The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
10X GENOMICS INC | CL A COM | 88025U109 | 2,227,208 | 39,800 | SH | SOLE | 0 | 0 | 39,800 | ||
ABCELLERA BIOLOGICS INC | COM | 00288U106 | 23,872,185 | 4,180,768 | SH | SOLE | 4,180,768 | 0 | 0 | ||
ACELYRIN INC | COM | 00445A100 | 29,852,764 | 4,001,711 | SH | SOLE | 4,001,711 | 0 | 0 | ||
ACUTUS MED INC | COM | 005111109 | 534,709 | 2,648,386 | SH | SOLE | 2,648,386 | 0 | 0 | ||
ADICET BIO INC | COM | 007002108 | 15,728,845 | 8,322,140 | SH | SOLE | 8,322,140 | 0 | 0 | ||
AEROVATE THERAPEUTICS INC | COM | 008064107 | 17,129,326 | 756,930 | SH | DFND | 1 | 215,100 | 0 | 541,830 | |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 1,002,150 | 45,000 | SH | SOLE | 0 | 0 | 45,000 | ||
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 15,197,954 | 79,400 | SH | DFND | 1 | 4,300 | 0 | 75,100 | |
ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 48,321,770 | 2,535,245 | SH | SOLE | 2,535,245 | 0 | 0 | ||
ALX ONCOLOGY HLDGS INC | COM | 00166B105 | 46,084,550 | 3,095,000 | SH | DFND | 1 | 840,000 | 0 | 2,255,000 | |
AMBRX BIOPHARMA INC | COM | 641871108 | 4,215,040 | 296,000 | SH | DFND | 1 | 146,000 | 0 | 150,000 | |
AMGEN INC | COM | 031162100 | 36,664,946 | 127,300 | SH | SOLE | 0 | 0 | 127,300 | ||
AMICUS THERAPEUTICS INC | COM | 03152W109 | 11,437,140 | 806,000 | SH | SOLE | 0 | 0 | 806,000 | ||
APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 55,202,892 | 922,200 | SH | DFND | 1 | 92,100 | 0 | 830,100 | |
APOGEE THERAPEUTICS INC | COM | 03770N101 | 35,704,554 | 1,277,901 | SH | SOLE | 1,277,901 | 0 | 0 | ||
APOLLOMICS INC | CL A SHS | G0411D107 | 8,265,665 | 8,565,456 | SH | SOLE | 8,565,456 | 0 | 0 | ||
ARCUS BIOSCIENCES INC | COM | 03969F109 | 2,234,700 | 117,000 | SH | DFND | 1 | 58,000 | 0 | 59,000 | |
ARGENX SE | SPONSORED ADR | 04016X101 | 32,184,378 | 84,600 | SH | DFND | 1 | 5,800 | 0 | 78,800 | |
ARROWHEAD PHARMACEUTICALS IN | COM | 04280A100 | 9,781,321 | 319,651 | SH | SOLE | 0 | 0 | 319,651 | ||
ARS PHARMACEUTICALS INC | COM | 82835W108 | 50,640,061 | 9,240,887 | SH | DFND | 1 | 8,288,510 | 0 | 952,377 | |
BIOGEN INC | COM | 09062X103 | 214,158,052 | 827,600 | SH | DFND | 1 | 83,700 | 0 | 743,900 | |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 151,515,352 | 1,571,410 | SH | DFND | 1 | 147,600 | 0 | 1,423,810 | |
BIOMX INC | COM | 09090D103 | 1,264,925 | 4,517,589 | SH | SOLE | 4,517,589 | 0 | 0 | ||
BOLT BIOTHERAPEUTICS INC | COM | 097702104 | 1,725,920 | 1,541,000 | SH | SOLE | 1,541,000 | 0 | 0 | ||
BOSTON SCIENTIFIC CORP | COM | 101137107 | 191,166,108 | 3,306,800 | SH | SOLE | 0 | 0 | 3,306,800 | ||
CALCIMEDICA INC | COM NEW | 38942Q202 | 850,507 | 297,380 | SH | SOLE | 297,380 | 0 | 0 | ||
CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | 2,332,008 | 58,800 | SH | SOLE | 0 | 0 | 58,800 | ||
CHEMOMAB THERAPEUTICS LTD | SPONSORED ADS | 16385C104 | 1,143,050 | 2,241,274 | SH | SOLE | 2,241,274 | 0 | 0 | ||
COMPASS THERAPEUTICS INC | COM | 20454B104 | 34,886,046 | 22,362,850 | SH | DFND | 1 | 18,791,422 | 0 | 3,571,428 | |
CORVUS PHARMACEUTICALS INC | COM | 221015100 | 12,220,831 | 6,943,654 | SH | SOLE | 6,943,654 | 0 | 0 | ||
CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | 59,324,669 | 1,667,360 | SH | SOLE | 1,667,360 | 0 | 0 | ||
CULLINAN ONCOLOGY INC | COM | 230031106 | 5,552,001 | 544,848 | SH | SOLE | 544,848 | 0 | 0 | ||
DEXCOM INC | COM | 252131107 | 9,083,388 | 73,200 | SH | SOLE | 0 | 0 | 73,200 | ||
DISC MEDICINE INC | COM | 254604101 | 98,321,209 | 1,702,237 | SH | SOLE | 1,702,237 | 0 | 0 | ||
EDGEWISE THERAPEUTICS INC | COM | 28036F105 | 159,364,905 | 14,567,176 | SH | DFND | 1 | 14,301,551 | 0 | 265,625 | |
ELEVANCE HEALTH INC | COM | 036752103 | 66,725,740 | 141,500 | SH | SOLE | 0 | 0 | 141,500 | ||
ELEVATION ONCOLOGY INC | COM | 28623U101 | 805,500 | 1,500,000 | SH | SOLE | 1,500,000 | 0 | 0 | ||
ELI LILLY & CO | COM | 532457108 | 212,998,968 | 365,400 | SH | SOLE | 0 | 0 | 365,400 | ||
ENLIVEN THERAPEUTICS INC | COM | 29337E102 | 124,536,998 | 8,998,338 | SH | DFND | 1 | 8,951,463 | 0 | 46,875 | |
EVOLENT HEALTH INC | CL A | 30050B101 | 90,717,952 | 2,746,532 | SH | DFND | 1 | 214,700 | 0 | 2,531,832 | |
FATE THERAPEUTICS INC | COM | 31189P102 | 1,975,019 | 528,080 | SH | DFND | 1 | 139,300 | 0 | 388,780 | |
FUSION PHARMACEUTICALS INC | COM | 36118A100 | 30,009,820 | 3,122,770 | SH | DFND | 1 | 2,930,670 | 0 | 192,100 | |
GERON CORP | COM | 374163103 | 1,023,350 | 485,000 | SH | SOLE | 0 | 0 | 485,000 | ||
GILEAD SCIENCES INC | COM | 375558103 | 8,101,000 | 100,000 | SH | SOLE | 0 | 0 | 100,000 | ||
GRACELL BIOTECHNOLOGIES INC | SPONSORED ADS | 38406L103 | 93,459,609 | 9,308,726 | SH | DFND | 1 | 7,552,828 | 0 | 1,755,898 | |
HERON THERAPEUTICS INC | COM | 427746102 | 10,078,605 | 5,928,591 | SH | DFND | 1 | 2,207,091 | 0 | 3,721,500 | |
HUMANA INC | COM | 444859102 | 50,313,319 | 109,900 | SH | SOLE | 0 | 0 | 109,900 | ||
ICON PLC | SHS | G4705A100 | 37,421,854 | 132,200 | SH | SOLE | 0 | 0 | 132,200 | ||
IKENA ONCOLOGY INC | COM | 45175G108 | 6,972,535 | 3,539,358 | SH | DFND | 1 | 2,542,303 | 0 | 997,055 | |
IKENA ONCOLOGY INC | NONVOTING | 000000000 | 12,546,116 | 6,368,587 | SH | DFND | 1 | 5,739,432 | 0 | 629,155 | |
ILLUMINA INC | COM | 452327109 | 4,218,972 | 30,300 | SH | SOLE | 0 | 0 | 30,300 | ||
IMMATICS N.V | SHS | N44445109 | 16,252,076 | 1,543,407 | SH | DFND | 1 | 531,000 | 0 | 1,012,407 | |
INSPIREMD INC | COM | 45779A846 | 5,994,868 | 2,133,405 | SH | SOLE | 2,133,405 | 0 | 0 | ||
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 168,342,640 | 499,000 | SH | SOLE | 0 | 0 | 499,000 | ||
INVIVYD INC | COM | 00534A102 | 16,262,606 | 4,127,565 | SH | SOLE | 4,127,565 | 0 | 0 | ||
IONIS PHARMACEUTICALS INC | COM | 462222100 | 104,458,080 | 2,064,797 | SH | DFND | 1 | 157,300 | 0 | 1,907,497 | |
IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 38,271,634 | 4,707,458 | SH | SOLE | 0 | 0 | 4,707,458 | ||
JANUX THERAPEUTICS INC | COM | 47103J105 | 35,601,357 | 3,317,927 | SH | DFND | 1 | 2,789,666 | 0 | 528,261 | |
KEROS THERAPEUTICS INC | COM | 492327101 | 50,444,864 | 1,268,734 | SH | SOLE | 1,268,734 | 0 | 0 | ||
KEZAR LIFE SCIENCES INC | COM | 49372L100 | 1,825,640 | 1,927,000 | SH | SOLE | 0 | 0 | 1,927,000 | ||
KINNATE BIOPHARMA INC | COM | 49705R105 | 18,983,058 | 8,009,729 | SH | DFND | 1 | 7,559,729 | 0 | 450,000 | |
KRYSTAL BIOTECH INC | COM | 501147102 | 12,865,022 | 103,700 | SH | SOLE | 0 | 0 | 103,700 | ||
MERCK & CO INC | COM | 58933Y105 | 115,016,100 | 1,055,000 | SH | SOLE | 0 | 0 | 1,055,000 | ||
MORPHIC HLDG INC | COM | 61775R105 | 7,895,792 | 273,400 | SH | DFND | 1 | 52,900 | 0 | 220,500 | |
NATERA INC | COM | 632307104 | 59,788,690 | 954,481 | SH | DFND | 1 | 88,600 | 0 | 865,881 | |
NEUMORA THERAPEUTICS INC. | COM | 640979100 | 25,575,000 | 1,500,000 | SH | DFND | 1 | 443,000 | 0 | 1,057,000 | |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 68,420,201 | 519,279 | SH | SOLE | 0 | 0 | 519,279 | ||
NEUROPACE INC | COM | 641288105 | 41,280,900 | 4,003,967 | SH | SOLE | 4,003,967 | 0 | 0 | ||
NEXTCURE INC | COM | 65343E108 | 3,090,555 | 2,711,013 | SH | SOLE | 2,711,013 | 0 | 0 | ||
ORIC PHARMACEUTICALS INC | COM | 68622P109 | 4,811,306 | 522,968 | SH | SOLE | 522,968 | 0 | 0 | ||
PASSAGE BIO INC | COM | 702712100 | 10,225,822 | 10,124,576 | SH | DFND | 1 | 8,034,000 | 0 | 2,090,576 | |
PFIZER INC | COM | 717081103 | 14,395,000 | 500,000 | SH | Call | DFND | 1 | 177,000 | 0 | 323,000 |
PMV PHARMACEUTICALS INC | COM | 69353Y103 | 20,073,402 | 6,475,291 | SH | SOLE | 6,475,291 | 0 | 0 | ||
PRELUDE THERAPEUTICS INC | COM | 74065P101 | 46,582,523 | 10,909,256 | SH | DFND | 1 | 10,119,756 | 0 | 789,500 | |
PRELUDE THERAPEUTICS INC | NONVOTING | 000000000 | 24,254,394 | 5,680,186 | SH | DFND | 1 | 5,596,886 | 0 | 83,300 | |
R1 RCM INC | COM | 77634L105 | 50,769,824 | 4,803,200 | SH | SOLE | 0 | 0 | 4,803,200 | ||
RAPT THERAPEUTICS INC | COM | 75382E109 | 6,993,113 | 281,413 | SH | DFND | 1 | 70,900 | 0 | 210,513 | |
RAYZEBIO INC | COM | 75525N107 | 147,045,292 | 2,365,213 | SH | SOLE | 2,365,213 | 0 | 0 | ||
REGENERON PHARMACEUTICALS | COM | 75886F107 | 11,856,915 | 13,500 | SH | SOLE | 0 | 0 | 13,500 | ||
REPARE THERAPEUTICS INC | COM | 760273102 | 24,254,162 | 3,322,488 | SH | DFND | 1 | 3,177,041 | 0 | 145,447 | |
RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | 24,669,433 | 536,642 | SH | DFND | 1 | 96,315 | 0 | 440,327 | |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 67,259,925 | 697,500 | SH | DFND | 1 | 58,500 | 0 | 639,000 | |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 79,806,000 | 4,245,000 | SH | DFND | 1 | 1,285,000 | 0 | 2,960,000 | |
SCPHARMACEUTICALS INC | COM | 810648105 | 34,858,241 | 5,559,528 | SH | SOLE | 5,559,528 | 0 | 0 | ||
SI-BONE INC | COM | 825704109 | 48,120,226 | 2,292,531 | SH | DFND | 1 | 147,900 | 0 | 2,144,631 | |
SINGULAR GENOMICS SYSTEMS IN | COM | 82933R100 | 248,775 | 540,697 | SH | SOLE | 540,697 | 0 | 0 | ||
SINOVAC BIOTECH LTD | SHS | P8696W104 | 340,000,000 | 2,718,735 | SH | SOLE | 0 | 0 | 2,718,735 | ||
SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 117,506,604 | 3,219,359 | SH | SOLE | 3,219,359 | 0 | 0 | ||
STRYKER CORPORATION | COM | 863667101 | 80,554,740 | 269,000 | SH | SOLE | 0 | 0 | 269,000 | ||
SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 37,795,890 | 1,749,000 | SH | DFND | 1 | 417,900 | 0 | 1,331,100 | |
TELA BIO INC | COM | 872381108 | 18,771,288 | 2,835,542 | SH | SOLE | 2,835,542 | 0 | 0 | ||
TENET HEALTHCARE CORP | COM NEW | 88033G407 | 92,527,908 | 1,224,400 | SH | SOLE | 0 | 0 | 1,224,400 | ||
TERNS PHARMACEUTICALS INC | COM | 880881107 | 49,448,186 | 7,619,135 | SH | SOLE | 7,619,135 | 0 | 0 | ||
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 76,327,602 | 143,800 | SH | SOLE | 0 | 0 | 143,800 | ||
THESEUS PHARMACEUTICALS INC | COM | 88369M101 | 71,740,080 | 17,713,600 | SH | SOLE | 17,713,600 | 0 | 0 | ||
THIRD HARMONIC BIO INC | COM | 88427A107 | 63,396,409 | 5,779,071 | SH | SOLE | 5,779,071 | 0 | 0 | ||
TURNSTONE BIOLOGICS CORP | COM | 90042W100 | 7,887,629 | 3,099,265 | SH | SOLE | 3,099,265 | 0 | 0 | ||
UNIQURE NV | SHS | N90064101 | 9,125,283 | 1,347,900 | SH | SOLE | 0 | 0 | 1,347,900 | ||
UNITED THERAPEUTICS CORP DEL | COM | 91307C102 | 84,899,529 | 386,100 | SH | DFND | 1 | 49,000 | 0 | 337,100 | |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 36,852,900 | 70,000 | SH | SOLE | 0 | 0 | 70,000 | ||
VAXCYTE INC | COM | 92243G108 | 72,414,115 | 1,153,091 | SH | DFND | 1 | 129,300 | 0 | 1,023,791 | |
VERA THERAPEUTICS INC | CL A | 92337R101 | 23,348,609 | 1,518,115 | SH | DFND | 1 | 648,815 | 0 | 869,300 | |
VERASTEM INC | COM NEW | 92337C203 | 12,446,996 | 1,529,115 | SH | SOLE | 1,529,115 | 0 | 0 | ||
VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 75,102,227 | 3,777,778 | SH | SOLE | 3,777,778 | 0 | 0 | ||
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 71,287,128 | 175,200 | SH | SOLE | 0 | 0 | 175,200 | ||
VIGIL NEUROSCIENCE INC | COM | 92673K108 | 1,517,252 | 448,891 | SH | SOLE | 448,891 | 0 | 0 | ||
VIR BIOTECHNOLOGY INC | COM | 92764N102 | 1,016,060 | 101,000 | SH | SOLE | 0 | 0 | 101,000 | ||
X4 PHARMACEUTICALS INC | COM | 98420X103 | 5,981,452 | 7,133,515 | SH | SOLE | 7,133,515 | 0 | 0 | ||
XENON PHARMACEUTICALS INC | COM | 98420N105 | 25,333,000 | 550,000 | SH | DFND | 1 | 143,300 | 0 | 406,700 | |
XTANT MED HLDGS INC | COM NEW | 98420P308 | 82,619,489 | 73,114,592 | SH | SOLE | 73,114,592 | 0 | 0 | ||
YS BIOPHARMA CO LTD | ORDINARY SHARES | G9845F109 | 1,653,755 | 3,236,311 | SH | DFND | 1 | 889,300 | 0 | 2,347,011 |