Orbimed Advisors 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
10X GENOMICS INC	CL A COM	88025U109	8,451,756	225,200	SH		DFND	1	66,500	0	158,700
ABCELLERA BIOLOGICS INC	COM	00288U106	18,938,879	4,180,768	SH		SOLE		4,180,768	0	0
ACELYRIN INC	COM	00445A100	27,011,549	4,001,711	SH		SOLE		4,001,711	0	0
ACUTUS MED INC	COM	005111109	497,897	2,648,386	SH		SOLE		2,648,386	0	0
ADICET BIO INC	COM	007002108	26,900,779	11,447,140	SH		SOLE		11,447,140	0	0
AEROVATE THERAPEUTICS INC	COM	008064107	16,718,109	565,374	SH		DFND	1	215,100	0	350,274
ALPINE IMMUNE SCIENCES INC	COM	02083G100	106,254,861	2,680,496	SH		SOLE		2,680,496	0	0
ALX ONCOLOGY HLDGS INC	COM	00166B105	30,305,366	2,717,970	SH		DFND	1	696,900	0	2,021,070
AMGEN INC	COM	031162100	18,025,888	63,400	SH		SOLE		0	0	63,400
AMICUS THERAPEUTICS INC	COM	03152W109	6,718,134	570,300	SH		SOLE		0	0	570,300
APELLIS PHARMACEUTICALS INC	COM	03753U106	76,284,684	1,297,800	SH		DFND	1	82,900	0	1,214,900
APELLIS PHARMACEUTICALS INC	COM	03753U106	8,817,000	150,000	SH	Call	DFND	1	61,000	0	89,000
APOGEE THERAPEUTICS INC	COM	03770N101	47,770,971	718,901	SH		SOLE		718,901	0	0
APOLLOMICS INC	CL A SHS	G0411D107	6,424,092	8,565,456	SH		SOLE		8,565,456	0	0
ARGENX SE	SPONSORED ADR	04016X101	59,687,952	151,600	SH		DFND	1	5,800	0	145,800
ARRIVENT BIOPHARMA INC	COM	04272N102	54,068,078	3,027,328	SH		SOLE		3,027,328	0	0
ARROWHEAD PHARMACEUTICALS IN	COM	04280A100	21,154,019	739,651	SH		DFND	1	136,700	0	602,951
ARS PHARMACEUTICALS INC	COM	82835W108	94,441,865	9,240,887	SH		DFND	1	8,288,510	0	952,377
AVIDITY BIOSCIENCES INC	COM	05370A108	25,369,432	994,100	SH		DFND	1	126,800	0	867,300
BIOGEN INC	COM	09062X103	194,261,067	900,900	SH		DFND	1	83,700	0	817,200
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	111,664,190	1,278,500	SH		DFND	1	124,000	0	1,154,500
BIOMX INC	COM	09090D103	2,032,915	4,517,589	SH		SOLE		4,517,589	0	0
BOLT BIOTHERAPEUTICS INC	COM	097702104	2,157,400	1,541,000	SH		SOLE		1,541,000	0	0
BOSTON SCIENTIFIC CORP	COM	101137107	224,167,770	3,273,000	SH		SOLE		0	0	3,273,000
CALCIMEDICA INC	COM NEW	38942Q202	1,237,101	297,380	SH		SOLE		297,380	0	0
CHEMOMAB THERAPEUTICS LTD	SPONSORED ADS	16385C104	1,745,952	2,241,274	SH		SOLE		2,241,274	0	0
COMPASS THERAPEUTICS INC	COM	20454B104	44,278,443	22,362,850	SH		DFND	1	18,791,422	0	3,571,428
CORVUS PHARMACEUTICALS INC	COM	221015100	12,359,704	6,943,654	SH		SOLE		6,943,654	0	0
CRINETICS PHARMACEUTICALS IN	COM	22663K107	64,831,850	1,385,000	SH		SOLE		1,385,000	0	0
CULLINAN ONCOLOGY INC	COM	230031106	8,820,006	517,606	SH		SOLE		517,606	0	0
CYTOKINETICS INC	COM NEW	23282W605	47,864,097	682,700	SH		DFND	1	61,700	0	621,000
CYTOMX THERAPEUTICS INC	COM	23284F105	7,727,180	3,544,578	SH		DFND	1	1,856,300	0	1,688,278
DEXCOM INC	COM	252131107	19,459,610	140,300	SH		SOLE		0	0	140,300
DISC MEDICINE INC	COM	254604101	105,981,276	1,702,237	SH		SOLE		1,702,237	0	0
DYNAVAX TECHNOLOGIES CORP	COM NEW	268158201	1,408,535	113,500	SH		SOLE		0	0	113,500
DYNE THERAPEUTICS INC	COM	26818M108	20,111,476	708,400	SH		DFND	1	191,700	0	516,700
EDGEWISE THERAPEUTICS INC	COM	28036F105	273,996,191	15,021,721	SH		DFND	1	14,756,096	0	265,625
ELEVANCE HEALTH INC	COM	036752103	87,166,574	168,100	SH		SOLE		0	0	168,100
ELEVATION ONCOLOGY INC	COM	28623U101	4,828,741	941,275	SH		SOLE		941,275	0	0
ELI LILLY & CO	COM	532457108	280,687,968	360,800	SH		SOLE		0	0	360,800
ENLIVEN THERAPEUTICS INC	COM	29337E102	158,280,765	8,998,338	SH		DFND	1	8,951,463	0	46,875
ESPERION THERAPEUTICS INC NE	COM	29664W105	36,739,399	13,708,731	SH		DFND	1	4,508,133	0	9,200,598
EVOLENT HEALTH INC	CL A	30050B101	85,438,116	2,605,615	SH		DFND	1	214,700	0	2,390,915
EXACT SCIENCES CORP	COM	30063P105	9,696,024	140,400	SH		DFND	1	41,600	0	98,800
FATE THERAPEUTICS INC	COM	31189P102	9,948,284	1,355,352	SH		DFND	1	397,600	0	957,752
GERON CORP	COM	374163103	42,548,916	12,893,611	SH		DFND	1	3,405,290	0	9,488,321
HERON THERAPEUTICS INC	COM	427746102	28,008,994	10,111,550	SH		DFND	1	3,662,000	0	6,449,550
ICON PLC	SHS	G4705A100	58,488,895	174,100	SH		SOLE		0	0	174,100
IKENA ONCOLOGY INC	NONVOTING	000000000	9,043,394	6,368,587	SH		DFND	1	5,739,432	0	629,155
IKENA ONCOLOGY INC	COM	45175G108	5,025,888	3,539,358	SH		DFND	1	2,542,303	0	997,055
IMMATICS N.V	SHS	N44445109	18,599,631	1,769,708	SH		DFND	1	572,200	0	1,197,508
INSPIREMD INC	COM	45779A846	5,056,383	2,133,405	SH		SOLE		2,133,405	0	0
INTUITIVE SURGICAL INC	COM NEW	46120E602	196,791,279	493,100	SH		SOLE		0	0	493,100
INVIVYD INC	COM	00534A102	11,944,932	2,690,300	SH		SOLE		2,690,300	0	0
IONIS PHARMACEUTICALS INC	COM	462222100	87,264,981	2,013,033	SH		DFND	1	157,300	0	1,855,733
JANUX THERAPEUTICS INC	COM	47103J105	160,974,570	4,275,553	SH		DFND	1	2,812,766	0	1,462,787
KEROS THERAPEUTICS INC	COM	492327101	83,990,191	1,268,734	SH		SOLE		1,268,734	0	0
KEZAR LIFE SCIENCES INC	COM	49372L100	1,737,383	1,927,000	SH		SOLE		0	0	1,927,000
KINNATE BIOPHARMA INC	COM	49705R105	21,305,879	8,009,729	SH		DFND	1	7,559,729	0	450,000
KRYSTAL BIOTECH INC	COM	501147102	6,612,946	37,166	SH		SOLE		0	0	37,166
LEXICON PHARMACEUTICALS INC	COM NEW	528872302	8,500,800	3,542,000	SH		DFND	1	1,050,000	0	2,492,000
LYELL IMMUNOPHARMA INC	COM	55083R104	444,885	199,500	SH		DFND	1	106,100	0	93,400
MERCK & CO INC	COM	58933Y105	173,646,200	1,316,000	SH		SOLE		0	0	1,316,000
MILESTONE PHARMACEUTICALS IN	COM	59935V107	3,580,000	2,000,000	SH		DFND	1	1,036,600	0	963,400
MINERALYS THERAPEUTICS INC	COM	603170101	26,096,584	2,021,424	SH		DFND	1	460,400	0	1,561,024
MORPHIC HLDG INC	COM	61775R105	19,659,200	558,500	SH		DFND	1	129,700	0	428,800
NATERA INC	COM	632307104	82,261,959	899,431	SH		DFND	1	88,600	0	810,831
NEUMORA THERAPEUTICS INC.	COM	640979100	20,625,000	1,500,000	SH		DFND	1	443,000	0	1,057,000
NEUROCRINE BIOSCIENCES INC	COM	64125C109	58,353,952	423,100	SH		SOLE		0	0	423,100
NEUROPACE INC	COM	641288105	52,852,364	4,003,967	SH		SOLE		4,003,967	0	0
NEXTCURE INC	COM	65343E108	2,544,876	1,141,200	SH		SOLE		1,141,200	0	0
NKARTA INC	COM	65487U108	8,648,000	800,000	SH		DFND	1	285,600	0	514,400
ORIC PHARMACEUTICALS INC	COM	68622P109	3,947,625	287,100	SH		SOLE		287,100	0	0
PASSAGE BIO INC	COM	702712100	13,668,178	10,124,576	SH		DFND	1	8,034,000	0	2,090,576
PERSPECTIVE THERAPEUTICS INC	COM	46489V104	7,741,902	6,505,800	SH		SOLE		6,505,800	0	0
PMV PHARMACEUTICALS INC	COM	69353Y103	11,007,995	6,475,291	SH		SOLE		6,475,291	0	0
PRAXIS PRECISION MEDICINES I	COM NEW	74006W207	28,100,442	460,512	SH		DFND	1	146,300	0	314,212
PRELUDE THERAPEUTICS INC	NONVOTING	000000000	26,924,082	5,680,186	SH		DFND	1	5,596,886	0	83,300
PRELUDE THERAPEUTICS INC	COM	74065P101	51,709,873	10,909,256	SH		DFND	1	10,119,756	0	789,500
PROGYNY INC	COM	74340E103	4,322,395	113,300	SH		DFND	1	45,900	0	67,400
Q32 BIO INC	COM	746964105	38,390,898	2,252,987	SH		SOLE		2,252,987	0	0
REGENERON PHARMACEUTICALS	COM	75886F107	21,944,772	22,800	SH		SOLE		0	0	22,800
REPARE THERAPEUTICS INC	COM	760273102	15,648,918	3,322,488	SH		DFND	1	3,177,041	0	145,447
RHYTHM PHARMACEUTICALS INC	COM	76243J105	30,540,804	704,842	SH		DFND	1	162,615	0	542,227
SAREPTA THERAPEUTICS INC	COM	803607100	90,298,350	697,500	SH		DFND	1	58,500	0	639,000
SCHOLAR ROCK HLDG CORP	COM	80706P103	63,485,464	3,574,632	SH		DFND	1	1,082,100	0	2,492,532
SCPHARMACEUTICALS INC	COM	810648105	27,908,831	5,559,528	SH		SOLE		5,559,528	0	0
SI-BONE INC	COM	825704109	4,092,500	250,000	SH	Call	DFND	1	96,000	0	154,000
SI-BONE INC	COM	825704109	51,966,909	3,174,521	SH		DFND	1	287,377	0	2,887,144
SINGULAR GENOMICS SYSTEMS IN	COM	82933R100	278,026	540,697	SH		SOLE		540,697	0	0
SINOVAC BIOTECH LTD	SHS	P8696W104	340,000,000	2,718,735	SH		SOLE		0	0	2,718,735
SPRINGWORKS THERAPEUTICS INC	COM	85205L107	84,034,832	1,707,331	SH		SOLE		1,707,331	0	0
STRYKER CORPORATION	COM	863667101	96,267,030	269,000	SH		SOLE		0	0	269,000
SYNDAX PHARMACEUTICALS INC	COM	87164F105	41,626,200	1,749,000	SH		DFND	1	417,900	0	1,331,100
TELA BIO INC	COM	872381108	16,077,523	2,835,542	SH		SOLE		2,835,542	0	0
TENET HEALTHCARE CORP	COM NEW	88033G407	123,325,563	1,173,300	SH		SOLE		0	0	1,173,300
TERNS PHARMACEUTICALS INC	COM	880881107	49,981,526	7,619,135	SH		SOLE		7,619,135	0	0
THERMO FISHER SCIENTIFIC INC	COM	883556102	76,719,720	132,000	SH		SOLE		0	0	132,000
THIRD HARMONIC BIO INC	COM	88427A107	54,554,430	5,779,071	SH		SOLE		5,779,071	0	0
TURNSTONE BIOLOGICS CORP	COM	90042W100	8,120,074	3,099,265	SH		SOLE		3,099,265	0	0
TYRA BIOSCIENCES INC	COM	90240B106	12,605,663	768,638	SH		DFND	1	384,319	0	384,319
UNITEDHEALTH GROUP INC	COM	91324P102	34,629,000	70,000	SH		SOLE		0	0	70,000
VAXCYTE INC	COM	92243G108	72,827,409	1,066,131	SH		DFND	1	129,300	0	936,831
VENTYX BIOSCIENCES INC	COM	92332V107	10,287,508	1,870,456	SH		DFND	1	552,056	0	1,318,400
VERA THERAPEUTICS INC	CL A	92337R101	29,143,601	675,872	SH		DFND	1	264,172	0	411,700
VERASTEM INC	COM NEW	92337C203	18,043,557	1,529,115	SH		SOLE		1,529,115	0	0
VERONA PHARMA PLC	SPONSORED ADS	925050106	54,674,898	3,398,067	SH		SOLE		3,398,067	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	51,289,827	122,700	SH		SOLE		0	0	122,700
VIGIL NEUROSCIENCE INC	COM	92673K108	1,530,718	448,891	SH		SOLE		448,891	0	0
VIR BIOTECHNOLOGY INC	COM	92764N102	6,483,200	640,000	SH		SOLE		0	0	640,000
X4 PHARMACEUTICALS INC	COM	98420X103	9,915,586	7,133,515	SH		SOLE		7,133,515	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	23,677,500	550,000	SH		DFND	1	143,300	0	406,700
XERIS BIOPHARMA HOLDINGS INC	COM	98422E103	177,728	80,420	SH		DFND	1	11,567	0	68,853
XTANT MED HLDGS INC	COM NEW	98420P308	85,544,073	73,114,592	SH		SOLE		73,114,592	0	0
YS BIOPHARMA CO LTD	ORDINARY SHARES	G9845F109	1,104,636	1,534,430	SH		SOLE		0	0	1,534,430