Orbimed Advisors 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
2SEVENTY BIO INC	COMMON STOCK	901384107	24,203,275	2,391,628	SH		DFND		667,300	0	1,724,328
ABCELLERA BIOLOGICS INC	COM	00288U106	27,007,761	4,180,768	SH		SOLE		4,180,768	0	0
ACELYRIN INC	COM	00445A100	111,319,712	5,326,302	SH		SOLE		5,326,302	0	0
ACUTUS MED INC	COM	005111109	2,351,767	2,648,386	SH		SOLE		2,648,386	0	0
ADICET BIO INC	COM	007002108	20,222,800	8,322,140	SH		SOLE		8,322,140	0	0
AEROVATE THERAPEUTICS INC	COM	008064107	12,981,350	756,930	SH		DFND		215,100	0	541,830
AKERO THERAPEUTICS INC	COM	00973Y108	9,314,655	199,500	SH		DFND		26,200	0	173,300
ALKERMES PLC	SHS	G01767105	4,738,820	151,400	SH		SOLE		0	0	151,400
ALPINE IMMUNE SCIENCES INC	COM	02083G100	41,958,766	4,081,592	SH		SOLE		4,081,592	0	0
ALTIMMUNE INC	COM NEW	02155H200	353,000	100,000	SH		DFND		35,500	0	64,500
ALX ONCOLOGY HLDGS INC	COM	00166B105	21,561,210	2,871,000	SH		DFND		605,000	0	2,266,000
AMGEN INC	COM	031162100	28,263,146	127,300	SH		SOLE		0	0	127,300
AMICUS THERAPEUTICS INC	COM	03152W109	23,316,384	1,856,400	SH		DFND		490,400	0	1,366,000
APELLIS PHARMACEUTICALS INC	COM	03753U106	82,919,220	910,200	SH		DFND		86,500	0	823,700
APOLLOMICS INC	CL A SHS	G0411D107	3,796,475	662,561	SH		SOLE		662,561	0	0
ARCUTIS BIOTHERAPEUTICS INC	COM	03969K108	18,244,985	1,914,479	SH		SOLE		1,914,479	0	0
ARGENX SE	SPONSORED ADR	04016X101	12,705,198	32,600	SH		SOLE		0	0	32,600
ARROWHEAD PHARMACEUTICALS IN	COM	04280A100	4,172,220	117,000	SH		DFND		30,000	0	87,000
ARS PHARMACEUTICALS INC	COM	82835W108	58,563,943	8,740,887	SH		DFND		7,788,510	0	952,377
BAXTER INTL INC	COM	071813109	13,668,000	300,000	SH	Call	DFND		104,500	0	195,500
BAXTER INTL INC	COM	071813109	153,765,000	3,375,000	SH		SOLE		0	0	3,375,000
BIOATLA INC	COM	09077B104	3,468,525	1,156,175	SH		DFND		358,600	0	797,575
BIOGEN INC	COM	09062X103	158,604,480	556,800	SH		DFND		51,400	0	505,400
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	140,006,403	1,615,210	SH		DFND		147,600	0	1,467,610
BIOMX INC	COM	09090D103	1,639,256	4,553,489	SH		SOLE		4,553,489	0	0
BOLT BIOTHERAPEUTICS INC	COM	097702104	1,972,480	1,541,000	SH		SOLE		1,541,000	0	0
BOSTON SCIENTIFIC CORP	COM	101137107	182,818,791	3,379,900	SH		SOLE		0	0	3,379,900
BRIDGEBIO PHARMA INC	NOTE 2.250% 2/0	10806XAD4	9,265,350	15,000,000	PRN		SOLE		15,000,000	0	0
BRISTOL-MYERS SQUIBB CO	COM	110122108	95,157,600	1,488,000	SH		SOLE		0	0	1,488,000
CALCIMEDICA INC	COM NEW	38942Q202	1,192,494	297,380	SH		SOLE		297,380	0	0
CHEMOMAB THERAPEUTICS LTD	SPONSORED ADS	16385C104	2,947,275	2,241,274	SH		SOLE		2,241,274	0	0
COMPASS THERAPEUTICS INC	COM	20454B104	71,113,863	22,362,850	SH		DFND		18,791,422	0	3,571,428
CORVUS PHARMACEUTICALS INC	COM	221015100	15,900,968	6,943,654	SH		SOLE		6,943,654	0	0
CRINETICS PHARMACEUTICALS IN	COM	22663K107	71,193,344	3,950,796	SH		DFND		3,196,876	0	753,920
CULLINAN ONCOLOGY INC	COM	230031106	5,862,564	544,848	SH		SOLE		544,848	0	0
CUTERA INC	COM	232109108	5,856,823	387,100	SH		DFND		138,200	0	248,900
DECIBEL THERAPEUTICS INC	COM	24343R106	19,038,989	4,945,192	SH		DFND		4,061,774	0	883,418
DISC MEDICINE INC	COM	254604101	100,771,883	2,269,637	SH		SOLE		2,269,637	0	0
EDGEWISE THERAPEUTICS INC	COM	28036F105	112,895,614	14,567,176	SH		DFND		14,301,551	0	265,625
EDWARDS LIFESCIENCES CORP	COM	28176E108	48,579,950	515,000	SH		SOLE		0	0	515,000
ELEVATION ONCOLOGY INC	COM	28623U101	2,280,000	1,500,000	SH		SOLE		1,500,000	0	0
ENLIVEN THERAPEUTICS INC	COM	29337E102	183,656,079	8,998,338	SH		DFND		8,951,463	0	46,875
ESSA PHARMA INC	COM NEW	29668H708	2,489,238	921,940	SH		DFND		419,000	0	502,940
EVOLENT HEALTH INC	CL A	30050B101	87,737,650	2,895,632	SH		DFND		214,700	0	2,680,932
FUSION PHARMACEUTICALS INC	COM	36118A100	14,583,336	3,122,770	SH		DFND		2,930,670	0	192,100
GALECTO INC	COM	36322Q107	9,662,277	3,834,237	SH		DFND		3,564,607	0	269,630
GH RESEARCH PLC	ORDINARY SHARES	G3855L106	8,736,377	736,315	SH		DFND		119,200	0	617,115
GILEAD SCIENCES INC	COM	375558103	7,707,000	100,000	SH		SOLE		0	0	100,000
GOODRX HLDGS INC	COM CL A	38246G108	9,873,072	1,788,600	SH		DFND		622,400	0	1,166,200
GRACELL BIOTECHNOLOGIES INC	SPONSORED ADS	38406L103	34,418,496	9,033,726	SH		DFND		7,277,828	0	1,755,898
HARPOON THERAPEUTICS INC	COM	41358P106	441,065	621,218	SH		SOLE		621,218	0	0
HERON THERAPEUTICS INC	COM	427746102	931,132	802,700	SH		SOLE		0	0	802,700
HORIZON THERAPEUTICS PUB L	SHS	G46188101	32,541,740	316,400	SH		DFND		85,300	0	231,100
HORIZON THERAPEUTICS PUB L	SHS	G46188101	5,142,500	50,000	SH	Put	DFND		17,500	0	32,500
HUMANA INC	COM	444859102	155,914,231	348,700	SH		SOLE		0	0	348,700
HUMANA INC	COM	444859102	11,178,250	25,000	SH	Call	DFND		9,000	0	16,000
IKENA ONCOLOGY INC	COM	45175G108	20,901,249	3,186,166	SH		DFND		2,189,111	0	997,055
IKENA ONCOLOGY INC	NONVOTING	000000000	40,773,457	6,215,466	SH		DFND		5,586,311	0	629,155
IMMATICS N.V	SHS	N44445109	11,157,207	966,829	SH		DFND		447,629	0	519,200
INSPIREMD INC	COM	45779A846	4,669,617	1,860,405	SH		SOLE		1,860,405	0	0
INTUITIVE SURGICAL INC	COM NEW	46120E602	212,173,770	620,500	SH		SOLE		0	0	620,500
INVIVYD INC	COM	00534A102	5,533,920	5,270,400	SH		SOLE		5,270,400	0	0
IONIS PHARMACEUTICALS INC	COM	462222100	89,014,585	2,169,500	SH		DFND		157,300	0	2,012,200
IOVANCE BIOTHERAPEUTICS INC	COM	462260100	33,140,504	4,707,458	SH		SOLE		0	0	4,707,458
JANUX THERAPEUTICS INC	COM	47103J105	33,667,902	2,836,386	SH		DFND		2,489,664	0	346,722
KEROS THERAPEUTICS INC	COM	492327101	60,862,012	1,514,734	SH		DFND		1,268,734	0	246,000
KEZAR LIFE SCIENCES INC	COM	49372L100	13,384,350	5,463,000	SH		DFND		1,339,000	0	4,124,000
KINNATE BIOPHARMA INC	COM	49705R105	24,269,479	8,009,729	SH		DFND		7,559,729	0	450,000
LILLY ELI & CO	COM	532457108	87,230,280	186,000	SH		SOLE		0	0	186,000
MADRIGAL PHARMACEUTICALS INC	COM	558868105	74,282,439	321,569	SH		DFND		31,200	0	290,369
MERSANA THERAPEUTICS INC	COM	59045L106	822,500	250,000	SH	Call	DFND		88,000	0	162,000
MERSANA THERAPEUTICS INC	COM	59045L106	23,737,143	7,214,937	SH		DFND		1,569,600	0	5,645,337
MIRATI THERAPEUTICS INC	COM	60468T105	33,010,175	913,650	SH		DFND		93,600	0	820,050
MOONLAKE IMMUNOTHERAPEUTICS	CLASS A ORD	61559X104	5,967,000	117,000	SH		DFND		67,000	0	50,000
MORPHIC HLDG INC	COM	61775R105	11,953,305	208,500	SH		DFND		52,900	0	155,600
NATERA INC	COM	632307104	47,374,451	973,581	SH		DFND		88,600	0	884,981
NEKTAR THERAPEUTICS	COM	640268108	296,228	515,000	SH	Call	DFND		182,000	0	333,000
NEUROCRINE BIOSCIENCES INC	COM	64125C109	46,112,700	489,000	SH		SOLE		0	0	489,000
NEUROPACE INC	COM	641288105	18,015,142	4,012,281	SH		SOLE		4,012,281	0	0
NEXTCURE INC	COM	65343E108	4,879,823	2,711,013	SH		SOLE		2,711,013	0	0
ORIC PHARMACEUTICALS INC	COM	68622P109	9,067,312	1,168,468	SH		SOLE		1,168,468	0	0
PASSAGE BIO INC	COM	702712100	9,530,263	10,124,576	SH		DFND		8,034,000	0	2,090,576
PMV PHARMACEUTICALS INC	COM	69353Y103	41,084,862	6,563,077	SH		SOLE		6,563,077	0	0
PRELUDE THERAPEUTICS INC	COM	74065P101	49,091,652	10,909,256	SH		DFND		10,119,756	0	789,500
PRELUDE THERAPEUTICS INC	NONVOTING	000000000	25,560,837	5,680,186	SH		DFND		5,596,886	0	83,300
PROTARA THERAPEUTICS INC	COM STK	74365U107	1,846,476	772,584	SH		DFND		147,800	0	624,784
R1 RCM INC	COM	77634L105	63,486,450	3,441,000	SH		SOLE		0	0	3,441,000
RAPT THERAPEUTICS INC	COM	75382E109	23,395,009	1,251,070	SH		DFND		310,400	0	940,670
REGENERON PHARMACEUTICALS	COM	75886F107	9,700,290	13,500	SH		SOLE		0	0	13,500
REPARE THERAPEUTICS INC	COM	760273102	35,151,923	3,322,488	SH		DFND		3,177,041	0	145,447
REVANCE THERAPEUTICS INC	COM	761330109	2,531,000	100,000	SH		SOLE		0	0	100,000
SAREPTA THERAPEUTICS INC	COM	803607100	74,896,080	654,000	SH		DFND		53,400	0	600,600
SCHOLAR ROCK HLDG CORP	COM	80706P103	5,546,763	735,645	SH		DFND		620,300	0	115,345
SCPHARMACEUTICALS INC	COM	810648105	56,651,590	5,559,528	SH		SOLE		5,559,528	0	0
SI-BONE INC	COM	825704109	61,852,486	2,292,531	SH		DFND		147,900	0	2,144,631
SINGULAR GENOMICS SYSTEMS IN	COM	82933R100	448,779	540,697	SH		SOLE		540,697	0	0
SINOVAC BIOTECH LTD	SHS	P8696W104	340,000,000	2,718,735	SH		SOLE		0	0	2,718,735
SPRINGWORKS THERAPEUTICS INC	COM	85205L107	109,562,577	4,178,588	SH		SOLE		4,178,588	0	0
STRYKER CORPORATION	COM	863667101	82,801,426	271,400	SH		SOLE		0	0	271,400
SYNDAX PHARMACEUTICALS INC	COM	87164F105	52,957,923	2,530,240	SH		DFND		614,800	0	1,915,440
SYNLOGIC INC	COM	87166L100	2,592,898	6,029,995	SH		SOLE		6,029,995	0	0
TELA BIO INC	COM	872381108	28,724,040	2,835,542	SH		SOLE		2,835,542	0	0
TENET HEALTHCARE CORP	COM NEW	88033G407	78,165,490	960,500	SH		SOLE		0	0	960,500
TENET HEALTHCARE CORP	COM NEW	88033G407	8,138,000	100,000	SH	Call	DFND		35,500	0	64,500
TERNS PHARMACEUTICALS INC	COM	880881107	66,667,431	7,619,135	SH		SOLE		7,619,135	0	0
TG THERAPEUTICS INC	COM	88322Q108	1,137,672	45,800	SH	Call	SOLE		0	0	45,800
THE CIGNA GROUP	COM	125523100	45,176,600	161,000	SH		SOLE		0	0	161,000
THERMO FISHER SCIENTIFIC INC	COM	883556102	84,940,900	162,800	SH		SOLE		0	0	162,800
THESEUS PHARMACEUTICALS INC	COM	88369M101	160,790,122	17,233,668	SH		SOLE		17,233,668	0	0
THIRD HARMONIC BIO INC	COM	88427A107	27,797,332	5,779,071	SH		SOLE		5,779,071	0	0
TRAVERE THERAPEUTICS INC	COM	89422G107	32,534,016	2,118,100	SH		DFND		510,200	0	1,607,900
UNIQURE NV	SHS	N90064101	23,658,654	2,064,455	SH		DFND		98,000	0	1,966,455
UNITED THERAPEUTICS CORP DEL	COM	91307C102	88,719,425	401,900	SH		DFND		49,000	0	352,900
UNITEDHEALTH GROUP INC	COM	91324P102	117,276,160	244,000	SH		SOLE		0	0	244,000
VAXCYTE INC	COM	92243G108	50,296,971	1,007,148	SH		DFND		122,700	0	884,448
VECTIVBIO HLDG AG	ORD SHS	H9060V101	87,661,537	5,156,561	SH		SOLE		5,156,561	0	0
VENTYX BIOSCIENCES INC	COM	92332V107	17,744,275	540,984	SH		DFND		174,500	0	366,484
VERA THERAPEUTICS INC	CL A	92337R101	28,196,640	1,756,800	SH		DFND		771,000	0	985,800
VERASTEM INC	COM NEW	92337C203	11,376,616	1,529,115	SH		SOLE		1,529,115	0	0
VERONA PHARMA PLC	SPONSORED ADS	925050106	79,862,227	3,777,778	SH		SOLE		3,777,778	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	58,205,914	165,400	SH		SOLE		0	0	165,400
VIGIL NEUROSCIENCE INC	COM	92673K108	4,219,575	448,891	SH		SOLE		448,891	0	0
X4 PHARMACEUTICALS INC	COM	98420X103	13,839,019	7,133,515	SH		SOLE		7,133,515	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	42,196,000	1,096,000	SH		DFND		230,000	0	866,000
XTANT MED HLDGS INC	COM NEW	98420P308	67,989,259	73,114,592	SH		SOLE		73,114,592	0	0
YS BIOPHARMA CO LTD	ORDINARY SHARES	G9845F109	5,931,882	4,298,465	SH		DFND		1,590,652	0	2,707,813
ZIMMER BIOMET HOLDINGS INC	COM	98956P102	35,672,000	245,000	SH		SOLE		0	0	245,000