Orbimed Advisors 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
10X GENOMICS INC	CL A COM	88025U109	5,777	92,700	SH		SOLE		0	0	92,700
89BIO INC	COM	282559103	101,112	4,004,442	SH		SOLE		4,004,442	0	0
ABBVIE INC	COM	00287Y109	17,448	229,000	SH		DFND	1	32,100	0	196,900
ACADIA HEALTHCARE COMPANY IN	COM	00404A109	25,326	1,380,160	SH		DFND	1	164,500	0	1,215,660
ACCELERON PHARMA INC	COM	00434H108	23,146	257,549	SH		DFND	1	18,500	0	239,049
ADAPTIMMUNE THERAPEUTICS PLC	SPONDS ADR	00653A107	6,870	2,525,654	SH		SOLE		2,525,654	0	0
ADVERUM BIOTECHNOLOGIES INC	COM	00773U108	33,713	3,450,644	SH		DFND	1	371,397	0	3,079,247
AEGLEA BIOTHERAPEUTICS INC	COM	00773J103	13,353	2,865,524	SH		SOLE		2,865,524	0	0
AERPIO PHARMACEUTICALS INC	COM	00810B105	2,856	5,193,946	SH		SOLE		5,193,946	0	0
AGILE THERAPEUTICS INC	COM	00847L100	2,232	1,200,000	SH		DFND	1	400,000	0	800,000
AGIOS PHARMACEUTICALS INC	COM	00847X104	58,638	1,652,696	SH		DFND	1	191,400	0	1,461,296
AGIOS PHARMACEUTICALS INC	COM	00847X104	8,870	250,000	SH	Call	DFND	1	79,500	0	170,500
ALCON INC	ORD SHS	H01301128	17,946	351,380	SH		DFND	1	125,800	0	225,580
ALECTOR INC	COM	014442107	200,947	8,327,691	SH		SOLE		8,327,691	0	0
ALEXION PHARMACEUTICALS INC	COM	015351109	185,990	2,071,385	SH		DFND	1	336,100	0	1,735,285
ALPINE IMMUNE SCIENCES INC	COM	02083G100	10,572	3,670,955	SH		SOLE		3,670,955	0	0
AMGEN INC	COM	031162100	21,327	105,200	SH		SOLE		0	0	105,200
ANAPTYSBIO INC	COM	032724106	5,310	375,800	SH		DFND	1	35,200	0	340,600
APELLIS PHARMACEUTICALS INC	COM	03753U106	1,352	50,485	SH		SOLE		0	0	50,485
APPLIED THERAPEUTICS INC	COM	03828A101	43,147	1,319,877	SH		DFND	1	60,832	0	1,259,045
APTINYX INC	COM	03836N103	2,510	1,162,108	SH		DFND	1	170,100	0	992,008
APTOSE BIOSCIENCES INC	COM NEW	03835T200	3,914	659,000	SH		DFND	1	104,100	0	554,900
ARCUTIS BIOTHERAPEUTICS INC	COM	03969K108	139,281	4,673,850	SH		DFND	1	4,067,564	0	606,286
ARENA PHARMACEUTICALS INC	COM NEW	040047607	5,603	133,400	SH		SOLE		0	0	133,400
ARGENX SE	SPONSORED ADR	04016X101	3,766	28,591	SH		SOLE		0	0	28,591
ARROWHEAD PHARMACEUTICALS IN	COM	04280A100	1,959	68,100	SH		SOLE		0	0	68,100
ARVINAS INC	COM	04335A105	40,099	995,000	SH		DFND	1	560,000	0	435,000
ASCENDIS PHARMA A S	SPONSORED ADR	04351P101	370,194	3,287,400	SH		DFND	1	3,011,900	0	275,500
ATHENEX INC	COM	04685N103	31,032	4,009,346	SH		DFND	1	229,000	0	3,780,346
ATRICURE INC	COM	04963C209	31,178	928,189	SH		DFND	1	143,500	0	784,689
AURINIA PHARMACEUTICALS INC	COM	05156V102	19,393	1,336,547	SH		SOLE		0	0	1,336,547
AVROBIO INC	COM	05455M100	10,319	663,174	SH		DFND	1	64,000	0	599,174
BAUSCH HEALTH COS INC	COM	071734107	37,198	2,399,880	SH		DFND	1	361,200	0	2,038,680
BELLUS HEALTH INC NEW	COM NEW	07987C204	69,370	7,025,832	SH		DFND	1	4,943,416	0	2,082,416
BENEFYTT TECHNOLOGIES INC	COM CL A	08182C106	21,559	962,900	SH		DFND	1	160,400	0	802,500
BIOGEN INC	COM	09062X103	151,989	480,400	SH		DFND	1	55,700	0	424,700
BIOLINERX LTD	SPONSORED ADS	09071M205	92	69,240	SH		SOLE		69,240	0	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	45,672	540,500	SH		DFND	1	45,000	0	495,500
BIOMX INC	COM	09090D103	16,194	2,313,489	SH		SOLE		2,313,489	0	0
BIOXCEL THERAPEUTICS INC	COM	09075P105	2,398	107,300	SH		DFND	1	19,000	0	88,300
BOSTON SCIENTIFIC CORP	COM	101137107	158,167	4,847,300	SH		DFND	1	939,400	0	3,907,900
BRISTOL-MYERS SQUIBB CO	COM	110122108	137,945	2,474,800	SH		DFND	1	428,700	0	2,046,100
BRISTOL-MYERS SQUIBB CO	RIGHT 99/99/9999	110122157	1,330	350,000	SH		DFND	1	120,140	0	229,860
CARA THERAPEUTICS INC	COM	140755109	7,831	592,800	SH		DFND	1	77,200	0	515,600
CASSAVA SCIENCES INC	COM	14817C107	1,530	250,000	SH	Call	DFND	1	97,500	0	152,500
CATABASIS PHARMACEUTICALS IN	COM NEW	14875P206	184	44,398	SH		SOLE		44,398	0	0
CENTENE CORP DEL	COM	15135B101	79,354	1,335,700	SH		DFND	1	179,300	0	1,156,400
CIGNA CORP NEW	COM	125523100	77,906	439,700	SH		DFND	1	84,900	0	354,800
CORVUS PHARMACEUTICALS INC	COM	221015100	14,280	6,767,584	SH		SOLE		6,767,584	0	0
CRINETICS PHARMACEUTICALS IN	COM	22663K107	29,977	2,039,282	SH		SOLE		2,039,282	0	0
CRISPR THERAPEUTICS AG	NAMEN AKT	H17182108	23,376	551,200	SH		DFND	1	37,400	0	513,800
CTI BIOPHARMA CORP	COM	12648L601	8,759	9,520,600	SH		SOLE		9,520,600	0	0
CURIS INC	COM NEW	231269200	956	1,358,363	SH		DFND	1	116,869	0	1,241,494
DECIPHERA PHARMACEUTICALS IN	COM	24344T101	47,658	1,157,600	SH		DFND	1	190,100	0	967,500
DEXCOM INC	COM	252131107	91,013	338,000	SH		DFND	1	50,000	0	288,000
EDWARDS LIFESCIENCES CORP	COM	28176E108	33,348	176,800	SH		DFND	1	27,800	0	149,000
EHEALTH INC	COM	28238P109	89,922	638,558	SH		DFND	1	86,021	0	552,537
ESSA PHARMA INC	COM NEW	29668H708	5,887	1,471,853	SH		SOLE		1,471,853	0	0
EXELIXIS INC	COM	30161Q104	54,761	3,180,100	SH		DFND	1	391,400	0	2,788,700
FLEXION THERAPEUTICS INC	COM	33938J106	1,047	133,000	SH		SOLE		0	0	133,000
GILEAD SCIENCES INC	COM	375558103	109,979	1,471,100	SH		DFND	1	128,600	0	1,342,500
GLAUKOS CORP	COM	377322102	47,760	1,547,646	SH		SOLE		1,547,646	0	0
HARPOON THERAPEUTICS INC	COM	41358P106	28,329	2,446,409	SH		DFND	1	1,360,704	0	1,085,705
HCA HEALTHCARE INC	COM	40412C101	63,776	709,800	SH		DFND	1	121,000	0	588,800
HEALTH CATALYST INC	COM	42225T107	4,696	179,598	SH		SOLE		179,598	0	0
HERON THERAPEUTICS INC	COM	427746102	6,309	537,420	SH		SOLE		0	0	537,420
HORIZON THERAPEUTICS PUB LTD	SHS	G46188101	69,361	2,341,700	SH		DFND	1	324,500	0	2,017,200
HUMANA INC	COM	444859102	88,020	280,300	SH		DFND	1	42,300	0	238,000
IGM BIOSCIENCES INC	COM	449585108	4,535	80,760	SH		DFND	1	7,460	0	73,300
IMARA INC	COM	45249V107	43,600	2,719,902	SH		DFND	1	2,532,402	0	187,500
IMMUNOVANT INC	COM	45258J102	2,794	179,500	SH		DFND	1	34,500	0	145,000
INFLARX NV	COM	N44821101	4,078	1,067,600	SH		DFND	1	403,800	0	663,800
INSPIRE MED SYS INC	COM	457730109	20,917	347,000	SH		SOLE		347,000	0	0
INTELLIA THERAPEUTICS INC	COM	45826J105	3,205	262,100	SH		SOLE		262,100	0	0
INTERSECT ENT INC	COM	46071F103	812	68,553	SH		DFND	1	6,600	0	61,953
INTUITIVE SURGICAL INC	COM NEW	46120E602	83,740	169,100	SH		DFND	1	27,700	0	141,400
IOVANCE BIOTHERAPEUTICS INC	COM	462260100	166,089	5,548,326	SH		DFND	1	1,337,800	0	4,210,526
IQVIA HLDGS INC	COM	46266C105	18,876	175,000	SH		SOLE		0	0	175,000
IVERIC BIO INC	COM	46583P102	2,580	750,000	SH		SOLE		0	0	750,000
KALA PHARMACEUTICALS INC	COM	483119103	47,490	5,402,730	SH		DFND	1	4,651,895	0	750,835
KALVISTA PHARMACEUTICALS INC	COM	483497103	3,218	420,641	SH		DFND	1	46,500	0	374,141
KITOV PHARMA LTD	SPONSORED ADS	49803V107	1,058	3,461,983	SH		SOLE		3,461,983	0	0
LOGICBIO THERAPEUTICS INC	COM	54142F102	31,946	6,466,783	SH		SOLE		6,466,783	0	0
MEIRAGTX HOLDINGS PLC	COM	G59665102	48,146	3,582,320	SH		DFND	1	133,500	0	3,448,820
MENLO THERAPEUTICS INC	COM	586858102	4,693	1,751,295	SH		SOLE		0	0	1,751,295
MERCK & CO. INC	COM	58933Y105	199,205	2,589,100	SH		DFND	1	382,100	0	2,207,000
MERSANA THERAPEUTICS INC	COM	59045L106	7,851	1,346,721	SH		SOLE		0	0	1,346,721
MIRATI THERAPEUTICS INC	COM	60468T105	109,409	1,423,300	SH		DFND	1	197,700	0	1,225,600
MUSTANG BIO INC	COM	62818Q104	675	251,685	SH		SOLE		251,685	0	0
NABRIVA THERAPEUTICS PLC	SHS	G63637105	2,671	4,644,600	SH		SOLE		4,644,600	0	0
NANOSTRING TECHNOLOGIES INC	COM	63009R109	28,677	1,192,400	SH		DFND	1	156,400	0	1,036,000
NATERA INC	COM	632307104	99,941	3,347,000	SH		DFND	1	989,200	0	2,357,800
NEOLEUKIN THERAPEUTICS INC	COM	64049K104	10,490	921,800	SH		DFND	1	159,000	0	762,800
NEUBASE THERAPEUTICS INC	COM	64132K102	2,642	371,114	SH		DFND	1	37,000	0	334,114
NEUROCRINE BIOSCIENCES INC	COM	64125C109	99,967	1,155,015	SH		DFND	1	137,470	0	1,017,545
NEXTCURE INC	COM	65343E108	100,497	2,711,013	SH		SOLE		2,711,013	0	0
NOVO-NORDISK A S	ADR	670100205	19,866	330,000	SH		SOLE		0	0	330,000
NOVUS THERAPEUTICS INC	COM	67011N105	1,241	3,183,314	SH		SOLE		3,183,314	0	0
OBSEVA SA	COM	H5861P103	6,279	2,605,531	SH		SOLE		2,605,531	0	0
OTONOMY INC	COM	68906L105	142	71,994	SH		SOLE		71,994	0	0
PASSAGE BIO INC	COM	702712100	109,666	6,962,899	SH		DFND	1	5,947,323	0	1,015,576
PFENEX INC	COM	717071104	11,510	1,305,034	SH		DFND	1	131,668	0	1,173,366
PFIZER INC	COM	717081103	98,315	3,012,100	SH		DFND	1	521,900	0	2,490,200
PFIZER INC	COM	717081103	16,320	500,000	SH	Call	DFND	1	159,000	0	341,000
PREVAIL THERAPEUTICS INC	COM	74140Y101	168,496	13,822,463	SH		SOLE		13,822,463	0	0
PROTAGONIST THERAPEUTICS INC	COM	74366E102	472	66,909	SH		SOLE		0	0	66,909
PROTHENA CORP PLC	SHS	G72800108	31,054	2,902,239	SH		DFND	1	613,800	0	2,288,439
PTC THERAPEUTICS INC	COM	69366J200	51,245	1,148,723	SH		DFND	1	184,300	0	964,423
REGENERON PHARMACEUTICALS	COM	75886F107	8,399	17,200	SH		SOLE		0	0	17,200
REGENXBIO INC	COM	75901B107	8,668	267,700	SH		DFND	1	33,200	0	234,500
RESTORBIO INC	COM	76133L103	4,975	4,830,387	SH		SOLE		4,830,387	0	0
REVOLUTION MEDICINES INC	COM	76155X100	6,573	300,000	SH		DFND	1	36,500	0	263,500
SAREPTA THERAPEUTICS INC	COM	803607100	88,278	902,449	SH		DFND	1	148,300	0	754,149
SCPHARMACEUTICALS INC	COM	810648105	25,233	3,409,865	SH		SOLE		3,409,865	0	0
SELECT SECTOR SPDR TR	SBI HEALTHCARE	81369Y209	10,027	113,200	SH		SOLE		113,200	0	0
SELECTA BIOSCIENCES INC	COM	816212104	6,251	2,593,869	SH		SOLE		2,593,869	0	0
SI BONE INC	COM	825704109	16,507	1,381,300	SH		DFND	1	76,000	0	1,305,300
SIERRA ONCOLOGY INC	COM NEW	82640U404	14,507	1,477,320	SH		DFND	1	1,306,860	0	170,460
SINOVAC BIOTECH LTD	SHS	P8696W104	17,151	2,839,500	SH		SOLE		0	0	2,839,500
SPDR S&P 500 ETF TR	TR UNIT	78462F103	15,774	50,000	SH	Put	DFND	1	15,500	0	34,500
SPDR SER TR	S&P BIOTECH	78464A870	9,850	127,200	SH		SOLE		127,200	0	0
SPRINGWORKS THERAPEUTICS INC	COM	85205L107	199,970	7,406,307	SH		SOLE		7,406,307	0	0
STRYKER CORP	COM	863667101	61,784	371,100	SH		DFND	1	63,000	0	308,100
SUTRO BIOPHARMA INC	COM	869367102	1,069	104,800	SH		SOLE		104,800	0	0
SYNDAX PHARMACEUTICALS INC	COM	87164F105	3,181	290,000	SH		DFND	1	212,000	0	78,000
SYNLOGIC INC	COM	87166L100	3,492	2,029,996	SH		SOLE		2,029,996	0	0
TELA BIO INC	COM	872381108	23,675	3,027,542	SH		SOLE		3,027,542	0	0
THERAVANCE BIOPHARMA INC	COM	G8807B106	4,889	211,545	SH		SOLE		0	0	211,545
THERMO FISHER SCIENTIFIC INC	COM	883556102	31,281	110,300	SH		DFND	1	16,800	0	93,500
TRICIDA INC	COM	89610F101	211,514	9,614,280	SH		SOLE		9,614,280	0	0
TRILLIUM THERAPEUTICS INC	COM NEW	89620X506	3,236	801,000	SH		DFND	1	391,800	0	409,200
TURNING POINT THERAPEUTICS I	COM	90041T108	122,606	2,745,327	SH		DFND	1	2,027,550	0	717,777
UNIQURE NV	SHS	N90064101	46,690	983,979	SH		DFND	1	153,000	0	830,979
VERONA PHARMA PLC	SPONSORED ADS	925050106	5,152	1,250,396	SH		SOLE		1,250,396	0	0
VERRICA PHARMACEUTICALS INC	COM	92511W108	16,173	1,479,733	SH		SOLE		1,479,733	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	175,464	737,400	SH		DFND	1	113,100	0	624,300
X4 PHARMACEUTICALS INC	COM	98420X103	10,865	1,086,493	SH		SOLE		1,086,493	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	18,856	1,662,812	SH		DFND	1	732,512	0	930,300
XTANT MED HLDGS INC	COM NEW	98420P308	6,169	9,207,012	SH		SOLE		9,207,012	0	0
ZAFGEN INC	COM	98885E103	852	1,106,529	SH		SOLE		1,106,529	0	0
ZAI LAB LTD	ADR	98887Q104	13,076	254,000	SH		SOLE		254,000	0	0
ZYMEWORKS INC	COM	98985W102	20,654	582,302	SH		DFND	1	15,300	0	567,002