Details of the Company’s significant subsidiaries or entities under the Company’s control at December 31, 2020 are as follows:
| Company | Country | Group ownership |
| ICON Clinical Research, S.A. | Argentina | 100% |
| ICON Clinical Research PTY Limited | Australia | 100% |
| MedPass International Pty Ltd | Australia | 100% |
| ICON Clinical Research Austria GmbH | Austria | 100% |
| DOCS International Belgium N.V. | Belgium | 100% |
| ICON Pesquisas Clínicas LTDA. | Brazil | 100% |
| ICON Clinical Research EOOD | Bulgaria | 100% |
| ICON Clinical Research (Canada) Inc. | Canada | 100% |
| ICON Life Sciences Canada Inc. | Canada | 100% |
| Oxford Outcomes LTD | Canada | 100% |
| ICON Chile Limitada | Chile | 100% |
| CRS (Beijing) Clinical Research Co., Limited | China | 100% |
| ICON Clinical Research (Beijing No.2) Co., Ltd | China | 100% |
| ICON Clinical Research (Beijing) Co., Ltd | China | 100% |
| ICON Clinical Research Hong Kong Limited | China (Hong Kong) | 100% |
| Ispitivanja ICON d.o.o (ICON Research Ltd.) | Croatia | 100% |
| ICON Clinical Research s.r.o. | Czech Republic | 100% |
| DOCS International Nordic Countries A/S | Denmark | 100% |
| DOCS International Finland Oy | Finland | 100% |
| DOCS International France S.A.S. | France | 100% |
| ICON Clinical Research SARL | France | 100% |
| Mapi Développement SAS | France | 100% |
| Mapi Research Trust* | France | 100% |
| Mapi SAS | France | 100% |
| MedPass International SAS | France | 100% |
| MedPass SAS | France | 100% |
| MPLR SAS | France | 100% |
| DOCS International Germany GmbH | Germany | 100% |
| ICON Clinical Research GmbH | Germany | 100% |
ICON Klinikai Kutató Korlátolt Felelősségű Társaság
(ICON Clinical Research Limited Liability Company) | Hungary | 100% |
| ICON Clinical Research India Private Limited | India | 100% |
| ICON Clinical Research Israel Limited | Israel | 100% |
| ICON Japan K.K. | Japan | 100% |
| ICON Investments Limited | Jersey | 100% |
ICON Clinical Research Korea Yuhan Hoesa (ICON Clinical Research Korea Ltd.) | Korea | 100% |
| ICON CRO Malaysia SDN. BHD. | Malaysia | 100% |
| ICON Clinical Research México, S.A. de C.V. | Mexico | 100% |
| DOCS Insourcing B.V. | Netherlands | 100% |
| DOCS International B.V. | Netherlands | 100% |
| ICON Contracting Solutions Holdings B.V. | Netherlands | 100% |
| ICON Clinical Research (New Zealand) Limited | New Zealand | 100% |
| ICON Clinical Research Perú S.A. | Peru | 100% |
| ICON Clinical Research Services Philippines, Inc. | Philippines | 100% |
| Country | Group ownership |
| DOCS International Poland Sp. z o.o. | Poland | 100% |
| ICON Clinical Research Sp. z o.o. | Poland | 100% |
| Symphony Clinical Research Sp. z o.o. | Poland | 100% |
| Accellacare Limited | Republic of Ireland | 100% |
| DOCS Resourcing Limited | Republic of Ireland | 100% |
| ICON (LR) Limited | Republic of Ireland | 100% |
| ICON Clinical International Unlimited Company | Republic of Ireland | 100% |
| ICON Clinical Research Limited | Republic of Ireland | 100% |
| ICON Clinical Research Property Development (Ireland) Limited | Republic of Ireland | 100% |
| ICON Global Treasury Unlimited Company | Republic of Ireland | 100% |
| ICON Holdings Unlimited Company | Republic of Ireland | 100% |
| ICON Holdings Clinical Research International Limited | Republic of Ireland | 100% |
| ICON Investments Five Unlimited Company | Republic of Ireland | 100% |
| ICON Investments Four Unlimited Company | Republic of Ireland | 100% |
| ICON Clinical Research S.R.L. | Romania | 100% |
| ICON Clinical Research (Rus) LLC | Russia | 100% |
| ICON Clinical Research d.o.o. Beograd | Serbia | 100% |
| ICON Clinical Research (Pte) Limited | Singapore | 100% |
| ICON Clinical Research Slovakia, s.r.o. | Slovakia | 100% |
| MeDiNova Merc Clinical Research (SA) Pty Limited | South Africa | 100% |
| ICON Clinical Research España, S.L. | Spain | 100% |
| MeDiNova Investigacion y Desarrollo S.L. | Spain | 100% |
| DOCS International Sweden AB | Sweden | 100% |
| DOCS International Switzerland GmbH | Switzerland | 100% |
| ICON Clinical Research (Switzerland) GmbH | Switzerland | 100% |
| ICON Clinical Research Taiwan Limited | Taiwan | 100% |
| ICON Clinical Research (Thailand) Limited | Thailand | 100% |
| ICON Ankara Klinik Arastirma Dis Ticaret Anonim Sirketi | Turkey | 100% |
| DOCS Ukraine LLC | Ukraine | 100% |
| ICON Clinical Research LLC | Ukraine | 100% |
| DOCS International UK Limited | United Kingdom | 100% |
| ICON Clinical Research (U.K.) Limited | United Kingdom | 100% |
| ICON Development Solutions Limited | United Kingdom | 100% |
| Mapi Life Sciences UK Limited | United Kingdom | 100% |
| VSK (Kenilworth) Limited | United Kingdom | 100% |
| MeDiNova Limited | United Kingdom | 100% |
| MeDiNova Lakeside Clinical Research Limited | United Kingdom | 100% |
| MeDiNova Merc (UK) Limited | United Kingdom | 100% |
| Improving Treatments Limited | United Kingdom | 100% |
| MedPass Group Limited | United Kingdom | 100% |
| MedPass Limited | United Kingdom | 100% |
| MedPass International Limited | United Kingdom | 100% |
| Addplan, Inc. | USA | 100% |
| Beacon Bioscience, Inc. | USA | 100% |
| C4 MedSolutions, LLC | USA | 100% |
| CHC Group, LLC | USA | 100% |
| Complete Healthcare Communications, LLC | USA | 100% |
| Complete Publication Solutions, LLC | USA | 100% |
| CRN Holdings, LLC | USA | 100% |
| Country | Group ownership |
| Clinical Resource Network, LLC | USA | 100% |
| CRN North America, LLC | USA | 100% |
| DOCS Global, Inc. | USA | 100% |
| Global Pharmaceutical Strategies Group, LLC | USA | 100% |
| ICON Clinical Research LLC | USA | 100% |
| ICON Early Phase Services, LLC | USA | 100% |
| ICON Government and Public Health Solutions, Inc. | USA | 100% |
| ICON Laboratory Services, Inc. | USA | 100% |
| ICON US Holdings Inc. | USA | 100% |
| Managed Care Strategic Solutions, L.L.C. | USA | 100% |
| MMMM Consulting, LLC | USA | 100% |
| MMMM Group, LLC | USA | 100% |
| Molecular MD Corp. | USA | 100% |
| PMG Research of Bristol, LLC | USA | 100% |
| PMG Research of Charleston, LLC | USA | 100% |
| PMG Research of Charlotte, LLC | USA | 100% |
| PMG Research of Christie Clinic, LLC | USA | 100% |
| PMG Research of Hickory, LLC | USA | 100% |
| PMG Research of Raleigh, LLC | USA | 100% |
| PMG Research of Rocky Mount, LLC | USA | 100% |
| PMG Research of Salisbury, LLC | USA | 100% |
| PMG Research of Wilmington, LLC | USA | 100% |
| PMG Research of Winston-Salem, LLC | USA | 100% |
| PMG Research, Inc. | USA | 100% |
| Pricespective, LLC | USA | 100% |
| PubsHub LLC | USA | 100% |
| *Mapi Research Trust is an association, its members are ICON Subsidiary entities. |
