The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
4D MOLECULAR THERAPEUTICS IN | COM | 35104E100 | 82,331,449 | 3,922,413 | SH | DFND | 1 | 0 | 3,922,413 | 0 | |
89BIO INC | COM | 282559103 | 60,623,517 | 7,568,479 | SH | DFND | 1 | 0 | 7,568,479 | 0 | |
AC IMMUNE SA | SHS | H00263105 | 75,151,395 | 18,834,936 | SH | DFND | 1 | 0 | 18,834,936 | 0 | |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 51,317,414 | 1,190,107 | SH | DFND | 1 | 0 | 1,190,107 | 0 | |
ALLAKOS INC | COM | 01671P100 | 16,552,417 | 16,552,417 | SH | DFND | 1 | 0 | 16,552,417 | 0 | |
ANNEXON INC | COM | 03589W102 | 34,300,000 | 7,000,000 | SH | DFND | 1 | 0 | 7,000,000 | 0 | |
ASLAN PHARMACEUTICALS LTD | SPON ADS NEW | 04522R200 | 315,000 | 1,049,999 | SH | DFND | 1 | 0 | 1,049,999 | 0 | |
AXSOME THERAPEUTICS INC | COM | 05464T104 | 76,877,500 | 955,000 | SH | DFND | 1 | 0 | 955,000 | 0 | |
CALLIDITAS THERAPEUTICS AB | SPONSERED ADS | 13124Q106 | 29,242,500 | 750,000 | SH | DFND | 1 | 0 | 750,000 | 0 | |
CELCUITY INC | COM | 15102K100 | 56,773,080 | 3,466,000 | SH | DFND | 1 | 0 | 3,466,000 | 0 | |
CG ONCOLOGY INC | COM | 156944100 | 76,332,629 | 2,417,885 | SH | DFND | 1 | 0 | 2,417,885 | 0 | |
CIDARA THERAPEUTICS INC | COM NEW | 171757206 | 4,096,077 | 343,055 | SH | DFND | 1 | 0 | 343,055 | 0 | |
CULLINAN THERAPEUTICS INC | COM | 230031106 | 100,291,912 | 5,750,683 | SH | DFND | 1 | 0 | 5,750,683 | 0 | |
CYTOMX THERAPEUTICS INC | COM | 23284F105 | 6,378,722 | 5,228,461 | SH | DFND | 1 | 0 | 5,228,461 | 0 | |
ELEDON PHARMACEUTICALS INC | COM | 28617K101 | 16,614,264 | 6,293,282 | SH | DFND | 1 | 0 | 6,293,282 | 0 | |
ELEVATION ONCOLOGY INC | COM | 28623U101 | 6,242,940 | 2,312,200 | SH | DFND | 1 | 0 | 2,312,200 | 0 | |
ENGENE HOLDINGS INC | COM | 29286M105 | 21,227,279 | 2,251,037 | SH | DFND | 1 | 0 | 2,251,037 | 0 | |
ENGENE HOLDINGS INC | *W EXP 10/31/202 | 29286M113 | 1,314,109 | 945,402 | SH | DFND | 1 | 0 | 945,402 | 0 | |
ESSA PHARMA INC | COM NEW | 29668H708 | 46,017,788 | 8,748,629 | SH | DFND | 1 | 0 | 8,748,629 | 0 | |
FOGHORN THERAPEUTICS INC | COM | 344174107 | 30,486,500 | 5,302,000 | SH | DFND | 1 | 0 | 5,302,000 | 0 | |
FORTE BIOSCIENCES INC | COM | 34962G109 | 1,601,390 | 2,982,105 | SH | DFND | 1 | 0 | 2,982,105 | 0 | |
GALAPAGOS NV | SPON ADR | 36315X101 | 38,890,277 | 1,569,422 | SH | DFND | 1 | 0 | 1,569,422 | 0 | |
GH RESEARCH PLC | ORDINARY SHARES | G3855L106 | 121,265,842 | 10,400,158 | SH | DFND | 1 | 0 | 10,400,158 | 0 | |
GLYCOMIMETICS INC | COM | 38000Q102 | 2,687,664 | 9,544,262 | SH | DFND | 1 | 0 | 9,544,262 | 0 | |
IDEAYA BIOSCIENCES INC | COM | 45166A102 | 40,808,564 | 1,162,306 | SH | DFND | 1 | 0 | 1,162,306 | 0 | |
IKENA ONCOLOGY INC | COM | 45175G108 | 7,869,121 | 4,769,164 | SH | DFND | 1 | 0 | 4,769,164 | 0 | |
IMMUNIC INC | COM | 4525EP101 | 9,882,299 | 8,902,972 | SH | DFND | 1 | 0 | 8,902,972 | 0 | |
INVENTIVA SA | ADS | 46124U107 | 2,023,818 | 686,040 | SH | DFND | 1 | 0 | 686,040 | 0 | |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 151,862,680 | 3,186,376 | SH | DFND | 1 | 0 | 3,186,376 | 0 | |
JANUX THERAPEUTICS INC | COM | 47103J105 | 18,495,608 | 441,528 | SH | DFND | 1 | 0 | 441,528 | 0 | |
KURA ONCOLOGY INC | COM | 50127T109 | 84,049,142 | 4,082,037 | SH | DFND | 1 | 0 | 4,082,037 | 0 | |
KYMERA THERAPEUTICS INC | COM | 501575104 | 154,079,760 | 5,161,801 | SH | DFND | 1 | 0 | 5,161,801 | 0 | |
MERUS N V | COM | N5749R100 | 75,681,329 | 1,279,049 | SH | DFND | 1 | 0 | 1,279,049 | 0 | |
MIRUM PHARMACEUTICALS INC | COM | 604749101 | 149,411,121 | 4,370,024 | SH | DFND | 1 | 0 | 4,370,024 | 0 | |
MOLECULAR PARTNERS AG | ADS | 60853G106 | 3,169,030 | 443,221 | SH | DFND | 1 | 0 | 443,221 | 0 | |
MOLECULAR TEMPLATES INC | COM NEW | 608550208 | 600,574 | 522,238 | SH | DFND | 1 | 0 | 522,238 | 0 | |
MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 | 956,403,957 | 21,751,284 | SH | DFND | 1 | 0 | 21,751,284 | 0 | |
NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | N62509109 | 29,236,621 | 1,521,948 | SH | DFND | 1 | 0 | 1,521,948 | 0 | |
NLS PHARMACEUTICS LTD | SHS | H57830103 | 1,246,552 | 5,747,126 | SH | DFND | 1 | 0 | 5,747,126 | 0 | |
OLEMA PHARMACEUTICALS INC | COM | 68062P106 | 98,850,362 | 9,135,893 | SH | DFND | 1 | 0 | 9,135,893 | 0 | |
OVID THERAPEUTICS INC | COM | 690469101 | 2,964,357 | 3,853,818 | SH | DFND | 1 | 0 | 3,853,818 | 0 | |
PIERIS PHARMACEUTICALS INC | COM NEW | 720795202 | 2,545,345 | 257,626 | SH | DFND | 1 | 0 | 257,626 | 0 | |
PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 115,013,399 | 3,319,290 | SH | DFND | 1 | 0 | 3,319,290 | 0 | |
REPARE THERAPEUTICS INC | COM | 760273102 | 34,100,880 | 10,333,600 | SH | DFND | 1 | 0 | 10,333,600 | 0 | |
REVOLUTION MEDICINES INC | COM | 76155X100 | 232,130,838 | 5,981,212 | SH | DFND | 1 | 0 | 5,981,212 | 0 | |
REZOLUTE INC | COM NEW | 76200L309 | 820,505 | 190,815 | SH | DFND | 1 | 0 | 190,815 | 0 | |
ROIVANT SCIENCES LTD | SHS | G76279101 | 28,987,263 | 2,742,409 | SH | DFND | 1 | 0 | 2,742,409 | 0 | |
SAB BIOTHERAPEUTICS INC | COM NEW | 78397T202 | 2,845,261 | 917,826 | SH | DFND | 1 | 0 | 917,826 | 0 | |
STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 | 97,694,414 | 2,487,762 | SH | DFND | 1 | 0 | 2,487,762 | 0 | |
THIRD HARMONIC BIO INC | COM | 88427A107 | 56,757,129 | 4,365,933 | SH | DFND | 1 | 0 | 4,365,933 | 0 | |
TSCAN THERAPEUTICS INC | COM | 89854M101 | 17,488,423 | 2,989,474 | SH | DFND | 1 | 0 | 2,989,474 | 0 | |
TYRA BIOSCIENCES INC | COM | 90240B106 | 74,532,492 | 4,661,194 | SH | DFND | 1 | 0 | 4,661,194 | 0 | |
UNICYCIVE THERAPEUTICS INC | COM | 90466Y103 | 1,102,420 | 2,200,000 | SH | DFND | 1 | 0 | 2,200,000 | 0 | |
VERASTEM INC | COM NEW | 92337C203 | 5,021,953 | 1,685,219 | SH | DFND | 1 | 0 | 1,685,219 | 0 | |
VERVE THERAPEUTICS INC | COM | 92539P101 | 3,172,000 | 650,000 | SH | DFND | 1 | 0 | 650,000 | 0 | |
VIGIL NEUROSCIENCE INC | COM | 92673K108 | 7,254,532 | 1,813,633 | SH | DFND | 1 | 0 | 1,813,633 | 0 | |
VIRACTA THERAPEUTICS INC | COM | 92765F108 | 1,965,292 | 3,614,662 | SH | DFND | 1 | 0 | 3,614,662 | 0 | |
VISTAGEN THERAPEUTICS INC | COM | 92840H400 | 6,960,000 | 2,000,000 | SH | DFND | 1 | 0 | 2,000,000 | 0 | |
XOMA CORP DEL | COM NEW | 98419J206 | 86,083,372 | 3,633,743 | SH | DFND | 1 | 0 | 3,633,743 | 0 | |
ZYMEWORKS INC | COM | 98985Y108 | 49,953,700 | 5,870,000 | SH | DFND | 1 | 0 | 5,870,000 | 0 |