The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
2SEVENTY BIO INC | COMMON STOCK | 901384107 | 9,756,981 | 1,041,300 | SH | DFND | 337,000 | 0 | 704,300 | ||
89BIO INC | COM | 282559103 | 46,577,402 | 3,658,869 | SH | SOLE | 3,658,869 | 0 | 0 | ||
ABCELLERA BIOLOGICS INC | COM | 00288U106 | 42,351,180 | 4,180,768 | SH | SOLE | 4,180,768 | 0 | 0 | ||
ACLARIS THERAPEUTICS INC | COM | 00461U105 | 43,445,336 | 2,758,434 | SH | DFND | 488,400 | 0 | 2,270,034 | ||
ACUTUS MED INC | COM | 005111109 | 3,045,644 | 2,648,386 | SH | SOLE | 2,648,386 | 0 | 0 | ||
ADICET BIO INC | COM | 007002108 | 66,577,432 | 7,447,140 | SH | SOLE | 7,447,140 | 0 | 0 | ||
AEGLEA BIOTHERAPEUTICS INC | COM | 00773J103 | 808,570 | 1,797,221 | SH | SOLE | 1,797,221 | 0 | 0 | ||
AEROVATE THERAPEUTICS INC | COM | 008064107 | 22,254,522 | 759,540 | SH | DFND | 215,800 | 0 | 543,740 | ||
ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 29,999,701 | 4,081,592 | SH | SOLE | 4,081,592 | 0 | 0 | ||
ALX ONCOLOGY HLDGS INC | COM | 00166B105 | 32,356,170 | 2,871,000 | SH | DFND | 605,000 | 0 | 2,266,000 | ||
AMICUS THERAPEUTICS INC | COM | 03152W109 | 6,300,360 | 516,000 | SH | DFND | 72,700 | 0 | 443,300 | ||
AMNEAL PHARMACEUTICALS INC | COM STK CL A | 03168L105 | 3,151,145 | 1,583,490 | SH | DFND | 471,800 | 0 | 1,111,690 | ||
APPLIED THERAPEUTICS INC | COM | 03828A101 | 2,318,700 | 3,050,921 | SH | SOLE | 3,050,921 | 0 | 0 | ||
ARCUTIS BIOTHERAPEUTICS INC | COM | 03969K108 | 36,409,598 | 2,460,108 | SH | SOLE | 2,460,108 | 0 | 0 | ||
ARGENX SE | SPONSORED ADR | 04016X101 | 6,137,046 | 16,200 | SH | DFND | 750 | 0 | 15,450 | ||
ARS PHARMACEUTICALS INC | COM | 82835W108 | 74,559,766 | 8,740,887 | SH | DFND | 7,788,510 | 0 | 952,377 | ||
BELLUS HEALTH INC NEW | COM NEW | 07987C204 | 38,658,842 | 4,708,900 | SH | DFND | 2,213,400 | 0 | 2,495,500 | ||
BIOATLA INC | COM | 09077B104 | 2,742,069 | 332,372 | SH | SOLE | 332,372 | 0 | 0 | ||
BIOGEN INC | COM | 09062X103 | 71,500,744 | 258,200 | SH | DFND | 37,000 | 0 | 221,200 | ||
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 167,158,083 | 1,615,210 | SH | DFND | 147,600 | 0 | 1,467,610 | ||
BIOMX INC | COM | 09090D103 | 525,278 | 2,813,489 | SH | SOLE | 2,813,489 | 0 | 0 | ||
BIONTECH SE | SPONSORED ADS | 09075V102 | 5,452,986 | 36,300 | SH | SOLE | 0 | 0 | 36,300 | ||
BOLT BIOTHERAPEUTICS INC | COM | 097702104 | 1,002,377 | 771,059 | SH | SOLE | 771,059 | 0 | 0 | ||
BOSTON SCIENTIFIC CORP | COM | 101137107 | 180,369,714 | 3,898,200 | SH | SOLE | 0 | 0 | 3,898,200 | ||
BRIDGEBIO PHARMA INC | NOTE 2.250% 2/0 | 10806XAD4 | 12,600,000 | 30,000,000 | PRN | SOLE | 30,000,000 | 0 | 0 | ||
BRIDGEBIO PHARMA INC | NOTE 2.500% 3/1 | 10806XAB8 | 7,950,000 | 20,000,000 | PRN | SOLE | 20,000,000 | 0 | 0 | ||
BRISTOL-MYERS SQUIBB CO | COM | 110122108 | 185,983,555 | 2,584,900 | SH | SOLE | 0 | 0 | 2,584,900 | ||
CHEMOMAB THERAPEUTICS LTD | SPONSORED ADS | 16385C104 | 8,250,157 | 2,578,174 | SH | SOLE | 2,578,174 | 0 | 0 | ||
CHINOOK THERAPEUTICS INC | COM | 16961L106 | 53,167,660 | 2,029,300 | SH | DFND | 478,300 | 0 | 1,551,000 | ||
CINCOR PHARMA INC | COM | 17240Y109 | 23,424,740 | 1,906,000 | SH | DFND | 514,000 | 0 | 1,392,000 | ||
COMPASS THERAPEUTICS INC | COM | 20454B104 | 112,485,136 | 22,362,850 | SH | DFND | 18,791,422 | 0 | 3,571,428 | ||
CORVUS PHARMACEUTICALS INC | COM | 221015100 | 5,902,106 | 6,943,654 | SH | SOLE | 6,943,654 | 0 | 0 | ||
CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | 58,502,831 | 3,196,876 | SH | SOLE | 3,196,876 | 0 | 0 | ||
CULLINAN ONCOLOGY INC | COM | 230031106 | 6,723,378 | 637,287 | SH | SOLE | 637,287 | 0 | 0 | ||
CYBIN INC | COM | 23256X100 | 1,651,629 | 5,386,299 | SH | SOLE | 0 | 0 | 5,386,299 | ||
DECIBEL THERAPEUTICS INC | COM | 24343R106 | 10,137,644 | 4,945,192 | SH | DFND | 4,061,774 | 0 | 883,418 | ||
DISC MEDICINE INC | COM | 254604101 | 42,981,116 | 2,160,941 | SH | SOLE | 2,160,941 | 0 | 0 | ||
EDGEWISE THERAPEUTICS INC | COM | 28036F105 | 130,230,553 | 14,567,176 | SH | DFND | 14,301,551 | 0 | 265,625 | ||
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 64,201,905 | 860,500 | SH | SOLE | 0 | 0 | 860,500 | ||
ESSA PHARMA INC | COM NEW | 29668H708 | 920,556 | 365,300 | SH | SOLE | 365,300 | 0 | 0 | ||
EVOLENT HEALTH INC | CL A | 30050B101 | 79,321,283 | 2,824,832 | SH | DFND | 143,900 | 0 | 2,680,932 | ||
EYEPOINT PHARMACEUTICALS INC | COM NEW | 30233G209 | 1,706,747 | 487,642 | SH | DFND | 117,200 | 0 | 370,442 | ||
FUSION PHARMACEUTICALS INC | COM | 36118A100 | 10,158,026 | 3,224,770 | SH | DFND | 2,930,670 | 0 | 294,100 | ||
GALECTO INC | COM | 36322Q107 | 4,704,578 | 4,090,937 | SH | DFND | 3,803,255 | 0 | 287,682 | ||
GH RESEARCH PLC | ORDINARY SHARES | G3855L106 | 15,766,423 | 1,622,060 | SH | DFND | 239,100 | 0 | 1,382,960 | ||
GOODRX HLDGS INC | COM CL A | 38246G108 | 1,806,062 | 387,567 | SH | DFND | 125,600 | 0 | 261,967 | ||
GRACELL BIOTECHNOLOGIES INC | SPONSORED ADS | 38406L103 | 18,135,201 | 7,884,870 | SH | DFND | 5,970,672 | 0 | 1,914,198 | ||
GRAYBUG VISION INC | COMMON | 38942Q103 | 2,081,674 | 4,163,347 | SH | SOLE | 4,163,347 | 0 | 0 | ||
HARPOON THERAPEUTICS INC | COM | 41358P106 | 1,100,521 | 1,516,496 | SH | DFND | 804,206 | 0 | 712,290 | ||
HORIZON THERAPEUTICS PUB L | SHS | G46188101 | 19,459,800 | 171,000 | SH | DFND | 33,100 | 0 | 137,900 | ||
HUMANA INC | COM | 444859102 | 178,600,653 | 348,700 | SH | SOLE | 0 | 0 | 348,700 | ||
IKENA ONCOLOGY INC | NONVOTING | 000000000 | 17,204,058 | 6,467,691 | SH | DFND | 5,838,536 | 0 | 629,155 | ||
IKENA ONCOLOGY INC | COM | 45175G108 | 7,804,283 | 2,933,941 | SH | DFND | 1,936,886 | 0 | 997,055 | ||
IMARA INC | COM | 45249V107 | 17,941,063 | 4,386,568 | SH | DFND | 4,199,068 | 0 | 187,500 | ||
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 164,649,675 | 620,500 | SH | SOLE | 0 | 0 | 620,500 | ||
INVIVYD INC | COM | 00534A102 | 7,905,600 | 5,270,400 | SH | SOLE | 5,270,400 | 0 | 0 | ||
IONIS PHARMACEUTICALS INC | COM | 462222100 | 75,298,272 | 1,993,600 | SH | DFND | 136,300 | 0 | 1,857,300 | ||
IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 12,827,657 | 2,007,458 | SH | SOLE | 0 | 0 | 2,007,458 | ||
JANUX THERAPEUTICS INC | COM | 47103J105 | 37,355,204 | 2,836,386 | SH | DFND | 2,489,664 | 0 | 346,722 | ||
KEROS THERAPEUTICS INC | COM | 492327101 | 80,645,604 | 1,679,417 | SH | DFND | 1,268,734 | 0 | 410,683 | ||
KEZAR LIFE SCIENCES INC | COM | 49372L100 | 32,273,627 | 4,584,322 | SH | DFND | 1,089,200 | 0 | 3,495,122 | ||
KINNATE BIOPHARMA INC | COM | 49705R105 | 24,666,137 | 4,043,629 | SH | DFND | 3,593,629 | 0 | 450,000 | ||
MEREO BIOPHARMA GROUP PLC | SPON ADS | 589492107 | 7,954,142 | 10,605,522 | SH | DFND | 5,777,210 | 0 | 4,828,312 | ||
MERRIMACK PHARMACEUTICALS IN | COM NEW | 590328209 | 843,456 | 73,600 | SH | DFND | 24,900 | 0 | 48,700 | ||
MERSANA THERAPEUTICS INC | COM | 59045L106 | 52,807,021 | 9,011,437 | SH | DFND | 1,928,600 | 0 | 7,082,837 | ||
MIRATI THERAPEUTICS INC | COM | 60468T105 | 58,164,085 | 1,283,692 | SH | DFND | 122,800 | 0 | 1,160,892 | ||
MODERNA INC | COM | 60770K107 | 14,827,631 | 82,550 | SH | SOLE | 0 | 0 | 82,550 | ||
MONTE ROSA THERAPEUTICS INC | COM | 61225M102 | 208,278 | 27,369 | SH | SOLE | 0 | 0 | 27,369 | ||
NATERA INC | COM | 632307104 | 78,185,000 | 1,946,353 | SH | DFND | 159,550 | 0 | 1,786,803 | ||
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 82,138,888 | 687,700 | SH | SOLE | 0 | 0 | 687,700 | ||
NEUROPACE INC | COM | 641288105 | 5,978,299 | 4,012,281 | SH | SOLE | 4,012,281 | 0 | 0 | ||
NEXTCURE INC | COM | 65343E108 | 3,822,528 | 2,711,013 | SH | SOLE | 2,711,013 | 0 | 0 | ||
ORIC PHARMACEUTICALS INC | COM | 68622P109 | 9,468,576 | 1,607,568 | SH | SOLE | 1,607,568 | 0 | 0 | ||
PASSAGE BIO INC | COM | 702712100 | 12,326,159 | 8,931,999 | SH | DFND | 6,841,423 | 0 | 2,090,576 | ||
PFIZER INC | COM | 717081103 | 71,408,064 | 1,393,600 | SH | SOLE | 0 | 0 | 1,393,600 | ||
PMV PHARMACEUTICALS INC | COM | 69353Y103 | 57,098,770 | 6,563,077 | SH | SOLE | 6,563,077 | 0 | 0 | ||
PRELUDE THERAPEUTICS INC | COM | 74065P101 | 60,639,734 | 10,039,691 | SH | DFND | 9,250,191 | 0 | 789,500 | ||
PRELUDE THERAPEUTICS INC | NONVOTING | 000000000 | 34,308,323 | 5,680,186 | SH | DFND | 5,596,886 | 0 | 83,300 | ||
PROGYNY INC | COM | 74340E103 | 32,240,250 | 1,035,000 | SH | SOLE | 0 | 0 | 1,035,000 | ||
PROTARA THERAPEUTICS INC | COM STK | 74365U107 | 2,226,118 | 830,641 | SH | DFND | 158,900 | 0 | 671,741 | ||
PYXIS ONCOLOGY INC | COMMON STOCK | 747324101 | 1,136,658 | 848,252 | SH | SOLE | 0 | 0 | 848,252 | ||
RAPT THERAPEUTICS INC | COM | 75382E109 | 24,771,186 | 1,251,070 | SH | DFND | 310,400 | 0 | 940,670 | ||
REPARE THERAPEUTICS INC | COM | 760273102 | 48,873,798 | 3,322,488 | SH | DFND | 3,177,041 | 0 | 145,447 | ||
RXSIGHT INC | COM | 78349D107 | 15,239,894 | 1,202,833 | SH | DFND | 279,100 | 0 | 923,733 | ||
SANOFI | SPONSORED ADR | 80105N105 | 4,843,000 | 100,000 | SH | Call | DFND | 33,000 | 0 | 67,000 | |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 125,990,634 | 972,300 | SH | DFND | 56,900 | 0 | 915,400 | ||
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 7,954,977 | 879,003 | SH | DFND | 378,921 | 0 | 500,082 | ||
SCPHARMACEUTICALS INC | COM | 810648105 | 39,861,816 | 5,559,528 | SH | SOLE | 5,559,528 | 0 | 0 | ||
SEAGEN INC | COM | 81181C104 | 117,433,980 | 913,812 | SH | DFND | 59,800 | 0 | 854,012 | ||
SI-BONE INC | COM | 825704109 | 45,804,800 | 3,368,000 | SH | DFND | 166,900 | 0 | 3,201,100 | ||
SINGULAR GENOMICS SYSTEMS IN | COM | 82933R100 | 1,086,801 | 540,697 | SH | SOLE | 540,697 | 0 | 0 | ||
SINOVAC BIOTECH LTD | COM | P8696W104 | 340,000,000 | 2,718,735 | SH | SOLE | 0 | 0 | 2,718,735 | ||
SPDR SER TR | S&P BIOTECH | 78464A870 | 6,341,200 | 76,400 | SH | DFND | 24,000 | 0 | 52,400 | ||
SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 136,552,500 | 5,250,000 | SH | SOLE | 5,250,000 | 0 | 0 | ||
STRYKER CORPORATION | COM | 863667101 | 117,599,690 | 481,000 | SH | SOLE | 0 | 0 | 481,000 | ||
SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 51,065,425 | 2,006,500 | SH | DFND | 444,000 | 0 | 1,562,500 | ||
SYNLOGIC INC | COM | 87166L100 | 4,582,796 | 6,029,995 | SH | SOLE | 6,029,995 | 0 | 0 | ||
TELA BIO INC | COM | 872381108 | 34,816,733 | 3,027,542 | SH | SOLE | 3,027,542 | 0 | 0 | ||
TENET HEALTHCARE CORP | COM NEW | 88033G407 | 59,538,437 | 1,220,300 | SH | SOLE | 0 | 0 | 1,220,300 | ||
TERNS PHARMACEUTICALS INC | COM | 880881107 | 77,562,794 | 7,619,135 | SH | SOLE | 7,619,135 | 0 | 0 | ||
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 111,349,518 | 202,200 | SH | SOLE | 0 | 0 | 202,200 | ||
THESEUS PHARMACEUTICALS INC | COM | 88369M101 | 85,823,667 | 17,233,668 | SH | SOLE | 17,233,668 | 0 | 0 | ||
THIRD HARMONIC BIO INC | COM | 88427A107 | 24,850,005 | 5,779,071 | SH | SOLE | 5,779,071 | 0 | 0 | ||
TRAVERE THERAPEUTICS INC | COM | 89422G107 | 26,353,324 | 1,253,130 | SH | DFND | 267,700 | 0 | 985,430 | ||
UNIQURE NV | SHS | N90064101 | 39,617,072 | 1,747,555 | SH | SOLE | 0 | 0 | 1,747,555 | ||
UNITEDHEALTH GROUP INC | COM | 91324P102 | 201,733,490 | 380,500 | SH | SOLE | 0 | 0 | 380,500 | ||
VAXCYTE INC | COM | 92243G108 | 61,525,892 | 1,283,126 | SH | DFND | 157,800 | 0 | 1,125,326 | ||
VECTIVBIO HLDG AG | ORD SHS | H9060V101 | 60,714,451 | 7,006,861 | SH | DFND | 6,713,561 | 0 | 293,300 | ||
VENTYX BIOSCIENCES INC | COM | 92332V107 | 30,330,750 | 925,000 | SH | DFND | 297,888 | 0 | 627,112 | ||
VERASTEM INC | COM | 92337C104 | 6,642,553 | 16,503,237 | SH | SOLE | 16,503,237 | 0 | 0 | ||
VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 119,473,912 | 4,572,289 | SH | DFND | 4,260,691 | 0 | 311,598 | ||
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 78,403,770 | 271,500 | SH | SOLE | 0 | 0 | 271,500 | ||
VIGIL NEUROSCIENCE INC | COM | 92673K108 | 5,611,138 | 448,891 | SH | SOLE | 448,891 | 0 | 0 | ||
X4 PHARMACEUTICALS INC | COM | 98420X103 | 5,777,002 | 5,817,726 | SH | SOLE | 5,817,726 | 0 | 0 | ||
XENON PHARMACEUTICALS INC | COM | 98420N105 | 45,309,013 | 1,149,100 | SH | DFND | 230,000 | 0 | 919,100 | ||
XTANT MED HLDGS INC | COM NEW | 98420P308 | 48,255,631 | 73,114,592 | SH | SOLE | 73,114,592 | 0 | 0 |