		DFND	1	120,140	0	229,860
CIGNA CORP NEW	COM	125523100	100,139	489,700	SH		DFND	1	95,000	0	394,700
CORVUS PHARMACEUTICALS INC	COM	221015100	36,816	6,767,584	SH		SOLE		6,767,584	0	0
CRINETICS PHARMACEUTICALS IN	COM	22663K107	51,166	2,039,282	SH		SOLE		2,039,282	0	0
CRISPR THERAPEUTICS AG	NAMEN AKT	H17182108	46,676	766,378	SH		DFND	1	60,000	0	706,378
CTI BIOPHARMA CORP	COM	12648L601	7,900	5,000,000	SH		SOLE		5,000,000	0	0
CURIS INC	COM NEW	231269200	2,309	1,358,363	SH		DFND	1	116,869	0	1,241,494
DANAHER CORPORATION	COM	235851102	98,058	638,900	SH		DFND	1	101,200	0	537,700
DECIPHERA PHARMACEUTICALS IN	COM	24344T101	94,242	1,514,171	SH		DFND	1	257,800	0	1,256,371
DERMIRA INC	COM	24983L104	3,790	250,000	SH	Call	DFND	1	84,000	0	166,000
DEXCOM INC	COM	252131107	51,382	234,900	SH		DFND	1	48,500	0	186,400
EDWARDS LIFESCIENCES CORP	COM	28176E108	101,458	434,900	SH		DFND	1	68,300	0	366,600
EHEALTH INC	COM	28238P109	106,833	1,111,914	SH		DFND	1	134,200	0	977,714
ESSA PHARMA INC	COM NEW	29668H708	8,095	1,471,853	SH		SOLE		1,471,853	0	0
EXELIXIS INC	COM	30161Q104	66,140	3,753,700	SH		DFND	1	555,200	0	3,198,500
FLEXION THERAPEUTICS INC	COM	33938J106	2,753	133,000	SH		SOLE		0	0	133,000
FOAMIX PHARMACEUTICALS LTD	SHS	M46135105	8,585	2,577,982	SH		SOLE		0	0	2,577,982
GILEAD SCIENCES INC	COM	375558103	21,190	326,100	SH		SOLE		0	0	326,100
GLAUKOS CORP	COM	377322102	84,300	1,547,646	SH		SOLE		1,547,646	0	0
HARPOON THERAPEUTICS INC	COM	41358P106	36,182	2,446,409	SH		DFND	1	1,360,704	0	1,085,705
HCA HEALTHCARE INC	COM	40412C101	28,084	190,000	SH		DFND	1	40,000	0	150,000
HEALTH CATALYST INC	COM	42225T107	6,232	179,598	SH		SOLE		179,598	0	0
HORIZON THERAPEUTICS PUB LTD	SHS	G46188101	57,279	1,582,300	SH		DFND	1	229,600	0	1,352,700
HUMANA INC	COM	444859102	143,639	391,900	SH		DFND	1	63,900	0	328,000
IMMUNOGEN INC	COM	45253H101	1,464	286,800	SH		SOLE		286,800	0	0
INCYTE CORP	COM	45337C102	5,196	59,500	SH		SOLE		0	0	59,500
INSMED INC	COM PAR $.01	457669307	1,409	59,000	SH		SOLE		0	0	59,000
INSPIRE MED SYS INC	COM	457730109	99,961	1,347,000	SH		SOLE		1,347,000	0	0
INTELLIA THERAPEUTICS INC	COM	45826J105	3,845	262,100	SH		SOLE		262,100	0	0
INTERCEPT PHARMACEUTICALS IN	COM	45845P108	2,825	22,800	SH		SOLE		0	0	22,800
INTUITIVE SURGICAL INC	COM NEW	46120E602	99,195	167,800	SH		DFND	1	26,400	0	141,400
IONIS PHARMACEUTICALS INC	COM	462222100	6,458	106,900	SH		SOLE		0	0	106,900
IOVANCE BIOTHERAPEUTICS INC	COM	462260100	153,578	5,548,326	SH		DFND	1	1,337,800	0	4,210,526
IQVIA HLDGS INC	COM	46266C105	27,039	175,000	SH		SOLE		0	0	175,000
IVERIC BIO INC	COM	46583P102	8,580	1,000,000	SH		DFND	1	250,000	0	750,000
KALA PHARMACEUTICALS INC	COM	483119103	12,723	3,447,840	SH		SOLE		3,447,840	0	0
KALVISTA PHARMACEUTICALS INC	COM	483497103	2,859	160,541	SH		DFND	1	6,900	0	153,641
KARYOPHARM THERAPEUTICS INC	COM	48576U106	11,922	621,900	SH		SOLE		0	0	621,900
KRYSTAL BIOTECH INC	COM	501147102	55,092	994,808	SH		DFND	1	61,300	0	933,508
LOGICBIO THERAPEUTICS INC	COM	54142F102	46,561	6,466,783	SH		SOLE		6,466,783	0	0
MEDIGUS LTD	SPONSORED ADS	58471G300	26	15,000	SH		SOLE		15,000	0	0
MEIRAGTX HOLDINGS PLC	COM	G59665102	69,129	3,453,020	SH		DFND	1	4,200	0	3,448,820
MERCK & CO INC	COM	58933Y105	177,725	1,954,100	SH		DFND	1	290,000	0	1,664,100
MERSANA THERAPEUTICS INC	COM	59045L106	11,880	2,073,319	SH		DFND	1	182,200	0	1,891,119
MILESTONE PHARMACEUTICALS IN	COM	59935V107	5,831	364,206	SH		DFND	1	19,700	0	344,506
MIRATI THERAPEUTICS INC	COM	60468T105	172,750	1,340,600	SH		DFND	1	170,400	0	1,170,200
MIRUM PHARMACEUTICALS INC	COM	604749101	1,748	71,300	SH		SOLE		71,300	0	0
MUSTANG BIO INC	COM	62818Q104	1,027	251,685	SH		SOLE		251,685	0	0
MYOKARDIA INC	COM	62857M105	2,033	27,900	SH		SOLE		0	0	27,900
NABRIVA THERAPEUTICS PLC	SHS	G63637105	6,131	4,644,600	SH		SOLE		4,644,600	0	0
NATERA INC	COM	632307104	82,224	2,440,613	SH		DFND	1	866,844	0	1,573,769
NEOLEUKIN THERAPEUTICS INC	COM	64049K104	11,088	900,000	SH		DFND	1	137,200	0	762,800
NEUROCRINE BIOSCIENCES INC	COM	64125C109	100,607	935,970	SH		DFND	1	101,170	0	834,800
NEXTCURE INC	COM	65343E108	152,711	2,711,013	SH		SOLE		2,711,013	0	0
NOVO-NORDISK A S	ADR	670100205	19,100	330,000	SH		SOLE		0	0	330,000
NOVUS THERAPEUTICS INC	COM	67011N105	1,846	3,183,314	SH		SOLE		3,183,314	0	0
OBSEVA SA	COM	H5861P103	9,953	2,605,531	SH		SOLE		2,605,531	0	0
OTONOMY INC	COM	68906L105	1,343	350,700	SH		SOLE		350,700	0	0
PERSONALIS INC	COM	71535D106	5,274	483,842	SH		SOLE		0	0	483,842
PFENEX INC	COM	717071104	6,751	614,868	SH		DFND	1	43,168	0	571,700
PREVAIL THERAPEUTICS INC	COM	74140Y101	218,810	13,822,463	SH		SOLE		13,822,463	0	0
PROTAGONIST THERAPEUTICS INC	COM	74366E102	1,348	191,209	SH		DFND	1	32,600	0	158,609
PROTHENA CORP PLC	SHS	G72800108	45,942	2,902,239	SH		DFND	1	613,800	0	2,288,439
PTC THERAPEUTICS INC	COM	69366J200	83,053	1,729,200	SH		DFND	1	253,400	0	1,475,800
REGENERON PHARMACEUTICALS	COM	75886F107	78,588	209,300	SH		DFND	1	54,000	0	155,300
REGENXBIO INC	COM	75901B107	1,098	26,800	SH		SOLE		0	0	26,800
RESTORBIO INC	COM	76133L103	7,197	4,830,387	SH		SOLE		4,830,387	0	0
RUBIUS THERAPEUTICS INC	COM	78116T103	950	100,000	SH	Put	DFND	1	39,000	0	61,000
SANOFI	SPONSORED ADR	80105N105	3,434	68,400	SH		SOLE		68,400	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	98,851	766,049	SH		DFND	1	134,800	0	631,249
SCPHARMACEUTICALS INC	COM	810648105	19,300	3,409,865	SH		SOLE		3,409,865	0	0
SELECT SECTOR SPDR TR	SBI HEALTHCARE	81369Y209	11,531	113,200	SH		SOLE		113,200	0	0
SELECTA BIOSCIENCES INC	COM	816212104	6,852	2,879,064	SH		SOLE		2,879,064	0	0
SINOVAC BIOTECH LTD	SHS	P8696W104	17,151	2,839,500	SH		SOLE		0	0	2,839,500
SPDR SERIES TRUST	S&P BIOTECH	78464A870	12,098	127,200	SH		SOLE		127,200	0	0
SPDR SERIES TRUST	S&P BIOTECH	78464A870	10,462	110,000	SH	Call	SOLE		110,000	0	0
SPERO THERAPEUTICS INC	COM	84833T103	1,266	131,653	SH		SOLE		0	0	131,653
SPRINGWORKS THERAPEUTICS INC	COM	85205L107	285,069	7,406,307	SH		SOLE		7,406,307	0	0
SUTRO BIOPHARMA INC	COM	869367102	1,153	104,800	SH		SOLE		104,800	0	0
SYNDAX PHARMACEUTICALS INC	COM	87164F105	1,861	212,000	SH		SOLE		212,000	0	0
SYNLOGIC INC	COM	87166L100	5,237	2,029,996	SH		SOLE		2,029,996	0	0
SYNTHORX INC	COM	87167A103	371,560	5,316,355	SH		SOLE		5,316,355	0	0
TANDEM DIABETES CARE INC	COM NEW	875372203	68,038	1,141,390	SH		DFND	1	174,200	0	967,190
TELA BIO INC	COM	872381108	39,207	3,027,542	SH		SOLE		3,027,542	0	0
THERMO FISHER SCIENTIFIC INC	COM	883556102	71,634	220,500	SH		DFND	1	33,600	0	186,900
TRICIDA INC	COM	89610F101	362,843	9,614,280	SH		SOLE		9,614,280	0	0
TURNING POINT THERAPEUTICS I	COM	90041T108	171,006	2,745,327	SH		DFND	1	2,027,550	0	717,777
UNIQURE NV	SHS	N90064101	77,519	1,081,765	SH		DFND	1	171,300	0	910,465
VERONA PHARMA PLC	SPONSORED ADS	925050106	7,190	1,250,396	SH		SOLE		1,250,396	0	0
VERRICA PHARMACEUTICALS INC	COM	92511W108	23,513	1,479,733	SH		SOLE		1,479,733	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	171,460	783,100	SH		DFND	1	113,100	0	670,000
X4 PHARMACEUTICALS INC	COM	98420X103	11,625	1,086,493	SH		SOLE		1,086,493	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	8,322	634,812	SH		SOLE		634,812	0	0
XTANT MED HLDGS INC	COM NEW	98420P308	14,731	9,207,012	SH		SOLE		9,207,012	0	0
ZAFGEN INC	COM	98885E103	911	821,000	SH		SOLE		821,000	0	0
ZAI LAB LTD	ADR	98887Q104	21,377	514,000	SH		SOLE		514,000	0	0
ZIMMER BIOMET HLDGS INC	COM	98956P102	26,748	178,700	SH		DFND	1	38,200	0	140,500
ZOGENIX INC	COM NEW	98978L204	6,516	125,000	SH	Call	DFND	1	42,000	0	83,000