Orbimed Advisors 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
89BIO INC	COM	282559103	11,782	3,658,869	SH		SOLE		3,658,869	0	0
9 METERS BIOPHARMA INC	COM	654405109	2,218	8,505,729	SH		SOLE		8,505,729	0	0
ABBVIE INC	COM	00287Y109	122,497	799,800	SH		DFND		28,000	0	771,800
ABCELLERA BIOLOGICS INC	COM	00288U106	44,525	4,180,768	SH		SOLE		4,180,768	0	0
ABCELLERA BIOLOGICS INC	COM	00288U106	2,663	250,000	SH	Call	DFND		69,000	0	181,000
ACHILLES THERAPEUTICS PLC	SPONSORED ADS	00449L102	3,994	1,584,845	SH		DFND		178,735	0	1,406,110
ACLARIS THERAPEUTICS INC	COM	00461U105	32,464	2,325,500	SH		DFND		420,400	0	1,905,100
ACUTUS MED INC	COM	005111109	2,966	2,648,386	SH		SOLE		2,648,386	0	0
ADAGIO THERAPEUTICS INC	COM	00534A102	16,584	5,056,000	SH		SOLE		5,056,000	0	0
ADICET BIO INC	COM	007002108	108,728	7,447,141	SH		SOLE		7,447,141	0	0
AEGLEA BIOTHERAPEUTICS INC	COM	00773J103	908	1,797,221	SH		SOLE		1,797,221	0	0
AEROVATE THERAPEUTICS INC	COM	008064107	7,480	478,579	SH		DFND		124,779	0	353,800
ALPINE IMMUNE SCIENCES INC	COM	02083G100	34,734	4,081,592	SH		SOLE		4,081,592	0	0
ALX ONCOLOGY HLDGS INC	COM	00166B105	17,687	2,186,269	SH		DFND		448,700	0	1,737,569
AMGEN INC	COM	031162100	13,892	57,100	SH		SOLE		0	0	57,100
APPLIED THERAPEUTICS INC	COM	03828A101	4,030	4,250,000	SH		SOLE		4,250,000	0	0
APTINYX INC	COM	03836N103	300	538,500	SH		SOLE		538,500	0	0
ARCUTIS BIOTHERAPEUTICS INC	COM	03969K108	101,897	4,781,646	SH		DFND		3,534,537	0	1,247,109
ARGENX SE	SPONSORED ADR	04016X101	73,503	194,000	SH		SOLE		0	0	194,000
BELLUS HEALTH INC NEW	COM NEW	07987C204	13,391	1,454,800	SH		SOLE		1,454,800	0	0
BIOGEN INC	COM	09062X103	22,760	111,600	SH		DFND		7,000	0	104,600
BIOHAVEN PHARMACTL HLDG CO L	COM	G11196105	104,770	719,034	SH		SOLE		719,034	0	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	140,855	1,699,710	SH		DFND		155,200	0	1,544,510
BIOMX INC	COM	09090D103	2,054	2,813,489	SH		SOLE		2,813,489	0	0
BOSTON SCIENTIFIC CORP	COM	101137107	162,851	4,369,500	SH		DFND		250,000	0	4,119,500
BRIDGEBIO PHARMA INC	NOTE 2.250% 2/0	10806XAD4	12,150	30,000,000	PRN		SOLE		30,000,000	0	0
BRIDGEBIO PHARMA INC	NOTE 2.500% 3/1	10806XAB8	9,000	20,000,000	PRN		SOLE		20,000,000	0	0
BRISTOL-MYERS SQUIBB CO	COM	110122108	193,940	2,518,700	SH		DFND		97,000	0	2,421,700
BURNING ROCK BIOTECH LTD	SPONSORED ADS	12233L107	4,044	1,389,802	SH		DFND		63,078	0	1,326,724
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	3,038	112,700	SH		DFND		12,700	0	100,000
CHEMOMAB THERAPEUTICS LTD	SPONSORED ADS	16385C104	9,539	2,578,174	SH		SOLE		2,578,174	0	0
CHINOOK THERAPEUTICS INC	COM	16961L106	33,166	1,896,300	SH		DFND		478,300	0	1,418,000
COMPASS THERAPEUTICS INC	COM	20454B104	58,196	21,960,850	SH		DFND		18,389,422	0	3,571,428
CORVUS PHARMACEUTICALS INC	COM	221015100	6,875	6,943,654	SH		SOLE		6,943,654	0	0
CRINETICS PHARMACEUTICALS IN	COM	22663K107	59,622	3,196,876	SH		SOLE		3,196,876	0	0
CULLINAN ONCOLOGY INC	COM	230031106	8,599	670,787	SH		SOLE		670,787	0	0
CYBIN INC	COM	23256X100	5,886	10,524,300	SH		SOLE		0	0	10,524,300
CYTOMX THERAPEUTICS INC	COM	23284F105	3,889	2,124,975	SH		DFND		544,559	0	1,580,416
DANAHER CORPORATION	5% CONV PFD B	235851409	10,637	8,039	PRN		SOLE		0	0	8,039
DECIBEL THERAPEUTICS INC	COM	24343R106	20,819	4,945,192	SH		DFND		4,061,774	0	883,418
EDGEWISE THERAPEUTICS INC	COM	28036F105	112,098	14,082,680	SH		DFND		13,817,055	0	265,625
EDWARDS LIFESCIENCES CORP	COM	28176E108	96,165	1,011,300	SH		DFND		45,000	0	966,300
ERASCA INC	COM	29479A108	9,289	1,667,693	SH		SOLE		0	0	1,667,693
EVOLENT HEALTH INC	CL A	30050B101	54,602	1,778,000	SH		SOLE		0	0	1,778,000
EYEPOINT PHARMACEUTICALS INC	COM NEW	30233G209	1,685	214,100	SH		SOLE		0	0	214,100
FUSION PHARMACEUTICALS INC	COM	36118A100	8,030	3,224,770	SH		DFND		2,930,670	0	294,100
GALECTO INC	COM	36322Q107	7,077	4,090,937	SH		DFND		3,803,255	0	287,682
GEMINI THERAPEUTICS INC	COM	36870G105	9,846	5,826,224	SH		SOLE		5,826,224	0	0
GH RESEARCH PLC	ORDINARY SHARES	G3855L106	16,188	1,622,060	SH		DFND		239,100	0	1,382,960
GILEAD SCIENCES INC	COM	375558103	17,777	287,600	SH		SOLE		0	0	287,600
GLOBAL BLOOD THERAPEUTICS IN	COM	37890U108	65,306	2,044,000	SH		DFND		185,000	0	1,859,000
GRACELL BIOTECHNOLOGIES INC	SPONSORED ADS	38406L103	43,367	7,884,870	SH		DFND		5,970,672	0	1,914,198
GRAPHITE BIO INC	COM	38870X104	2,333	848,412	SH		SOLE		0	0	848,412
GRAYBUG VISION INC	COM SHS	38942Q103	4,538	4,163,347	SH		SOLE		4,163,347	0	0
GUARDANT HEALTH INC	COM	40131M109	2,017	50,000	SH	Call	DFND		13,500	0	36,500
GUARDANT HEALTH INC	COM	40131M109	41,687	1,033,400	SH		DFND		41,000	0	992,400
HARPOON THERAPEUTICS INC	COM	41358P106	5,805	3,039,508	SH		DFND		1,371,608	0	1,667,900
HORIZON THERAPEUTICS PUB L	SHS	G46188101	168,178	2,108,555	SH		DFND		97,000	0	2,011,555
HUMANA INC	COM	444859102	171,173	365,700	SH		DFND		17,000	0	348,700
IKENA ONCOLOGY INC	COM	45175G108	12,997	2,933,941	SH		DFND		1,936,886	0	997,055
IKENA ONCOLOGY INC	NONVOTING	000000000	28,652	6,467,691	SH		DFND		5,838,536	0	629,155
IMARA INC	COM	45249V107	5,352	4,386,568	SH		DFND		4,199,068	0	187,500
IMMUNOCORE HLDGS PLC	ADS	45258D105	4,891	131,100	SH		SOLE		131,100	0	0
INTUITIVE SURGICAL INC	COM NEW	46120E602	103,807	517,200	SH		DFND		19,000	0	498,200
IONIS PHARMACEUTICALS INC	COM	462222100	16,785	453,400	SH		SOLE		0	0	453,400
IOVANCE BIOTHERAPEUTICS INC	COM	462260100	30,895	2,798,441	SH		DFND		400,000	0	2,398,441
IVERIC BIO INC	COM	46583P102	13,097	1,361,400	SH		DFND		164,000	0	1,197,400
JANUX THERAPEUTICS INC	COM	47103J105	34,632	2,836,386	SH		DFND		2,489,664	0	346,722
JOUNCE THERAPEUTICS INC	COM	481116101	8,875	2,928,900	SH		DFND		728,700	0	2,200,200
KALVISTA PHARMACEUTICALS INC	COM	483497103	1,824	185,400	SH		SOLE		0	0	185,400
KEROS THERAPEUTICS INC	COM	492327101	46,402	1,679,417	SH		DFND		1,268,734	0	410,683
KEZAR LIFE SCIENCES INC	COM	49372L100	11,743	1,419,900	SH		DFND		391,200	0	1,028,700
KINNATE BIOPHARMA INC	COM	49705R105	50,990	4,043,629	SH		DFND		3,593,629	0	450,000
LOGICBIO THERAPEUTICS INC	COM	54142F102	2,967	8,466,783	SH		DFND		7,948,265	0	518,518
LONGBOARD PHARMACEUTICALS IN	COM	54300N103	351	113,500	SH		SOLE		0	0	113,500
MAGENTA THERAPEUTICS INC	COM	55910K108	2,701	2,250,953	SH		DFND		543,000	0	1,707,953
MEIRAGTX HLDGS PLC	COM	G59665102	18,937	2,501,618	SH		DFND		103,100	0	2,398,518
MEREO BIOPHARMA GROUP PLC	ADS	589492107	7,963	7,109,954	PRN		DFND		4,739,969	0	2,369,985
MEREO BIOPHARMA GROUP PLC	ADS	589492107	2,914	2,601,468	SH		DFND		441,174	0	2,160,294
MERSANA THERAPEUTICS INC	COM	59045L106	41,633	9,011,437	SH		DFND		1,928,600	0	7,082,837
MILESTONE PHARMACEUTICALS IN	COM	59935V107	11,178	1,817,521	SH		SOLE		0	0	1,817,521
MIRATI THERAPEUTICS INC	COM	60468T105	73,199	1,090,400	SH		DFND		139,800	0	950,600
MIRUM PHARMACEUTICALS INC	COM	604749101	5,439	279,500	SH		SOLE		279,500	0	0
NANOSTRING TECHNOLOGIES INC	NOTE 2.625% 3/0	63009RAD1	4,851	6,000,000	PRN		SOLE		0	0	6,000,000
NATERA INC	COM	632307104	5,316	150,000	SH	Call	DFND		72,500	0	77,500
NATERA INC	COM	632307104	58,878	1,661,353	SH		DFND		102,700	0	1,558,653
NEUROCRINE BIOSCIENCES INC	COM	64125C109	82,814	849,545	SH		DFND		27,000	0	822,545
NEUROPACE INC	COM	641288105	19,861	4,012,281	SH		SOLE		4,012,281	0	0
NEXTCURE INC	COM	65343E108	12,742	2,711,013	SH		SOLE		2,711,013	0	0
NOVAVAX INC	COM NEW	670002401	3,857	75,000	SH	Call	DFND		21,000	0	54,000
ONCOCYTE CORP	COM	68235C107	2,553	2,837,800	SH		DFND		710,700	0	2,127,100
ORIC PHARMACEUTICALS INC	COM	68622P109	9,352	2,087,568	SH		SOLE		2,087,568	0	0
PASSAGE BIO INC	COM	702712100	21,080	8,931,999	SH		DFND		6,841,423	0	2,090,576
PFIZER INC	COM	717081103	143,868	2,744,000	SH		DFND		145,000	0	2,599,000
PMV PHARMACEUTICALS INC	COM	69353Y103	93,524	6,563,077	SH		SOLE		6,563,077	0	0
PRELUDE THERAPEUTICS INC	COM	74065P101	52,407	10,039,691	SH		DFND		9,250,191	0	789,500
PRELUDE THERAPEUTICS INC	NONVOTING	000000000	29,651	5,680,186	SH		DFND		5,596,886	0	83,300
PROGYNY INC	COM	74340E103	18,156	625,000	SH		SOLE		0	0	625,000
PROTARA THERAPEUTICS INC	COM STK	74365U107	2,434	830,641	SH		DFND		158,900	0	671,741
PULMONX CORP	COM	745848101	6,403	435,000	SH		DFND		83,600	0	351,400
RAPT THERAPEUTICS INC	COM	75382E109	15,812	866,396	SH		DFND		231,800	0	634,596
REGENERON PHARMACEUTICALS	COM	75886F107	13,123	22,200	SH		SOLE		0	0	22,200
REPARE THERAPEUTICS INC	COM	760273102	46,482	3,322,488	SH		DFND		3,177,041	0	145,447
RXSIGHT INC	COM	78349D107	19,480	1,383,500	SH		DFND		321,000	0	1,062,500
SAREPTA THERAPEUTICS INC	COM	803607100	1,499	20,000	SH		SOLE		20,000	0	0
SCHOLAR ROCK HLDG CORP	COM	80706P103	5,910	1,076,540	SH		DFND		294,400	0	782,140
SCPHARMACEUTICALS INC	COM	810648105	23,122	4,797,148	SH		SOLE		4,797,148	0	0
SEAGEN INC	COM	81181C104	121,646	687,500	SH		DFND		61,700	0	625,800
SEAGEN INC	COM	81181C104	8,847	50,000	SH	Call	DFND		14,000	0	36,000
SI-BONE INC	COM	825704109	44,458	3,368,000	SH		DFND		166,900	0	3,201,100
SIERRA ONCOLOGY INC	COM NEW	82640U404	108,043	1,964,770	SH		DFND		1,738,066	0	226,704
SIGHT SCIENCES INC	COM	82657M105	1,798	200,000	SH		SOLE		0	0	200,000
SIGNIFY HEALTH INC	CL A COM	82671G100	12,420	900,000	SH		SOLE		0	0	900,000
SILVERBACK THERAPEUTICS INC	COM	82835W108	37,061	8,740,887	SH		DFND		7,788,510	0	952,377
SINGULAR GENOMICS SYSTEMS IN	COM	82933R100	2,065	540,697	SH		SOLE		540,697	0	0
SINOVAC BIOTECH LTD	SHS	P8696W104	349,500	2,718,735	SH		SOLE		0	0	2,718,735
SONENDO INC	COM	835431107	1,244	723,478	SH		SOLE		723,478	0	0
SPDR SER TR	S&P BIOTECH	78464A870	8,303	111,800	SH		SOLE		111,800	0	0
SPRINGWORKS THERAPEUTICS INC	COM	85205L107	148,417	6,028,307	SH		SOLE		6,028,307	0	0
STRYKER CORPORATION	COM	863667101	87,748	441,100	SH		DFND		18,000	0	423,100
SYNDAX PHARMACEUTICALS INC	COM	87164F105	44,700	2,323,300	SH		DFND		552,000	0	1,771,300
SYNLOGIC INC	COM	87166L100	6,934	6,029,995	SH		SOLE		6,029,995	0	0
TALARIS THERAPEUTICS INC	COM	87410C104	1,064	235,995	SH		SOLE		0	0	235,995
TELA BIO INC	COM	872381108	21,223	3,027,542	SH		SOLE		3,027,542	0	0
TENET HEALTHCARE CORP	COM NEW	88033G407	34,495	656,300	SH		DFND		13,000	0	643,300
TERNS PHARMACEUTICALS INC	COM	880881107	9,402	3,791,204	SH		SOLE		3,791,204	0	0
THERAVANCE BIOPHARMA INC	COM	G8807B106	12,414	1,370,250	SH		SOLE		0	0	1,370,250
THERMO FISHER SCIENTIFIC INC	COM	883556102	61,608	113,400	SH		DFND		5,000	0	108,400
THESEUS PHARMACEUTICALS INC	COM	88369M101	94,240	17,041,668	SH		SOLE		17,041,668	0	0
TRAVERE THERAPEUTICS INC	COM	89422G107	18,710	772,200	SH		DFND		138,200	0	634,000
TRICIDA INC	COM	89610F101	99,520	10,280,947	SH		SOLE		10,280,947	0	0
TURNING POINT THERAPEUTICS I	COM	90041T108	151,422	2,012,250	SH		DFND		1,548,350	0	463,900
UNIQURE NV	SHS	N90064101	16,307	874,849	SH		DFND		50,000	0	824,849
UNITEDHEALTH GROUP INC	COM	91324P102	144,433	281,200	SH		DFND		14,000	0	267,200
VAXCYTE INC	COM	92243G108	32,937	1,513,659	SH		DFND		207,945	0	1,305,714
VECTIVBIO HLDG AG	ORD SHS	H9060V101	34,957	6,473,561	SH		DFND		6,180,261	0	293,300
VENTYX BIOSCIENCES INC	COM	92332V107	15,768	1,289,280	SH		SOLE		1,289,280	0	0
VERONA PHARMA PLC	SPONSORED ADS	925050106	23,861	5,694,841	SH		DFND		5,028,174	0	666,667
VERTEX PHARMACEUTICALS INC	COM	92532F100	109,109	387,200	SH		DFND		14,000	0	373,200
VIGIL NEUROSCIENCE INC	COM	92673K108	1,061	411,191	SH		SOLE		411,191	0	0
VISTAGEN THERAPEUTICS INC	COM NEW	92840H202	11,811	13,421,283	SH		DFND		2,902,043	0	10,519,240
VOR BIOPHARMA INC	COM	929033108	4,142	833,333	SH		SOLE		0	0	833,333
X4 PHARMACEUTICALS INC	COM	98420X103	1,326	1,373,849	SH		SOLE		1,373,849	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	40,434	1,329,200	SH		DFND		218,200	0	1,111,000
XTANT MED HLDGS INC	COM NEW	98420P308	37,894	72,943,918	SH		SOLE		72,943,918	0	0