Orbimed Advisors 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
89BIO INC	COM	282559103	95,697	3,729,442	SH		SOLE		3,729,442	0	0
9 METERS BIOPHARMA INC	COM	654405109	20,489	25,716,755	SH		SOLE		25,716,755	0	0
ABBVIE INC	COM	00287Y109	40,642	464,000	SH		DFND	1	65,100	0	398,900
ACADIA HEALTHCARE COMPANY IN	COM	00404A109	32,854	1,114,466	SH		DFND	1	133,000	0	981,466
ACADIA PHARMACEUTICALS INC	COM	004225108	4,414	107,000	SH		SOLE		0	0	107,000
ACCELERON PHARMA INC	COM	00434H108	67,638	601,066	SH		DFND	1	51,300	0	549,766
ACUTUS MED INC	COM	005111109	163,243	5,477,958	SH		SOLE		5,477,958	0	0
ADICET BIO INC	COM	007002108	79,764	6,708,507	SH		SOLE		6,708,507	0	0
ADVERUM BIOTECHNOLOGIES INC	COM	00773U108	47,219	4,584,344	SH		DFND	1	546,597	0	4,037,747
AEGLEA BIOTHERAPEUTICS INC	COM	00773J103	28,470	4,015,524	SH		SOLE		4,015,524	0	0
AERPIO PHARMACEUTICALS INC	COM	00810B105	7,791	5,193,946	SH		SOLE		5,193,946	0	0
AGIOS PHARMACEUTICALS INC	COM	00847X104	77,256	2,207,321	SH		DFND	1	258,200	0	1,949,121
AKOUOS INC	COM	00973J101	7,204	315,000	SH		SOLE		0	0	315,000
ALBIREO PHARMA INC	COM	01345P106	10,958	328,385	SH		DFND	1	56,300	0	272,085
ALCON AG	ORD SHS	H01301128	19,945	351,380	SH		DFND	1	125,800	0	225,580
ALECTOR INC	COM	014442107	28,711	2,725,313	SH		SOLE		2,725,313	0	0
ALEXION PHARMACEUTICALS INC	COM	015351109	249,972	2,184,500	SH		DFND	1	311,300	0	1,873,200
ALEXION PHARMACEUTICALS INC	COM	015351109	14,304	125,000	SH	Call	DFND	1	38,000	0	87,000
ALPINE IMMUNE SCIENCES INC	COM	02083G100	32,268	3,670,955	SH		SOLE		3,670,955	0	0
AMGEN INC	COM	031162100	23,256	91,500	SH		SOLE		0	0	91,500
ANAPTYSBIO INC	COM	032724106	2,662	180,442	SH		DFND	1	17,200	0	163,242
ANNEXON INC	COM	03589W102	11,486	379,947	SH		SOLE		0	0	379,947
APPLIED THERAPEUTICS INC	COM	03828A101	32,109	1,546,687	SH		DFND	1	97,806	0	1,448,881
APTOSE BIOSCIENCES INC	COM NEW	03835T200	5,385	897,541	SH		SOLE		0	0	897,541
ARCTURUS THERAPEUTICS HLDGS	COM	03969T109	26,537	618,586	SH		DFND	1	48,726	0	569,860
ARCUTIS BIOTHERAPEUTICS INC	COM	03969K108	136,944	4,673,850	SH		DFND	1	4,067,564	0	606,286
ARENA PHARMACEUTICALS INC	COM NEW	040047607	4,988	66,700	SH		SOLE		0	0	66,700
ASCENDIS PHARMA A/S	SPONSORED ADR	04351P101	113,348	734,500	SH		DFND	1	459,000	0	275,500
ATHENEX INC	COM	04685N103	48,133	3,977,950	SH		DFND	1	227,400	0	3,750,550
ATRICURE INC	COM	04963C209	49,005	1,228,189	SH		DFND	1	187,000	0	1,041,189
AURINIA PHARMACEUTICALS INC	COM	05156V102	70,026	4,754,000	SH		DFND	1	590,000	0	4,164,000
AVIDITY BIOSCIENCES INC	COM	05370A108	1,798	63,860	SH		SOLE		0	0	63,860
AVROBIO INC	COM	05455M100	10,334	793,712	SH		DFND	1	129,000	0	664,712
BELLUS HEALTH INC NEW	COM NEW	07987C204	11,728	5,137,216	SH		DFND	1	3,954,800	0	1,182,416
BIOGEN INC	COM	09062X103	203,087	715,900	SH		DFND	1	79,200	0	636,700
BIOLINERX LTD	SPONSORED ADS	09071M205	114	69,240	SH		SOLE		69,240	0	0
BIOMX INC	COM	09090D103	14,668	2,313,489	SH		SOLE		2,313,489	0	0
BOSTON SCIENTIFIC CORP	COM	101137107	185,215	4,847,300	SH		DFND	1	939,400	0	3,907,900
BRISTOL-MYERS SQUIBB CO	COM	110122108	213,975	3,549,100	SH		DFND	1	545,300	0	3,003,800
BRISTOL-MYERS SQUIBB CO	RIGHT 99/99/9999	110122157	900	400,000	SH		DFND	1	135,306	0	264,694
BURNING ROCK BIOTECH LTD	SPONSORED ADS	12233L107	119,032	4,746,075	SH		DFND	1	523,599	0	4,222,476
CALLIDITAS THERAPEUTICS AB	SPONSERED ADS	13124Q106	425	17,696	SH		SOLE		0	0	17,696
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	9,269	625,000	SH		DFND	1	84,800	0	540,200
CENTENE CORP DEL	COM	15135B101	77,911	1,335,700	SH		DFND	1	179,300	0	1,156,400
CHANGE HEALTHCARE INC	COM	15912K100	44,890	3,093,700	SH		DFND	1	398,000	0	2,695,700
COMPASS PATHWAYS PLC	SPONSORED ADS	20451W101	12,215	350,000	SH		DFND	1	106,300	0	243,700
CORVUS PHARMACEUTICALS INC	COM	221015100	27,138	6,767,584	SH		SOLE		6,767,584	0	0
CRINETICS PHARMACEUTICALS IN	COM	22663K107	43,148	2,753,567	SH		SOLE		2,753,567	0	0
CRISPR THERAPEUTICS AG	NAMEN AKT	H17182108	52,694	630,004	SH		DFND	1	56,200	0	573,804
CTI BIOPHARMA CORP	COM	12648L601	20,469	9,520,600	SH		SOLE		9,520,600	0	0
CURIS INC	COM NEW	231269200	1,453	1,241,494	SH		SOLE		0	0	1,241,494
DECIPHERA PHARMACEUTICALS IN	COM	24344T101	57,748	1,125,700	SH		DFND	1	190,100	0	935,600
DEXCOM INC	COM	252131107	93,329	226,400	SH		DFND	1	33,500	0	192,900
DYNE THERAPEUTICS INC	COM	26818M108	7,067	350,000	SH		SOLE		0	0	350,000
EDWARDS LIFESCIENCES CORP	COM	28176E108	56,393	706,500	SH		DFND	1	106,500	0	600,000
EHEALTH INC	COM	28238P109	50,446	638,558	SH		DFND	1	86,021	0	552,537
ESSA PHARMA INC	COM NEW	29668H708	8,125	1,177,483	SH		SOLE		1,177,483	0	0
EXELIXIS INC	COM	30161Q104	58,780	2,404,100	SH		DFND	1	288,800	0	2,115,300
FLEXION THERAPEUTICS INC	COM	33938J106	17,530	1,684,000	SH		DFND	1	84,100	0	1,599,900
FLUIDIGM CORP DEL	COM	34385P108	26,404	3,553,703	SH		DFND	1	348,600	0	3,205,103
FORTE BIOSCIENCES INC	COM	34962G109	16,517	340,480	SH		DFND	1	71,789	0	268,691
FUSION PHARMACEUTICALS INC	COM	36118A100	38,762	3,224,770	SH		DFND	1	2,930,670	0	294,100
GILEAD SCIENCES INC	COM	375558103	12,145	192,200	SH		SOLE		0	0	192,200
GRAYBUG VISION INC	COM SHS	38942Q103	56,888	4,475,847	SH		DFND	1	4,163,347	0	312,500
GUARDANT HEALTH INC	COM	40131M109	17,248	154,300	SH		DFND	1	17,300	0	137,000
HARPOON THERAPEUTICS INC	COM	41358P106	31,189	1,835,704	SH		DFND	1	1,020,704	0	815,000
HEALTH CATALYST INC	COM	42225T107	6,573	179,598	SH		SOLE		179,598	0	0
HEALTH SCIENCES ACQ CORP 2	ORD SHS	G4411D109	5,500	500,000	SH		DFND	1	100,000	0	400,000
HERON THERAPEUTICS INC	COM	427746102	17,663	1,191,846	SH		SOLE		0	0	1,191,846
HORIZON THERAPEUTICS PUB L	SHS	G46188101	233,720	3,008,755	SH		DFND	1	357,500	0	2,651,255
HUMANA INC	COM	444859102	116,013	280,300	SH		DFND	1	42,300	0	238,000
I MAB	SPONSORED ADS	44975P103	28,503	606,070	SH		DFND	1	136,360	0	469,710
IMARA INC	COM	45249V107	55,323	2,719,902	SH		DFND	1	2,532,402	0	187,500
INFLARX NV	COM	N44821101	2,891	678,525	SH		DFND	1	122,500	0	556,025
INOZYME PHARMA INC	COM	45790W108	10,527	400,400	SH		SOLE		0	0	400,400
INTUITIVE SURGICAL INC	COM NEW	46120E602	80,036	112,800	SH		DFND	1	18,500	0	94,300
IOVANCE BIOTHERAPEUTICS INC	COM	462260100	218,757	6,645,100	SH		DFND	1	1,337,800	0	5,307,300
IVERIC BIO INC	COM	46583P102	19,243	3,411,806	SH		DFND	1	505,756	0	2,906,050
KALA PHARMACEUTICALS INC	COM	483119103	40,988	5,465,030	SH		DFND	1	4,714,195	0	750,835
KEROS THERAPEUTICS INC	COM	492327101	64,775	1,679,417	SH		DFND	1	1,268,734	0	410,683
KITOV PHARMA LTD	SPONSORD ADS NEW	49803V206	1,527	346,197	SH		SOLE		346,197	0	0
KYMERA THERAPEUTICS INC	COM	501575104	3,231	100,000	SH		SOLE		0	0	100,000
LARIMAR THERAPEUTICS INC	COM	517125100	13,449	886,560	SH		DFND	1	154,237	0	732,323
LOGICBIO THERAPEUTICS INC	COM	54142F102	58,718	6,466,783	SH		SOLE		6,466,783	0	0
MEIRAGTX HLDGS PLC	COM	G59665102	49,171	3,713,820	SH		DFND	1	133,500	0	3,580,320
MERCK & CO. INC	COM	58933Y105	214,766	2,589,100	SH		DFND	1	382,100	0	2,207,000
MERSANA THERAPEUTICS INC	COM	59045L106	24,743	1,328,852	SH		DFND	1	52,550	0	1,276,302
MILESTONE PHARMACEUTICALS IN	COM	59935V107	2,824	385,791	SH		SOLE		0	0	385,791
MIRATI THERAPEUTICS INC	COM	60468T105	218,688	1,317,000	SH		DFND	1	188,400	0	1,128,600
MYOVANT SCIENCES LTD	COM	G637AM102	703	50,000	SH	Call	DFND	1	18,500	0	31,500
MYOVANT SCIENCES LTD	COM	G637AM102	5,121	364,500	SH		DFND	1	59,500	0	305,000
NABRIVA THERAPEUTICS PLC	SHS	G63637105	1,410	2,644,600	SH		SOLE		2,644,600	0	0
NANOSTRING TECHNOLOGIES INC	COM	63009R109	52,885	1,183,100	SH		DFND	1	147,100	0	1,036,000
NATERA INC	COM	632307104	152,477	2,110,700	SH		DFND	1	273,300	0	1,837,400
NEUROCRINE BIOSCIENCES INC	COM	64125C109	125,173	1,301,715	SH		DFND	1	137,470	0	1,164,245
NEXTCURE INC	COM	65343E108	23,857	2,711,013	SH		SOLE		2,711,013	0	0
NOVO-NORDISK A S	ADR	670100205	22,912	330,000	SH		SOLE		0	0	330,000
NOVUS THERAPEUTICS INC	COM	67011N105	54,435	3,183,314	SH		SOLE		3,183,314	0	0
NURIX THERAPEUTICS INC	COM	67080M103	10,473	300,000	SH		SOLE		0	0	300,000
OAK STR HEALTH INC	COM	67181A107	17,870	334,400	SH		DFND	1	35,900	0	298,500
OBSEVA SA	COM	H5861P103	3,231	1,303,000	SH		SOLE		1,303,000	0	0
ORIC PHARMACEUTICALS INC	COM	68622P109	73,078	2,921,967	SH		DFND	1	2,765,717	0	156,250
OTONOMY INC	COM	68906L105	13,163	3,250,000	SH		DFND	1	769,200	0	2,480,800
OUTSET MED INC	COM	690145107	6,250	125,000	SH		DFND	1	16,000	0	109,000
PANDION THERAPEUTICS INC	COM	698340106	16,972	1,480,940	SH		DFND	1	1,040,825	0	440,115
PASSAGE BIO INC	COM	702712100	91,284	6,962,899	SH		DFND	1	5,947,323	0	1,015,576
PFIZER INC	COM	717081103	27,525	750,000	SH	Call	DFND	1	232,500	0	517,500
PMV PHARMACEUTICALS INC	COM	69353Y103	260,230	7,330,423	SH		DFND	1	6,589,330	0	741,093
PRELUDE THERAPEUTICS INC	COM	74065P101	469,874	15,594,877	SH		DFND	1	14,805,377	0	789,500
PREVAIL THERAPEUTICS INC	COM	74140Y101	140,713	13,822,463	SH		SOLE		13,822,463	0	0
PROGYNY INC	COM	74340E103	49,310	1,675,500	SH		DFND	1	189,700	0	1,485,800
PROTARA THERAPEUTICS INC	COM STK	74365U107	7,574	450,000	SH		DFND	1	60,000	0	390,000
PROTHENA CORP PLC	SHS	G72800108	35,409	3,544,475	SH		DFND	1	613,800	0	2,930,675
RELAY THERAPEUTICS INC	COM	75943R102	14,907	350,000	SH		SOLE		0	0	350,000
REPARE THERAPEUTICS INC	COM	760273102	105,428	3,426,325	SH		DFND	1	3,276,325	0	150,000
ROCKET PHARMACEUTICALS INC	COM	77313F106	5,786	253,108	SH		DFND	1	37,430	0	215,678
SAREPTA THERAPEUTICS INC	COM	803607100	75,699	539,049	SH		DFND	1	68,000	0	471,049
SCPHARMACEUTICALS INC	COM	810648105	35,739	4,797,148	SH		SOLE		4,797,148	0	0
SELECTA BIOSCIENCES INC	COM	816212104	5,193	2,093,869	SH		SOLE		2,093,869	0	0
SI BONE INC	COM	825704109	32,461	1,368,500	SH		DFND	1	63,200	0	1,305,300
SIERRA ONCOLOGY INC	COM NEW	82640U404	15,763	1,477,320	SH		DFND	1	1,306,860	0	170,460
SINOVAC BIOTECH LTD	SHS	P8696W104	27,300	2,839,500	SH		SOLE		0	0	2,839,500
SPRINGWORKS THERAPEUTICS INC	COM	85205L107	353,059	7,406,307	SH		SOLE		7,406,307	0	0
STRONGBRIDGE BIOPHARMA PLC	SHS USD	G85347105	7,328	3,489,369	SH		DFND	1	502,500	0	2,986,869
STRYKER CORPORATION	COM	863667101	48,967	235,000	SH		DFND	1	42,200	0	192,800
SYNDAX PHARMACEUTICALS INC	COM	87164F105	16,149	1,094,100	SH		DFND	1	78,600	0	1,015,500
SYNLOGIC INC	COM	87166L100	4,101	2,029,996	SH		SOLE		2,029,996	0	0
TELA BIO INC	COM	872381108	50,076	3,027,542	SH		SOLE		3,027,542	0	0
TEVA PHARMACEUTICAL INDS LTD	SPONSORED ADS	881624209	17,436	1,935,200	SH		DFND	1	269,500	0	1,665,700
THERAVANCE BIOPHARMA INC	COM	G8807B106	91,950	6,219,110	SH		DFND	1	674,898	0	5,544,212
THERMO FISHER SCIENTIFIC INC	COM	883556102	48,700	110,300	SH		DFND	1	16,800	0	93,500
TRICIDA INC	COM	89610F101	87,105	9,614,280	SH		SOLE		9,614,280	0	0
TRILLIUM THERAPEUTICS INC	COM NEW	89620X506	17,799	1,252,600	SH		DFND	1	283,400	0	969,200
TURNING POINT THERAPEUTICS I	COM	90041T108	239,832	2,745,327	SH		DFND	1	2,027,550	0	717,777
UNIQURE NV	SHS	N90064101	35,691	969,079	SH		DFND	1	138,100	0	830,979
VAXCYTE INC	COM	92243G108	31,641	640,760	SH		SOLE		0	0	640,760
VERONA PHARMA PLC	SPONSORED ADS	925050106	35,536	5,694,841	SH		DFND	1	5,028,174	0	666,667
VERRICA PHARMACEUTICALS INC	COM	92511W108	11,453	1,479,733	SH		SOLE		1,479,733	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	181,259	666,100	SH		DFND	1	113,100	0	553,000
X4 PHARMACEUTICALS INC	COM	98420X103	7,356	1,086,493	SH		SOLE		1,086,493	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	27,652	2,497,917	SH		DFND	1	786,612	0	1,711,305
XTANT MED HLDGS INC	COM NEW	98420P308	7,618	9,248,678	SH		SOLE		9,248,678	0	0
ZYMEWORKS INC	COM	98985W102	15,889	341,102	SH		SOLE		0	0	341,102