| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ABBVIE INC | COM | 00287Y109 | 49,189,800 | 330,000 | SH | | SOLE | | 0 | 0 | 330,000 |
| ABCELLERA BIOLOGICS INC | COM | 00288U106 | 19,231,533 | 4,180,768 | SH | | SOLE | | 4,180,768 | 0 | 0 |
| ACELYRIN INC | COM | 00445A100 | 54,168,491 | 5,326,302 | SH | | SOLE | | 5,326,302 | 0 | 0 |
| ACUTUS MED INC | COM | 005111109 | 1,844,866 | 2,648,386 | SH | | SOLE | | 2,648,386 | 0 | 0 |
| ADICET BIO INC | COM | 007002108 | 11,401,332 | 8,322,140 | SH | | SOLE | | 8,322,140 | 0 | 0 |
| AEROVATE THERAPEUTICS INC | COM | 008064107 | 10,271,540 | 756,930 | SH | | DFND | 1 | 215,100 | 0 | 541,830 |
| AKERO THERAPEUTICS INC | COM | 00973Y108 | 17,703,000 | 350,000 | SH | | DFND | 1 | 46,000 | 0 | 304,000 |
| ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 46,734,228 | 4,081,592 | SH | | SOLE | | 4,081,592 | 0 | 0 |
| ALTIMMUNE INC | COM NEW | 02155H200 | 260,000 | 100,000 | SH | | DFND | 1 | 35,500 | 0 | 64,500 |
| ALX ONCOLOGY HLDGS INC | COM | 00166B105 | 13,780,800 | 2,871,000 | SH | | DFND | 1 | 605,000 | 0 | 2,266,000 |
| AMGEN INC | COM | 031162100 | 34,213,148 | 127,300 | SH | | SOLE | | 0 | 0 | 127,300 |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 47,949,420 | 1,260,500 | SH | | DFND | 1 | 123,600 | 0 | 1,136,900 |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 2,948,100 | 77,500 | SH | Call | DFND | 1 | 27,500 | 0 | 50,000 |
| APOGEE THERAPEUTICS INC | COM | 03770N101 | 30,414,291 | 1,427,901 | SH | | SOLE | | 1,427,901 | 0 | 0 |
| APOLLOMICS INC | CL A SHS | G0411D107 | 67,386,163 | 17,993,635 | SH | | SOLE | | 17,993,635 | 0 | 0 |
| ARCUTIS BIOTHERAPEUTICS INC | COM | 03969K108 | 10,165,883 | 1,914,479 | SH | | SOLE | | 1,914,479 | 0 | 0 |
| ARGENX SE | SPONSORED ADR | 04016X101 | 16,027,138 | 32,600 | SH | | SOLE | | 0 | 0 | 32,600 |
| ARROWHEAD PHARMACEUTICALS IN | COM | 04280A100 | 11,652,202 | 433,651 | SH | | DFND | 1 | 114,000 | 0 | 319,651 |
| ARS PHARMACEUTICALS INC | COM | 82835W108 | 34,930,553 | 9,240,887 | SH | | DFND | 1 | 8,288,510 | 0 | 952,377 |
| ASTRAZENECA PLC | SPONSORED ADR | 046353108 | 16,930,000 | 250,000 | SH | Call | DFND | 1 | 90,500 | 0 | 159,500 |
| BAXTER INTL INC | COM | 071813109 | 84,533,826 | 2,239,900 | SH | | DFND | 1 | 48,500 | 0 | 2,191,400 |
| BIOATLA INC | COM | 09077B104 | 1,715,774 | 1,009,279 | SH | | DFND | 1 | 313,038 | 0 | 696,241 |
| BIOGEN INC | COM | 09062X103 | 143,103,168 | 556,800 | SH | | DFND | 1 | 51,400 | 0 | 505,400 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 142,913,781 | 1,615,210 | SH | | DFND | 1 | 147,600 | 0 | 1,467,610 |
| BIOMX INC | COM | 09090D103 | 1,602,828 | 4,553,489 | SH | | SOLE | | 4,553,489 | 0 | 0 |
| BOLT BIOTHERAPEUTICS INC | COM | 097702104 | 1,602,640 | 1,541,000 | SH | | SOLE | | 1,541,000 | 0 | 0 |
| BOSTON SCIENTIFIC CORP | COM | 101137107 | 174,599,040 | 3,306,800 | SH | | SOLE | | 0 | 0 | 3,306,800 |
| CALCIMEDICA INC | COM NEW | 38942Q202 | 790,882 | 297,380 | SH | | SOLE | | 297,380 | 0 | 0 |
| CHEMOMAB THERAPEUTICS LTD | SPONSORED ADS | 16385C104 | 2,005,940 | 2,241,274 | SH | | SOLE | | 2,241,274 | 0 | 0 |
| COMPASS THERAPEUTICS INC | COM | 20454B104 | 44,054,815 | 22,362,850 | SH | | DFND | 1 | 18,791,422 | 0 | 3,571,428 |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 10,137,735 | 6,943,654 | SH | | SOLE | | 6,943,654 | 0 | 0 |
| CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | 86,129,241 | 2,896,074 | SH | | DFND | 1 | 2,596,994 | 0 | 299,080 |
| CULLINAN ONCOLOGY INC | COM | 230031106 | 4,930,874 | 544,848 | SH | | SOLE | | 544,848 | 0 | 0 |
| CUTERA INC | COM | 232109108 | 3,630,662 | 603,100 | SH | | DFND | 1 | 219,700 | 0 | 383,400 |
| DEXCOM INC | COM | 252131107 | 4,665,000 | 50,000 | SH | Call | DFND | 1 | 18,000 | 0 | 32,000 |
| DISC MEDICINE INC | COM | 254604101 | 106,627,546 | 2,269,637 | SH | | SOLE | | 2,269,637 | 0 | 0 |
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 | 83,469,918 | 14,567,176 | SH | | DFND | 1 | 14,301,551 | 0 | 265,625 |
| ELEVATION ONCOLOGY INC | COM | 28623U101 | 993,900 | 1,500,000 | SH | | SOLE | | 1,500,000 | 0 | 0 |
| ELI LILLY & CO | COM | 532457108 | 99,906,180 | 186,000 | SH | | SOLE | | 0 | 0 | 186,000 |
| ENLIVEN THERAPEUTICS INC | COM | 29337E102 | 122,917,297 | 8,998,338 | SH | | DFND | 1 | 8,951,463 | 0 | 46,875 |
| ESSA PHARMA INC | COM NEW | 29668H708 | 2,602,911 | 842,366 | SH | | DFND | 1 | 383,400 | 0 | 458,966 |
| EVOLENT HEALTH INC | CL A | 30050B101 | 78,848,059 | 2,895,632 | SH | | DFND | 1 | 214,700 | 0 | 2,680,932 |
| FUSION PHARMACEUTICALS INC | COM | 36118A100 | 8,119,202 | 3,122,770 | SH | | DFND | 1 | 2,930,670 | 0 | 192,100 |
| GALECTO INC | COM | 36322Q107 | 665,385 | 924,788 | SH | | DFND | 1 | 867,476 | 0 | 57,312 |
| GILEAD SCIENCES INC | COM | 375558103 | 7,494,000 | 100,000 | SH | | SOLE | | 0 | 0 | 100,000 |
| GOODRX HLDGS INC | COM CL A | 38246G108 | 8,979,850 | 1,595,000 | SH | | DFND | 1 | 577,000 | 0 | 1,018,000 |
| GRACELL BIOTECHNOLOGIES INC | SPONSORED ADS | 38406L103 | 26,809,131 | 9,308,726 | SH | | DFND | 1 | 7,552,828 | 0 | 1,755,898 |
| HARPOON THERAPEUTICS INC | COM NEW | 41358P205 | 250,348 | 62,121 | SH | | SOLE | | 62,121 | 0 | 0 |
| HERON THERAPEUTICS INC | COM | 427746102 | 826,781 | 802,700 | SH | | SOLE | | 0 | 0 | 802,700 |
| HORIZON THERAPEUTICS PUB L | SHS | G46188101 | 30,819,816 | 266,400 | SH | | DFND | 1 | 67,300 | 0 | 199,100 |
| HUMANA INC | COM | 444859102 | 166,633,100 | 342,500 | SH | | SOLE | | 0 | 0 | 342,500 |
| ICON PLC | SHS | G4705A100 | 32,554,250 | 132,200 | SH | | SOLE | | 0 | 0 | 132,200 |
| IKENA ONCOLOGY INC | COM | 45175G108 | 13,796,099 | 3,186,166 | SH | | DFND | 1 | 2,189,111 | 0 | 997,055 |
| IKENA ONCOLOGY INC | NONVOTING | 000000000 | 27,575,982 | 6,368,587 | SH | | DFND | 1 | 5,739,432 | 0 | 629,155 |
| IMMATICS N.V | SHS | N44445109 | 1,447,500 | 125,000 | SH | Call | DFND | 1 | 44,000 | 0 | 81,000 |
| IMMATICS N.V | SHS | N44445109 | 12,161,316 | 1,050,200 | SH | | DFND | 1 | 531,000 | 0 | 519,200 |
| INSPIREMD INC | COM | 45779A846 | 6,083,524 | 1,860,405 | SH | | SOLE | | 1,860,405 | 0 | 0 |
| INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 145,852,710 | 499,000 | SH | | SOLE | | 0 | 0 | 499,000 |
| INVIVYD INC | COM | 00534A102 | 8,959,680 | 5,270,400 | SH | | SOLE | | 5,270,400 | 0 | 0 |
| IONIS PHARMACEUTICALS INC | COM | 462222100 | 98,408,520 | 2,169,500 | SH | | DFND | 1 | 157,300 | 0 | 2,012,200 |
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 21,418,934 | 4,707,458 | SH | | SOLE | | 0 | 0 | 4,707,458 |
| JANUX THERAPEUTICS INC | COM | 47103J105 | 33,444,704 | 3,317,927 | SH | | DFND | 1 | 2,789,666 | 0 | 528,261 |
| KARUNA THERAPEUTICS INC | COM | 48576A100 | 2,367,260 | 14,000 | SH | | SOLE | | 0 | 0 | 14,000 |
| KENVUE INC | COM | 49177J102 | 5,020,000 | 250,000 | SH | Call | DFND | 1 | 88,000 | 0 | 162,000 |
| KENVUE INC | COM | 49177J102 | 6,273,072 | 312,404 | SH | | DFND | 1 | 112,466 | 0 | 199,938 |
| KEROS THERAPEUTICS INC | COM | 492327101 | 48,289,720 | 1,514,734 | SH | | DFND | 1 | 1,268,734 | 0 | 246,000 |
| KEZAR LIFE SCIENCES INC | COM | 49372L100 | 6,500,970 | 5,463,000 | SH | | DFND | 1 | 1,339,000 | 0 | 4,124,000 |
| KINNATE BIOPHARMA INC | COM | 49705R105 | 11,213,621 | 8,009,729 | SH | | DFND | 1 | 7,559,729 | 0 | 450,000 |
| MADRIGAL PHARMACEUTICALS INC | COM | 558868105 | 36,993,246 | 253,309 | SH | | DFND | 1 | 25,100 | 0 | 228,209 |
| MERCK & CO INC | COM | 58933Y105 | 108,612,250 | 1,055,000 | SH | | SOLE | | 0 | 0 | 1,055,000 |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 85,336,218 | 1,959,050 | SH | | DFND | 1 | 237,300 | 0 | 1,721,750 |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 4,356,000 | 100,000 | SH | Call | DFND | 1 | 35,000 | 0 | 65,000 |
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 | 6,669,000 | 117,000 | SH | | DFND | 1 | 67,000 | 0 | 50,000 |
| MORPHIC HLDG INC | COM | 61775R105 | 4,776,735 | 208,500 | SH | | DFND | 1 | 52,900 | 0 | 155,600 |
| NATERA INC | COM | 632307104 | 40,735,709 | 920,581 | SH | | DFND | 1 | 88,600 | 0 | 831,981 |
| NEUMORA THERAPEUTICS INC. | COM | 640979100 | 21,165,000 | 1,500,000 | SH | | DFND | 1 | 443,000 | 0 | 1,057,000 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 46,788,750 | 415,900 | SH | | SOLE | | 0 | 0 | 415,900 |
| NEUROPACE INC | COM | 641288105 | 39,039,494 | 4,012,281 | SH | | SOLE | | 4,012,281 | 0 | 0 |
| NEXTCURE INC | COM | 65343E108 | 3,497,207 | 2,711,013 | SH | | SOLE | | 2,711,013 | 0 | 0 |
| ORIC PHARMACEUTICALS INC | COM | 68622P109 | 5,406,691 | 893,668 | SH | | SOLE | | 893,668 | 0 | 0 |
| PASSAGE BIO INC | COM | 702712100 | 6,661,971 | 10,124,576 | SH | | DFND | 1 | 8,034,000 | 0 | 2,090,576 |
| PMV PHARMACEUTICALS INC | COM | 69353Y103 | 40,297,293 | 6,563,077 | SH | | SOLE | | 6,563,077 | 0 | 0 |
| PRELUDE THERAPEUTICS INC | COM | 74065P101 | 33,709,601 | 10,909,256 | SH | | DFND | 1 | 10,119,756 | 0 | 789,500 |
| PRELUDE THERAPEUTICS INC | NONVOTING | 000000000 | 17,551,775 | 5,680,186 | SH | | DFND | 1 | 5,596,886 | 0 | 83,300 |
| PROTARA THERAPEUTICS INC | COM STK | 74365U107 | 1,290,215 | 772,584 | SH | | DFND | 1 | 147,800 | 0 | 624,784 |
| R1 RCM INC | COM | 77634L105 | 51,855,870 | 3,441,000 | SH | | SOLE | | 0 | 0 | 3,441,000 |
| RAPT THERAPEUTICS INC | COM | 75382E109 | 20,690,986 | 1,244,945 | SH | | DFND | 1 | 308,800 | 0 | 936,145 |
| RAYZEBIO INC | COM | 75525N107 | 58,228,580 | 2,622,909 | SH | | SOLE | | 2,622,909 | 0 | 0 |
| REGENERON PHARMACEUTICALS | COM | 75886F107 | 11,109,960 | 13,500 | SH | | SOLE | | 0 | 0 | 13,500 |
| RELAY THERAPEUTICS INC | COM | 75943R102 | 4,221,534 | 501,966 | SH | | DFND | 1 | 180,643 | 0 | 321,323 |
| REPARE THERAPEUTICS INC | COM | 760273102 | 40,135,655 | 3,322,488 | SH | | DFND | 1 | 3,177,041 | 0 | 145,447 |
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | 13,379,993 | 583,642 | SH | | DFND | 1 | 96,315 | 0 | 487,327 |
| SAREPTA THERAPEUTICS INC | COM | 803607100 | 64,149,624 | 529,200 | SH | | DFND | 1 | 49,000 | 0 | 480,200 |
| SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 14,439,902 | 2,033,789 | SH | | DFND | 1 | 785,800 | 0 | 1,247,989 |
| SCPHARMACEUTICALS INC | COM | 810648105 | 39,583,839 | 5,559,528 | SH | | SOLE | | 5,559,528 | 0 | 0 |
| SEAGEN INC | COM | 81181C104 | 10,607,500 | 50,000 | SH | Call | DFND | 1 | 17,500 | 0 | 32,500 |
| SEAGEN INC | COM | 81181C104 | 9,037,590 | 42,600 | SH | | SOLE | | 0 | 0 | 42,600 |
| SI-BONE INC | COM | 825704109 | 48,693,358 | 2,292,531 | SH | | DFND | 1 | 147,900 | 0 | 2,144,631 |
| SINGULAR GENOMICS SYSTEMS IN | COM | 82933R100 | 206,006 | 540,697 | SH | | SOLE | | 540,697 | 0 | 0 |
| SINOVAC BIOTECH LTD | SHS | P8696W104 | 340,000,000 | 2,718,735 | SH | | SOLE | | 0 | 0 | 2,718,735 |
| SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 91,753,755 | 3,968,588 | SH | | SOLE | | 3,968,588 | 0 | 0 |
| STRYKER CORPORATION | COM | 863667101 | 73,509,630 | 269,000 | SH | | SOLE | | 0 | 0 | 269,000 |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 18,643,680 | 1,284,000 | SH | | DFND | 1 | 336,000 | 0 | 948,000 |
| SYNLOGIC INC | COM NEW | 87166L209 | 1,129,614 | 401,998 | SH | | SOLE | | 401,998 | 0 | 0 |
| TELA BIO INC | COM | 872381108 | 22,684,336 | 2,835,542 | SH | | SOLE | | 2,835,542 | 0 | 0 |
| TELADOC HEALTH INC | COM | 87918A105 | 2,044,900 | 110,000 | SH | | DFND | 1 | 40,000 | 0 | 70,000 |
| TENET HEALTHCARE CORP | COM NEW | 88033G407 | 80,675,716 | 1,224,400 | SH | | SOLE | | 0 | 0 | 1,224,400 |
| TERNS PHARMACEUTICALS INC | COM | 880881107 | 38,324,249 | 7,619,135 | SH | | SOLE | | 7,619,135 | 0 | 0 |
| THE CIGNA GROUP | COM | 125523100 | 66,225,205 | 231,500 | SH | | SOLE | | 0 | 0 | 231,500 |
| THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 72,787,246 | 143,800 | SH | | SOLE | | 0 | 0 | 143,800 |
| THESEUS PHARMACEUTICALS INC | COM | 88369M101 | 47,649,584 | 17,713,600 | SH | | SOLE | | 17,713,600 | 0 | 0 |
| THIRD HARMONIC BIO INC | COM | 88427A107 | 36,928,264 | 5,779,071 | SH | | SOLE | | 5,779,071 | 0 | 0 |
| TURNSTONE BIOLOGICS CORP | COM | 90042W100 | 12,211,104 | 3,099,265 | SH | | SOLE | | 3,099,265 | 0 | 0 |
| UNIQURE NV | SHS | N90064101 | 13,852,493 | 2,064,455 | SH | | DFND | 1 | 98,000 | 0 | 1,966,455 |
| UNITED THERAPEUTICS CORP DEL | COM | 91307C102 | 90,777,153 | 401,900 | SH | | DFND | 1 | 49,000 | 0 | 352,900 |
| UNITEDHEALTH GROUP INC | COM | 91324P102 | 35,293,300 | 70,000 | SH | | SOLE | | 0 | 0 | 70,000 |
| VAXCYTE INC | COM | 92243G108 | 51,344,405 | 1,007,148 | SH | | DFND | 1 | 122,700 | 0 | 884,448 |
| VENTYX BIOSCIENCES INC | COM | 92332V107 | 11,821,536 | 340,384 | SH | | DFND | 1 | 100,900 | 0 | 239,484 |
| VERA THERAPEUTICS INC | CL A | 92337R101 | 20,813,357 | 1,518,115 | SH | | DFND | 1 | 648,815 | 0 | 869,300 |
| VERASTEM INC | COM NEW | 92337C203 | 12,431,705 | 1,529,115 | SH | | SOLE | | 1,529,115 | 0 | 0 |
| VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 61,577,781 | 3,777,778 | SH | | SOLE | | 3,777,778 | 0 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 57,516,196 | 165,400 | SH | | SOLE | | 0 | 0 | 165,400 |
| VIGIL NEUROSCIENCE INC | COM | 92673K108 | 2,419,522 | 448,891 | SH | | SOLE | | 448,891 | 0 | 0 |
| X4 PHARMACEUTICALS INC | COM | 98420X103 | 7,775,531 | 7,133,515 | SH | | SOLE | | 7,133,515 | 0 | 0 |
| XENCOR INC | COM | 98401F105 | 385,711 | 19,142 | SH | | SOLE | | 0 | 0 | 19,142 |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 32,752,369 | 958,793 | SH | | DFND | 1 | 195,100 | 0 | 763,693 |
| XTANT MED HLDGS INC | COM NEW | 98420P308 | 80,426,051 | 73,114,592 | SH | | SOLE | | 73,114,592 | 0 | 0 |
| YS BIOPHARMA CO LTD | ORDINARY SHARES | G9845F109 | 3,633,138 | 4,541,422 | SH | | DFND | 1 | 1,590,652 | 0 | 2,950,770 |
