Orbimed Advisors 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
89BIO INC	COM	282559103	73,060	3,729,442	SH		SOLE		3,729,442	0	0
9 METERS BIOPHARMA INC	COM	654405109	11,136	8,565,974	SH		SOLE		8,565,974	0	0
AADI BIOSCIENCES INC	COM	00032Q104	10,170	346,262	SH		SOLE		346,262	0	0
ABBVIE INC	COM	00287Y109	153,240	1,420,600	SH		DFND		228,100	0	1,192,500
ABCELLERA BIOLOGICS INC	COM	00288U106	83,783	4,180,768	SH		SOLE		4,180,768	0	0
ACHILLES THERAPEUTICS PLC	SPONSORED ADS	00449L102	12,346	1,584,845	SH		DFND		178,735	0	1,406,110
ACLARIS THERAPEUTICS INC	COM	00461U105	11,732	651,783	SH		SOLE		0	0	651,783
ACUTUS MED INC	COM	005111109	23,412	2,648,386	SH		SOLE		2,648,386	0	0
ADAGENE INC	ADS	005329107	3,950	275,000	SH		SOLE		275,000	0	0
ADAGIO THERAPEUTICS INC	COM	00534A102	227,399	5,383,500	SH		SOLE		5,383,500	0	0
ADICET BIO INC	COM	007002108	56,706	7,232,856	SH		SOLE		7,232,856	0	0
AEGLEA BIOTHERAPEUTICS INC	COM	00773J103	31,923	4,015,524	SH		SOLE		4,015,524	0	0
AEROVATE THERAPEUTICS INC	COM	008064107	11,239	535,714	SH		DFND		107,114	0	428,600
ALPINE IMMUNE SCIENCES INC	COM	02083G100	43,551	4,081,592	SH		SOLE		4,081,592	0	0
ALX ONCOLOGY HLDGS INC	COM	00166B105	11,079	150,000	SH		SOLE		0	0	150,000
AMGEN INC	COM	031162100	12,142	57,100	SH		SOLE		0	0	57,100
ANTHEM INC	COM	036752103	77,207	207,100	SH		DFND		29,600	0	177,500
APPLIED THERAPEUTICS INC	COM	03828A101	37,473	2,257,387	SH		DFND		156,706	0	2,100,681
APTINYX INC	COM	03836N103	359	153,285	SH		SOLE		153,285	0	0
APTOSE BIOSCIENCES INC	COM NEW	03835T200	5,656	2,594,348	SH		SOLE		0	0	2,594,348
ARCUTIS BIOTHERAPEUTICS INC	COM	03969K108	145,104	6,073,850	SH		DFND		4,267,564	0	1,806,286
ASLAN PHARMACEUTICALS LTD	ADS	04522R101	3,507	1,970,000	SH		SOLE		0	0	1,970,000
ASTRAZENECA PLC	SPONSORED ADR	046353108	312	5,200	SH	Call	DFND		2,200	0	3,000
BELLUS HEALTH INC NEW	COM NEW	07987C204	14,960	2,454,800	SH		SOLE		2,454,800	0	0
BIOGEN INC	COM	09062X103	66,276	234,200	SH		DFND		17,300	0	216,900
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	8,571	110,900	SH		SOLE		0	0	110,900
BIOMX INC	COM	09090D103	8,609	2,813,489	SH		SOLE		2,813,489	0	0
BOSTON SCIENTIFIC CORP	COM	101137107	253,120	5,833,600	SH		DFND		827,400	0	5,006,200
BRISTOL-MYERS SQUIBB CO	COM	110122108	267,176	4,515,400	SH		DFND		569,100	0	3,946,300
BURNING ROCK BIOTECH LTD	SPONSORED ADS	12233L107	33,189	1,856,201	SH		DFND		197,799	0	1,658,402
CABALETTA BIO INC	COM	12674W109	3,679	302,509	SH		SOLE		0	0	302,509
CATALYST BIOSCIENCES INC	COM NEW	14888D208	11,145	2,711,600	SH		DFND		593,000	0	2,118,600
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	22,368	414,300	SH		DFND		57,800	0	356,500
CENTURY THERAPEUTICS INC	COM	15673T100	10,241	407,047	SH		DFND		115,414	0	291,633
CHEMOMAB THERAPEUTICS LTD	SPONSORED ADS	16385C104	28,566	2,578,174	SH		SOLE		2,578,174	0	0
CHINOOK THERAPEUTICS INC	COM	16961L106	18,127	1,420,637	SH		DFND		420,636	0	1,000,001
CONVEY HLDG PARENT INC	COM	21258C108	8,400	1,000,000	SH		DFND		107,000	0	893,000
CORVUS PHARMACEUTICALS INC	COM	221015100	33,607	6,943,654	SH		SOLE		6,943,654	0	0
CRINETICS PHARMACEUTICALS IN	COM	22663K107	63,084	2,996,876	SH		SOLE		2,996,876	0	0
CRISPR THERAPEUTICS AG	NAMEN AKT	H17182108	68,580	612,700	SH		DFND		47,500	0	565,200
CTI BIOPHARMA CORP	COM	12648L601	22,186	7,520,600	SH		SOLE		7,520,600	0	0
CULLINAN ONCOLOGY INC	COM	230031106	25,868	1,146,145	SH		DFND		959,245	0	186,900
CURIS INC	COM NEW	231269200	27,573	3,521,400	SH		DFND		371,600	0	3,149,800
CVRX INC	COM	126638105	13,230	799,861	SH		DFND		148,300	0	651,561
CYBIN INC	COM	23256X100	29,463	13,447,121	SH		SOLE		0	0	13,447,121
CYTEK BIOSCIENCES INC	COM	23285D109	41,174	1,923,139	SH		DFND		961,569	0	961,570
CYTOMX THERAPEUTICS INC	COM	23284F105	9,273	1,821,868	SH		DFND		729,668	0	1,092,200
DECIBEL THERAPEUTICS INC	COM	24343R106	38,127	4,945,192	SH		DFND		4,061,774	0	883,418
DECIPHERA PHARMACEUTICALS IN	COM	24344T101	74,183	2,183,143	SH		DFND		294,600	0	1,888,543
DEXCOM INC	COM	252131107	124,684	228,000	SH		DFND		23,600	0	204,400
DICE THERAPEUTICS INC	COM	23345J104	14,410	440,000	SH		DFND		176,000	0	264,000
EDGEWISE THERAPEUTICS INC	COM	28036F105	231,482	13,944,680	SH		DFND		13,679,055	0	265,625
EDWARDS LIFESCIENCES CORP	COM	28176E108	127,520	1,126,400	SH		DFND		151,600	0	974,800
ERASCA INC	COM	29479A108	45,991	2,167,341	SH		SOLE		0	0	2,167,341
EVOLENT HEALTH INC	CL A	30050B101	10,695	345,000	SH		SOLE		0	0	345,000
EVOLENT HEALTH INC	CL A	30050B101	7,750	250,000	SH	Call	DFND		105,000	0	145,000
FIELD TRIP HEALTH LTD	COM	31656R102	6,996	1,538,470	SH		SOLE		0	0	1,538,470
FLEXION THERAPEUTICS INC	COM	33938J106	16,893	2,769,383	SH		DFND		301,600	0	2,467,783
FLUIDIGM CORP DEL	COM	34385P108	30,311	4,599,571	SH		DFND		484,800	0	4,114,771
FUSION PHARMACEUTICALS INC	COM	36118A100	25,540	3,224,770	SH		DFND		2,930,670	0	294,100
GALAPAGOS NV	SPON ADR	36315X101	38,061	723,457	SH		DFND		100,900	0	622,557
GALECTO INC	COM	36322Q107	14,686	4,090,937	SH		DFND		3,803,255	0	287,682
GEMINI THERAPEUTICS INC	COM	36870G105	23,538	5,826,224	SH		SOLE		5,826,224	0	0
GH RESEARCH PLC	ORDINARY SHARES	G3855L106	31,516	1,428,666	SH		DFND		125,000	0	1,303,666
GILEAD SCIENCES INC	COM	375558103	20,089	287,600	SH		SOLE		0	0	287,600
GRACELL BIOTECHNOLOGIES INC	SPONSORED ADS	38406L103	109,363	7,884,870	SH		DFND		5,970,672	0	1,914,198
GRAPHITE BIO INC	COM	38870X104	23,764	1,449,904	SH		DFND		314,092	0	1,135,812
GRAYBUG VISION INC	COM SHS	38942Q103	13,822	4,163,347	SH		SOLE		4,163,347	0	0
GUARDANT HEALTH INC	COM	40131M109	153,437	1,227,400	SH		DFND		108,700	0	1,118,700
HARPOON THERAPEUTICS INC	COM	41358P106	20,629	2,611,308	SH		DFND		943,408	0	1,667,900
HCA HEALTHCARE INC	COM	40412C101	47,039	193,800	SH		DFND		20,200	0	173,600
HEALTH SCIENCES ACQ CORP 2	ORD SHS	G4411D109	4,945	500,000	SH		DFND		100,000	0	400,000
HORIZON THERAPEUTICS PUB L	SHS	G46188101	285,938	2,610,355	SH		DFND		306,300	0	2,304,055
HUMACYTE INC	COM	44486Q103	17,415	1,500,000	SH		DFND		300,000	0	1,200,000
HUMANA INC	COM	444859102	130,365	335,000	SH		DFND		55,000	0	280,000
I MAB	SPONSORED ADS	44975P103	8,055	111,120	SH		DFND		25,000	0	86,120
IKENA ONCOLOGY INC	COM	45175G108	37,026	2,933,941	SH		DFND		1,936,886	0	997,055
IKENA ONCOLOGY INC	NONVOTING	000000000	78,439	6,215,466	SH		DFND		5,586,311	0	629,155
IMARA INC	COM	45249V107	17,897	4,386,568	SH		DFND		4,199,068	0	187,500
IMMUNOGEN INC	COM	45253H101	84,471	14,897,914	SH		DFND		1,852,600	0	13,045,314
INFLARX NV	COM	N44821101	2,756	1,064,118	SH		SOLE		0	0	1,064,118
INOZYME PHARMA INC	COM	45790W108	3,407	294,000	SH		SOLE		294,000	0	0
INTELLIA THERAPEUTICS INC	COM	45826J105	7,137	53,200	SH		SOLE		0	0	53,200
INTUITIVE SURGICAL INC	COM NEW	46120E602	138,783	139,600	SH		DFND		20,800	0	118,800
IOVANCE BIOTHERAPEUTICS INC	COM	462260100	163,868	6,645,100	SH		DFND		1,337,800	0	5,307,300
JANUX THERAPEUTICS INC	COM	47103J105	74,978	3,466,386	SH		DFND		3,042,764	0	423,622
JOUNCE THERAPEUTICS INC	COM	481116101	19,731	2,655,600	SH		DFND		659,700	0	1,995,900
KALA PHARMACEUTICALS INC	COM	483119103	9,010	3,438,998	SH		DFND		2,966,523	0	472,475
KEROS THERAPEUTICS INC	COM	492327101	66,438	1,679,417	SH		DFND		1,268,734	0	410,683
KEZAR LIFE SCIENCES INC	COM	49372L100	9,936	1,150,000	SH		SOLE		1,150,000	0	0
KEZAR LIFE SCIENCES INC	COM	49372L100	980	113,400	SH	Call	DFND		47,000	0	66,400
KINNATE BIOPHARMA INC	COM	49705R105	88,579	3,847,929	SH		DFND		3,397,929	0	450,000
LANDOS BIOPHARMA INC	COM	515069102	4,135	283,217	SH		SOLE		0	0	283,217
LOGICBIO THERAPEUTICS INC	COM	54142F102	38,778	8,466,783	SH		DFND		7,948,265	0	518,518
LONGBOARD PHARMACEUTICALS IN	COM	54300N103	1,004	113,500	SH		SOLE		0	0	113,500
MAGENTA THERAPEUTICS INC	COM	55910K108	13,781	1,892,953	SH		DFND		185,000	0	1,707,953
MEIRAGTX HLDGS PLC	COM	G59665102	54,077	4,102,925	SH		DFND		133,500	0	3,969,425
MERCK & CO INC	COM	58933Y105	280,341	3,732,400	SH		DFND		465,000	0	3,267,400
MEREO BIOPHARMA GROUP PLC	ADS	589492107	41,781	17,264,764	SH		DFND		9,210,992	0	8,053,772
MERSANA THERAPEUTICS INC	COM	59045L106	27,242	2,888,847	SH		DFND		464,000	0	2,424,847
MILESTONE PHARMACEUTICALS IN	COM	59935V107	14,754	2,583,821	SH		SOLE		0	0	2,583,821
MIRATI THERAPEUTICS INC	COM	60468T105	242,933	1,373,200	SH		DFND		222,700	0	1,150,500
NANOBIOTIX SA	SPONSORED ADS	63009J107	5,680	500,000	SH		SOLE		0	0	500,000
NANOSTRING TECHNOLOGIES INC	COM	63009R109	26,694	556,000	SH		DFND		62,900	0	493,100
NANOSTRING TECHNOLOGIES INC	NOTE 2.625% 3/0	63009RAD1	7,855	6,000,000	PRN		SOLE		0	0	6,000,000
NATERA INC	COM	632307104	175,273	1,572,800	SH		DFND		191,900	0	1,380,900
NAUTILUS BIOTECHNOLOGY INC	COM	63909J108	8,920	1,452,774	SH		DFND		353,674	0	1,099,100
NEUROCRINE BIOSCIENCES INC	COM	64125C109	114,326	1,192,015	SH		DFND		137,470	0	1,054,545
NEUROPACE INC	COM	641288105	63,595	4,012,281	SH		SOLE		4,012,281	0	0
NEXTCURE INC	COM	65343E108	18,272	2,711,013	SH		SOLE		2,711,013	0	0
NOVAVAX INC	COM NEW	670002401	9,449	45,580	SH		SOLE		0	0	45,580
NURIX THERAPEUTICS INC	COM	67080M103	17,334	578,583	SH		DFND		73,400	0	505,183
OAK STR HEALTH INC	COM	67181A107	56,493	1,328,300	SH		DFND		136,700	0	1,191,600
OLEMA PHARMACEUTICALS INC	COM	68062P106	22,263	807,792	SH		DFND		282,392	0	525,400
ONCOCYTE CORP	COM	68235C107	10,167	2,856,000	SH		DFND		551,000	0	2,305,000
ORIC PHARMACEUTICALS INC	COM	68622P109	48,879	2,337,574	SH		DFND		2,212,571	0	125,003
OWLET INC	*W EXP 09/14/202	69120X115	207	220,704	SH	Call	DFND		82,544	0	138,160
OWLET INC	COM CL A	69120X107	6,708	1,200,000	SH		DFND		200,000	0	1,000,000
PASSAGE BIO INC	COM	702712100	69,350	6,962,899	SH		DFND		5,947,323	0	1,015,576
PHASEBIO PHARMACEUTICALS INC	COM	717224109	551	177,113	SH		SOLE		177,113	0	0
PMV PHARMACEUTICALS INC	COM	69353Y103	218,447	7,330,423	SH		DFND		6,589,330	0	741,093
PRELUDE THERAPEUTICS INC	COM	74065P101	313,740	10,039,691	SH		DFND		9,250,191	0	789,500
PRELUDE THERAPEUTICS INC	NONVOTING	000000000	177,506	5,680,186	SH		DFND		5,596,886	0	83,300
PROCEPT BIOROBOTICS CORP	COM	74276L105	5,150	135,000	SH		DFND		39,700	0	95,300
PROGYNY INC	COM	74340E103	71,123	1,270,045	SH		DFND		151,085	0	1,118,960
PROMETHEUS BIOSCIENCES INC	COM	74349U108	5,928	250,000	SH		SOLE		0	0	250,000
PROTARA THERAPEUTICS INC	COM STK	74365U107	3,114	450,000	SH		DFND		60,000	0	390,000
PULMONX CORP	COM	745848101	15,651	435,000	SH		DFND		83,600	0	351,400
REGENERON PHARMACEUTICALS	COM	75886F107	8,206	13,560	SH		DFND		1,860	0	11,700
REPARE THERAPEUTICS INC	COM	760273102	87,182	3,322,488	SH		DFND		3,177,041	0	145,447
REPLIGEN CORP	COM	759916109	4,255	14,724	SH		SOLE		14,724	0	0
RXSIGHT INC	COM	78349D107	15,838	1,250,000	SH		DFND		187,500	0	1,062,500
SAREPTA THERAPEUTICS INC	COM	803607100	5,983	64,700	SH		SOLE		64,700	0	0
SCPHARMACEUTICALS INC	COM	810648105	31,901	4,797,148	SH		SOLE		4,797,148	0	0
SEAGEN INC	COM	81181C104	45,506	268,000	SH		DFND		24,000	0	244,000
SELECT MED HLDGS CORP	COM	81619Q105	45,976	1,271,100	SH		DFND		135,900	0	1,135,200
SI-BONE INC	COM	825704109	48,152	2,248,000	SH		SOLE		0	0	2,248,000
SIERRA ONCOLOGY INC	COM NEW	82640U404	32,383	1,477,320	SH		DFND		1,306,860	0	170,460
SIGHT SCIENCES INC	COM	82657M105	4,540	200,000	SH		SOLE		0	0	200,000
SILVERBACK THERAPEUTICS INC	COM	82835W108	87,234	8,740,887	SH		DFND		7,788,510	0	952,377
SINGULAR GENOMICS SYSTEMS IN	COM	82933R100	22,363	1,998,521	SH		DFND		683,626	0	1,314,895
SINOVAC BIOTECH LTD	SHS	P8696W104	78,400	2,839,500	SH		SOLE		0	0	2,839,500
SPDR SER TR	S&P BIOTECH	78464A870	133,969	1,065,700	SH		DFND		167,800	0	897,900
SPRINGWORKS THERAPEUTICS INC	COM	85205L107	382,436	6,028,307	SH		SOLE		6,028,307	0	0
STRONGBRIDGE BIOPHARMA PLC	SHS USD	G85347105	1,621	794,675	SH		DFND		114,300	0	680,375
STRYKER CORPORATION	COM	863667101	88,979	337,400	SH		DFND		53,200	0	284,200
SURFACE ONCOLOGY INC	COM	86877M209	6,886	909,666	SH		DFND		188,546	0	721,120
SYNDAX PHARMACEUTICALS INC	COM	87164F105	3,642	190,600	SH		SOLE		0	0	190,600
SYNLOGIC INC	COM	87166L100	18,391	6,029,995	SH		SOLE		6,029,995	0	0
SYROS PHARMACEUTICALS INC	COM	87184Q107	8,214	1,837,500	SH		SOLE		0	0	1,837,500
TALARIS THERAPEUTICS INC	COM	87410C104	3,353	247,240	SH		SOLE		0	0	247,240
TELA BIO INC	COM	872381108	41,356	3,027,542	SH		SOLE		3,027,542	0	0
TENET HEALTHCARE CORP	COM NEW	88033G407	20,709	311,700	SH		DFND		44,200	0	267,500
TERNS PHARMACEUTICALS INC	COM	880881107	39,504	3,791,204	SH		SOLE		3,791,204	0	0
THERAVANCE BIOPHARMA INC	COM	G8807B106	43,624	5,895,159	SH		DFND		558,385	0	5,336,774
THERMO FISHER SCIENTIFIC INC	COM	883556102	63,018	110,300	SH		DFND		16,800	0	93,500
TRICIDA INC	COM	89610F101	44,610	9,614,280	SH		SOLE		9,614,280	0	0
TURNING POINT THERAPEUTICS I	COM	90041T108	156,863	2,361,327	SH		DFND		1,743,950	0	617,377
UNIQURE NV	SHS	N90064101	18,744	585,574	SH		DFND		94,400	0	491,174
UNITEDHEALTH GROUP INC	COM	91324P102	152,271	389,700	SH		DFND		56,500	0	333,200
VAXCYTE INC	COM	92243G108	26,249	1,034,665	SH		SOLE		0	0	1,034,665
VECTIVBIO HLDG AG	ORD SHS	H9060V101	39,578	5,123,304	SH		DFND		4,830,004	0	293,300
VERONA PHARMA PLC	SPONSORED ADS	925050106	31,208	5,694,841	SH		DFND		5,028,174	0	666,667
VERRICA PHARMACEUTICALS INC	COM	92511W108	18,497	1,479,733	SH		SOLE		1,479,733	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	159,152	877,400	SH		DFND		89,500	0	787,900
VISTAGEN THERAPEUTICS INC	COM NEW	92840H202	35,371	12,909,283	SH		DFND		2,390,043	0	10,519,240
VOR BIOPHARMA INC	COM	929033108	13,067	833,333	SH		SOLE		0	0	833,333
WM TECHNOLOGY INC	*W EXP 06/16/202	92971A117	649	150,200	SH	Call	SOLE		0	0	150,200
WM TECHNOLOGY INC	COM	92971A109	10,156	700,400	SH		SOLE		0	0	700,400
X4 PHARMACEUTICALS INC	COM	98420X103	7,268	1,373,849	SH		SOLE		1,373,849	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	7,289	477,000	SH		DFND		250,000	0	227,000
XTANT MED HLDGS INC	COM NEW	98420P308	80,890	72,873,494	SH		SOLE		72,873,494	0	0
ZIMMER BIOMET HOLDINGS INC	COM	98956P102	96,715	660,800	SH		DFND		68,400	0	592,400