Orbimed Advisors 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
2SEVENTY BIO INC	COMMON STOCK	901384107	24,394,606	2,391,628	SH		DFND		667,300	0	1,724,328
ABCELLERA BIOLOGICS INC	COM	00288U106	31,522,991	4,180,768	SH		SOLE		4,180,768	0	0
ACUTUS MED INC	COM	005111109	1,996,883	2,648,386	SH		SOLE		2,648,386	0	0
ADICET BIO INC	COM	007002108	42,895,526	7,447,140	SH		SOLE		7,447,140	0	0
AEGLEA BIOTHERAPEUTICS INC	COM	00773J103	521,194	1,797,221	SH		SOLE		1,797,221	0	0
AEROVATE THERAPEUTICS INC	COM	008064107	15,267,278	756,930	SH		DFND		215,100	0	541,830
ALPINE IMMUNE SCIENCES INC	COM	02083G100	31,509,890	4,081,592	SH		SOLE		4,081,592	0	0
ALTIMMUNE INC	COM NEW	02155H200	422,000	100,000	SH	Call	DFND		35,500	0	64,500
ALTIMMUNE INC	COM NEW	02155H200	213,532	50,600	SH		DFND		18,000	0	32,600
ALX ONCOLOGY HLDGS INC	COM	00166B105	12,976,920	2,871,000	SH		DFND		605,000	0	2,266,000
AMGEN INC	COM	031162100	18,542,225	76,700	SH		SOLE		0	0	76,700
AMICUS THERAPEUTICS INC	COM	03152W109	12,986,390	1,171,000	SH		DFND		333,000	0	838,000
AMYLYX PHARMACEUTICALS INC	COM	03237H101	23,868,090	813,500	SH		DFND		202,000	0	611,500
APELLIS PHARMACEUTICALS INC	COM	03753U106	60,036,792	910,200	SH		DFND		86,500	0	823,700
APOLLOMICS INC	CL A SHS	G0411D107	16,033,976	662,561	SH		SOLE		662,561	0	0
ARCUTIS BIOTHERAPEUTICS INC	COM	03969K108	21,059,269	1,914,479	SH		SOLE		1,914,479	0	0
ARGENX SE	SPONSORED ADR	04016X101	16,579,810	44,500	SH		SOLE		0	0	44,500
ARS PHARMACEUTICALS INC	COM	82835W108	56,903,174	8,740,887	SH		DFND		7,788,510	0	952,377
BAXTER INTL INC	COM	071813109	14,196,000	350,000	SH	Call	DFND		123,500	0	226,500
BAXTER INTL INC	COM	071813109	63,354,720	1,562,000	SH		SOLE		0	0	1,562,000
BELLUS HEALTH INC NEW	COM NEW	07987C204	36,755,893	5,108,900	SH		DFND		2,333,300	0	2,775,600
BIOATLA INC	COM	09077B104	10,347,480	3,861,000	SH		DFND		1,197,000	0	2,664,000
BIOGEN INC	COM	09062X103	140,405,150	505,000	SH		DFND		44,800	0	460,200
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	157,063,020	1,615,210	SH		DFND		147,600	0	1,467,610
BIOMX INC	COM	09090D103	964,254	3,161,489	SH		SOLE		3,161,489	0	0
BOLT BIOTHERAPEUTICS INC	COM	097702104	2,141,990	1,541,000	SH		SOLE		1,541,000	0	0
BOSTON SCIENTIFIC CORP	COM	101137107	189,613,700	3,790,000	SH		SOLE		0	0	3,790,000
BRIDGEBIO PHARMA INC	NOTE 2.250% 2/0	10806XAD4	12,853,200	20,000,000	PRN		SOLE		20,000,000	0	0
BRIDGEBIO PHARMA INC	NOTE 2.500% 3/1	10806XAB8	9,468,750	12,500,000	PRN		SOLE		12,500,000	0	0
BRISTOL-MYERS SQUIBB CO	COM	110122108	162,185,400	2,340,000	SH		SOLE		0	0	2,340,000
CHEMOMAB THERAPEUTICS LTD	SPONSORED ADS	16385C104	3,563,626	2,241,274	SH		SOLE		2,241,274	0	0
CHINOOK THERAPEUTICS INC	COM	16961L106	46,978,295	2,029,300	SH		DFND		478,300	0	1,551,000
COMPASS THERAPEUTICS INC	COM	20454B104	73,126,520	22,362,850	SH		DFND		18,791,422	0	3,571,428
CORVUS PHARMACEUTICALS INC	COM	221015100	6,318,725	6,943,654	SH		SOLE		6,943,654	0	0
CRINETICS PHARMACEUTICALS IN	COM	22663K107	63,449,784	3,950,796	SH		DFND		3,196,876	0	753,920
CULLINAN ONCOLOGY INC	COM	230031106	6,193,109	605,387	SH		SOLE		605,387	0	0
DECIBEL THERAPEUTICS INC	COM	24343R106	14,934,480	4,945,192	SH		DFND		4,061,774	0	883,418
DISC MEDICINE INC	COM	254604101	48,093,608	2,269,637	SH		SOLE		2,269,637	0	0
EDGEWISE THERAPEUTICS INC	COM	28036F105	97,163,064	14,567,176	SH		DFND		14,301,551	0	265,625
EDWARDS LIFESCIENCES CORP	COM	28176E108	52,119,900	630,000	SH		SOLE		0	0	630,000
ENLIVEN THERAPEUTICS INC	COM	29337E102	197,017,065	8,996,213	SH		DFND		8,949,338	0	46,875
ESSA PHARMA INC	COM NEW	29668H708	3,559,061	1,198,337	SH		DFND		542,900	0	655,437
EVOLENT HEALTH INC	CL A	30050B101	93,963,258	2,895,632	SH		DFND		214,700	0	2,680,932
FUSION PHARMACEUTICALS INC	COM	36118A100	11,772,843	3,122,770	SH		DFND		2,930,670	0	192,100
GALECTO INC	COM	36322Q107	8,140,965	4,090,937	SH		DFND		3,803,255	0	287,682
GH RESEARCH PLC	ORDINARY SHARES	G3855L106	13,255,530	1,659,015	SH		DFND		239,100	0	1,419,915
GOODRX HLDGS INC	COM CL A	38246G108	10,625,000	1,700,000	SH		DFND		600,000	0	1,100,000
GRACELL BIOTECHNOLOGIES INC	SPONSORED ADS	38406L103	17,665,860	9,497,774	SH		DFND		7,583,576	0	1,914,198
HARPOON THERAPEUTICS INC	COM	41358P106	462,310	621,218	SH		SOLE		621,218	0	0
HERON THERAPEUTICS INC	COM	427746102	1,212,077	802,700	SH		SOLE		0	0	802,700
HORIZON THERAPEUTICS PUB L	SHS	G46188101	21,828,000	200,000	SH		DFND		70,700	0	129,300
HORIZON THERAPEUTICS PUB L	SHS	G46188101	5,457,000	50,000	SH	Put	DFND		17,500	0	32,500
HUMANA INC	COM	444859102	169,279,902	348,700	SH		SOLE		0	0	348,700
IKENA ONCOLOGY INC	COM	45175G108	10,992,273	3,186,166	SH		DFND		2,189,111	0	997,055
IKENA ONCOLOGY INC	NONVOTING	000000000	21,443,358	6,215,466	SH		DFND		5,586,311	0	629,155
IMMATICS N.V	SHS	N44445109	6,536,011	947,248	SH		DFND		436,248	0	511,000
INTELLIA THERAPEUTICS INC	COM	45826J105	6,135,648	164,627	SH		DFND		35,200	0	129,427
INTUITIVE SURGICAL INC	COM NEW	46120E602	158,519,135	620,500	SH		SOLE		0	0	620,500
INVIVYD INC	COM	00534A102	6,324,480	5,270,400	SH		SOLE		5,270,400	0	0
IONIS PHARMACEUTICALS INC	COM	462222100	75,929,630	2,124,500	SH		DFND		136,300	0	1,988,200
IOVANCE BIOTHERAPEUTICS INC	COM	462260100	28,762,568	4,707,458	SH		SOLE		0	0	4,707,458
JANUX THERAPEUTICS INC	COM	47103J105	34,320,271	2,836,386	SH		DFND		2,489,664	0	346,722
KEROS THERAPEUTICS INC	COM	492327101	71,711,106	1,679,417	SH		DFND		1,268,734	0	410,683
KEZAR LIFE SCIENCES INC	COM	49372L100	17,099,190	5,463,000	SH		DFND		1,339,000	0	4,124,000
KINNATE BIOPHARMA INC	COM	49705R105	32,147,681	5,143,629	SH		DFND		4,693,629	0	450,000
LILLY ELI & CO	COM	532457108	63,876,120	186,000	SH		SOLE		0	0	186,000
MEREO BIOPHARMA GROUP PLC	SPON ADS	589492107	5,476,984	7,747,891	SH		DFND		4,220,555	0	3,527,336
MERSANA THERAPEUTICS INC	COM	59045L106	865,977	210,700	SH	Call	DFND		73,500	0	137,200
MERSANA THERAPEUTICS INC	COM	59045L106	37,037,006	9,011,437	SH		DFND		1,928,600	0	7,082,837
MIRATI THERAPEUTICS INC	COM	60468T105	5,577,000	150,000	SH	Call	DFND		51,500	0	98,500
MIRATI THERAPEUTICS INC	COM	60468T105	33,969,507	913,650	SH		DFND		93,600	0	820,050
NATERA INC	COM	632307104	54,053,217	973,581	SH		DFND		88,600	0	884,981
NEKTAR THERAPEUTICS	COM	640268108	726,840	1,034,059	SH		DFND		258,300	0	775,759
NEKTAR THERAPEUTICS	COM	640268108	383,081	545,000	SH	Call	DFND		192,500	0	352,500
NEUROCRINE BIOSCIENCES INC	COM	64125C109	49,496,580	489,000	SH		SOLE		0	0	489,000
NEUROPACE INC	COM	641288105	18,616,984	4,012,281	SH		SOLE		4,012,281	0	0
NEXTCURE INC	COM	65343E108	4,012,299	2,711,013	SH		SOLE		2,711,013	0	0
ORIC PHARMACEUTICALS INC	COM	68622P109	7,834,468	1,374,468	SH		SOLE		1,374,468	0	0
PASSAGE BIO INC	COM	702712100	8,554,175	8,931,999	SH		DFND		6,841,423	0	2,090,576
PMV PHARMACEUTICALS INC	COM	69353Y103	31,305,877	6,563,077	SH		SOLE		6,563,077	0	0
PRELUDE THERAPEUTICS INC	COM	74065P101	57,226,239	10,039,691	SH		DFND		9,250,191	0	789,500
PRELUDE THERAPEUTICS INC	NONVOTING	000000000	32,377,060	5,680,186	SH		DFND		5,596,886	0	83,300
PROGYNY INC	COM	74340E103	33,337,733	1,037,912	SH		SOLE		0	0	1,037,912
PROTAGONIST THERAPEUTICS INC	COM	74366E102	6,923,000	301,000	SH		DFND		105,000	0	196,000
PROTARA THERAPEUTICS INC	COM STK	74365U107	2,483,837	793,558	SH		DFND		151,800	0	641,758
R1 RCM INC	COM	77634L105	26,250,000	1,750,000	SH		SOLE		0	0	1,750,000
RAPT THERAPEUTICS INC	COM	75382E109	22,957,135	1,251,070	SH		DFND		310,400	0	940,670
REGENERON PHARMACEUTICALS	COM	75886F107	19,720,080	24,000	SH		SOLE		0	0	24,000
REPARE THERAPEUTICS INC	COM	760273102	32,693,282	3,322,488	SH		DFND		3,177,041	0	145,447
REVANCE THERAPEUTICS INC	COM	761330109	1,610,500	50,000	SH		SOLE		0	0	50,000
RXSIGHT INC	COM	78349D107	20,063,254	1,202,833	SH		DFND		279,100	0	923,733
SAREPTA THERAPEUTICS INC	COM	803607100	10,337,250	75,000	SH	Call	DFND		26,000	0	49,000
SAREPTA THERAPEUTICS INC	COM	803607100	119,236,733	865,100	SH		DFND		56,900	0	808,200
SCHOLAR ROCK HLDG CORP	COM	80706P103	4,120,000	515,000	SH		SOLE		515,000	0	0
SCPHARMACEUTICALS INC	COM	810648105	50,424,919	5,559,528	SH		SOLE		5,559,528	0	0
SI-BONE INC	COM	825704109	57,425,660	2,919,454	SH		DFND		166,900	0	2,752,554
SINGULAR GENOMICS SYSTEMS IN	COM	82933R100	654,243	540,697	SH		SOLE		540,697	0	0
SINOVAC BIOTECH LTD	SHS	P8696W104	340,000,000	2,718,735	SH		SOLE		0	0	2,718,735
SPDR SER TR	S&P BIOTECH	78464A870	20,881,540	274,000	SH		DFND		96,900	0	177,100
SPDR SER TR	S&P BIOTECH	78464A870	7,621,000	100,000	SH	Call	DFND		34,000	0	66,000
SPRINGWORKS THERAPEUTICS INC	COM	85205L107	115,801,686	4,498,900	SH		SOLE		4,498,900	0	0
STRYKER CORPORATION	COM	863667101	104,938,772	367,600	SH		SOLE		0	0	367,600
SYNDAX PHARMACEUTICALS INC	COM	87164F105	36,150,576	1,711,675	SH		DFND		401,200	0	1,310,475
SYNLOGIC INC	COM	87166L100	3,810,957	6,029,995	SH		SOLE		6,029,995	0	0
TELA BIO INC	COM	872381108	32,213,047	3,027,542	SH		SOLE		3,027,542	0	0
TENET HEALTHCARE CORP	COM NEW	88033G407	72,510,226	1,220,300	SH		SOLE		0	0	1,220,300
TERNS PHARMACEUTICALS INC	COM	880881107	90,210,558	7,619,135	SH		SOLE		7,619,135	0	0
THERMO FISHER SCIENTIFIC INC	COM	883556102	85,187,486	147,800	SH		SOLE		0	0	147,800
THESEUS PHARMACEUTICALS INC	COM	88369M101	153,034,972	17,233,668	SH		SOLE		17,233,668	0	0
THIRD HARMONIC BIO INC	COM	88427A107	23,809,773	5,779,071	SH		SOLE		5,779,071	0	0
TRAVERE THERAPEUTICS INC	COM	89422G107	39,229,307	1,744,300	SH		DFND		419,700	0	1,324,600
UNIQURE NV	SHS	N90064101	41,578,124	2,064,455	SH		DFND		98,000	0	1,966,455
UNITEDHEALTH GROUP INC	COM	91324P102	130,434,840	276,000	SH		SOLE		0	0	276,000
VAXCYTE INC	COM	92243G108	27,339,374	729,439	SH		DFND		90,600	0	638,839
VECTIVBIO HLDG AG	ORD SHS	H9060V101	43,882,334	5,156,561	SH		SOLE		5,156,561	0	0
VENTYX BIOSCIENCES INC	COM	92332V107	19,597,500	585,000	SH		DFND		195,000	0	390,000
VERA THERAPEUTICS INC	CL A	92337R101	10,572,224	1,362,400	SH		DFND		620,200	0	742,200
VERASTEM INC	COM	92337C104	6,852,144	16,503,237	SH		SOLE		16,503,237	0	0
VERONA PHARMA PLC	SPONSORED ADS	925050106	85,554,675	4,260,691	SH		SOLE		4,260,691	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	55,956,432	177,600	SH		SOLE		0	0	177,600
VIGIL NEUROSCIENCE INC	COM	92673K108	4,394,643	448,891	SH		SOLE		448,891	0	0
X4 PHARMACEUTICALS INC	COM	98420X103	5,061,422	5,817,726	SH		SOLE		5,817,726	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	41,126,289	1,149,100	SH		DFND		230,000	0	919,100
XTANT MED HLDGS INC	COM NEW	98420P308	46,610,552	73,114,592	SH		SOLE		73,114,592	0	0
YS BIOPHARMA CO LTD	ORDINARY SHARES	G9845F109	6,877,542	4,298,464	SH		DFND		1,590,652	0	2,707,812