| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 4D MOLECULAR THERAPEUTICS IN | COM | 35104E100 | 5,181 | 125,000 | SH | | SOLE | | 0 | 0 | 125,000 |
| 89BIO INC | COM | 282559103 | 90,887 | 3,729,442 | SH | | SOLE | | 3,729,442 | 0 | 0 |
| 9 METERS BIOPHARMA INC | COM | 654405109 | 22,091 | 25,716,755 | SH | | SOLE | | 25,716,755 | 0 | 0 |
| 908 DEVICES INC | COM | 65443P102 | 2,278 | 40,000 | SH | | SOLE | | 40,000 | 0 | 0 |
| ABBVIE INC | COM | 00287Y109 | 92,395 | 862,300 | SH | | DFND | 1 | 125,000 | 0 | 737,300 |
| ABCELLERA BIOLOGICS INC | COM | 00288U106 | 338,047 | 8,400,768 | SH | | DFND | 1 | 8,200,768 | 0 | 200,000 |
| ACADIA HEALTHCARE COMPANY IN | COM | 00404A109 | 52,027 | 1,035,160 | SH | | DFND | 1 | 123,500 | 0 | 911,660 |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 | 14,208 | 265,772 | SH | | SOLE | | 0 | 0 | 265,772 |
| ACUTUS MED INC | COM | 005111109 | 157,820 | 5,477,958 | SH | | SOLE | | 5,477,958 | 0 | 0 |
| ADICET BIO INC | COM | 007002108 | 94,255 | 6,708,507 | SH | | SOLE | | 6,708,507 | 0 | 0 |
| ADVERUM BIOTECHNOLOGIES INC | COM | 00773U108 | 59,632 | 5,501,144 | SH | | DFND | 1 | 655,897 | 0 | 4,845,247 |
| AEGLEA BIOTHERAPEUTICS INC | COM | 00773J103 | 31,602 | 4,015,524 | SH | | SOLE | | 4,015,524 | 0 | 0 |
| AERPIO PHARMACEUTICALS INC | COM | 00810B105 | 5,090 | 5,193,946 | SH | | SOLE | | 5,193,946 | 0 | 0 |
| AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 95,643 | 2,207,321 | SH | | DFND | 1 | 258,200 | 0 | 1,949,121 |
| AKOUOS INC | COM | 00973J101 | 6,246 | 315,000 | SH | | SOLE | | 0 | 0 | 315,000 |
| ALCON AG | ORD SHS | H01301128 | 23,357 | 351,380 | SH | | DFND | 1 | 125,800 | 0 | 225,580 |
| ALECTOR INC | COM | 014442107 | 33,602 | 2,225,313 | SH | | SOLE | | 2,225,313 | 0 | 0 |
| ALEXION PHARMACEUTICALS INC | COM | 015351109 | 26,405 | 169,000 | SH | | SOLE | | 0 | 0 | 169,000 |
| ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 38,694 | 3,070,955 | SH | | SOLE | | 3,070,955 | 0 | 0 |
| ALX ONCOLOGY HLDGS INC | COM | 00166B105 | 12,930 | 150,000 | SH | | SOLE | | 0 | 0 | 150,000 |
| AMGEN INC | COM | 031162100 | 21,038 | 91,500 | SH | | SOLE | | 0 | 0 | 91,500 |
| ANTHEM INC | COM | 036752103 | 99,698 | 310,500 | SH | | DFND | 1 | 39,800 | 0 | 270,700 |
| APPLIED THERAPEUTICS INC | COM | 03828A101 | 38,998 | 1,771,831 | SH | | DFND | 1 | 105,006 | 0 | 1,666,825 |
| APTOSE BIOSCIENCES INC | COM NEW | 03835T200 | 35,171 | 8,030,000 | SH | | SOLE | | 0 | 0 | 8,030,000 |
| ARCTURUS THERAPEUTICS HLDGS | COM | 03969T109 | 55,530 | 1,280,086 | SH | | DFND | 1 | 159,626 | 0 | 1,120,460 |
| ARCUTIS BIOTHERAPEUTICS INC | COM | 03969K108 | 170,857 | 6,073,850 | SH | | DFND | 1 | 4,267,564 | 0 | 1,806,286 |
| ASCENDIS PHARMA A/S | SPONSORED ADR | 04351P101 | 56,121 | 336,500 | SH | | DFND | 1 | 61,000 | 0 | 275,500 |
| ATHENEX INC | COM | 04685N103 | 40,856 | 3,694,061 | SH | | DFND | 1 | 211,800 | 0 | 3,482,261 |
| ATRICURE INC | COM | 04963C209 | 68,373 | 1,228,189 | SH | | DFND | 1 | 187,000 | 0 | 1,041,189 |
| AURINIA PHARMACEUTICALS INC | COM | 05156V102 | 65,748 | 4,754,000 | SH | | DFND | 1 | 590,000 | 0 | 4,164,000 |
| AVROBIO INC | COM | 05455M100 | 11,064 | 793,712 | SH | | DFND | 1 | 129,000 | 0 | 664,712 |
| BELLUS HEALTH INC NEW | COM NEW | 07987C204 | 12,573 | 4,189,593 | SH | | DFND | 1 | 3,954,800 | 0 | 234,793 |
| BIOGEN INC | COM | 09062X103 | 129,629 | 529,400 | SH | | DFND | 1 | 59,400 | 0 | 470,000 |
| BIOMX INC | COM | 09090D103 | 14,760 | 2,313,489 | SH | | SOLE | | 2,313,489 | 0 | 0 |
| BOSTON SCIENTIFIC CORP | COM | 101137107 | 234,502 | 6,523,000 | SH | | DFND | 1 | 939,400 | 0 | 5,583,600 |
| BRISTOL-MYERS SQUIBB CO | COM | 110122108 | 220,151 | 3,549,100 | SH | | DFND | 1 | 545,300 | 0 | 3,003,800 |
| BRISTOL-MYERS SQUIBB CO | RIGHT 99/99/9999 | 110122157 | 276 | 400,000 | SH | | DFND | 1 | 135,907 | 0 | 264,093 |
| BURNING ROCK BIOTECH LTD | SPONSORED ADS | 12233L107 | 96,135 | 4,161,675 | SH | | DFND | 1 | 404,099 | 0 | 3,757,576 |
| CALITHERA BIOSCIENCES INC | COM | 13089P101 | 1,229 | 250,300 | SH | Put | DFND | 1 | 91,000 | 0 | 159,300 |
| CENTENE CORP DEL | COM | 15135B101 | 119,682 | 1,993,700 | SH | | DFND | 1 | 277,100 | 0 | 1,716,600 |
| CHANGE HEALTHCARE INC | COM | 15912K100 | 57,698 | 3,093,700 | SH | | DFND | 1 | 398,000 | 0 | 2,695,700 |
| CHINOOK THERAPEUTICS INC | COM | 16961L106 | 19,825 | 1,250,001 | SH | | DFND | 1 | 250,000 | 0 | 1,000,001 |
| COGENT BIOSCIENCES INC | COM | 19240Q201 | 7,356 | 655,000 | SH | | DFND | 1 | 187,350 | 0 | 467,650 |
| COMPASS PATHWAYS PLC | SPONSORED ADS | 20451W101 | 16,674 | 350,000 | SH | | DFND | 1 | 106,300 | 0 | 243,700 |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 24,093 | 6,767,584 | SH | | SOLE | | 6,767,584 | 0 | 0 |
| CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | 38,853 | 2,753,567 | SH | | SOLE | | 2,753,567 | 0 | 0 |
| CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 69,175 | 451,800 | SH | | DFND | 1 | 42,300 | 0 | 409,500 |
| CTI BIOPHARMA CORP | COM | 12648L601 | 30,656 | 9,520,600 | SH | | SOLE | | 9,520,600 | 0 | 0 |
| CURIS INC | COM NEW | 231269200 | 35,762 | 4,366,494 | SH | | DFND | 1 | 195,900 | 0 | 4,170,594 |
| DECIPHERA PHARMACEUTICALS IN | COM | 24344T101 | 64,244 | 1,125,700 | SH | | DFND | 1 | 190,100 | 0 | 935,600 |
| DEXCOM INC | COM | 252131107 | 103,189 | 279,100 | SH | | DFND | 1 | 37,000 | 0 | 242,100 |
| DYNE THERAPEUTICS INC | COM | 26818M108 | 7,350 | 350,000 | SH | | SOLE | | 0 | 0 | 350,000 |
| EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 93,584 | 1,025,800 | SH | | DFND | 1 | 151,600 | 0 | 874,200 |
| EHEALTH INC | COM | 28238P109 | 59,598 | 844,046 | SH | | DFND | 1 | 113,200 | 0 | 730,846 |
| ESSA PHARMA INC | COM NEW | 29668H708 | 5,494 | 460,500 | SH | | SOLE | | 460,500 | 0 | 0 |
| FLEXION THERAPEUTICS INC | COM | 33938J106 | 26,635 | 2,308,083 | SH | | DFND | 1 | 84,100 | 0 | 2,223,983 |
| FLUIDIGM CORP DEL | COM | 34385P108 | 23,354 | 3,892,346 | SH | | DFND | 1 | 393,100 | 0 | 3,499,246 |
| FORTE BIOSCIENCES INC | COM | 34962G109 | 3,357 | 92,200 | SH | | DFND | 1 | 19,439 | 0 | 72,761 |
| FUSION PHARMACEUTICALS INC | COM | 36118A100 | 37,891 | 3,224,770 | SH | | DFND | 1 | 2,930,670 | 0 | 294,100 |
| GALECTO INC | COM | 36322Q107 | 51,178 | 4,090,937 | SH | | DFND | 1 | 3,803,255 | 0 | 287,682 |
| GILEAD SCIENCES INC | COM | 375558103 | 11,198 | 192,200 | SH | | SOLE | | 0 | 0 | 192,200 |
| GRAYBUG VISION INC | COM SHS | 38942Q103 | 129,889 | 4,475,847 | SH | | DFND | 1 | 4,163,347 | 0 | 312,500 |
| GUARDANT HEALTH INC | COM | 40131M109 | 69,363 | 538,200 | SH | | DFND | 1 | 58,100 | 0 | 480,100 |
| HARPOON THERAPEUTICS INC | COM | 41358P106 | 30,491 | 1,835,704 | SH | | DFND | 1 | 1,020,704 | 0 | 815,000 |
| HEALTH CATALYST INC | COM | 42225T107 | 7,818 | 179,598 | SH | | SOLE | | 179,598 | 0 | 0 |
| HEALTH SCIENCES ACQ CORP 2 | ORD SHS | G4411D109 | 6,405 | 500,000 | SH | | DFND | 1 | 100,000 | 0 | 400,000 |
| HERON THERAPEUTICS INC | COM | 427746102 | 25,225 | 1,191,846 | SH | | SOLE | | 0 | 0 | 1,191,846 |
| HORIZON THERAPEUTICS PUB L | SHS | G46188101 | 220,090 | 3,008,755 | SH | | DFND | 1 | 357,500 | 0 | 2,651,255 |
| HUMANA INC | COM | 444859102 | 117,378 | 286,100 | SH | | DFND | 1 | 48,100 | 0 | 238,000 |
| I MAB | SPONSORED ADS | 44975P103 | 28,576 | 606,070 | SH | | DFND | 1 | 136,360 | 0 | 469,710 |
| IMARA INC | COM | 45249V107 | 59,974 | 2,719,902 | SH | | DFND | 1 | 2,532,402 | 0 | 187,500 |
| IMMUNOGEN INC | COM | 45253H101 | 16,473 | 2,553,900 | SH | | DFND | 1 | 322,900 | 0 | 2,231,000 |
| INFLARX NV | COM | N44821101 | 2,797 | 556,025 | SH | | SOLE | | 0 | 0 | 556,025 |
| INOZYME PHARMA INC | COM | 45790W108 | 8,264 | 400,400 | SH | | SOLE | | 0 | 0 | 400,400 |
| INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 92,282 | 112,800 | SH | | DFND | 1 | 18,500 | 0 | 94,300 |
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 308,333 | 6,645,100 | SH | | DFND | 1 | 1,337,800 | 0 | 5,307,300 |
| KALA PHARMACEUTICALS INC | COM | 483119103 | 37,053 | 5,465,030 | SH | | DFND | 1 | 4,714,195 | 0 | 750,835 |
| KEROS THERAPEUTICS INC | COM | 492327101 | 118,466 | 1,679,417 | SH | | DFND | 1 | 1,268,734 | 0 | 410,683 |
| KINNATE BIOPHARMA INC | COM | 49705R105 | 153,071 | 3,847,929 | SH | | DFND | 1 | 3,397,929 | 0 | 450,000 |
| LARIMAR THERAPEUTICS INC | COM | 517125100 | 18,981 | 886,560 | SH | | DFND | 1 | 154,237 | 0 | 732,323 |
| LOGICBIO THERAPEUTICS INC | COM | 54142F102 | 64,602 | 8,466,783 | SH | | DFND | 1 | 7,948,265 | 0 | 518,518 |
| MEIRAGTX HLDGS PLC | COM | G59665102 | 62,118 | 4,102,925 | SH | | DFND | 1 | 133,500 | 0 | 3,969,425 |
| MERCK & CO. INC | COM | 58933Y105 | 217,531 | 2,659,300 | SH | | DFND | 1 | 382,100 | 0 | 2,277,200 |
| MEREO BIOPHARMA GROUP PLC | ADS | 589492107 | 49,463 | 13,816,488 | PRN | | DFND | 1 | 9,210,992 | 0 | 4,605,496 |
| MERSANA THERAPEUTICS INC | COM | 59045L106 | 20,579 | 773,348 | SH | | DFND | 1 | 41,550 | 0 | 731,798 |
| MILESTONE PHARMACEUTICALS IN | COM | 59935V107 | 16,704 | 2,493,109 | SH | | SOLE | | 0 | 0 | 2,493,109 |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 251,554 | 1,145,300 | SH | | DFND | 1 | 170,900 | 0 | 974,400 |
| MOLINA HEALTHCARE INC | COM | 60855R100 | 34,539 | 162,400 | SH | | DFND | 1 | 20,600 | 0 | 141,800 |
| NANOBIOTIX SA | SPONSORED ADS | 63009J107 | 8,250 | 500,000 | SH | | SOLE | | 0 | 0 | 500,000 |
| NANOSTRING TECHNOLOGIES INC | COM | 63009R109 | 108,807 | 1,626,900 | SH | | DFND | 1 | 180,700 | 0 | 1,446,200 |
| NATERA INC | COM | 632307104 | 210,057 | 2,110,700 | SH | | DFND | 1 | 273,300 | 0 | 1,837,400 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 124,769 | 1,301,715 | SH | | DFND | 1 | 137,470 | 0 | 1,164,245 |
| NEXTCURE INC | COM | 65343E108 | 29,550 | 2,711,013 | SH | | SOLE | | 2,711,013 | 0 | 0 |
| NOVUS THERAPEUTICS INC | COM | 67011N204 | 1,105 | 73,650 | SH | | SOLE | | 73,650 | 0 | 0 |
| NURIX THERAPEUTICS INC | COM | 67080M103 | 9,864 | 300,000 | SH | | SOLE | | 0 | 0 | 300,000 |
| OAK STR HEALTH INC | COM | 67181A107 | 27,406 | 448,100 | SH | | DFND | 1 | 54,000 | 0 | 394,100 |
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 | 31,300 | 650,992 | SH | | DFND | 1 | 225,992 | 0 | 425,000 |
| ORIC PHARMACEUTICALS INC | COM | 68622P109 | 98,909 | 2,921,967 | SH | | DFND | 1 | 2,765,717 | 0 | 156,250 |
| OTONOMY INC | COM | 68906L105 | 21,028 | 3,250,000 | SH | | DFND | 1 | 769,200 | 0 | 2,480,800 |
| OUTSET MED INC | COM | 690145107 | 7,105 | 125,000 | SH | | DFND | 1 | 16,000 | 0 | 109,000 |
| PANDION THERAPEUTICS INC | COM | 698340106 | 21,992 | 1,480,940 | SH | | DFND | 1 | 1,040,825 | 0 | 440,115 |
| PASSAGE BIO INC | COM | 702712100 | 178,041 | 6,962,899 | SH | | DFND | 1 | 5,947,323 | 0 | 1,015,576 |
| PFIZER INC | COM | 717081103 | 133,127 | 3,616,600 | SH | | DFND | 1 | 501,700 | 0 | 3,114,900 |
| PMV PHARMACEUTICALS INC | COM | 69353Y103 | 450,894 | 7,330,423 | SH | | DFND | 1 | 6,589,330 | 0 | 741,093 |
| PRAXIS PRECISION MEDICINES I | COM | 74006W108 | 14,063 | 255,600 | SH | | SOLE | | 0 | 0 | 255,600 |
| PRELUDE THERAPEUTICS INC | COM | 74065P101 | 1,115,813 | 15,594,877 | SH | | DFND | 1 | 14,805,377 | 0 | 789,500 |
| PREVAIL THERAPEUTICS INC | COM | 74140Y101 | 318,884 | 13,822,463 | SH | | SOLE | | 13,822,463 | 0 | 0 |
| PROGYNY INC | COM | 74340E103 | 71,024 | 1,675,500 | SH | | DFND | 1 | 189,700 | 0 | 1,485,800 |
| PROTARA THERAPEUTICS INC | COM STK | 74365U107 | 10,895 | 450,000 | SH | | DFND | 1 | 60,000 | 0 | 390,000 |
| PROTHENA CORP PLC | SHS | G72800108 | 21,587 | 1,797,458 | SH | | DFND | 1 | 312,000 | 0 | 1,485,458 |
| PULMONX CORP | COM | 745848101 | 8,628 | 125,000 | SH | | SOLE | | 0 | 0 | 125,000 |
| PURPLE BIOTECH LTD | SPONSORED ADS | 74638P109 | 1,319 | 346,197 | SH | | SOLE | | 346,197 | 0 | 0 |
| RELAY THERAPEUTICS INC | COM | 75943R102 | 14,546 | 350,000 | SH | | SOLE | | 0 | 0 | 350,000 |
| REPARE THERAPEUTICS INC | COM | 760273102 | 117,523 | 3,426,325 | SH | | DFND | 1 | 3,276,325 | 0 | 150,000 |
| SAREPTA THERAPEUTICS INC | COM | 803607100 | 91,902 | 539,049 | SH | | DFND | 1 | 68,000 | 0 | 471,049 |
| SAREPTA THERAPEUTICS INC | COM | 803607100 | 8,525 | 50,000 | SH | Call | DFND | 1 | 15,000 | 0 | 35,000 |
| SCPHARMACEUTICALS INC | COM | 810648105 | 25,377 | 4,797,148 | SH | | SOLE | | 4,797,148 | 0 | 0 |
| SELECTA BIOSCIENCES INC | COM | 816212104 | 1,634 | 539,169 | SH | | SOLE | | 539,169 | 0 | 0 |
| SI BONE INC | COM | 825704109 | 40,918 | 1,368,500 | SH | | DFND | 1 | 63,200 | 0 | 1,305,300 |
| SIERRA ONCOLOGY INC | COM NEW | 82640U404 | 23,681 | 1,477,320 | SH | | DFND | 1 | 1,306,860 | 0 | 170,460 |
| SILVERBACK THERAPEUTICS INC | COM | 82835W108 | 405,053 | 8,740,887 | SH | | DFND | 1 | 7,788,510 | 0 | 952,377 |
| SINOVAC BIOTECH LTD | SHS | P8696W104 | 72,000 | 2,839,500 | SH | | SOLE | | 0 | 0 | 2,839,500 |
| SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 537,105 | 7,406,307 | SH | | SOLE | | 7,406,307 | 0 | 0 |
| STRONGBRIDGE BIOPHARMA PLC | SHS USD | G85347105 | 8,479 | 3,489,369 | SH | | DFND | 1 | 502,500 | 0 | 2,986,869 |
| STRYKER CORPORATION | COM | 863667101 | 57,584 | 235,000 | SH | | DFND | 1 | 42,200 | 0 | 192,800 |
| SUTRO BIOPHARMA INC | COM | 869367102 | 7,599 | 350,000 | SH | | SOLE | | 0 | 0 | 350,000 |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 26,041 | 1,170,900 | SH | | DFND | 1 | 85,800 | 0 | 1,085,100 |
| SYNLOGIC INC | COM | 87166L100 | 4,385 | 2,029,996 | SH | | SOLE | | 2,029,996 | 0 | 0 |
| SYROS PHARMACEUTICALS INC | COM | 87184Q107 | 16,953 | 1,562,500 | SH | | SOLE | | 0 | 0 | 1,562,500 |
| TCR2 THERAPEUTICS INC | COM | 87808K106 | 7,710 | 249,279 | SH | | SOLE | | 0 | 0 | 249,279 |
| TELA BIO INC | COM | 872381108 | 45,534 | 3,027,542 | SH | | SOLE | | 3,027,542 | 0 | 0 |
| TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADS | 881624209 | 18,675 | 1,935,200 | SH | | DFND | 1 | 269,500 | 0 | 1,665,700 |
| THERAVANCE BIOPHARMA INC | COM | G8807B106 | 110,514 | 6,219,110 | SH | | DFND | 1 | 674,898 | 0 | 5,544,212 |
| THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 51,376 | 110,300 | SH | | DFND | 1 | 16,800 | 0 | 93,500 |
| TRICIDA INC | COM | 89610F101 | 67,781 | 9,614,280 | SH | | SOLE | | 9,614,280 | 0 | 0 |
| TRILLIUM THERAPEUTICS INC | COM NEW | 89620X506 | 43,545 | 2,960,200 | SH | | DFND | 1 | 206,900 | 0 | 2,753,300 |
| TURNING POINT THERAPEUTICS I | COM | 90041T108 | 334,518 | 2,745,327 | SH | | DFND | 1 | 2,027,550 | 0 | 717,777 |
| UNIQURE NV | SHS | N90064101 | 35,013 | 969,079 | SH | | DFND | 1 | 138,100 | 0 | 830,979 |
| UNITEDHEALTH GROUP INC | COM | 91324P102 | 136,870 | 390,300 | SH | | DFND | 1 | 56,500 | 0 | 333,800 |
| VAXCYTE INC | COM | 92243G108 | 16,746 | 630,260 | SH | | SOLE | | 0 | 0 | 630,260 |
| VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 39,864 | 5,694,841 | SH | | DFND | 1 | 5,028,174 | 0 | 666,667 |
| VERRICA PHARMACEUTICALS INC | COM | 92511W108 | 17,032 | 1,479,733 | SH | | SOLE | | 1,479,733 | 0 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 197,131 | 834,100 | SH | | DFND | 1 | 134,300 | 0 | 699,800 |
| VIATRIS INC | COM | 92556V106 | 10,029 | 535,149 | SH | | DFND | 1 | 69,607 | 0 | 465,542 |
| VISTAGEN THERAPEUTICS INC | COM NEW | 92840H202 | 14,550 | 7,500,000 | SH | | DFND | 1 | 1,875,000 | 0 | 5,625,000 |
| X4 PHARMACEUTICALS INC | COM | 98420X103 | 6,986 | 1,086,493 | SH | | SOLE | | 1,086,493 | 0 | 0 |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 38,418 | 2,497,917 | SH | | DFND | 1 | 786,612 | 0 | 1,711,305 |
| XTANT MED HLDGS INC | COM NEW | 98420P308 | 87,080 | 72,803,072 | SH | | SOLE | | 72,803,072 | 0 | 0 |
| ZYMEWORKS INC | COM | 98985W102 | 14,982 | 317,002 | SH | | SOLE | | 0 | 0 | 317,002 |
