Document and Entity Information
Document and Entity Information Document - shares | 9 Months Ended | |
Sep. 30, 2016 | Nov. 03, 2016 | |
Document Information [Line Items] | ||
Entity Registrant Name | LEXICON PHARMACEUTICALS, INC./DE | |
Entity Central Index Key | 1,062,822 | |
Document Type | 10-Q | |
Document Period End Date | Sep. 30, 2016 | |
Amendment Flag | false | |
Document Fiscal Year Focus | 2,016 | |
Document Fiscal Period Focus | Q3 | |
Current Fiscal Year End Date | --12-31 | |
Entity Current Reporting Status | Yes | |
Entity Filer Category | Accelerated Filer | |
Entity Common Stock, Shares Outstanding | 104,036,346 |
Consolidated Balance Sheets (Un
Consolidated Balance Sheets (Unaudited) - USD ($) $ in Thousands | Sep. 30, 2016 | Dec. 31, 2015 |
Current assets: | ||
Cash and cash equivalents | $ 38,772 | $ 202,989 |
Short-term investments | 356,784 | 318,363 |
Accounts receivable, net of allowances of $4 | 738 | 911 |
Prepaid expenses and other current assets | 2,443 | 10,137 |
Total current assets | 398,737 | 532,400 |
Property and equipment, net of accumulated depreciation and amortization of $59,367 and $59,428, respectively | 19,854 | 21,227 |
Goodwill | 44,543 | 44,543 |
Other intangible assets | 53,357 | 53,357 |
Other assets | 454 | 433 |
Total assets | 516,945 | 651,960 |
Current liabilities: | ||
Accounts payable | 41,545 | 19,725 |
Accrued liabilities | 32,906 | 24,757 |
Current portion of deferred revenue | 78,870 | 76,499 |
Current portion of long-term debt, net of deferred issuance costs | 16,792 | 1,976 |
Total current liabilities | 170,113 | 122,957 |
Deferred revenue, net of current portion | 55,438 | 109,151 |
Long-term debt, net of deferred issuance costs | 85,038 | 100,960 |
Deferred tax liabilities | 18,675 | 18,675 |
Other long-term liabilities | 2,500 | 14,367 |
Total liabilities | 331,764 | 366,110 |
Commitments and contingencies | ||
Equity: | ||
Preferred stock, $.01 par value; 5,000 shares authorized; no shares issued and outstanding | 0 | 0 |
Common stock, $.001 par value; 225,000 shares authorized; 104,323 and 103,860 shares issued, respectively | 104 | 104 |
Additional paid-in capital | 1,406,311 | 1,397,646 |
Accumulated deficit | (1,217,944) | (1,108,934) |
Accumulated other comprehensive gain (loss) | 78 | (219) |
Treasury stock, at cost, 306 and 237 shares, respectively | (3,368) | (2,747) |
Total equity | 185,181 | 285,850 |
Total liabilities and equity | $ 516,945 | $ 651,960 |
Balance Sheet Parenthetical (Pa
Balance Sheet Parenthetical (Parenthetical) - USD ($) shares in Thousands, $ in Thousands | Sep. 30, 2016 | Dec. 31, 2015 |
Allowances for accounts receivable | $ 4 | $ 4 |
Accumulated depreciation and amortization, property and equipment | $ 59,367 | $ 59,428 |
Preferred stock, par value per share | $ 0.01 | $ 0.01 |
Preferred stock, shares authorized | 5,000 | 5,000 |
Preferred stock, shares issued | 0 | 0 |
Preferred stock, shares outstanding | 0 | 0 |
Common stock, par value per share | $ 0.001 | $ 0.001 |
Common stock, shares authorized | 225,000 | 225,000 |
Treasury stock, shares | 306 | 237 |
Common Stock | ||
Common stock, shares issued | 104,323 | 103,860 |
Consolidated Statements of Comp
Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands | 3 Months Ended | 9 Months Ended | ||
Sep. 30, 2016 | Sep. 30, 2015 | Sep. 30, 2016 | Sep. 30, 2015 | |
Revenues: | ||||
Collaborative agreements | $ 27,686 | $ 505 | $ 60,181 | $ 2,635 |
Subscription and license fees | 31 | 61 | 119 | 99 |
Total revenues | 27,717 | 566 | 60,300 | 2,734 |
Operating expenses: | ||||
Research and development, including stock-based compensation of $1,051, $893, $3,013 and $2,865, respectively | 52,533 | 23,111 | 137,751 | 64,745 |
Increase (decrease) in fair value of Symphony Icon, Inc. purchase liability | (2,146) | 3,404 | (703) | 5,145 |
General and administrative, including stock-based compensation of $879, $779, $2,709 and $2,548, respectively | 12,263 | 5,379 | 29,077 | 17,387 |
Impairment loss on buildings | 0 | 2,349 | 0 | 2,349 |
Total operating expenses | 62,650 | 34,243 | 166,125 | 89,626 |
Loss from operations | (34,933) | (33,677) | (105,825) | (86,892) |
Interest expense | (1,646) | (1,687) | (4,933) | (5,044) |
Interest and other income, net | 564 | 82 | 1,748 | 504 |
Net loss | $ (36,015) | $ (35,282) | $ (109,010) | $ (91,432) |
Net loss per common share, basic and diluted | $ (0.35) | $ (0.34) | $ (1.05) | $ (0.88) |
Shares used in computing consolidated net loss per common share, basic and diluted | 103,885 | 103,616 | 103,799 | 103,580 |
Unrealized gain on investments | $ (258) | $ (40) | $ 297 | $ 121 |
Comprehensive loss | $ (36,273) | $ (35,322) | $ (108,713) | $ (91,311) |
Statements of Comprehensive Los
Statements of Comprehensive Loss Parenthetical (Parenthetical) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended | ||
Sep. 30, 2016 | Sep. 30, 2015 | Sep. 30, 2016 | Sep. 30, 2015 | |
Stock-based compensation expense associated with research and development expense | $ 1,051 | $ 893 | $ 3,013 | $ 2,865 |
Stock-based compensation expense associated with general and administrative expense | $ 879 | $ 779 | $ 2,709 | $ 2,548 |
Consolidated Statements of Stoc
Consolidated Statements of Stockholders' Equity (Unaudited) - USD ($) shares in Thousands, $ in Thousands | Total | Common Stock | Additional Paid-In Capital | Accumulated Deficit | Accumulated Other Comprehensive Gain (Loss) | Treasury Stock |
Balance, shares at Dec. 31, 2014 | 103,663 | |||||
Balance, value at Dec. 31, 2014 | $ 284,018 | $ 104 | $ 1,390,619 | $ (1,104,252) | $ (63) | $ (2,390) |
Stock-based compensation | 5,413 | $ 0 | 5,413 | 0 | 0 | 0 |
Issuance of common stock under Equity Incentive Plans, shares | 197 | |||||
Issuance of common stock under Equity Incentive Plans, value | 114 | $ 0 | 114 | 0 | 0 | 0 |
Repurchase of common stock | (357) | 0 | 0 | 0 | 0 | (357) |
Net loss | (91,432) | 0 | 0 | (91,432) | 0 | 0 |
Unrealized gain on investments | 121 | 0 | 0 | 0 | 121 | 0 |
Other | 61 | $ 0 | 61 | 0 | 0 | 0 |
Balance, shares at Sep. 30, 2015 | 103,860 | |||||
Balance, value at Sep. 30, 2015 | 197,938 | $ 104 | 1,396,207 | (1,195,684) | 58 | (2,747) |
Balance, shares at Dec. 31, 2015 | 103,860 | |||||
Balance, value at Dec. 31, 2015 | 285,850 | $ 104 | 1,397,646 | (1,108,934) | (219) | (2,747) |
Stock-based compensation | 5,722 | $ 0 | 5,722 | 0 | 0 | 0 |
Issuance of common stock under Equity Incentive Plans, shares | 463 | |||||
Issuance of common stock under Equity Incentive Plans, value | 2,943 | $ 0 | 2,943 | 0 | 0 | 0 |
Repurchase of common stock | (621) | 0 | 0 | 0 | 0 | (621) |
Net loss | (109,010) | 0 | 0 | (109,010) | 0 | 0 |
Unrealized gain on investments | 297 | $ 0 | 0 | 0 | 297 | 0 |
Balance, shares at Sep. 30, 2016 | 104,323 | |||||
Balance, value at Sep. 30, 2016 | $ 185,181 | $ 104 | $ 1,406,311 | $ (1,217,944) | $ 78 | $ (3,368) |
Consolidated Statements of Cash
Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 9 Months Ended | |
Sep. 30, 2016 | Sep. 30, 2015 | |
Cash flows from operating activities: | ||
Net loss | $ (109,010) | $ (91,432) |
Adjustments to reconcile consolidated net loss to net cash used in operating activities: | ||
Depreciation and amortization | 1,548 | 661 |
Impairment of fixed assets | 0 | 2,349 |
Increase (decrease) in fair value of Symphony Icon, Inc. purchase liability | (703) | 5,145 |
Stock-based compensation | 5,722 | 5,413 |
Amortization of debt issuance costs | 389 | 380 |
(Gain) loss on disposal of property and equipment | 12 | (47) |
Changes in operating assets and liabilities: | ||
Decrease in accounts receivable | 173 | 963 |
(Increase) decrease in prepaid expenses and other current assets | 7,694 | (6,189) |
Increase in other assets | (25) | (469) |
Increase in accounts payable and other liabilities | 18,705 | 2,924 |
Decrease in deferred revenue | (51,342) | (846) |
Net cash used in operating activities | (126,837) | (81,148) |
Cash flows from investing activities: | ||
Purchases of property and equipment | (83) | (664) |
Proceeds from disposal of property and equipment | 0 | 335 |
Purchases of investments | (336,649) | (82,554) |
Maturities of investments | 298,525 | 90,000 |
Net cash provided by (used in) investing activities | (38,207) | 7,117 |
Cash flows from financing activities: | ||
Proceeds from issuance of common stock | 2,943 | 114 |
Repurchase of common stock | (621) | (357) |
Repayment of debt borrowings | (1,495) | (1,379) |
Other financing activities | 0 | 61 |
Net cash provided by (used in) financing activities | 827 | (1,561) |
Net decrease in cash and cash equivalents | (164,217) | (75,592) |
Cash and cash equivalents at beginning of period | 202,989 | 137,266 |
Cash and cash equivalents at end of period | 38,772 | 61,674 |
Supplemental disclosure of cash flow information: | ||
Cash paid for interest | 3,406 | 3,586 |
Supplemental disclosure of non-cash investing and financing activities: | ||
Unrealized gain on investments | $ 297 | $ 121 |
Basis of Presentation
Basis of Presentation | 9 Months Ended |
Sep. 30, 2016 | |
Basis of Presentation [Abstract] | |
Organization, Consolidation and Presentation of Financial Statements Disclosure | Basis of Presentation The accompanying unaudited consolidated financial statements of Lexicon Pharmaceuticals, Inc. (“Lexicon” or the “Company”) have been prepared in accordance with generally accepted accounting principles for interim financial information and pursuant to the rules and regulations of the Securities and Exchange Commission (“SEC”). Accordingly, they do not include all of the information and footnotes required by generally accepted accounting principles for complete financial statements. In the opinion of management, all adjustments (consisting of normal recurring adjustments) considered necessary for a fair presentation have been included. Operating results for the nine -month period ended September 30, 2016 are not necessarily indicative of the results that may be expected for the year ended December 31, 2016 . The accompanying consolidated financial statements include the accounts of Lexicon and its wholly-owned subsidiaries. Intercompany transactions and balances are eliminated in consolidation. For further information, refer to the financial statements and footnotes thereto included in Lexicon’s annual report on Form 10-K for the year ended December 31, 2015 , as filed with the SEC. |
Net Loss Per Share
Net Loss Per Share | 9 Months Ended |
Sep. 30, 2016 | |
Net Loss Per Share [Abstract] | |
Earnings Per Share | Net Loss Per Share Net loss per share is computed using the weighted average number of shares of common stock outstanding during the applicable period and excludes shares underlying convertible debt, stock options and restricted stock units because they are antidilutive. There are no differences between basic and diluted net loss per share for all periods presented. |
Stock-Based Compensation
Stock-Based Compensation | 9 Months Ended |
Sep. 30, 2016 | |
Stock-Based Compensation [Abstract] | |
Disclosure of Share-based Compensation Arrangements by Share-based Payment Award | Stock-Based Compensation The Company recorded $1.9 million and $1.7 million of stock-based compensation expense for the three months ended September 30, 2016 and 2015 , respectively. The Company recorded $5.7 million and $5.4 million of stock-based compensation expense for the nine months ended September 30, 2016 and 2015 , respectively. The Company utilized the Black-Scholes valuation model for estimating the fair value of the stock compensation granted, with the following weighted-average assumptions for options granted in the nine months ended September 30, 2016 and 2015 : Expected Volatility Risk-free Interest Rate Expected Term Dividend Rate September 30, 2016: Employees 63 % 1.1 % 4 — % Officers and non-employee directors 83 % 1.6 % 8 — % September 30, 2015: Employees 63 % 1.2 % 4 — % Officers and non-employee directors 81 % 1.8 % 8 — % The following is a summary of option activity under Lexicon’s stock-based compensation plans for the nine months ended September 30, 2016 : Options Weighted Average Exercise Price (in thousands) Outstanding at December 31, 2015 4,217 $ 12.35 Granted 1,302 10.06 Exercised (236 ) 12.05 Expired (167 ) 27.29 Forfeited (33 ) 11.24 Outstanding at September 30, 2016 5,083 11.30 Exercisable at September 30, 2016 2,874 $ 12.80 During the nine months ended September 30, 2016 , Lexicon also granted its employees annual restricted stock units. These restricted stock units vest in four annual installments. The following is a summary of restricted stock units activity under Lexicon’s stock-based compensation plans for the nine months ended September 30, 2016 : Shares Weighted Average Grant Date Fair Value (in thousands) Outstanding at December 31, 2015 637 $ 8.74 Granted 496 8.20 Vested (206 ) 9.75 Forfeited (35 ) 10.77 Nonvested at September 30, 2016 892 $ 8.12 During the nine months ended September 30, 2016 , Lexicon granted its non-employee directors 11,456 shares of restricted stock awards. The restricted stock awards had a weighted average grant date fair value of $13.96 per share and vested immediately. |
Recent Accounting Pronouncement
Recent Accounting Pronouncements | 9 Months Ended |
Sep. 30, 2016 | |
Recent Accounting Pronouncements [Abstract] | |
New Accounting Pronouncements, Policy | Recent Accounting Pronouncements In May 2014, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) No. 2014-09, “Revenue from Contracts with Customers”, which amends FASB ASC Topic 606. ASU 2014-09 provides a single, comprehensive revenue recognition model for all contracts with customers. This standard contains principles for the determination of the measurement of revenue and the timing of when such revenue is recognized. Revenue recognition will reflect the transfer of goods or services to customers at an amount that is expected to be earned in exchange for those goods or services. ASU 2014-09 was scheduled to be effective for annual reporting periods beginning after December 15, 2016, and early adoption was not permitted. In August 2015, the FASB issued ASU No. 2015-14, “Revenue from Contracts with Customers: Deferral of Effective Date”, which defers the effective date of ASU 2014-09 by one year. ASU 2014-09 is now effective for annual periods after December 15, 2017 including interim periods within that reporting period. Early application is permitted only for annual periods beginning after December 15, 2016, including interim periods within that reporting period. Management is currently evaluating the impact of these pronouncements on Lexicon’s consolidated financial statements. In April 2015, the FASB issued ASU No. 2015-03, “Simplifying the Presentation of Debt Issuance Costs.” ASU 2015-03 requires that debt issuance costs related to a recognized debt liability be presented in the balance sheet as a direct deduction from the carrying amount of that debt liability, consistent with debt discounts. During the nine months ended September 30, 2016 , the Company adopted ASU No. 2015-03 retrospectively for all periods presented in the accompanying consolidated balance sheets. The reclassification of debt issuance costs resulted in reductions in other assets, current portion of long-term debt and long-term debt of $2.9 million , $39,000 and $2.8 million , respectively, as of December 31, 2015. In November 2015, the FASB issued ASU No. 2015-17, “Income Taxes.” ASU 2015-17 simplifies the presentation of deferred income taxes, requiring that deferred tax assets and liabilities be classified as noncurrent in a classified balance sheet. The pronouncement is effective for fiscal years, and interim periods within those years, beginning after December 31, 2016, and early adoption is permitted. Management does not expect the adoption of this pronouncement to have a material impact on Lexicon’s consolidated financial statements. In January 2016, the FASB issued ASU No. 2016-01, “Recognition and Measurement of Financial Assets and Financial Liabilities.” ASU 2016-01 requires that most equity investments be measured at fair value, with subsequent changes in fair value recognized in net income. The pronouncement also impacts financial liabilities under the fair value option and the presentation and disclosure requirements for financial instruments. This pronouncement is effective for fiscal years, and interim periods within those years, beginning after December 15, 2017, and early adoption is not permitted. Management does not expect the adoption of this pronouncement to have a material impact on Lexicon’s consolidated financial statements. In February 2016, the FASB issued ASU No. 2016-02, “Leases.” ASU 2016-02 requires companies that lease assets to recognize a right-of-use asset and a lease liability, initially measured at the present value of the lease payments, in its balance sheet. The pronouncement will also require additional disclosures about the amount, timing and uncertainty of cash flows arising from leases. This pronouncement is effective for fiscal years, and interim periods within those years, beginning after December 15, 2018, and early adoption is permitted. Management is currently evaluating the impact of this pronouncement on Lexicon’s consolidated financial statements. In March 2016, the FASB issued ASU No. 2016-09, “Stock Compensation,” which is intended to simplify several aspects of the accounting for share-based payment award transactions. This pronouncement is effective for fiscal years, and interim periods within those years, beginning after December 15, 2016, and early adoption is permitted. Management is currently evaluating the impact of this pronouncement on Lexicon’s consolidated financial statements. |
Cash and Cash Equivalents and I
Cash and Cash Equivalents and Investments | 9 Months Ended |
Sep. 30, 2016 | |
Cash and Cash Equivalents and Investments [Abstract] | |
Cash and Cash Equivalents Disclosure | Cash and Cash Equivalents and Investments The fair value of cash and cash equivalents and investments held at September 30, 2016 and December 31, 2015 are as follows: As of September 30, 2016 Amortized Cost Gross Unrealized Gains Gross Unrealized Losses Estimated Fair Value (in thousands) Cash and cash equivalents $ 38,772 $ — $ — $ 38,772 Securities maturing within one year: U.S. treasury securities 318,979 119 (20 ) 319,078 Corporate debt securities 37,727 5 (26 ) 37,706 Total short-term investments $ 356,706 $ 124 $ (46 ) $ 356,784 Total cash and cash equivalents and investments $ 395,478 $ 124 $ (46 ) $ 395,556 As of December 31, 2015 Amortized Cost Gross Unrealized Gains Gross Unrealized Losses Estimated Fair Value (in thousands) Cash and cash equivalents $ 202,989 $ — $ — $ 202,989 Securities maturing within one year: U.S. treasury securities 313,105 2 (219 ) 312,888 Corporate debt securities 5,477 — (2 ) 5,475 Total short-term investments $ 318,582 $ 2 $ (221 ) $ 318,363 Total cash and cash equivalents and investments $ 521,571 $ 2 $ (221 ) $ 521,352 There were no realized gains or losses for the nine months ended September 30, 2016 , and no realized gains or losses for the nine months ended September 30, 2015 . The cost of securities sold is based on the specific identification method. |
Fair Value Measurements
Fair Value Measurements | 9 Months Ended |
Sep. 30, 2016 | |
Fair Value Measurements [Abstract] | |
Fair Value, Measurement Inputs, Disclosure | Fair Value Measurements The Company uses various inputs in determining the fair value of its investments and measures these assets on a recurring basis. Assets and liabilities recorded at fair value in the consolidated balance sheets are categorized by the level of objectivity associated with the inputs used to measure their fair value. The following levels are directly related to the amount of subjectivity associated with the inputs to fair valuation of these assets and liabilities: • Level 1 - quoted prices in active markets for identical investments, which include U.S. treasury securities • Level 2 - other significant observable inputs (including quoted prices for similar investments, market corroborated inputs, etc.), which includes corporate debt securities • Level 3 - significant unobservable inputs (including the Company’s own assumptions in determining the fair value of the Symphony Icon purchase consideration liability) The inputs or methodology used for valuing securities are not necessarily an indication of the credit risk associated with investing in those securities. The following table provides the fair value measurements of applicable Company assets and liabilities that are measured at fair value on a recurring basis according to the fair value levels described above as of September 30, 2016 and December 31, 2015 . Assets and Liabilities at Fair Value as of September 30, 2016 Level 1 Level 2 Level 3 Total (in thousands) Assets Cash and cash equivalents $ 38,772 $ — $ — $ 38,772 Short-term investments 319,078 37,706 — 356,784 Total cash and cash equivalents and investments $ 357,850 $ 37,706 $ — $ 395,556 Liabilities Accrued liabilities $ — $ — $ 18,912 $ 18,912 Total liabilities $ — $ — $ 18,912 $ 18,912 Assets and Liabilities at Fair Value as of December 31, 2015 Level 1 Level 2 Level 3 Total (in thousands) Assets Cash and cash equivalents $ 200,526 $ 2,463 $ — $ 202,989 Short-term investments 312,888 5,475 — 318,363 Total cash and cash equivalents and investments $ 513,414 $ 7,938 $ — $ 521,352 Liabilities Accrued liabilities $ — $ — $ 12,453 $ 12,453 Other long-term liabilities — — 10,362 10,362 Total liabilities $ — $ — $ 22,815 $ 22,815 The Company’s Level 3 liabilities, which consist of the Symphony Icon purchase consideration liability, is estimated using a probability-based income approach utilizing an appropriate discount rate. Subsequent changes in the fair value of the Symphony Icon purchase consideration liability are recorded as an increase or decrease in Symphony Icon purchase liability expense in the accompanying consolidated statements of comprehensive loss. The following table summarizes the change in consolidated balance sheet carrying value associated with Level 3 liabilities for the nine months ended September 30, 2016 and 2015 (in thousands). Balance at December 31, 2015 $ 22,815 Change in valuation of purchase consideration payable to former Symphony Icon stockholders (703 ) Payment of contingent payment obligation with cash (3,200 ) Balance at September 30, 2016 $ 18,912 Balance at December 31, 2014 $ 17,638 Change in valuation of purchase consideration payable to former Symphony Icon stockholders 5,145 Payment of contingent payment obligation with cash (750 ) Balance at September 30, 2015 $ 22,033 The Company also has assets that under certain conditions are subject to measurement at fair value on a non-recurring basis. These assets include goodwill associated with the acquisitions of Coelacanth Corporation in 2001 and Symphony Icon in 2010 and intangible assets associated with the acquisition of Symphony Icon in 2010. For these assets, measurement at fair value in periods subsequent to their initial recognition is applicable if one or more is determined to be impaired. |
Buildings and Land Held for Sal
Buildings and Land Held for Sale | 9 Months Ended |
Sep. 30, 2016 | |
Property, Plant and Equipment Impairment or Disposal [Abstract] | |
Disclosure of Long Lived Assets Held-for-sale | Buildings and Land Held and Used In 2014, Lexicon reclassified its buildings and land in The Woodlands, Texas to assets held for sale on its consolidated balance sheet, as it intended to sell these assets. In the fourth quarter of 2015, Lexicon made a change to its plan of sale and reclassified its buildings and land as assets held and used in accordance with the accounting guidance regarding selling assets with a leaseback requirement. The Company estimated the fair value of the net assets to be sold at approximately $21.5 million as of September 30, 2015 , which represented estimated selling price less costs to sell. This resulted in an impairment loss on the assets held for sale of $2.3 million in the nine months ended September 30, 2015 , which was recorded in impairment loss on buildings in the accompanying consolidated statement of comprehensive loss. The fair value of the net assets to be sold was determined using Level 2 inputs using sales prices in similar real estate sales and offers received from potential purchasers of the building. In January 2016, Lexicon entered into a Real Estate Purchase and Sale Agreement (“Real Estate Agreement”) with TC Houston Office Development, Inc. (“Purchaser”). Under the Real Estate Agreement, Lexicon agreed to sell these assets to the Purchaser for a purchase price of $21.2 million , subject to the negotiation and execution by the parties of a leaseback agreement with respect to a portion of the property. In March 2016, the Purchaser terminated the Real Estate Agreement due to uncertainty in real estate and financing market conditions. Lexicon intends to explore other strategic alternatives with respect to its strategy to reduce facilities costs, including the potential sale of the facilities to an alternative third party. Due to the likelihood that any sale will require a leaseback of a portion of the property, the buildings and land remain classified as assets held and used as of September 30, 2016 . When events or changes in circumstances indicate the carrying amount of property and equity and intangible or other long-lived assets related to specifically acquired assets may not be recoverable, an evaluation of the recoverability of currently recorded costs is performed. When an evaluation is performed, the estimated value of undiscounted future net cash flows associated with the asset is compared to the assets carrying value to determine whether a write-down to fair value is required. If such assets are considered to be impaired, the impairment to be recognized is measured by the amount by which the carrying amount of the assets exceeds the fair value of the assets. The Company did not recognize any impairment of long-lived assets in the nine months ended September 30, 2016 . |
Debt Obligations
Debt Obligations | 9 Months Ended |
Sep. 30, 2016 | |
Debt Obligations [Abstract] | |
Debt Disclosure | Debt Obligations Convertible Debt. In November 2014, Lexicon completed an offering of $87.5 million in aggregate principal amount of its 5.25% Convertible Senior Notes due 2021 (the “Notes”). The conversion feature did not meet the criteria for bifurcation as required by generally accepted accounting principles and the entire principal amount was recorded as long-term debt on the Company’s consolidated balance sheet. The Notes are governed by an indenture (the “Indenture”), dated as of November 26, 2014, between the Company and Wells Fargo Bank, N.A., as trustee. The Notes bear interest at a rate of 5.25% per year, payable semiannually in arrears on June 1 and December 1 of each year, beginning on June 1, 2015. The Notes mature on December 1, 2021. The Company may not redeem the Notes prior to the maturity date, and no sinking fund is provided for the Notes. Holders of the Notes may convert their Notes at their option at any time prior to the close of business on the business day immediately preceding the maturity date. Upon conversion, the Company will deliver for each $1,000 principal amount of converted Notes a number of shares of its common stock equal to the conversion rate, as described in the Indenture. The conversion rate is initially 118.4553 shares of common stock per $1,000 principal amount of Notes (equivalent to an initial conversion price of $8.442 per share of common stock). The conversion rate is subject to adjustment in some events but will not be adjusted for any accrued and unpaid interest. In addition, following certain corporate events that occur prior to the maturity date, the Company will increase the conversion rate for a holder who elects to convert its Notes in connection with such a corporate event in certain circumstances. If the Company undergoes a fundamental change, holders may require the Company to repurchase for cash all or any portion of their Notes at a fundamental change repurchase price equal to 100% of the principal amount of the Notes to be repurchased, plus accrued and unpaid interest to, but excluding, the fundamental change repurchase date. In connection with the issuance of the Notes, the Company incurred $3.4 million of debt issuance costs, which offsets long-term debt on the consolidated balance sheets. The debt issuance costs are amortized as interest expense over the expected life of the Notes using the effective interest method. The Company determined the expected life of the debt was equal to the seven-year term of the Notes. As of September 30, 2016 , the balance of unamortized debt issuance costs was $2.5 million . The fair value of the Notes was $197.7 million as of September 30, 2016 and was determined using Level 2 inputs based on the indicative pricing published by certain investment banks or trading levels of the Notes, which are not listed on any securities exchange or quoted on an inter-dealer automated quotation system. Mortgage Loan. In April 2004, Lexicon obtained a $34.0 million mortgage on its facilities in The Woodlands, Texas. The mortgage loan originally had a ten-year term with a 20-year amortization and a fixed interest rate of 8.23% . The mortgage was amended in September 2013 to extend the maturity date from April 2014 to April 2017, with the mortgage loan’s monthly payment amount and fixed interest rate each remaining unchanged. The mortgage had a principal balance outstanding of $16.8 million as of September 30, 2016 . The entire principal balance is recorded as current portion of long-term debt in the accompanying consolidated balance sheet as of September 30, 2016 as there is a balloon payment due in April 2017. Lexicon intends to refinance this debt prior to paying the balloon payment. The buildings and land that serve as collateral for the mortgage loan are included in property and equipment at $59.2 million and $2.7 million , respectively, before accumulated depreciation, as of September 30, 2016 . The fair value of Lexicon’s mortgage loan approximates its carrying value. The fair value of Lexicon’s mortgage loan was determined using Level 2 inputs using discounted cash flow analysis, based on the Company’s estimated current incremental borrowing rate. |
Arrangements with Symphony Icon
Arrangements with Symphony Icon Inc | 9 Months Ended |
Sep. 30, 2016 | |
Arrangements with Symphony Icon Inc [Abstract] | |
Arrangements with Symphony Icon Inc | Arrangements with Symphony Icon, Inc. On June 15, 2007, Lexicon entered into a series of related agreements providing for the financing of the clinical development of certain of its drug candidates, including telotristat ethyl (previously referred to as telotristat etiprate) (LX1032) and LX1033, along with any other pharmaceutical compositions modulating the same targets as those drug candidates (the “Programs”). The agreements included a Novated and Restated Technology License Agreement pursuant to which the Company licensed to Symphony Icon, a then wholly-owned subsidiary of Symphony Icon Holdings LLC (“Holdings”), the Company's intellectual property rights related to the Programs. Holdings contributed $45 million to Symphony Icon in order to fund the clinical development of the Programs. Under a Share Purchase Agreement, dated June 15, 2007, between the Company and Holdings, the Company issued and sold to Holdings 1,092,946 shares of its common stock on June 15, 2007 in exchange for $15 million and an exclusive purchase option (the “Purchase Option”) that gave the Company the right to acquire all of the equity of Symphony Icon, thereby allowing the Company to reacquire all of the Programs. On July 30, 2010, Lexicon entered into an Amended and Restated Purchase Option Agreement (the “Purchase Option Agreement”) with Symphony Icon and Holdings and simultaneously exercised the Purchase Option, thereby reacquiring the Programs. Pursuant to the amended terms of the Purchase Option, Lexicon paid Holdings $10 million on July 30, 2010 and issued 1,891,074 shares of common stock to designees of Holdings on July 30, 2012 in satisfaction of an additional $35 million base payment obligation. Lexicon also agreed to make up to $45 million in additional contingent payments, consisting of 50% of any consideration Lexicon receives pursuant to any licensing transaction (a “Licensing Transaction”) under which Lexicon grants a third party rights to commercialize telotristat ethyl or other pharmaceutical compositions modulating the same target as telotristat ethyl (the “LG103 Programs”), subject to certain exceptions. The contingent payments would be due if and when Lexicon receives such consideration from a Licensing Transaction. In the event Lexicon receives regulatory approval in the United States for the marketing and sale of any product resulting from the LG103 Programs prior to entering into a Licensing Transaction for the commercialization of such product in the United States, in lieu of any contingent payment from such a Licensing Transaction, Lexicon would pay Holdings the sum of $15 million and the amount of certain expenses Lexicon incurred after its exercise of the Purchase Option which are attributable to the development of such product, reduced by up to 50% of such sum on account of any contingent payments paid prior to such United States regulatory approval attributable to any such Licensing Transaction outside of the United States with respect to such product. In the event Lexicon makes any such payment upon United States regulatory approval, Lexicon would have no obligation to make subsequent contingent payments attributable to any such Licensing Transactions for the commercialization of such product outside the United States until the proceeds of such Licensing Transactions exceed 50% of the payment made as a result of such United States regulatory approval. The contingent payments may be paid in cash or a combination of cash and common stock, in Lexicon’s discretion, provided that no more than 50% of any contingent payment would be paid in common stock. In December 2014, Lexicon paid $5.8 million in cash and issued 666,111 shares of common stock to designees of Holdings in satisfaction of a $11.5 million contingent payment obligation as a result of receiving an upfront payment pursuant to Lexicon’s license and collaboration agreement with Ipsen Pharma SAS. In April 2015, Lexicon paid $0.75 million in cash to Holdings in satisfaction of its contingent payment obligation as a result of receiving an additional upfront payment from Ipsen in March 2015. In September 2016, Lexicon paid $3.2 million in cash to Holdings in satisfaction of its contingent payment obligation as a result of receiving a milestone payment from Ipsen in August 2016 (see Note 11, Collaboration and License Agreements). In September 2016, Lexicon entered into an amendment (the “Amendment”) to the Purchase Option Agreement with Holdings and Symphony Icon. Under the Amendment, Lexicon will pay Holdings $21.0 million in the event Lexicon receives regulatory approval in the United States for the marketing and sale of telotristat ethyl, such buyout amount to be in lieu of any remaining payments which may be or become payable to Holdings under the Purchase Option Agreement. The buyout amount may be paid in cash or a combination of cash and common stock, in Lexicon’s discretion, provided that no more than 50% of any contingent payment will be paid in common stock. Either Lexicon or Holdings may terminate the Amendment in the event Lexicon has not received United States regulatory approval for telotristat ethyl by February 28, 2017, in which case the financial terms previously in effect would be restored. Lexicon accounted for the exercise of the Purchase Option and acquisition of Symphony Icon as a business combination. In connection with its acquisition of Symphony Icon, Lexicon paid $10.0 million in cash, and has also agreed to pay Holdings additional base and contingent payments as discussed above. The fair value of the base and contingent consideration payments was $45.6 million and was estimated by applying a probability-based income approach utilizing an appropriate discount rate. This estimation was based on significant inputs that are not observable in the market, referred to as Level 3 inputs. Key assumptions include: (1) a discount rate of 14% for the base payments; (2) a discount rate of 18% for the contingent payments; and (3) a probability adjusted contingency. No discount rate was used in the valuation of the contingent consideration liability as of September 30, 2016 as the expected buyout is short-term in nature. As programs progress, the probability adjusted contingency is adjusted as necessary. Subsequent changes in the fair value of the Symphony Icon purchase consideration liability are recorded as increase or decrease in fair value of Symphony Icon purchase liability expense in the accompanying consolidated statements of comprehensive loss. The fair value of the Symphony Icon purchase consideration liability decreased by $0.7 million during the nine months ended September 30, 2016 and increased by $5.1 million during the nine months ended September 30, 2015 . |
Commitments and Contingencies
Commitments and Contingencies | 9 Months Ended |
Sep. 30, 2016 | |
Commitments and Contingencies [Abstract] | |
Commitments and Contingencies Disclosure | Commitments and Contingencies Operating Lease Obligations : A Lexicon subsidiary leases office space in Basking Ridge, New Jersey under an operating lease agreement, the term of which began in June 2015 and terminates in December 2022. Rent expense is recognized on a straight-line basis over the lease term. Lexicon is the guarantor of the obligations of its subsidiary under this lease agreement. The maximum potential amount of future payments the Company could be required to make under this agreement is $3.9 million as of September 30, 2016 . Additionally, Lexicon leases certain equipment under operating leases. Legal Proceedings. Lexicon is from time to time party to claims and legal proceedings that arise in the normal course of its business and that it believes will not have, individually or in the aggregate, a material adverse effect on its results of operations, financial condition or liquidity. |
Collaboration and License Agree
Collaboration and License Agreements | 9 Months Ended |
Sep. 30, 2016 | |
Collaboration and License Agreements [Abstract] | |
Collaborative Arrangement Disclosure | Collaboration and License Agreements Lexicon has derived substantially all of its revenues from drug discovery and development collaborations, target validation collaborations for the development and, in some cases, analysis of the physiological effects of genes altered in knockout mice, government grants and contracts, technology licenses, subscriptions to its databases and compound library sales. Sanofi. In November 2015, Lexicon entered into a Collaboration and License Agreement (the “Sanofi Agreement”) with Sanofi for the worldwide development of Lexicon’s diabetes drug candidate sotagliflozin (LX4211). Under the Sanofi Agreement, Lexicon granted Sanofi an exclusive, worldwide, royalty-bearing right and license under its patent rights and know-how to develop, manufacture and commercialize sotagliflozin. Subject to specified exceptions, neither party may (a) perform clinical development activities relating to any other compound which inhibits sodium-glucose cotransporters type 1 or type 2 or (b) commercialize any such compounds in the United States, countries of the European Union and certain other specified countries, in each case during the royalty terms applicable in such countries. Among the specified exceptions is a right Lexicon retained to pursue the development of its LX2761 drug candidate, with respect to which Lexicon granted Sanofi certain rights of first negotiation specified in the Sanofi Agreement. Under the Sanofi Agreement, Sanofi has paid an aggregate of $301.8 million through September 30, 2016 , consisting of $300.0 million in an upfront payment and $1.8 million as reimbursement for clinical materials transferred to Sanofi. In addition, Lexicon is eligible to receive from Sanofi (a) up to an aggregate of $430 million upon the achievement of specified development and regulatory milestones and (b) up to an aggregate of $990 million upon the achievement of specified sales milestones. Due to the uncertainty surrounding the achievement of the future development, regulatory and sales milestones, these payments will not be recognized as revenue unless and until they are earned as the Company is not able to reasonably predict if and when the milestones will be achieved. Lexicon is also entitled to tiered, escalating royalties ranging from low double digit percentages to forty percent of net sales of sotagliflozin, based on indication and territory, with royalties for the higher band of such range attributable to net sales for type 1 diabetes in the United States, and subject in each case to customary royalty reduction provisions. Royalties payable with respect to net sales of sotagliflozin for type 1 diabetes in the United States will also be reduced in the event Lexicon does not exercise its co-promotion option described below. Lexicon will continue to be responsible for all clinical development activities relating to type 1 diabetes and will retain an exclusive option to co-promote and have a significant role, in collaboration with Sanofi, in the commercialization of sotagliflozin for the treatment of type 1 diabetes in the United States. If Lexicon exercises its co-promotion option, Lexicon will fund forty percent of the commercialization costs relating to such co-promotion activities. Sanofi will be responsible for all clinical development and commercialization of sotagliflozin for the treatment of type 2 diabetes worldwide and will be solely responsible for the commercialization of sotagliflozin for the treatment of type 1 diabetes outside the United States. Lexicon will share in the funding of a portion of the planned type 2 diabetes development costs over the next three years, up to an aggregate of $100 million . Sanofi will book sales worldwide in all indications. The parties are responsible for using commercially reasonable efforts to perform their development and commercialization obligations pursuant to mutually approved development and commercialization plans. The parties’ activities under the Sanofi Agreement are governed by a joint steering committee and certain other governance committees which reflect equal or other appropriate representation from both parties. If the applicable governance committee is not able to make a decision by consensus and the parties are not able to resolve the issue through escalation to specified senior executive officers of the parties, then Sanofi will have final decision-making authority, subject to limitations specified in the Sanofi Agreement. The Sanofi Agreement will expire upon the expiration of all applicable royalty terms for all licensed products in all countries. The royalty term for each licensed product in each country is the period commencing on the effective date of the Sanofi Agreement and ending on the latest of expiration of specified patent coverage, expiration of specified regulatory exclusivity and 10 years following the first commercial sale in the applicable country. Either party may terminate the Sanofi Agreement in the event of an uncured material breach by the other party. Prior to completion of the core development activities for type 2 diabetes specified in the development plan, Sanofi may terminate the Sanofi Agreement on a country-by-country and licensed product-by-licensed product basis, in the event of (a) notification of a material safety issue relating to the licensed product or the class of sodium-glucose cotransporters type 1 or type 2 inhibitors resulting in a recommendation or requirement that Lexicon or Sanofi cease development, (b) failure to achieve positive results with respect to certain clinical trial results, (c) the occurrence of specified fundamental adverse events or (d) the exploitation of the licensed product infringing third party intellectual property rights in specified major markets and Sanofi is unable to obtain a license to such third party intellectual property rights. The Company considered the following deliverables with respect to the revenue recognition of the $300 million upfront payment: • The exclusive worldwide license granted to Sanofi to develop and commercialize sotagliflozin; • The development services Lexicon is performing for sotagliflozin relating to type 1 diabetes; and • The funding Lexicon will provide for development relating to type 2 diabetes. The Company determined that the license had stand-alone value because it is an exclusive license that gives Sanofi the right to develop and commercialize sotagliflozin or to sublicense its rights. In addition, sotagliflozin is currently in development and it is possible that Sanofi or another third party could conduct clinical trials without assistance from Lexicon. As a result, the Company considers the license and the development services under the Sanofi Agreement to be separate units of accounting. The Company recognized the portion of the consideration allocated to the license immediately because Lexicon delivered the license and earned the revenue at the inception of the arrangement. The Company is recognizing as revenue the amount allocated to the development services for type 1 diabetes and the obligation to provide funding for development services for type 2 diabetes over the period of time Lexicon performs services or provides funding, currently expected to be through 2020. The Company determined that the initial allocable arrangement consideration was the $300 million upfront payment because it was the only payment that was fixed and determinable at the inception of the arrangement. There was considerable uncertainty at the date of the agreement as to whether Lexicon would earn milestone payments or royalty payments. As such, the Company did not include those payments in the allocable consideration. The Company allocated the allocable consideration based on the relative best estimate of selling price of each unit of accounting. The Company estimated the selling price of the license deliverable by applying a probability-based income approach utilizing an appropriate discount rate. The significant inputs the Company used to determine the projected income of the license included: exercising the option to copromote, estimated future product sales, estimated cost of goods sold, estimated operating expenses, income taxes, and an appropriate discount rate. The Company estimated the selling price of the development services for type 1 diabetes by using internal estimates of the cost to hire third parties to perform the services over the expected period to perform the development. The Company estimated the obligation to provide funding for type 2 diabetes by using internal estimates of the expected cash flows and timing for $100 million in funding. As a result of the allocation, the Company recognized $126.8 million of the $300 million upfront payment for the license in 2015. The Company is recognizing the $113.8 million allocated to the development services deliverable and the $59.4 million allocated to the funding deliverable over the estimated period of performance as the development and funding occurs. Revenue recognized under the Sanofi Agreement was $52.7 million for the nine months ended September 30, 2016 . During the three months ended September 30, 2016 , the Company determined that $4.5 million in expense was incurred in the fourth quarter of 2015 relating to a payment due under its clinical development funding agreement with an independent, non-profit organization as a result of the Company’s entry into the Sanofi Agreement. Under the clinical development funding agreement, the non-profit organization provided funding in support of certain sotagliflozin Phase 2 clinical development activities, and the Company is obligated to make payments to the non-profit organization, in amounts tied to the funding amount, upon certain triggering events relating to sotagliflozin. Management evaluated the impact of the adjustment and determined that the amount was immaterial to the consolidated financial statements for the current year and prior year. As such, the entire amount was recorded during the three and nine months ended September 30, 2016 . Ipsen Pharma SAS. In October 2014, Lexicon entered into a License and Collaboration Agreement, which was subsequently amended in March 2015 (collectively, the “Ipsen Agreement”), with Ipsen Pharma SAS (“Ipsen”) for the development and commercialization of Lexicon’s drug candidate telotristat ethyl (LX1032) outside of the United States and Japan (the “Licensed Territory”). Under the Ipsen Agreement, Lexicon granted Ipsen an exclusive, royalty-bearing right and license under its patent rights and know-how to commercialize telotristat ethyl in the Licensed Territory. Ipsen is responsible for using diligent efforts to commercialize telotristat ethyl in the Licensed Territory pursuant to a mutually approved commercialization plan. Subject to certain exceptions, Lexicon will be responsible for conducting clinical trials required to obtain regulatory approval for telotristat ethyl for carcinoid syndrome in the European Union, including those contemplated by a mutually approved initial development plan, and will have the first right to conduct most other clinical trials of telotristat ethyl. Lexicon is responsible for the costs of all clinical trials contemplated by the initial development plan. The costs of additional clinical trials will be allocated between the parties based on the nature of such clinical trials. Under the Ipsen Agreement, Ipsen has paid Lexicon an aggregate of $30.9 million through September 30, 2016 , consisting of $24.5 million in upfront payments and a $6.4 million milestone payment in August 2016 upon the acceptance of the filing submitted by Ipsen to the European Medicines Agency for telotristat ethyl as an adjunct to somatostatin analog therapy for the long-term treatment of carcinoid syndrome. In addition, Lexicon is eligible to receive from Ipsen (a) up to an aggregate of approximately $27 million upon the achievement of specified regulatory and commercial launch milestones and (b) up to an aggregate of €72 million upon the achievement of specified sales milestones. Due to the uncertainty surrounding the achievement of the future regulatory and sales milestones, these payments will not be recognized as revenue unless and until they are earned as the Company is not able to reasonably predict if and when the milestones will be achieved. Lexicon is also entitled to tiered, escalating royalties ranging from low twenties to mid-thirties percentages of net sales of telotristat ethyl in the Licensed Territory, subject to a credit for amounts previously paid to Lexicon by Ipsen for the manufacture and supply of such units of telotristat ethyl. Lexicon’s receipt of these payments under the Ipsen Agreement triggers its obligation to make certain contingent payments to Holdings (see Note 9, Arrangements with Symphony Icon, Inc.). Lexicon and Ipsen have entered into a commercial supply agreement pursuant to which Lexicon will supply Ipsen’s commercial requirements of telotristat ethyl, and Ipsen will pay an agreed upon transfer price for such commercial supply. The Company considered the following deliverables with respect to the revenue recognition of the $24.5 million upfront payments: • The exclusive license granted to Ipsen to develop and commercialize telotristat ethyl in the Licensed Territory; • The development services Lexicon is performing for telotristat ethyl; • The obligation to participate in committees which govern the development of telotristat ethyl until commercialization; and • The obligation to supply commercial supply of telotristat ethyl, under a commercial supply agreement. The Company determined that the license had stand-alone value because it is an exclusive license that gives Ipsen the right to develop and commercialize telotristat ethyl or to sublicense its rights. In addition, telotristat ethyl is currently in development and it is possible that Ipsen or another third party could conduct clinical trials without assistance from Lexicon. As a result, the Company considers the license and the development services under the Ipsen Agreement to be separate units of accounting. The Company recognized the portion of the consideration allocated to the license immediately because Lexicon delivered the license and earned the revenue at the inception of the arrangement. The Company is recognizing as revenue the amount allocated to the development services and the obligation to participate in committees over the period of time Lexicon performs services, currently expected to be through mid-2017. Due to the inherent uncertainty in obtaining regulatory approval, the applicability of the commercial supply agreement is outside the control of Lexicon and Ipsen. Accordingly, the Company has determined the commercial supply agreement is a contingent deliverable at the onset of the Ipsen Agreement. As a result, the Company has determined the commercial supply agreement does not meet the definition of a deliverable that needs to be accounted for at the inception of the arrangement. The Company has also determined that there is no significant and incremental discount related to the commercial supply agreement that should be accounted for at the inception of the arrangement. The Company determined that the initial allocable arrangement consideration was the $24.5 million upfront payments because they were the only payments that were fixed and determinable at the inception of the arrangement. There was considerable uncertainty at the date of the agreement as to whether Lexicon would earn milestone payments, royalty payments or payments for finished drug product. As such, the Company did not include those payments in the allocable consideration. The Company allocated the allocable consideration based on the relative best estimate of selling price of each unit of accounting. The Company estimated the selling price of the license deliverable by applying a probability-based income approach utilizing an appropriate discount rate. The significant inputs the Company used to determine the projected income of the license included: estimated future product sales, estimated cost of goods sold, estimated operating expenses, income taxes, and an appropriate discount rate. The Company estimated the selling price of the development services by using internal estimates of the cost to hire third parties to perform the services over the expected period to perform the development. The Company estimated the selling price of the obligation to participate in committees by using internal estimates of the number of internal hours and salary and benefits costs to perform these services. As a result of the allocation, the Company recognized $21.2 million of the $24.5 million upfront payments for the license in 2014, and an additional $1.4 million in 2015 upon entering into the amendment. The Company is recognizing the $1.7 million allocated to the development services deliverable over the estimated period of performance as development occurs, and is recognizing the $0.1 million allocated to the committee participation deliverable ratably over the estimated period of performance. Milestone payments that are contingent upon the achievement of a substantive milestone are recognized in their entirety in the period in which the milestone is achieved. The Company recognized the $6.4 million milestone payment received in the three and nine months ended September 30, 2016 . Revenue recognized under the Ipsen Agreement was $6.8 million and $2.3 million for the nine months ended September 30, 2016 and 2015 , respectively. |
Net Loss Per Share Accounting P
Net Loss Per Share Accounting Policies (Policies) | 9 Months Ended |
Sep. 30, 2016 | |
Net Loss Per Share [Abstract] | |
Earnings Per Share, Policy | Net loss per share is computed using the weighted average number of shares of common stock outstanding during the applicable period and excludes shares underlying convertible debt, stock options and restricted stock units because they are antidilutive. |
Stock-Based Compensation (Table
Stock-Based Compensation (Tables) | 9 Months Ended |
Sep. 30, 2016 | |
Stock-Based Compensation [Abstract] | |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] | Expected Volatility Risk-free Interest Rate Expected Term Dividend Rate September 30, 2016: Employees 63 % 1.1 % 4 — % Officers and non-employee directors 83 % 1.6 % 8 — % September 30, 2015: Employees 63 % 1.2 % 4 — % Officers and non-employee directors 81 % 1.8 % 8 — % |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block] | Options Weighted Average Exercise Price (in thousands) Outstanding at December 31, 2015 4,217 $ 12.35 Granted 1,302 10.06 Exercised (236 ) 12.05 Expired (167 ) 27.29 Forfeited (33 ) 11.24 Outstanding at September 30, 2016 5,083 11.30 Exercisable at September 30, 2016 2,874 $ 12.80 |
Schedule of Share-based Compensation, Restricted Stock Units Award Activity [Table Text Block] | Shares Weighted Average Grant Date Fair Value (in thousands) Outstanding at December 31, 2015 637 $ 8.74 Granted 496 8.20 Vested (206 ) 9.75 Forfeited (35 ) 10.77 Nonvested at September 30, 2016 892 $ 8.12 |
Cash and Cash Equivalents and21
Cash and Cash Equivalents and Investments (Tables) | 9 Months Ended |
Sep. 30, 2016 | |
Cash and Cash Equivalents and Investments [Abstract] | |
Schedule of Cash, Cash Equivalents and Short-term Investments [Table Text Block] | As of September 30, 2016 Amortized Cost Gross Unrealized Gains Gross Unrealized Losses Estimated Fair Value (in thousands) Cash and cash equivalents $ 38,772 $ — $ — $ 38,772 Securities maturing within one year: U.S. treasury securities 318,979 119 (20 ) 319,078 Corporate debt securities 37,727 5 (26 ) 37,706 Total short-term investments $ 356,706 $ 124 $ (46 ) $ 356,784 Total cash and cash equivalents and investments $ 395,478 $ 124 $ (46 ) $ 395,556 As of December 31, 2015 Amortized Cost Gross Unrealized Gains Gross Unrealized Losses Estimated Fair Value (in thousands) Cash and cash equivalents $ 202,989 $ — $ — $ 202,989 Securities maturing within one year: U.S. treasury securities 313,105 2 (219 ) 312,888 Corporate debt securities 5,477 — (2 ) 5,475 Total short-term investments $ 318,582 $ 2 $ (221 ) $ 318,363 Total cash and cash equivalents and investments $ 521,571 $ 2 $ (221 ) $ 521,352 |
Fair Value Measurements (Tables
Fair Value Measurements (Tables) | 9 Months Ended |
Sep. 30, 2016 | |
Fair Value Measurements [Abstract] | |
Fair Value, by Balance Sheet Grouping [Table Text Block] | Assets and Liabilities at Fair Value as of September 30, 2016 Level 1 Level 2 Level 3 Total (in thousands) Assets Cash and cash equivalents $ 38,772 $ — $ — $ 38,772 Short-term investments 319,078 37,706 — 356,784 Total cash and cash equivalents and investments $ 357,850 $ 37,706 $ — $ 395,556 Liabilities Accrued liabilities $ — $ — $ 18,912 $ 18,912 Total liabilities $ — $ — $ 18,912 $ 18,912 Assets and Liabilities at Fair Value as of December 31, 2015 Level 1 Level 2 Level 3 Total (in thousands) Assets Cash and cash equivalents $ 200,526 $ 2,463 $ — $ 202,989 Short-term investments 312,888 5,475 — 318,363 Total cash and cash equivalents and investments $ 513,414 $ 7,938 $ — $ 521,352 Liabilities Accrued liabilities $ — $ — $ 12,453 $ 12,453 Other long-term liabilities — — 10,362 10,362 Total liabilities $ — $ — $ 22,815 $ 22,815 |
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block] | Balance at December 31, 2015 $ 22,815 Change in valuation of purchase consideration payable to former Symphony Icon stockholders (703 ) Payment of contingent payment obligation with cash (3,200 ) Balance at September 30, 2016 $ 18,912 Balance at December 31, 2014 $ 17,638 Change in valuation of purchase consideration payable to former Symphony Icon stockholders 5,145 Payment of contingent payment obligation with cash (750 ) Balance at September 30, 2015 $ 22,033 |
Stock-Based Compensation (Detai
Stock-Based Compensation (Details 1) - USD ($) $ in Millions | 3 Months Ended | 9 Months Ended | ||
Sep. 30, 2016 | Sep. 30, 2015 | Sep. 30, 2016 | Sep. 30, 2015 | |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] | ||||
Allocated Share-based Compensation Expense | $ 1.9 | $ 1.7 | $ 5.7 | $ 5.4 |
Stock-Based Compensation (Det24
Stock-Based Compensation (Details 2) - Stock Option [Member] | 9 Months Ended | |
Sep. 30, 2016 | Sep. 30, 2015 | |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||
Expected Volatility Rate, Employees | 63.00% | 63.00% |
Expected Volatility Rate, Officers and Non-employee Directors | 83.00% | 81.00% |
Risk Free Interest Rate, Employees | 1.10% | 1.20% |
Risk Free Interest Rate, Officers and Non-employee Directors | 1.60% | 1.80% |
Expected Term, Employees | 4 years | 4 years |
Expected Term, Officers and Non-employee Directors | 8 years | 8 years |
Expected Dividend Rate, Employees | 0.00% | 0.00% |
Expected Dividend Rate, Officers and Non-employee Directors | 0.00% | 0.00% |
Stock-Based Compensation (Det25
Stock-Based Compensation (Details 3) - Stock Options [Member] - $ / shares shares in Thousands | 9 Months Ended | |
Sep. 30, 2016 | Dec. 31, 2015 | |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||
Stock Options Outstanding | 5,083 | 4,217 |
Stock Options Outstanding, Weighted Average Exercise Price | $ 11.30 | $ 12.35 |
Stock Options Granted | 1,302 | |
Stock Options Granted, Weighted Average Exercise Price | $ 10.06 | |
Stock Options Exercised | (236) | |
Stock Options Exercised, Weighted Average Exercise Price | $ 12.05 | |
Stock Options Expired | (167) | |
Stock Options Expired, Weighted Average Exercise Price | $ 27.29 | |
Stock Options Forfeited | (33) | |
Stock Options Forfeited, Weighted Average Exercise Price | $ 11.24 | |
Stock Options Exercisable | 2,874 | |
Stock Options Exercisable, Weighted Average Exercise Price | $ 12.80 |
Stock-Based Compensation (Det26
Stock-Based Compensation (Details 4) - Restricted Stock Units [Member] - $ / shares shares in Thousands | 9 Months Ended | |
Sep. 30, 2016 | Dec. 31, 2015 | |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||
Restricted Stock Units Outstanding | 892 | 637 |
Restricted Stock Units Outstanding, Weighted Average Grant Date Fair Value | $ 8.12 | $ 8.74 |
Restricted Stock Units Granted | 496 | |
Restricted Stock Units Granted, Weighted Average Grant Date Fair Value | $ 8.20 | |
Restricted Stock Units Vested | (206) | |
Restricted Stock Units Vested, Weighted Average Grant Date Fair Value | $ 9.75 | |
Restricted Stock Units Forfeited | (35) | |
Restricted Stock Units Forfeited, Weighted Average Grant Date Fair Value | $ 10.77 |
Stock-Based Compensation (Det27
Stock-Based Compensation (Details 5) | 9 Months Ended |
Sep. 30, 2016$ / sharesshares | |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |
Share-based Compensation Arrangement by Share-based Payment Award Stock Bonus and Restricted Stock Grants in Period Shares | shares | 11,456 |
Share Based Compensation Arrangement By Share Based Payment Award Stock Bonus and Restricted Stock Grants in Period Weighted Average Grant Date Fair Value | $ / shares | $ 13.96 |
Recent Accounting Pronounceme28
Recent Accounting Pronouncements (Details) | Dec. 31, 2015USD ($) |
Recent Accounting Pronouncements [Abstract] | |
Reclassification of Debt Issuance Costs Impact to Other Assets | $ 2,900,000 |
Reclassification of Debt Issuance Costs Impact to Current Portion of Long-term Debt | 39,000 |
Reclassification of Debt Issuance Costs Impact to Long-term Debt | $ 2,800,000 |
Cash and Cash Equivalents and29
Cash and Cash Equivalents and Investments (Details 1) - USD ($) $ in Thousands | Sep. 30, 2016 | Dec. 31, 2015 |
Cash and Cash Equivalents | ||
Fair Value | ||
Amortized Cost | $ 38,772 | $ 202,989 |
Gross Unrealized Gains | 0 | 0 |
Gross Unrealized Losses | 0 | 0 |
Estimated Fair Value | 38,772 | 202,989 |
U.S. Treasury Securities | ||
Fair Value | ||
Amortized Cost | 318,979 | 313,105 |
Gross Unrealized Gains | 119 | 2 |
Gross Unrealized Losses | (20) | (219) |
Estimated Fair Value | 319,078 | 312,888 |
Corporate Debt Securities | ||
Fair Value | ||
Amortized Cost | 37,727 | 5,477 |
Gross Unrealized Gains | 5 | 0 |
Gross Unrealized Losses | (26) | (2) |
Estimated Fair Value | 37,706 | 5,475 |
Total Short-term Investments | ||
Fair Value | ||
Amortized Cost | 356,706 | 318,582 |
Gross Unrealized Gains | 124 | 2 |
Gross Unrealized Losses | (46) | (221) |
Estimated Fair Value | 356,784 | 318,363 |
Total Cash and Cash Equivalents and Investments | ||
Fair Value | ||
Amortized Cost | 395,478 | 521,571 |
Gross Unrealized Gains | 124 | 2 |
Gross Unrealized Losses | (46) | (221) |
Estimated Fair Value | $ 395,556 | $ 521,352 |
Cash and Cash Equivalents and30
Cash and Cash Equivalents and Investments (Details 2) - USD ($) | 9 Months Ended | |
Sep. 30, 2016 | Sep. 30, 2015 | |
Schedule of Investments [Line Items] | ||
Realized Investment Gains (Losses) | $ 0 | $ 0 |
Fair Value Measurements (Detail
Fair Value Measurements (Details 1) - USD ($) $ in Thousands | Sep. 30, 2016 | Dec. 31, 2015 |
Fair Value, Level 1 | ||
Fair Value | ||
Cash and Cash Equivalents | $ 38,772 | $ 200,526 |
Short-term Investments | 319,078 | 312,888 |
Total Cash and Cash Equivalents and Investments | 357,850 | 513,414 |
Accrued Liabilities | 0 | 0 |
Other Long-term Liabilities | 0 | |
Total Liabilities | 0 | 0 |
Fair Value, Level 2 | ||
Fair Value | ||
Cash and Cash Equivalents | 0 | 2,463 |
Short-term Investments | 37,706 | 5,475 |
Total Cash and Cash Equivalents and Investments | 37,706 | 7,938 |
Accrued Liabilities | 0 | 0 |
Other Long-term Liabilities | 0 | |
Total Liabilities | 0 | 0 |
Fair Value, Level 3 | ||
Fair Value | ||
Cash and Cash Equivalents | 0 | 0 |
Short-term Investments | 0 | 0 |
Total Cash and Cash Equivalents and Investments | 0 | 0 |
Accrued Liabilities | 18,912 | 12,453 |
Other Long-term Liabilities | 10,362 | |
Total Liabilities | 18,912 | 22,815 |
Fair Value, Total | ||
Fair Value | ||
Cash and Cash Equivalents | 38,772 | 202,989 |
Short-term Investments | 356,784 | 318,363 |
Total Cash and Cash Equivalents and Investments | 395,556 | 521,352 |
Accrued Liabilities | 18,912 | 12,453 |
Other Long-term Liabilities | 10,362 | |
Total Liabilities | $ 18,912 | $ 22,815 |
Fair Value Measurements (Deta32
Fair Value Measurements (Details 2) - USD ($) $ in Thousands | 9 Months Ended | |||
Sep. 30, 2016 | Sep. 30, 2015 | Dec. 31, 2015 | Dec. 31, 2014 | |
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation | ||||
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) Included in Earnings | $ (703) | $ 5,145 | ||
Fair Value, Measurement with Unobservable Inputs Reconciliations, Recurring Basis, Liability Value | 18,912 | 22,033 | $ 22,815 | $ 17,638 |
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Settlements | $ (3,200) | $ (750) |
Fair Value Measurements (Deta33
Fair Value Measurements (Details 3) $ in Millions | Jul. 30, 2012USD ($)shares |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | |
Symphony Base Payment in Shares | shares | 1,891,074 |
Symphony Base Payment Obligation | $ | $ 35 |
Buildings and Land Held for S34
Buildings and Land Held for Sale (Details) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 9 Months Ended | ||
Jan. 31, 2016 | Sep. 30, 2016 | Sep. 30, 2015 | Sep. 30, 2016 | Sep. 30, 2015 | |
Property, Plant and Equipment Impairment or Disposal [Abstract] | |||||
Real Estate Held-for-sale | $ 21,500 | $ 21,500 | |||
Asset Impairment Charges | $ 0 | $ 2,349 | $ 0 | $ 2,349 | |
Real Estate Selling Price | $ 21,200 |
Debt Obligations (Details)
Debt Obligations (Details) $ / shares in Units, $ in Millions | 1 Months Ended | ||
Nov. 30, 2014USD ($) | Apr. 30, 2004USD ($) | Sep. 30, 2016USD ($)$ / shares | |
Debt Instrument [Line Items] | |||
Proceeds from Convertible Debt | $ 87.5 | ||
Convertible Debt Instrument Interest Rate Stated Percentage | 5.25% | ||
Debt Instrument, Convertible, Conversion Ratio | 118.4553 | ||
Debt Instrument, Convertible, Conversion Price | $ / shares | $ 8.442 | ||
Debt Issuance Cost | $ 3.4 | ||
Unamortized Debt Issuance Expense | $ 2.5 | ||
Debt Instrument, Fair Value Disclosure | 197.7 | ||
Buildings Collateral | 59.2 | ||
Land Collateral | $ 2.7 | ||
Mortgage Loans on Real Estate, New Mortgage Loans | $ 34 | ||
Debt Instrument, Interest Rate, Stated Percentage | 8.23% | ||
Mortgage Loans on Real Estate, Carrying Amount of Mortgages | $ 16.8 |
Arrangements with Symphony Ic36
Arrangements with Symphony Icon Inc (Details) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | 9 Months Ended | |||||||
Sep. 30, 2016 | Apr. 30, 2015 | Dec. 31, 2014 | Sep. 30, 2016 | Sep. 30, 2015 | Sep. 30, 2016 | Sep. 30, 2015 | Jul. 30, 2012 | Jul. 30, 2010 | Jun. 15, 2007 | |
Loss Contingencies [Line Items] | ||||||||||
Holdings Contribution to Icon | $ 45,000 | |||||||||
Lexicon Sold Shares to Holdings | 1,092,946 | |||||||||
Lexicon Received Cash from Holdings | $ 15,000 | |||||||||
Lexicon Paid Holdings Cash | $ 10,000 | |||||||||
Symphony Base Payment in Shares | 1,891,074 | |||||||||
Symphony Base Payment Obligation | $ 35,000 | |||||||||
Symphony Contingent Payment Maximum | $ 45,000 | |||||||||
Symphony Contingent Payment Percentage | 50.00% | |||||||||
Symphony Regulatory Approval Payment | $ 15,000 | |||||||||
Symphony Regulatory Approval Reduction Percentage | 50.00% | |||||||||
Symphony Regulatory Approval Percentage Limit | 50.00% | |||||||||
Symphony Payment in Stock Limitation | 50.00% | |||||||||
Symphony Contingent Payment In Cash | $ 3,200 | $ 750 | $ 5,800 | |||||||
Symphony Amendment Buyout | $ 21,000 | |||||||||
Symphony Contingent Payment in Shares | 666,111 | |||||||||
Symphony Contingent Payment Total | $ 11,500 | |||||||||
Symphony Fair Value of Base and Contingent Payments | $ 45,600 | |||||||||
Symphony Base Payment Discount Rate | 14.00% | |||||||||
Symphony Contingent Payment Discount Rate | 18.00% | |||||||||
Increase (decrease) in fair value of Symphony Icon, Inc. purchase liability | $ (2,146) | $ 3,404 | $ (703) | $ 5,145 |
Commitments and Contingencies (
Commitments and Contingencies (Details) $ in Millions | Sep. 30, 2016USD ($) |
Operating Leased Assets [Line Items] | |
Guarantor Obligations, Maximum Exposure, Undiscounted | $ 3.9 |
Collaboration and License Agr38
Collaboration and License Agreements (Details) € in Millions, $ in Millions | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended | ||||||
Aug. 31, 2016USD ($) | Nov. 30, 2015USD ($) | Mar. 31, 2015USD ($) | Oct. 31, 2014USD ($) | Oct. 31, 2014EUR (€) | Sep. 30, 2016USD ($) | Sep. 30, 2016USD ($) | Sep. 30, 2015USD ($) | Dec. 31, 2015USD ($) | Dec. 31, 2014USD ($) | |
Collaboration and License Agreements [Abstract] | ||||||||||
Sanofi Total Payments | $ 301.8 | $ 301.8 | ||||||||
Sanofi Upfront Payment | $ 300 | |||||||||
Sanofi Clinical Materials Payment | 1.8 | 1.8 | ||||||||
Sanofi Development and Regulatory Milestone Payments | 430 | |||||||||
Sanofi Sales Milestone Payments | 990 | |||||||||
Sanofi Commercialization Costs Funded by Lexicon Maximum Amount | 100 | |||||||||
Sanofi Revenue Allocated to License Deliverable | 126.8 | |||||||||
Sanofi Revenue Allocated to Development Deliverable | 113.8 | |||||||||
Sanofi Revenue Allocated to Funding Deliverable | $ 59.4 | |||||||||
Sanofi Revenue Recognized | 52.7 | |||||||||
Sanofi Triggered Expense | 4.5 | |||||||||
Ipsen Total Payments | $ 30.9 | 30.9 | ||||||||
Ipsen Maximum Regulatory And Commercial Milestones | $ 27 | |||||||||
Ipsen Maximum Sales Milestones | € | € 72 | |||||||||
Ipsen Total Upfront Payments | $ 24.5 | |||||||||
Ipsen Milestone Payment | $ 6.4 | |||||||||
Ipsen Revenue Allocated to License Deliverable | $ 1.4 | $ 21.2 | ||||||||
Ipsen Revenue Allocated to Development Deliverable | 1.7 | |||||||||
Ipsen Revenue Allocated to Committee Deliverable | $ 0.1 | |||||||||
Ipsen Revenue Recognized | $ 6.8 | $ 2.3 |