The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
2SEVENTY BIO INC | COMMON STOCK | 901384107 | 15,151 | 1,041,300 | SH | DFND | 337,000 | 0 | 704,300 | ||
89BIO INC | COM | 282559103 | 21,185 | 3,658,869 | SH | SOLE | 3,658,869 | 0 | 0 | ||
ABBVIE INC | COM | 00287Y109 | 80,526 | 600,000 | SH | SOLE | 0 | 0 | 600,000 | ||
ABCELLERA BIOLOGICS INC | COM | 00288U106 | 41,348 | 4,180,768 | SH | SOLE | 4,180,768 | 0 | 0 | ||
ACHILLES THERAPEUTICS PLC | SPONSORED ADS | 00449L102 | 3,307 | 1,463,251 | SH | DFND | 165,001 | 0 | 1,298,250 | ||
ACLARIS THERAPEUTICS INC | COM | 00461U105 | 43,418 | 2,758,434 | SH | DFND | 488,400 | 0 | 2,270,034 | ||
ACUTUS MED INC | COM | 005111109 | 2,331 | 2,648,386 | SH | SOLE | 2,648,386 | 0 | 0 | ||
ADICET BIO INC | COM | 007002108 | 105,898 | 7,447,140 | SH | SOLE | 7,447,140 | 0 | 0 | ||
AEGLEA BIOTHERAPEUTICS INC | COM | 00773J103 | 945 | 1,797,221 | SH | SOLE | 1,797,221 | 0 | 0 | ||
AEROVATE THERAPEUTICS INC | COM | 008064107 | 13,181 | 795,000 | SH | DFND | 227,000 | 0 | 568,000 | ||
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 50,140 | 250,500 | SH | DFND | 23,000 | 0 | 227,500 | ||
ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 29,387 | 4,081,592 | SH | SOLE | 4,081,592 | 0 | 0 | ||
ALX ONCOLOGY HLDGS INC | COM | 00166B105 | 27,475 | 2,871,000 | SH | DFND | 605,000 | 0 | 2,266,000 | ||
AMNEAL PHARMACEUTICALS INC | COM STK CL A | 03168L105 | 3,199 | 1,583,490 | SH | DFND | 471,800 | 0 | 1,111,690 | ||
APPLIED THERAPEUTICS INC | COM | 03828A101 | 3,953 | 4,250,000 | SH | SOLE | 4,250,000 | 0 | 0 | ||
ARCUS BIOSCIENCES INC | COM | 03969F109 | 7,926 | 303,000 | SH | DFND | 152,000 | 0 | 151,000 | ||
ARCUTIS BIOTHERAPEUTICS INC | COM | 03969K108 | 53,508 | 2,800,000 | SH | SOLE | 2,800,000 | 0 | 0 | ||
ARGENX SE | SPONSORED ADR | 04016X101 | 95,218 | 269,700 | SH | DFND | 10,200 | 0 | 259,500 | ||
BELLUS HEALTH INC NEW | COM NEW | 07987C204 | 48,971 | 4,634,900 | SH | DFND | 2,139,400 | 0 | 2,495,500 | ||
BIOGEN INC | COM | 09062X103 | 59,968 | 224,600 | SH | DFND | 37,000 | 0 | 187,600 | ||
BIOHAVEN PHARMACTL HLDG CO L | COM | G11196105 | 25,815 | 170,769 | SH | SOLE | 170,769 | 0 | 0 | ||
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 145,576 | 1,717,310 | SH | DFND | 122,200 | 0 | 1,595,110 | ||
BIOMX INC | COM | 09090D103 | 957 | 2,813,489 | SH | SOLE | 2,813,489 | 0 | 0 | ||
BOLT BIOTHERAPEUTICS INC | COM | 097702104 | 1,141 | 771,059 | SH | SOLE | 771,059 | 0 | 0 | ||
BOSTON SCIENTIFIC CORP | COM | 101137107 | 150,977 | 3,898,200 | SH | SOLE | 0 | 0 | 3,898,200 | ||
BRIDGEBIO PHARMA INC | NOTE 2.500% 3/1 | 10806XAB8 | 11,760 | 20,000,000 | PRN | SOLE | 20,000,000 | 0 | 0 | ||
BRIDGEBIO PHARMA INC | NOTE 2.250% 2/0 | 10806XAD4 | 12,509 | 30,000,000 | PRN | SOLE | 30,000,000 | 0 | 0 | ||
BRISTOL-MYERS SQUIBB CO | COM | 110122108 | 183,761 | 2,584,900 | SH | SOLE | 0 | 0 | 2,584,900 | ||
BURNING ROCK BIOTECH LTD | SPONSORED ADS | 12233L107 | 3,066 | 1,282,816 | SH | DFND | 58,222 | 0 | 1,224,594 | ||
CHEMOMAB THERAPEUTICS LTD | SPONSORED ADS | 16385C104 | 6,420 | 2,578,174 | SH | SOLE | 2,578,174 | 0 | 0 | ||
CHINOOK THERAPEUTICS INC | COM | 16961L106 | 39,896 | 2,029,300 | SH | DFND | 478,300 | 0 | 1,551,000 | ||
CINCOR PHARMA INC | COM | 17240Y109 | 10,312 | 314,202 | SH | DFND | 93,700 | 0 | 220,502 | ||
COMPASS THERAPEUTICS INC | COM | 20454B104 | 50,071 | 21,960,850 | SH | DFND | 18,389,422 | 0 | 3,571,428 | ||
CORVUS PHARMACEUTICALS INC | COM | 221015100 | 5,683 | 6,943,654 | SH | SOLE | 6,943,654 | 0 | 0 | ||
CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | 62,787 | 3,196,876 | SH | SOLE | 3,196,876 | 0 | 0 | ||
CULLINAN ONCOLOGY INC | COM | 230031106 | 8,170 | 637,287 | SH | SOLE | 637,287 | 0 | 0 | ||
CYBIN INC | COM | 23256X100 | 5,082 | 10,453,600 | SH | SOLE | 0 | 0 | 10,453,600 | ||
DECIBEL THERAPEUTICS INC | COM | 24343R106 | 17,110 | 4,945,192 | SH | DFND | 4,061,774 | 0 | 883,418 | ||
DYNE THERAPEUTICS INC | COM | 26818M108 | 2,799 | 220,400 | SH | SOLE | 0 | 0 | 220,400 | ||
EDGEWISE THERAPEUTICS INC | COM | 28036F105 | 143,341 | 14,567,176 | SH | DFND | 14,301,551 | 0 | 265,625 | ||
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 79,845 | 966,300 | SH | SOLE | 0 | 0 | 966,300 | ||
ESSA PHARMA INC | COM NEW | 29668H708 | 1,166 | 640,645 | SH | SOLE | 640,645 | 0 | 0 | ||
EVOLENT HEALTH INC | CL A | 30050B101 | 71,670 | 1,994,717 | SH | SOLE | 0 | 0 | 1,994,717 | ||
EYEPOINT PHARMACEUTICALS INC | COM NEW | 30233G209 | 7,680 | 970,860 | SH | DFND | 232,000 | 0 | 738,860 | ||
FUSION PHARMACEUTICALS INC | COM | 36118A100 | 9,707 | 3,224,770 | SH | DFND | 2,930,670 | 0 | 294,100 | ||
GALECTO INC | COM | 36322Q107 | 7,732 | 4,090,937 | SH | DFND | 3,803,255 | 0 | 287,682 | ||
GEMINI THERAPEUTICS INC | COM | 36870G105 | 9,555 | 5,826,223 | SH | SOLE | 5,826,223 | 0 | 0 | ||
GH RESEARCH PLC | ORDINARY SHARES | G3855L106 | 18,848 | 1,622,060 | SH | DFND | 239,100 | 0 | 1,382,960 | ||
GRACELL BIOTECHNOLOGIES INC | SPONSORED ADS | 38406L103 | 25,389 | 7,884,870 | SH | DFND | 5,970,672 | 0 | 1,914,198 | ||
GRAPHITE BIO INC | COM | 38870X104 | 2,689 | 848,412 | SH | SOLE | 0 | 0 | 848,412 | ||
GRAYBUG VISION INC | COMMON | 38942Q103 | 3,915 | 4,163,347 | SH | SOLE | 4,163,347 | 0 | 0 | ||
GUARDANT HEALTH INC | COM | 40131M109 | 53,421 | 992,400 | SH | SOLE | 0 | 0 | 992,400 | ||
HARPOON THERAPEUTICS INC | COM | 41358P106 | 2,935 | 3,025,908 | SH | DFND | 1,368,808 | 0 | 1,657,100 | ||
HERON THERAPEUTICS INC | COM | 427746102 | 4,739 | 1,123,000 | SH | SOLE | 0 | 0 | 1,123,000 | ||
HUMANA INC | COM | 444859102 | 169,186 | 348,700 | SH | SOLE | 0 | 0 | 348,700 | ||
IKENA ONCOLOGY INC | COM | 45175G108 | 10,415 | 2,933,941 | SH | DFND | 1,936,886 | 0 | 997,055 | ||
IKENA ONCOLOGY INC | NONVOTING | 000000000 | 22,960 | 6,467,691 | SH | DFND | 5,838,536 | 0 | 629,155 | ||
IMARA INC | COM | 45249V107 | 10,001 | 4,386,568 | SH | DFND | 4,199,068 | 0 | 187,500 | ||
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 107,347 | 572,700 | SH | SOLE | 0 | 0 | 572,700 | ||
INVIVYD INC | COM | 00534A102 | 16,496 | 5,270,400 | SH | SOLE | 5,270,400 | 0 | 0 | ||
IONIS PHARMACEUTICALS INC | COM | 462222100 | 34,008 | 768,900 | SH | SOLE | 0 | 0 | 768,900 | ||
IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 19,231 | 2,007,458 | SH | SOLE | 0 | 0 | 2,007,458 | ||
JANUX THERAPEUTICS INC | COM | 47103J105 | 38,405 | 2,836,386 | SH | DFND | 2,489,664 | 0 | 346,722 | ||
JOUNCE THERAPEUTICS INC | COM | 481116101 | 6,854 | 2,928,900 | SH | DFND | 728,700 | 0 | 2,200,200 | ||
KALVISTA PHARMACEUTICALS INC | COM | 483497103 | 15,119 | 1,042,000 | SH | DFND | 243,000 | 0 | 799,000 | ||
KEROS THERAPEUTICS INC | COM | 492327101 | 63,180 | 1,679,417 | SH | DFND | 1,268,734 | 0 | 410,683 | ||
KEZAR LIFE SCIENCES INC | COM | 49372L100 | 15,254 | 1,771,700 | SH | DFND | 452,000 | 0 | 1,319,700 | ||
KINNATE BIOPHARMA INC | COM | 49705R105 | 48,321 | 4,043,629 | SH | DFND | 3,593,629 | 0 | 450,000 | ||
LILLY ELI & CO | COM | 532457108 | 4,850 | 15,000 | SH | Call | DFND | 4,500 | 0 | 10,500 | |
LOGICBIO THERAPEUTICS INC | COM | 54142F102 | 2,307 | 8,466,783 | SH | DFND | 7,948,265 | 0 | 518,518 | ||
LONGBOARD PHARMACEUTICALS IN | COM | 54300N103 | 422 | 113,500 | SH | SOLE | 0 | 0 | 113,500 | ||
MAGENTA THERAPEUTICS INC | COM | 55910K108 | 3,174 | 2,250,953 | SH | DFND | 543,000 | 0 | 1,707,953 | ||
MEIRAGTX HLDGS PLC | COM | G59665102 | 17,729 | 2,108,143 | SH | DFND | 87,800 | 0 | 2,020,343 | ||
MEREO BIOPHARMA GROUP PLC | SPON ADS | 589492107 | 9,132 | 10,605,522 | SH | DFND | 5,777,210 | 0 | 4,828,312 | ||
MERSANA THERAPEUTICS INC | COM | 59045L106 | 60,917 | 9,011,437 | SH | DFND | 1,928,600 | 0 | 7,082,837 | ||
MIRATI THERAPEUTICS INC | COM | 60468T105 | 99,095 | 1,418,892 | SH | DFND | 131,500 | 0 | 1,287,392 | ||
MIRUM PHARMACEUTICALS INC | COM | 604749101 | 10,965 | 521,891 | SH | DFND | 279,500 | 0 | 242,391 | ||
MONTE ROSA THERAPEUTICS INC | COM | 61225M102 | 960 | 117,455 | SH | SOLE | 0 | 0 | 117,455 | ||
NATERA INC | COM | 632307104 | 65,956 | 1,505,153 | SH | DFND | 15,400 | 0 | 1,489,753 | ||
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 95,222 | 896,545 | SH | SOLE | 0 | 0 | 896,545 | ||
NEUROPACE INC | COM | 641288105 | 15,046 | 4,012,281 | SH | SOLE | 4,012,281 | 0 | 0 | ||
NEXTCURE INC | COM | 65343E108 | 7,455 | 2,711,013 | SH | SOLE | 2,711,013 | 0 | 0 | ||
ONCOCYTE CORP | COM | 68235C107 | 1,374 | 1,882,768 | SH | DFND | 438,600 | 0 | 1,444,168 | ||
ORIC PHARMACEUTICALS INC | COM | 68622P109 | 6,680 | 2,087,568 | SH | SOLE | 2,087,568 | 0 | 0 | ||
PASSAGE BIO INC | COM | 702712100 | 11,165 | 8,931,999 | SH | DFND | 6,841,423 | 0 | 2,090,576 | ||
PFIZER INC | COM | 717081103 | 113,732 | 2,599,000 | SH | SOLE | 0 | 0 | 2,599,000 | ||
PMV PHARMACEUTICALS INC | COM | 69353Y103 | 78,101 | 6,563,077 | SH | SOLE | 6,563,077 | 0 | 0 | ||
PRELUDE THERAPEUTICS INC | COM | 74065P101 | 66,362 | 10,039,691 | SH | DFND | 9,250,191 | 0 | 789,500 | ||
PRELUDE THERAPEUTICS INC | NONVOTING | 000000000 | 37,546 | 5,680,186 | SH | DFND | 5,596,886 | 0 | 83,300 | ||
PROGYNY INC | COM | 74340E103 | 42,028 | 1,134,053 | SH | SOLE | 0 | 0 | 1,134,053 | ||
PROTARA THERAPEUTICS INC | COM STK | 74365U107 | 2,459 | 830,641 | SH | DFND | 158,900 | 0 | 671,741 | ||
PULMONX CORP | COM | 745848101 | 7,247 | 435,000 | SH | DFND | 83,600 | 0 | 351,400 | ||
PYXIS ONCOLOGY INC | COMMON STOCK | 747324101 | 1,671 | 848,252 | SH | SOLE | 0 | 0 | 848,252 | ||
RAPT THERAPEUTICS INC | COM | 75382E109 | 30,101 | 1,251,070 | SH | DFND | 310,400 | 0 | 940,670 | ||
REPARE THERAPEUTICS INC | COM | 760273102 | 40,302 | 3,322,488 | SH | DFND | 3,177,041 | 0 | 145,447 | ||
RXSIGHT INC | COM | 78349D107 | 14,434 | 1,202,833 | SH | DFND | 279,100 | 0 | 923,733 | ||
SAREPTA THERAPEUTICS INC | COM | 803607100 | 101,531 | 918,500 | SH | DFND | 43,000 | 0 | 875,500 | ||
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 4,629 | 667,943 | SH | DFND | 267,689 | 0 | 400,254 | ||
SCPHARMACEUTICALS INC | COM | 810648105 | 31,277 | 4,797,148 | SH | SOLE | 4,797,148 | 0 | 0 | ||
SEAGEN INC | COM | 81181C104 | 3,421 | 25,000 | SH | Call | DFND | 8,000 | 0 | 17,000 | |
SEAGEN INC | COM | 81181C104 | 104,347 | 762,600 | SH | DFND | 59,800 | 0 | 702,800 | ||
SI-BONE INC | COM | 825704109 | 58,805 | 3,368,000 | SH | DFND | 166,900 | 0 | 3,201,100 | ||
SILVERBACK THERAPEUTICS INC | COM | 82835W108 | 46,152 | 8,740,887 | SH | DFND | 7,788,510 | 0 | 952,377 | ||
SINGULAR GENOMICS SYSTEMS IN | COM | 82933R100 | 1,352 | 540,697 | SH | SOLE | 540,697 | 0 | 0 | ||
SINOVAC BIOTECH LTD | SHS | P8696W104 | 340,500 | 2,718,735 | SH | SOLE | 0 | 0 | 2,718,735 | ||
SPDR SER TR | S&P BIOTECH | 78464A870 | 6,060 | 76,400 | SH | DFND | 24,000 | 0 | 52,400 | ||
SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 157,655 | 5,525,926 | SH | SOLE | 5,525,926 | 0 | 0 | ||
STRYKER CORPORATION | COM | 863667101 | 85,695 | 423,100 | SH | SOLE | 0 | 0 | 423,100 | ||
SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 48,216 | 2,006,500 | SH | DFND | 444,000 | 0 | 1,562,500 | ||
SYNLOGIC INC | COM | 87166L100 | 5,728 | 6,029,995 | SH | SOLE | 6,029,995 | 0 | 0 | ||
TELA BIO INC | COM | 872381108 | 25,795 | 3,027,542 | SH | SOLE | 3,027,542 | 0 | 0 | ||
TENET HEALTHCARE CORP | COM NEW | 88033G407 | 33,181 | 643,300 | SH | SOLE | 0 | 0 | 643,300 | ||
TERNS PHARMACEUTICALS INC | COM | 880881107 | 44,064 | 7,481,204 | SH | SOLE | 7,481,204 | 0 | 0 | ||
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 102,554 | 202,200 | SH | SOLE | 0 | 0 | 202,200 | ||
THESEUS PHARMACEUTICALS INC | COM | 88369M101 | 98,842 | 17,041,668 | SH | SOLE | 17,041,668 | 0 | 0 | ||
THIRD HARMONIC BIO INC | COM | 88427A107 | 109,629 | 5,779,071 | SH | SOLE | 5,779,071 | 0 | 0 | ||
TRAVERE THERAPEUTICS INC | COM | 89422G107 | 30,877 | 1,253,130 | SH | DFND | 267,700 | 0 | 985,430 | ||
TRICIDA INC | COM | 89610F101 | 107,744 | 10,280,947 | SH | SOLE | 10,280,947 | 0 | 0 | ||
UNIQURE NV | SHS | N90064101 | 29,960 | 1,597,000 | SH | SOLE | 0 | 0 | 1,597,000 | ||
UNITEDHEALTH GROUP INC | COM | 91324P102 | 134,947 | 267,200 | SH | SOLE | 0 | 0 | 267,200 | ||
VAXCYTE INC | COM | 92243G108 | 6,000 | 250,000 | SH | Call | DFND | 76,000 | 0 | 174,000 | |
VAXCYTE INC | COM | 92243G108 | 17,230 | 717,900 | SH | DFND | 161,000 | 0 | 556,900 | ||
VECTIVBIO HLDG AG | ORD SHS | H9060V101 | 38,841 | 6,473,561 | SH | DFND | 6,180,261 | 0 | 293,300 | ||
VENTYX BIOSCIENCES INC | COM | 92332V107 | 7,855 | 225,000 | SH | DFND | 103,788 | 0 | 121,212 | ||
VERASTEM INC | COM | 92337C104 | 14,620 | 17,200,000 | SH | SOLE | 17,200,000 | 0 | 0 | ||
VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 58,201 | 5,694,841 | SH | DFND | 5,028,174 | 0 | 666,667 | ||
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 108,056 | 373,200 | SH | SOLE | 0 | 0 | 373,200 | ||
VIGIL NEUROSCIENCE INC | COM | 92673K108 | 3,742 | 411,191 | SH | SOLE | 411,191 | 0 | 0 | ||
VOR BIOPHARMA INC | COM | 929033108 | 445 | 111,808 | SH | SOLE | 0 | 0 | 111,808 | ||
X4 PHARMACEUTICALS INC | COM | 98420X103 | 8,596 | 5,026,817 | SH | SOLE | 5,026,817 | 0 | 0 | ||
XENON PHARMACEUTICALS INC | COM | 98420N105 | 41,057 | 1,137,300 | SH | DFND | 218,200 | 0 | 919,100 | ||
XTANT MED HLDGS INC | COM NEW | 98420P308 | 52,628 | 73,114,592 | SH | SOLE | 73,114,592 | 0 | 0 |