The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
4D MOLECULAR THERAPEUTICS IN | COM | 35104E100 | 81,190,187 | 4,007,413 | SH | DFND | 1 | 0 | 4,007,413 | 0 | |
89BIO INC | COM | 282559103 | 45,208,944 | 4,047,354 | SH | DFND | 1 | 0 | 4,047,354 | 0 | |
AC IMMUNE SA | SHS | H00263105 | 72,856,180 | 14,571,236 | SH | DFND | 1 | 0 | 14,571,236 | 0 | |
ALLAKOS INC | COM | 01671P100 | 23,348,098 | 8,552,417 | SH | DFND | 1 | 0 | 8,552,417 | 0 | |
AN2 THERAPEUTICS INC | COM | 037326105 | 32,045,602 | 1,563,963 | SH | DFND | 1 | 0 | 1,563,963 | 0 | |
ANNEXON INC | COM | 03589W102 | 31,780,000 | 7,000,000 | SH | DFND | 1 | 0 | 7,000,000 | 0 | |
ASLAN PHARMACEUTICALS LTD | SPON ADS NEW | 04522R200 | 548,204 | 1,049,999 | SH | DFND | 1 | 0 | 1,049,999 | 0 | |
AXSOME THERAPEUTICS INC | COM | 05464T104 | 157,675,749 | 1,981,100 | SH | DFND | 1 | 0 | 1,981,100 | 0 | |
CALLIDITAS THERAPEUTICS AB | SPONSERED ADS | 13124Q106 | 19,327,500 | 750,000 | SH | DFND | 1 | 0 | 750,000 | 0 | |
CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 | 69,845,577 | 8,774,570 | SH | DFND | 1 | 0 | 8,774,570 | 0 | |
CIDARA THERAPEUTICS INC | COM | 171757107 | 5,447,735 | 6,861,127 | SH | DFND | 1 | 0 | 6,861,127 | 0 | |
CORVUS PHARMACEUTICALS INC | COM | 221015100 | 2,412,867 | 1,370,947 | SH | DFND | 1 | 0 | 1,370,947 | 0 | |
CULLINAN ONCOLOGY INC | COM | 230031106 | 32,574,383 | 3,196,701 | SH | DFND | 1 | 0 | 3,196,701 | 0 | |
CYTOMX THERAPEUTICS INC | COM | 23284F105 | 10,223,492 | 6,595,801 | SH | DFND | 1 | 0 | 6,595,801 | 0 | |
DELCATH SYS INC | COM NEW | 24661P807 | 4,060,780 | 976,149 | SH | DFND | 1 | 0 | 976,149 | 0 | |
ELEDON PHARMACEUTICALS INC | COM | 28617K101 | 7,788,078 | 4,326,710 | SH | DFND | 1 | 0 | 4,326,710 | 0 | |
ELEVATION ONCOLOGY INC | COM | 28623U101 | 1,241,651 | 2,312,200 | SH | DFND | 1 | 0 | 2,312,200 | 0 | |
ENGENE HOLDINGS INC | COM | 29286M105 | 20,777,072 | 2,251,037 | SH | DFND | 1 | 0 | 2,251,037 | 0 | |
ENGENE HOLDINGS INC | *W EXP 10/31/202 | 29286M113 | 803,592 | 945,402 | SH | DFND | 1 | 0 | 945,402 | 0 | |
ESSA PHARMA INC | COM NEW | 29668H708 | 57,740,951 | 8,748,629 | SH | DFND | 1 | 0 | 8,748,629 | 0 | |
FORTE BIOSCIENCES INC | COM | 34962G109 | 2,450,396 | 2,982,105 | SH | DFND | 1 | 0 | 2,982,105 | 0 | |
GALAPAGOS NV | SPON ADR | 36315X101 | 77,849,181 | 1,915,109 | SH | DFND | 1 | 0 | 1,915,109 | 0 | |
GH RESEARCH PLC | ORDINARY SHARES | G3855L106 | 60,320,916 | 10,400,158 | SH | DFND | 1 | 0 | 10,400,158 | 0 | |
GLYCOMIMETICS INC | COM | 38000Q102 | 22,524,458 | 9,544,262 | SH | DFND | 1 | 0 | 9,544,262 | 0 | |
IDEAYA BIOSCIENCES INC | COM | 45166A102 | 61,519,350 | 1,729,043 | SH | DFND | 1 | 0 | 1,729,043 | 0 | |
IKENA ONCOLOGY INC | COM | 45175G108 | 9,395,253 | 4,769,164 | SH | DFND | 1 | 0 | 4,769,164 | 0 | |
IMMUNOVANT INC | COM | 45258J102 | 12,639,000 | 300,000 | SH | DFND | 1 | 0 | 300,000 | 0 | |
INVENTIVA SA | ADS | 46124U107 | 3,073,459 | 686,040 | SH | DFND | 1 | 0 | 686,040 | 0 | |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 122,863,532 | 2,428,613 | SH | DFND | 1 | 0 | 2,428,613 | 0 | |
ITEOS THERAPEUTICS INC | COM | 46565G104 | 13,791,262 | 1,259,476 | SH | DFND | 1 | 0 | 1,259,476 | 0 | |
JANUX THERAPEUTICS INC | COM | 47103J105 | 49,141,447 | 4,579,818 | SH | DFND | 1 | 0 | 4,579,818 | 0 | |
KRONOS BIO INC | COM | 50107A104 | 3,631,304 | 2,905,043 | SH | DFND | 1 | 0 | 2,905,043 | 0 | |
KURA ONCOLOGY INC | COM | 50127T109 | 106,027,019 | 7,373,228 | SH | DFND | 1 | 0 | 7,373,228 | 0 | |
KYMERA THERAPEUTICS INC | COM | 501575104 | 131,419,453 | 5,161,801 | SH | DFND | 1 | 0 | 5,161,801 | 0 | |
LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 37,386,517 | 24,435,632 | SH | DFND | 1 | 0 | 24,435,632 | 0 | |
MERUS N V | COM | N5749R100 | 75,691,550 | 2,752,420 | SH | DFND | 1 | 0 | 2,752,420 | 0 | |
MIRUM PHARMACEUTICALS INC | COM | 604749101 | 129,003,108 | 4,370,024 | SH | DFND | 1 | 0 | 4,370,024 | 0 | |
MOLECULAR PARTNERS AG | ADS | 60853G106 | 1,764,020 | 443,221 | SH | DFND | 1 | 0 | 443,221 | 0 | |
MOLECULAR TEMPLATES INC | COM NEW | 608550208 | 1,968,541 | 532,038 | SH | DFND | 1 | 0 | 532,038 | 0 | |
MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 | 1,313,560,041 | 21,751,284 | SH | DFND | 1 | 0 | 21,751,284 | 0 | |
NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | N62509109 | 17,000,159 | 1,521,948 | SH | DFND | 1 | 0 | 1,521,948 | 0 | |
NLS PHARMACEUTICS LTD | SHS | H57830103 | 3,390,230 | 5,747,126 | SH | DFND | 1 | 0 | 5,747,126 | 0 | |
OLEMA PHARMACEUTICALS INC | COM | 68062P106 | 128,176,579 | 9,135,893 | SH | DFND | 1 | 0 | 9,135,893 | 0 | |
OVID THERAPEUTICS INC | COM | 690469101 | 22,060,384 | 6,851,051 | SH | DFND | 1 | 0 | 6,851,051 | 0 | |
PIERIS PHARMACEUTICALS INC | COM | 720795103 | 3,750,995 | 20,609,863 | SH | DFND | 1 | 0 | 20,609,863 | 0 | |
PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 131,729,365 | 5,744,848 | SH | DFND | 1 | 0 | 5,744,848 | 0 | |
RAIN ONCOLOGY INC | COM | 75082Q105 | 4,232,075 | 3,526,729 | SH | DFND | 1 | 0 | 3,526,729 | 0 | |
RELAY THERAPEUTICS INC | COM | 75943R102 | 43,710,195 | 3,970,045 | SH | DFND | 1 | 0 | 3,970,045 | 0 | |
REPARE THERAPEUTICS INC | COM | 760273102 | 75,435,280 | 10,333,600 | SH | DFND | 1 | 0 | 10,333,600 | 0 | |
REVOLUTION MEDICINES INC | COM | 76155X100 | 171,541,160 | 5,981,212 | SH | DFND | 1 | 0 | 5,981,212 | 0 | |
REZOLUTE INC | COM NEW | 76200L309 | 189,384 | 190,815 | SH | DFND | 1 | 0 | 190,815 | 0 | |
ROIVANT SCIENCES LTD | SHS | G76279101 | 30,797,253 | 2,742,409 | SH | DFND | 1 | 0 | 2,742,409 | 0 | |
SAB BIOTHERAPEUTICS INC | COM | 78397T103 | 6,310,069 | 9,178,282 | SH | DFND | 1 | 0 | 9,178,282 | 0 | |
SILENCE THERAPEUTICS PLC | ADS | 82686Q101 | 26,201,186 | 1,508,416 | SH | DFND | 1 | 0 | 1,508,416 | 0 | |
SPYRE THERAPEUTICS INC | COM NEW | 00773J202 | 14,785,962 | 687,080 | SH | DFND | 1 | 0 | 687,080 | 0 | |
STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 | 33,137,391 | 812,988 | SH | DFND | 1 | 0 | 812,988 | 0 | |
SUTRO BIOPHARMA INC | COM | 869367102 | 14,362,688 | 3,347,946 | SH | DFND | 1 | 0 | 3,347,946 | 0 | |
SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 40,518,750 | 1,875,000 | SH | DFND | 1 | 0 | 1,875,000 | 0 | |
THIRD HARMONIC BIO INC | COM | 88427A107 | 47,894,285 | 4,365,933 | SH | DFND | 1 | 0 | 4,365,933 | 0 | |
TSCAN THERAPEUTICS INC | COM | 89854M101 | 17,428,633 | 2,989,474 | SH | DFND | 1 | 0 | 2,989,474 | 0 | |
TYRA BIOSCIENCES INC | COM | 90240B106 | 37,943,391 | 2,739,595 | SH | DFND | 1 | 0 | 2,739,595 | 0 | |
UNICYCIVE THERAPEUTICS INC | COM | 90466Y103 | 1,837,909 | 2,118,139 | SH | DFND | 1 | 0 | 2,118,139 | 0 | |
VERASTEM INC | COM NEW | 92337C203 | 13,717,683 | 1,685,219 | SH | DFND | 1 | 0 | 1,685,219 | 0 | |
VERVE THERAPEUTICS INC | COM | 92539P101 | 9,061,000 | 650,000 | SH | DFND | 1 | 0 | 650,000 | 0 | |
VIGIL NEUROSCIENCE INC | COM | 92673K108 | 6,130,080 | 1,813,633 | SH | DFND | 1 | 0 | 1,813,633 | 0 | |
VIRACTA THERAPEUTICS INC | COM | 92765F108 | 2,060,357 | 3,614,662 | SH | DFND | 1 | 0 | 3,614,662 | 0 | |
VISTAGEN THERAPEUTICS INC | COM | 92840H400 | 10,280,000 | 2,000,000 | SH | DFND | 1 | 0 | 2,000,000 | 0 | |
XENON PHARMACEUTICALS INC | COM | 98420N105 | 40,996,716 | 890,072 | SH | DFND | 1 | 0 | 890,072 | 0 | |
XOMA CORP DEL | COM NEW | 98419J206 | 67,224,246 | 3,633,743 | SH | DFND | 1 | 0 | 3,633,743 | 0 | |
ZYMEWORKS INC | COM | 98985Y108 | 60,989,300 | 5,870,000 | SH | DFND | 1 | 0 | 5,870,000 | 0 |