Document and Entity Information
Document and Entity Information - shares | 6 Months Ended | |
Jun. 30, 2022 | Aug. 03, 2022 | |
Cover [Abstract] | ||
Document Type | 10-Q | |
Document Fiscal Period Focus | Q2 | |
Document Quarterly Report | true | |
Document Period End Date | Jun. 30, 2022 | |
Document Transition Report | false | |
Amendment Flag | false | |
Document Fiscal Year Focus | 2022 | |
Current Fiscal Year End Date | --12-31 | |
Entity File Number | 000-30111 | |
Entity Registrant Name | Lexicon Pharmaceuticals, Inc. | |
Entity Central Index Key | 0001062822 | |
Entity Incorporation, State or Country Code | DE | |
Entity Tax Identification Number | 76-0474169 | |
Entity Address, Address Line One | 2445 Technology Forest Blvd. | |
Entity Address, Address Line Two | 11th Floor | |
Entity Address, City or Town | The Woodlands | |
Entity Address, State or Province | TX | |
Entity Address, Postal Zip Code | 77381 | |
City Area Code | 281 | |
Local Phone Number | 863-3000 | |
Title of 12(b) Security | Common Stock, par value $0.001 | |
Trading Symbol | LXRX | |
Security Exchange Name | NASDAQ | |
Entity Current Reporting Status | Yes | |
Entity Interactive Data Current | Yes | |
Entity Filer Category | Non-accelerated Filer | |
Entity Small Business | true | |
Entity Emerging Growth Company | false | |
Entity Shell Company | false | |
Entity Common Stock, Shares Outstanding | 183,625,743 |
Consolidated Balance Sheets-Una
Consolidated Balance Sheets-Unaudited - USD ($) $ in Thousands | Jun. 30, 2022 | Dec. 31, 2021 |
Current assets: | ||
Cash and cash equivalents | $ 21,450 | $ 64,065 |
Short-term investments | 40,518 | 22,678 |
Accounts receivable, net | 34 | 14 |
Prepaid expenses and other current assets | 2,896 | 2,164 |
Total current assets | 64,898 | 88,921 |
Property and equipment, net of accumulated depreciation and amortization of $5,070 and $4,853, respectively | 1,035 | 1,176 |
Goodwill | 44,543 | 44,543 |
Other assets | 1,849 | 2,269 |
Total assets | 112,325 | 136,909 |
Current liabilities: | ||
Accounts payable | 7,347 | 9,152 |
Accrued liabilities | 9,515 | 12,972 |
Total current liabilities | 16,862 | 22,124 |
Other long-term liabilities | 1,002 | 1,190 |
Total liabilities | 41,495 | 23,314 |
Commitments and contingencies | ||
Equity: | ||
Preferred stock, $0.01 par value; 5,000 shares authorized; no shares issued and outstanding | 0 | 0 |
Common stock, $0.001 par value; 300,000 shares authorized; 150,114 and 150,082 shares issued, respectively | 150 | 150 |
Additional paid-in capital | 1,608,730 | 1,608,749 |
Accumulated deficit | (1,535,839) | (1,487,776) |
Accumulated other comprehensive loss | (150) | (10) |
Treasury stock, at cost, 488 and 1,165 shares, respectively | (2,061) | (7,518) |
Total stockholder's equity (deficit) | 70,830 | 113,595 |
Total liabilities and equity | 112,325 | 136,909 |
Long-term debt, net of deferred issuance costs | $ 23,631 | $ 0 |
Consolidated Balance Sheets Par
Consolidated Balance Sheets Parentheticals - USD ($) shares in Thousands, $ in Thousands | Jun. 30, 2022 | Dec. 31, 2021 |
Consolidated Balance Sheets [Abstract] | ||
Accumulated depreciation and amortization, property and equipment | $ 5,070 | $ 4,853 |
Preferred stock, par value per share | $ 0.01 | $ 0.01 |
Preferred stock, shares authorized | 5,000 | 5,000 |
Preferred stock, shares issued | 0 | 0 |
Preferred stock, shares outstanding | 0 | 0 |
Common stock, par value per share | $ 0.001 | $ 0.001 |
Common stock, shares authorized | 300,000 | 300,000 |
Common stock, shares issued | 150,114 | 150,082 |
Treasury stock, shares | 488 | 1,165 |
Consolidated Statements of Comp
Consolidated Statements of Comprehensive Loss-Unaudited - USD ($) shares in Thousands | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2022 | Jun. 30, 2021 | Jun. 30, 2022 | Jun. 30, 2021 | |
Revenues: | ||||
Royalties and other revenue | $ 35,000 | $ 234,000 | $ 72,000 | $ 261,000 |
Stock-based compensation expense associated with research and development expense | 1,098,000 | 1,184,000 | 2,130,000 | 2,470,000 |
Operating expenses: | ||||
Research and development, including stock-based compensation of $1,098, $1,184, $2,130 and $2,470 respectively | 13,356,000 | 10,257,000 | 28,282,000 | 22,866,000 |
Selling, general and administrative, including stock-based compensation of $1,734, $1,602, $3,474 and $3,167 respectively | 10,686,000 | 7,936,000 | 19,177,000 | 16,193,000 |
Total operating expenses | (24,042,000) | 18,193,000 | 47,459,000 | 39,059,000 |
Loss from operations | (24,007,000) | (17,959,000) | (47,387,000) | (38,798,000) |
Interest expense | (703,000) | (169,000) | (813,000) | (336,000) |
Interest and other income, net | 123,000 | 61,000 | 137,000 | 109,000 |
Net loss | $ (24,587,000) | $ (18,067,000) | $ (48,063,000) | $ (39,025,000) |
Net income (loss) per common share, Basic | $ (0.16) | $ (0.13) | $ (0.32) | $ (0.27) |
Shares used in computing net loss per common share, Basic | 149,616 | 144,451 | 149,384 | 143,917 |
Unrealized gain on investments | $ (113,000) | $ (10,000) | $ (140,000) | $ 1,000 |
Comprehensive loss | (24,700,000) | (18,077,000) | (48,203,000) | (39,024,000) |
Supplemental Income Statement Elements [Abstract] | ||||
Stock-based compensation expense associated with selling, general and administrative expense | $ 1,734,000 | $ 1,602,000 | 3,474,000 | 3,167,000 |
Business Exit Costs | $ 1,500 | $ 0 |
Consolidated Statements of Co_2
Consolidated Statements of Comprehensive Loss Parentheticals - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2022 | Jun. 30, 2021 | Jun. 30, 2022 | Jun. 30, 2021 | |
Consolidated Statements of Operations [Abstract] | ||||
Stock-based compensation expense associated with research and development expense | $ 1,098 | $ 1,184 | $ 2,130 | $ 2,470 |
Stock-based compensation expense associated with selling, general and administrative expense | $ 1,734 | $ 1,602 | $ 3,474 | $ 3,167 |
Consolidated Statements of Cash
Consolidated Statements of Cash Flows (Unaudited) | 3 Months Ended | 6 Months Ended | |
Jun. 30, 2022 USD ($) | Jun. 30, 2022 USD ($) | Jun. 30, 2021 USD ($) | |
Cash flows from operating activities: | |||
Net loss | $ (24,587,000) | $ (48,063,000) | $ (39,025,000) |
Adjustments to reconcile net loss to net cash used in operating activities: | |||
Depreciation and amortization | 216,000 | 79,000 | |
Stock-based compensation | 5,604,000 | 5,637,000 | |
Amortization of debt issuance costs | 179,000 | 29,000 | |
Changes in operating assets and liabilities: | |||
(Increase) decrease in accounts receivable | (20,000) | 236,000 | |
(Increase) decrease in prepaid expenses and other current assets | (732,000) | 451,000 | |
Decrease in other assets | 420,000 | 261,000 | |
Decrease in accounts payable and other liabilities | (5,447,000) | (14,707,000) | |
Net cash provided by (used in) operating activities | (47,843,000) | (47,039,000) | |
Cash and cash equivalents | 21,450,000 | 21,450,000 | 89,887,000 |
Cash paid for interest | 634,000 | 307,000 | |
Initial recognition of right of use asset | 0 | 0 | 1,704,000 |
Issuance of Stock and Warrants for Services or Claims | 698 | ||
Adjustments to Additional Paid in Capital, Warrant Issued | 700,000 | 0 | |
Stock Issued During Period, Value, Treasury Stock Reissued | 6,321 | 0 | |
Business Exit Costs | 1,500 | 0 | |
Issuance of common stock under Equity Incentive Plans, value | 0 | ||
Cash flows from investing activities: | |||
Purchases of property and equipment | (76,000) | (985,000) | |
Purchases of investments | (40,171,000) | (24,373,000) | |
Maturities of investments | 22,191,000 | 21,772,000 | |
Net cash (used in) provided by investing activities | (18,056,000) | (3,586,000) | |
Cash flows from financing activities: | |||
Proceeds from issuance of common stock | 0 | 16,924,000 | |
Repurchase of common stock | (864,000) | (2,675,000) | |
Proceeds from debt borrowings, net of fees | 24,148,000 | 0 | |
Net cash used in financing activities | 23,284,000 | 14,249,000 | |
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect | (42,615,000) | (36,376,000) | |
Cash and cash equivalents at beginning of period | 64,065,000 | 126,263,000 | |
Cash and cash equivalents at end of period | 21,450,000 | 21,450,000 | 89,887,000 |
Supplemental disclosure of cash flow information: | |||
Cash paid for interest | 634,000 | 307,000 | |
Initial recognition of right of use asset | 0 | $ 0 | $ 1,704,000 |
Issuance of common stock under Equity Incentive Plans, value | $ 0 |
Consolidated Statements of Stoc
Consolidated Statements of Stockholders' Equity/Deficit-Unaudited - USD ($) shares in Thousands | Total | Common Stock | Additional Paid-In Capital | Accumulated Deficit | Accumulated Other Comprehensive Gain (Loss) | Treasury Stock |
Balance, shares at Dec. 31, 2020 | 142,289 | |||||
Balance, value at Dec. 31, 2020 | $ 156,371,000 | $ 142,000 | $ 1,561,096,000 | $ (1,400,018,000) | $ (6,000) | $ (4,843,000) |
Stock-based compensation | 2,851,000 | $ 0 | 2,851,000 | 0 | 0 | 0 |
Issuance of common stock under Equity Incentive Plans, shares | 2,000 | |||||
Issuance of common stock under Equity Incentive Plans, value | (16,399,000) | $ (2,000) | (16,397,000) | 0 | 0 | 0 |
Repurchase of common stock | (2,675,000) | 0 | 0 | 0 | 0 | (2,675,000) |
Net loss | 0 | 0 | (20,958,000) | 0 | 0 | |
Unrealized gain on investments | 11,000 | $ 0 | 0 | 0 | 11,000 | 0 |
Balance, shares at Mar. 31, 2021 | 145,552 | |||||
Balance, value at Mar. 31, 2021 | 152,547,000 | $ 145,000 | 1,580,891,000 | (1,420,976,000) | 5,000 | (7,518,000) |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Net of Forfeitures | 1,263 | |||||
Shares Issued, Value, Share-based Payment Arrangement, after Forfeiture | 548,000 | $ 1,000 | 547,000 | 0 | 0 | 0 |
Balance, shares at Dec. 31, 2020 | 142,289 | |||||
Balance, value at Dec. 31, 2020 | 156,371,000 | $ 142,000 | 1,561,096,000 | (1,400,018,000) | (6,000) | (4,843,000) |
Net loss | (39,025,000) | |||||
Unrealized gain on investments | 1,000 | |||||
Balance, shares at Jun. 30, 2021 | 145,640 | |||||
Balance, value at Jun. 30, 2021 | 137,233,000 | $ 146,000 | 1,583,653,000 | (1,439,043,000) | (5,000) | (7,518,000) |
Stock Issued During Period, Value, Treasury Stock Reissued | 0 | |||||
Balance, shares at Mar. 31, 2021 | 145,552 | |||||
Balance, value at Mar. 31, 2021 | 152,547,000 | $ 145,000 | 1,580,891,000 | (1,420,976,000) | 5,000 | (7,518,000) |
Stock-based compensation | 2,786,000 | 0 | 2,786,000 | 0 | 0 | 0 |
Payments of Stock Issuance Costs | (31,000) | 0 | (31,000) | 0 | 0 | 0 |
Net loss | (18,067,000) | 0 | 0 | (18,067,000) | 0 | 0 |
Unrealized gain on investments | (10,000) | $ 0 | 0 | 0 | (10,000) | 0 |
Balance, shares at Jun. 30, 2021 | 145,640 | |||||
Balance, value at Jun. 30, 2021 | 137,233,000 | $ 146,000 | 1,583,653,000 | (1,439,043,000) | (5,000) | (7,518,000) |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Net of Forfeitures | 88 | |||||
Shares Issued, Value, Share-based Payment Arrangement, after Forfeiture | $ 8,000 | $ 1,000 | 7,000 | 0 | 0 | 0 |
Balance, shares at Dec. 31, 2021 | 150,082 | 150,082 | ||||
Balance, value at Dec. 31, 2021 | $ 113,595,000 | $ 150,000 | 1,608,749,000 | (1,487,776,000) | (10,000) | (7,518,000) |
Stock-based compensation | 2,772,000 | $ 0 | 2,772,000 | 0 | 0 | 0 |
Issuance of common stock under Equity Incentive Plans, shares | 0 | |||||
Issuance of common stock under Equity Incentive Plans, value | (864,000) | $ 0 | 0 | 0 | 0 | 864,000 |
Net loss | (23,476,000) | 0 | 0 | (23,476,000) | 0 | 0 |
Unrealized gain on investments | (27,000) | $ 0 | 0 | 0 | (27,000) | 0 |
Balance, shares at Mar. 31, 2022 | 150,082 | |||||
Balance, value at Mar. 31, 2022 | 92,698,000 | $ 150,000 | 1,605,898,000 | (1,511,252,000) | (37,000) | (2,061,000) |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Net of Forfeitures | 0 | |||||
Shares Issued, Value, Share-based Payment Arrangement, after Forfeiture | 698,000 | $ 0 | 698,000 | 0 | 0 | 0 |
Stock Issued During Period, Value, Treasury Stock Reissued | $ 0 | $ 0 | (6,321,000) | 0 | 0 | (6,321,000) |
Stock Issued During Period, Shares, Treasury Stock Reissued | 0 | |||||
Balance, shares at Dec. 31, 2021 | 150,082 | 150,082 | ||||
Balance, value at Dec. 31, 2021 | $ 113,595,000 | $ 150,000 | 1,608,749,000 | (1,487,776,000) | (10,000) | (7,518,000) |
Net loss | (48,063,000) | |||||
Unrealized gain on investments | $ (140,000) | |||||
Balance, shares at Jun. 30, 2022 | 150,114 | 150,114 | ||||
Balance, value at Jun. 30, 2022 | $ 70,830,000 | $ 150,000 | 1,608,730,000 | (1,535,839,000) | (150,000) | (2,061,000) |
Stock Issued During Period, Value, Treasury Stock Reissued | (6,321) | |||||
Balance, shares at Mar. 31, 2022 | 150,082 | |||||
Balance, value at Mar. 31, 2022 | 92,698,000 | $ 150,000 | 1,605,898,000 | (1,511,252,000) | (37,000) | (2,061,000) |
Stock-based compensation | 2,832,000 | $ 0 | 2,832,000 | 0 | 0 | 0 |
Issuance of common stock under Equity Incentive Plans, shares | 32 | |||||
Issuance of common stock under Equity Incentive Plans, value | 0 | $ 0 | 0 | 0 | 0 | 0 |
Net loss | (24,587,000) | 0 | 0 | (24,587,000) | 0 | 0 |
Unrealized gain on investments | $ (113,000) | $ 0 | 0 | 0 | (113,000) | 0 |
Balance, shares at Jun. 30, 2022 | 150,114 | 150,114 | ||||
Balance, value at Jun. 30, 2022 | $ 70,830,000 | $ 150,000 | $ 1,608,730,000 | $ (1,535,839,000) | $ (150,000) | $ (2,061,000) |
Summary of Significant Accounti
Summary of Significant Accounting Policies (Notes) | 6 Months Ended |
Jun. 30, 2022 | |
Summary of Significant Accounting Policies [Abstract] | |
Significant Accounting Policies [Text Block] | Summary of Significant Accounting Policies Basis of Presentation: The accompanying unaudited condensed consolidated financial statements of Lexicon Pharmaceuticals, Inc. (“Lexicon” or the “Company”) have been prepared in accordance with generally accepted accounting principles for interim financial information and pursuant to the rules and regulations of the Securities and Exchange Commission (“SEC”). Accordingly, they do not include all of the information and footnotes required by generally accepted accounting principles for complete financial statements. In the opinion of management, all adjustments (consisting of normal recurring adjustments) considered necessary for a fair presentation have been included. Operating results for the six-month period ended June 30, 2022 are not necessarily indicative of the results that may be expected for the year ended December 31, 2022. The accompanying condensed consolidated financial statements include the accounts of Lexicon and its wholly-owned subsidiaries. Intercompany transactions and balances are eliminated in consolidation. For further information, refer to the financial statements and footnotes thereto included in Lexicon’s annual report on Form 10-K for the year ended December 31, 2021, as filed with the SEC. Use of Estimates: The preparation of financial statements in conformity with U.S. generally accepted accounting principles requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the period. Actual results could differ from those estimates. Cash, Cash Equivalents and Short-Term Investments: Lexicon considers all highly-liquid investments with original maturities of three months or less to be cash equivalents. As of June 30, 2022 and December 31, 2021, short-term investments consisted of U.S. treasury bills and corporate debt securities. The Company’s short-term investments are classified as available-for-sale securities and are carried at fair value, based on quoted market prices of the securities. The Company views its available-for-sale securities as available for use in current operations as they all contain maturities of less than one year. Unrealized gains and losses on such securities are reported as a separate component of stockholders’ equity. Net realized gains and losses, interest and dividends are included in interest income. The cost of securities sold is based on the specific identification method. Accrued liabilities: Accrued liabilities consisted of the following: As of June 30, As of December 31, 2022 2021 (in thousands) Accrued research and development services $ 3,920 $ 3,669 Accrued compensation and benefits 4,329 5,711 Short term lease liability 789 1,089 Other 477 2,503 Total accrued liabilities $ 9,515 $ 12,972 Leases: Lexicon determines if a contract is or contains a lease at inception or upon modification of the contract. A contract is or contains a lease if it conveys the right to control the use of an identified asset for a period in exchange for consideration. Control over the use of the identified asset means the lessee has both (a) the right to obtain substantially all of the economic benefits from the use of the asset and (b) the right to direct the use of the asset. Lexicon does not apply this accounting to those leases with terms of twelve (12) months or less. Operating lease right-of-use assets and associated lease liabilities are recorded in the balance sheet at the lease commencement date based on the present value of future lease payments to be made over the expected lease term. As the implicit rate is not determinable in its leases, Lexicon used a borrowing rate of 9% at the commencement date in determining the present value of future payments. Revenue Recognition: The Company performs the following five steps in determining the amount of revenue to recognize as its performance obligations under each of its contracts with customers: (i) identify the contract(s) with a customer; (ii) identify the performance obligation in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligation in the contract, and (v) recognize revenue when (or as) we satisfy the performance obligation. At contract inception, the Company evaluates whether development milestones are considered probable of being reached and estimates the amount to be included in the transaction price using the most likely amount method. If it is probable that a significant revenue reversal will not occur, the associated development milestone value is included in the transaction price. Development milestones that are not within the control of the Company or the licensee, including those requiring regulatory approval, are not considered probable of being achieved until those milestones are achieved. The transaction price is allocated to each performance obligation on a relative stand-alone selling price basis, for which the Company recognizes revenue when (or as) the performance obligation is satisfied. At the end of each reporting period, the Company re-evaluates the probability of achievement of the development milestones and any related constraint, and if necessary, adjusts its estimates of the overall transaction price. Any such adjustments are recorded on a cumulative catch-up basis, which would affect collaboration revenues in the period of adjustment. In agreements in which a license to the Company’s intellectual property is determined distinct from other performance obligations identified in the agreement, the Company recognizes revenue when the license is transferred to the licensee and the licensee is able to use and benefit from the license. The Company may receive payments from its licensees based on billing schedules established in each contract. Upfront payments and fees are recorded as deferred revenue upon receipt or when due, and may require deferral of revenue recognition to a future period until the Company performs its obligations under the relevant agreement. Amounts are recorded as accounts receivable when the Company’s right to consideration is unconditional. Research and Development Expenses: Research and development expenses consist of costs incurred for company-sponsored as well as collaborative research and development activities. These costs include direct and research-related overhead expenses and are expensed as incurred. Technology license fees for technologies that are utilized in research and development and have no alternative future use are expensed when incurred. Substantial portions of the Company’s preclinical and clinical trials are performed by third-party laboratories, medical centers, contract research organizations and other vendors. For preclinical studies, the Company accrues expenses based upon estimated percentage of work completed and the contract milestones remaining. For clinical studies, expenses are accrued based upon the number of patients enrolled and the duration of the study. The Company monitors patient enrollment, the progress of clinical studies and related activities to the extent possible through internal reviews of data reported to the Company by the vendors and clinical site visits. The Company’s estimates depend on the timeliness and accuracy of the data provided by the vendors regarding the status of each program and total program spending. The Company periodically evaluates the estimates to determine if adjustments are necessary or appropriate based on information it receives. Stock-Based Compensation: The Company recognizes compensation expense in its condensed consolidated statements of comprehensive loss for share-based payments, including stock options and restricted stock units granted to employees, based on their fair values on the date of the grant, with the compensation expense recognized over the period in which an employee is required to provide service in exchange for the stock award. Stock-based compensation expense for awards without performance conditions is recognized on a straight-line basis. Stock-based compensation expense for awards with performance conditions is recognized over the period from the date the performance condition is determined to be probable of occurring through the time the applicable condition is met. The fair value of stock options is estimated at the date of grant using the Black-Scholes method. The Black-Scholes option-pricing model requires the input of subjective assumptions. Because the Company’s employee stock options have characteristics significantly different from those of traded options, and because changes in the subjective input assumptions can materially affect the fair value estimate, in management’s opinion, the existing models do not necessarily provide a reliable single measure of the fair value of its employee stock options. For purposes of determining the fair value of stock options, the Company segregates its options into two homogeneous groups, based on exercise and post-vesting employment termination behaviors, resulting in a change in the assumptions used for expected option lives. Historical data is used to estimate the expected option life for each group. Expected volatility is based on the historical volatility in the Company’s stock price. The Company utilized the Black-Scholes valuation model for estimating the fair value of the stock option compensation granted, with the following weighted-average assumptions for stock options granted in the six months ended June 30, 2022 and 2021: Expected Volatility Risk-free Interest Rate Expected Term Dividend June 30, 2022: Employees 106 % 2.1 % 4 — % Officers and non-employee directors 91 % 1.9 % 7 — % June 30, 2021: Employees 101 % 0.6 % 4 — % Officers and non-employee directors 90 % 1.1 % 7 — % The following is a summary of stock option activity under Lexicon’s stock-based compensation plans for the six months ended June 30, 2022: Options Weighted Average Exercise Price (in thousands) Outstanding at December 31, 2021 8,367 $ 6.80 Granted 4,257 3.06 Expired (163) 12.50 Forfeited (353) 9.20 Outstanding at June 30, 2022 12,108 5.34 Exercisable at June 30, 2022 5,423 $ 7.35 During the six months ended June 30, 2022, Lexicon granted its employees and non-employee directors annual restricted stock units. Outstanding employee restricted stock units vest in three annual installments. Outstanding non-employee director restricted stock units vest fully on the first anniversary of the grant. The following is a summary of restricted stock units activity under Lexicon’s stock-based compensation plans for the six months ended June 30, 2022: Shares Weighted Average Grant Date (in thousands) Outstanding at December 31, 2021 1,854 $ 5.16 Granted 2,185 2.25 Vested (1,012) 4.86 Forfeited (108) 3.40 Outstanding at June 30, 2022 2,919 $ 3.17 |
Recent Accounting Pronouncement
Recent Accounting Pronouncements Level 1 (Notes) | 6 Months Ended |
Jun. 30, 2022 | |
Recent Accounting Pronouncements [Abstract] | |
New Accounting Pronouncements, Policy | Recent Accounting Pronouncements In December 2019, the FASB issued Accounting Standards Update (“ASU”) No. 2019-12, Income Taxes (Topic 740) Simplifying Accounting for Income Taxes, as part of its initiative to reduce complexity in the accounting standards. The guidance amended certain disclosure requirements that had become redundant, outdated or superseded. Additionally, this guidance amends accounting for the interim period effects of changes in tax laws or rates, and simplifies aspects of the accounting for franchise taxes. The guidance is effective for annual periods beginning after December 15, 2020, including interim periods therein. The adoption of ASU 2019-12 in the first quarter of 2021 did not have a material impact on the condensed consolidated financial statements. In August 2020, the FASB issued ASU No. 2020-06, Debt - Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging - Contracts in Entity’s Own Equity (Subtopic 815-40), which removes the separation models for convertible debt with cash conversion or beneficial conversion features. ASU 2020-06 also requires the application of the if-converted method for calculating earnings per diluted share, as the treasury stock method will no longer be permitted for convertible instruments. The adoption of ASU 2020-06 during the first quarter of 2022 did not have a material impact on the condensed consolidated financial statements. |
Cash and Cash Equivalents and I
Cash and Cash Equivalents and Investments | 6 Months Ended |
Jun. 30, 2022 | |
Cash and Cash Equivalents and Investments [Abstract] | |
Cash and Cash Equivalents Disclosure | Cash and Cash Equivalents and Investments The fair value of cash and cash equivalents and investments held at June 30, 2022 and December 31, 2021 are as follows: As of June 30, 2022 Amortized Cost Gross Unrealized Gains Gross Unrealized Losses Estimated Fair Value (in thousands) Cash and cash equivalents $ 21,450 $ — $ — $ 21,450 Securities maturing within one year: U.S. treasury securities 30,419 — (89) 30,330 Corporate debt securities 10,249 — (61) 10,188 Total short-term investments $ 40,668 $ — $ (150) $ 40,518 Total cash and cash equivalents and investments $ 62,118 $ — $ (150) $ 61,968 As of December 31, 2021 Amortized Cost Gross Unrealized Gains Gross Unrealized Losses Estimated Fair Value (in thousands) Cash and cash equivalents $ 64,066 $ — $ (1) $ 64,065 Securities maturing within one year: U.S. treasury securities 7,562 — (1) 7,561 Corporate debt securities 15,125 — (8) 15,117 Total short-term investments $ 22,687 $ — $ (9) $ 22,678 Total cash and cash equivalents and investments $ 86,753 $ — $ (10) $ 86,743 There were no realized losses during either of the six months ended June 30, 2022 and 2021, respectively. The cost of securities sold is based on the specific identification method. |
Fair Value Measurements
Fair Value Measurements | 6 Months Ended |
Jun. 30, 2022 | |
Fair Value Measurements [Abstract] | |
Fair Value, Measurement Inputs, Disclosure | Fair Value Measurements The Company uses various inputs in determining the fair value of its investments and measures these assets on a recurring basis. Assets and liabilities recorded at fair value in the condensed consolidated balance sheets are categorized by the level of objectivity associated with the inputs used to measure their fair value. The following levels are directly related to the amount of subjectivity associated with the inputs to fair valuation of these assets and liabilities: • Level 1 - quoted prices in active markets for identical investments, which include U.S. treasury securities • Level 2 - other significant observable inputs (including quoted prices for similar investments, market corroborated inputs, etc.), which includes corporate debt securities • Level 3 - significant unobservable inputs The inputs or methodology used for valuing securities are not necessarily an indication of the credit risk associated with investing in those securities. The following table provides the fair value measurements of applicable Company assets that are measured at fair value on a recurring basis according to the fair value levels defined above as of June 30, 2022 and December 31, 2021. Assets and Liabilities at Fair Value as of June 30, 2022 Level 1 Level 2 Level 3 Total (in thousands) Assets Cash and cash equivalents $ 21,450 $ — $ — $ 21,450 Short-term investments 30,330 10,188 — 40,518 Total cash and cash equivalents and investments $ 51,780 $ 10,188 $ — $ 61,968 Assets and Liabilities at Fair Value as of December 31, 2021 Level 1 Level 2 Level 3 Total (in thousands) Assets Cash and cash equivalents $ 64,065 $ — $ — $ 64,065 Short-term investments 7,561 15,117 — 22,678 Total cash and cash equivalents and investments $ 71,626 $ 15,117 $ — $ 86,743 The Company did not have any Level 3 assets or liabilities as of June 30, 2022 or December 31, 2021. Transfers between levels are recognized at the actual date of the circumstance that caused the transfer. There were no transfers between Level 1 and Level 2 during the periods presented. Refer to Note 5, Debt Obligations, for fair value measurements of debt obligations. |
Debt Obligations
Debt Obligations | 6 Months Ended |
Jun. 30, 2022 | |
Debt Obligations [Abstract] | |
Debt Disclosure | Debt Obligations On March 17, 2022, Lexicon and one of its subsidiaries entered into a loan and security agreement with Oxford Finance LLC (“Oxford”) that provides up to $150 million in borrowing capacity (the “Oxford Term Loans”) available in four tranches, each maturing in March 2027. Monthly interest-only payments are due during an initial 36-month period, which may be extended at Lexicon’s option to 48 months if Lexicon maintains compliance with a financial covenant relating to net sales of sotagliflozin following regulatory approval. The interest-only period will be followed by principal payments of $8.7 million, $13.0 million, and $4.8 million during the fiscal years ended December 31, 2025, December 31, 2026 and December 31, 2027, respectively. The first $25 million tranche was funded at closing. The second $25 million tranche is available for draw at Lexicon’s option prior to August 25, 2022. The third $50 million tranche is available for draw at Lexicon’s option prior to June 30, 2023, but within 60 days of U.S. regulatory approval of sotagliflozin for heart failure. The fourth $50 million tranche is available for draw at Lexicon’s option, subject to Oxford’s consent, at any time prior to the expiration of the interest-only payment period. The loan and security agreement provides that, upon funding of the first three tranches, Lexicon will grant Oxford a warrant to purchase shares of its common stock having a value equal to 3.50%, 1.75% and 0.875%, respectively, of each such tranche, as determined by reference to a 10-day average closing price of the shares. Each warrant will have an exercise price equal to such average closing price, be exercisable for a five-year period from the date of issuance and feature a net cashless exercise provision. Concurrent with the funding of the first tranche, Lexicon granted Oxford a warrant to purchase 420,673 shares of Lexicon’s common stock at an exercise price of $2.08 per share. The warrant is exercisable through March 1, 2027 and is classified as an equity instrument. The Company allocated the proceeds from the first tranche to the warrant using the relative fair value method and used the Black-Scholes model to calculate the fair value of the warrants. The fair value of the warrant of $0.7 million was recognized as equity with a corresponding debt discount of $0.7 million. The Oxford Term Loans bear interest at a floating rate equal to the 30-day U.S. Dollar LIBOR plus 7.90%, but not less than 8.01%, subject to additional interest if an event of default occurs and is continuing. As of June 30, 2022, the interest rate was 9.02%. If an event of default occurs and is continuing, Oxford may declare all amounts outstanding under the loan and security agreement to be immediately due and payable. Lexicon may prepay the Oxford Term Loans in whole at its option at any time. Any prepayment of the Oxford Term Loans is subject to prepayment fees for up to three years after the funding of each tranche of the loans. A final payment exit fee equal to 6% of the amount funded under the Oxford Term Loans is due upon prepayment or maturity, which final payment will be adjusted to 7% of the amount funded upon extension of the interest-only payment period. The final payment exit fee of $1.5 million was recorded as a debt discount on the closing date of the first tranche. During March 2022, in connection with the first tranche of the loan and security agreement, the Company received cash proceeds of $24.2 million, net of debt issuance costs of $0.4 million and a facility fee of $0.5 million. The debt issuance costs and facility fee have been recorded as a debt discount on the Company’s condensed consolidated balance sheet, which together with the final payment exit fee of $1.5 million and warrant fair value of $0.7 million are being amortized to interest expense throughout the life of the term loan using the effective interest rate method. As of June 30, 2022, the balance of the debt discount was $2.9 million. During the six months ended June 30, 2022, the Company recognized interest expense of $0.8 million. As of June 30, 2022, the carrying value of the Oxford Term Loans was $23.6 million. The fair value of the Oxford Term Loans approximates its carrying value and was determined using Level 2 inputs using discounted cash flow analysis, based on the Company’s estimated current incremental borrowing rate. Lexicon’s obligations under the Oxford Term Loans are secured by a first lien security interest in all of the assets of the Company and its subsidiaries. The loan and security agreement contains certain customary representations and warranties, affirmative and negative covenants and events of default applicable to Lexicon and its subsidiaries. In addition to the financial covenant, additional covenants include those restricting dispositions, fundamental changes to its business, mergers or acquisitions, indebtedness, encumbrances, distributions, investments, transactions with affiliates and subordinated debt. The Company was in compliance with its debt covenants as of June 30, 2022. Convertible Debt. In November 2014, Lexicon completed an offering of $87.5 million in aggregate principal amount of its 5.25% Convertible Senior Notes due 2021 (the “Convertible Notes”). The conversion feature did not meet the criteria for bifurcation as required by generally accepted accounting principles and the entire principal amount was recorded as long-term debt on the Company’s condensed consolidated balance sheets. |
Commitments and Contingencies
Commitments and Contingencies | 6 Months Ended |
Jun. 30, 2022 | |
Commitments and Contingencies Disclosure [Abstract] | |
Commitments and Contingencies Disclosure | Commitments and Contingencies Operating Lease Obligations : Lexicon’s operating leases include office space in The Woodlands, Texas and Basking Ridge, New Jersey and will expire in August 2025 and December 2022, respectively. Under its lease agreements, Lexicon is obligated to pay property taxes, insurance, and maintenance costs. In July 2022, the Company entered into a lease agreement for a 22,000 square-foot office space in Bridgewater, New Jersey to which it plans to relocate the New Jersey offices. The term of the lease is expected to commence in December 2022, will extend for ten years and 11 months from such commencement date and provides for escalating yearly base rent payments starting at $820,000 and increasing to $986,000 in the final year of the lease. As of June 30, 2022, the right-of-use assets for the office space leases had a balance of $1.8 million, which is included in other assets in the condensed consolidated balance sheet. Current and non-current liabilities relating to the leases were $0.8 million and $1.0 million, respectively, which are included in accrued liabilities and other long-term liabilities in the condensed consolidated balance sheet, respectively. The following table reconciles the undiscounted cash flows of the operating lease liability to the recorded lease liability at June 30, 2022: (in thousands) 2022 $ 583 2023 531 2024 544 2025 370 2026 — Thereafter — Total undiscounted operating lease liability 2,028 Less: amount of lease payments representing interest (237) Present value of future lease payments 1,791 Less: short-term operating lease liability (789) Long-term operating lease liability $ 1,002 Legal Proceedings. Lexicon is from time to time party to claims and legal proceedings that arise in the normal course of its business and that it believes will not have, individually or in the aggregate, a material adverse effect on its results of operations, financial condition or liquidity. |
Collaboration and License Agree
Collaboration and License Agreements | 6 Months Ended |
Jun. 30, 2022 | |
Collaboration and License Agreements [Abstract] | |
Collaborative Arrangement Disclosure | Collaboration and License Agreements Lexicon has derived substantially all of its revenues from drug discovery and development alliances, target validation collaborations for the development and, in some cases, analysis of the physiological effects of genes altered in knockout mice, product sales, government grants and contracts, technology licenses, subscriptions to its databases and compound library sales, as well as from commercial sales of its XERMELO product following its commercial launch in February 2017 until its sale of XERMELO and related assets to TerSera Therapeutics, LLC in September 2020. |
Other Capital Agreements
Other Capital Agreements | 3 Months Ended | 6 Months Ended |
Sep. 30, 2022 | Jun. 30, 2022 | |
Equity [Abstract] | ||
Other Capital Agreements | Other Capital Agreements Common Stock : In 2020, Lexicon entered into an Open Market Sale Agreement SM (the “Sales Agreement”) with Jefferies LLC (“Jefferies”) relating to the shares of its common stock. In January 2021, Lexicon sold 2,000,000 shares of its common stock at a price of $8.463 per share pursuant to the Sales Agreement, resulting in net proceeds of $16.4 million. In August and September 2021, Lexicon sold an aggregate of 4,176,953 shares of its common stock at a price of $4.732 per share pursuant to the Sales Agreement, resulting in net proceeds of $19.1 million. The net proceeds are reflected as issuances of common stock in the accompanying condensed consolidated financial statements. | |
Subsequent Events | Subsequent Events Common Stock : In August 2022, Lexicon sold an aggregate of 34,000,000 shares of its common stock at a price of $2.50 per share in a public offering and concurrent private placement to two affiliates of Invus, L.P., resulting in net proceeds of approximately $82.2 million, after deducting underwriting discounts and commissions and estimated offering expenses. |
Summary of Significant Accoun_2
Summary of Significant Accounting Policies (Policies) | 6 Months Ended |
Jun. 30, 2022 | |
Summary of Significant Accounting Policies [Abstract] | |
Consolidation, Policy [Policy Text Block] | The accompanying condensed consolidated financial statements include the accounts of Lexicon and its wholly-owned subsidiaries. Intercompany transactions and balances are eliminated in consolidation. |
Use of Estimates, Policy [Policy Text Block] | Use of Estimates: The preparation of financial statements in conformity with U.S. generally accepted accounting principles requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the period. Actual results could differ from those estimates. |
Cash and Cash Equivalents, Policy [Policy Text Block] | Cash, Cash Equivalents and Short-Term Investments: Lexicon considers all highly-liquid investments with original maturities of three months or less to be cash equivalents. As of June 30, 2022 and December 31, 2021, short-term investments consisted of U.S. treasury bills and corporate debt securities. The Company’s short-term investments are classified as available-for-sale securities and are carried at fair value, based on quoted market prices of the securities. The Company views its available-for-sale securities as available for use in current operations as they all contain maturities of less than one year. Unrealized gains and losses on such securities are reported as a separate component of stockholders’ equity. Net realized gains and losses, interest and dividends are included in interest income. The cost of securities sold is based on the specific identification method. |
Revenue [Policy Text Block] | Revenue Recognition: The Company performs the following five steps in determining the amount of revenue to recognize as its performance obligations under each of its contracts with customers: (i) identify the contract(s) with a customer; (ii) identify the performance obligation in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligation in the contract, and (v) recognize revenue when (or as) we satisfy the performance obligation. At contract inception, the Company evaluates whether development milestones are considered probable of being reached and estimates the amount to be included in the transaction price using the most likely amount method. If it is probable that a significant revenue reversal will not occur, the associated development milestone value is included in the transaction price. Development milestones that are not within the control of the Company or the licensee, including those requiring regulatory approval, are not considered probable of being achieved until those milestones are achieved. The transaction price is allocated to each performance obligation on a relative stand-alone selling price basis, for which the Company recognizes revenue when (or as) the performance obligation is satisfied. At the end of each reporting period, the Company re-evaluates the probability of achievement of the development milestones and any related constraint, and if necessary, adjusts its estimates of the overall transaction price. Any such adjustments are recorded on a cumulative catch-up basis, which would affect collaboration revenues in the period of adjustment. In agreements in which a license to the Company’s intellectual property is determined distinct from other performance obligations identified in the agreement, the Company recognizes revenue when the license is transferred to the licensee and the licensee is able to use and benefit from the license. |
Research and Development Expense, Policy [Policy Text Block] | Research and Development Expenses: Research and development expenses consist of costs incurred for company-sponsored as well as collaborative research and development activities. These costs include direct and research-related overhead expenses and are expensed as incurred. Technology license fees for technologies that are utilized in research and development and have no alternative future use are expensed when incurred. Substantial portions of the Company’s preclinical and clinical trials are performed by third-party laboratories, medical centers, contract research organizations and other vendors. For preclinical studies, the Company accrues expenses based upon estimated percentage of work completed and the contract milestones remaining. For clinical studies, expenses are accrued based upon the number of patients enrolled and the duration of the study. The Company monitors patient enrollment, the progress of clinical studies and related activities to the extent possible through internal reviews of data reported to the Company by the vendors and clinical site visits. The Company’s estimates depend on the timeliness and accuracy of the data provided by the vendors regarding the status of each program and total program spending. The Company periodically evaluates the estimates to determine if adjustments are necessary or appropriate based on information it receives. |
Share-based Payment Arrangement [Policy Text Block] | Stock-Based Compensation: The Company recognizes compensation expense in its condensed consolidated statements of comprehensive loss for share-based payments, including stock options and restricted stock units granted to employees, based on their fair values on the date of the grant, with the compensation expense recognized over the period in which an employee is required to provide service in exchange for the stock award. Stock-based compensation expense for awards without performance conditions is recognized on a straight-line basis. Stock-based compensation expense for awards with performance conditions is recognized over the period from the date the performance condition is determined to be probable of occurring through the time the applicable condition is met. The fair value of stock options is estimated at the date of grant using the Black-Scholes method. The Black-Scholes option-pricing model requires the input of subjective assumptions. Because the Company’s employee stock options have characteristics significantly different from those of traded options, and because changes in the subjective input assumptions can materially affect the fair value estimate, in management’s opinion, the existing models do not necessarily provide a reliable single measure of the fair value of its employee stock options. For purposes of determining the fair value of stock options, the Company segregates its options into two homogeneous groups, based on exercise and post-vesting employment termination |
Earnings Per Share, Policy [Policy Text Block] | Net Loss per Common Share: Net loss per common share is computed using the weighted average number of shares of common stock outstanding. Shares associated with convertible debt, stock options and restricted stock units are not included because they are antidilutive. |
Recognition of Asset and Liability for Lease of Acquiree | Leases: Lexicon determines if a contract is or contains a lease at inception or upon modification of the contract. A contract is or contains a lease if it conveys the right to control the use of an identified asset for a period in exchange for consideration. Control over the use of the identified asset means the lessee has both (a) the right to obtain substantially all of the economic benefits from the use of the asset and (b) the right to direct the use of the asset. Lexicon does not apply this accounting to those leases with terms of twelve (12) months or less. |
Summary of Significant Accoun_3
Summary of Significant Accounting Policies Equity Incentive Awards (Tables) | 6 Months Ended |
Jun. 30, 2022 | |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Abstract] | |
Schedule of Accrued Liabilities | Accrued liabilities: Accrued liabilities consisted of the following: As of June 30, As of December 31, 2022 2021 (in thousands) Accrued research and development services $ 3,920 $ 3,669 Accrued compensation and benefits 4,329 5,711 Short term lease liability 789 1,089 Other 477 2,503 Total accrued liabilities $ 9,515 $ 12,972 |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] | Expected Volatility Risk-free Interest Rate Expected Term Dividend June 30, 2022: Employees 106 % 2.1 % 4 — % Officers and non-employee directors 91 % 1.9 % 7 — % June 30, 2021: Employees 101 % 0.6 % 4 — % Officers and non-employee directors 90 % 1.1 % 7 — % |
Share-based Payment Arrangement, Option, Activity [Table Text Block] | Options Weighted Average Exercise Price (in thousands) Outstanding at December 31, 2021 8,367 $ 6.80 Granted 4,257 3.06 Expired (163) 12.50 Forfeited (353) 9.20 Outstanding at June 30, 2022 12,108 5.34 Exercisable at June 30, 2022 5,423 $ 7.35 |
Schedule of Nonvested Restricted Stock Units Activity [Table Text Block] | Shares Weighted Average Grant Date (in thousands) Outstanding at December 31, 2021 1,854 $ 5.16 Granted 2,185 2.25 Vested (1,012) 4.86 Forfeited (108) 3.40 Outstanding at June 30, 2022 2,919 $ 3.17 |
Cash and Cash Equivalents and_2
Cash and Cash Equivalents and Investments (Tables) | 6 Months Ended |
Jun. 30, 2022 | |
Cash and Cash Equivalents and Investments [Abstract] | |
Schedule of Cash, Cash Equivalents and Short-term Investments [Table Text Block] | As of June 30, 2022 Amortized Cost Gross Unrealized Gains Gross Unrealized Losses Estimated Fair Value (in thousands) Cash and cash equivalents $ 21,450 $ — $ — $ 21,450 Securities maturing within one year: U.S. treasury securities 30,419 — (89) 30,330 Corporate debt securities 10,249 — (61) 10,188 Total short-term investments $ 40,668 $ — $ (150) $ 40,518 Total cash and cash equivalents and investments $ 62,118 $ — $ (150) $ 61,968 As of December 31, 2021 Amortized Cost Gross Unrealized Gains Gross Unrealized Losses Estimated Fair Value (in thousands) Cash and cash equivalents $ 64,066 $ — $ (1) $ 64,065 Securities maturing within one year: U.S. treasury securities 7,562 — (1) 7,561 Corporate debt securities 15,125 — (8) 15,117 Total short-term investments $ 22,687 $ — $ (9) $ 22,678 Total cash and cash equivalents and investments $ 86,753 $ — $ (10) $ 86,743 |
Fair Value Measurements (Tables
Fair Value Measurements (Tables) | 6 Months Ended |
Jun. 30, 2022 | |
Fair Value Measurements [Abstract] | |
Fair Value, by Balance Sheet Grouping [Table Text Block] | Assets and Liabilities at Fair Value as of June 30, 2022 Level 1 Level 2 Level 3 Total (in thousands) Assets Cash and cash equivalents $ 21,450 $ — $ — $ 21,450 Short-term investments 30,330 10,188 — 40,518 Total cash and cash equivalents and investments $ 51,780 $ 10,188 $ — $ 61,968 Assets and Liabilities at Fair Value as of December 31, 2021 Level 1 Level 2 Level 3 Total (in thousands) Assets Cash and cash equivalents $ 64,065 $ — $ — $ 64,065 Short-term investments 7,561 15,117 — 22,678 Total cash and cash equivalents and investments $ 71,626 $ 15,117 $ — $ 86,743 |
Summary of Significant Accoun_4
Summary of Significant Accounting Policies Stock-based Compensation Valuation (Details) - Equity Option [Member] | 6 Months Ended | |
Jun. 30, 2022 | Jun. 30, 2021 | |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, ExpectedVolatilityRate, Employees | 106% | 101% |
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Employee | 2.10% | 0.60% |
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term, Employees | 4 years | 4 years |
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate, Employees | 0% | 0% |
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Officers and Non-employee Directors | 91% | 90% |
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Officers and Non-employee Directors | 1.90% | 1.10% |
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term, Officers and Non-employee Directors | 7 years | 7 years |
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate, Officers and Non-employee Directors | 0% | 0% |
Summary of Significant Accoun_5
Summary of Significant Accounting Policies Stock-based Compensation Summary (Details 1) - $ / shares shares in Thousands | 6 Months Ended | |
Jun. 30, 2022 | Dec. 31, 2021 | |
Share-based Payment Arrangement, Option [Member] | ||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number | 12,108 | 8,367 |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price | $ 5.34 | $ 6.80 |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Net of Forfeitures | 4,257 | |
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price | $ 3.06 | |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period | 163 | |
Share-based Compensation Arrangements by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price | $ 12.50 | |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period | 353 | |
Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price | $ 9.20 | |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number | 5,423 | |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price | $ 7.35 | |
Restricted Stock Units (RSUs) [Member] | ||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number | 2,919 | 1,854 |
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value | $ 3.17 | $ 5.16 |
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period | 2,185 | |
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value | $ 2.25 | |
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period | 1,012 | |
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value | $ 4.86 | |
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period | 108 | |
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value | $ 3.40 |
Summary of Significant Accoun_6
Summary of Significant Accounting Policies Accrued Liabilities (Details) - USD ($) | Jun. 30, 2022 | Dec. 31, 2021 | Mar. 01, 2021 |
Accrued Liabilities [Line Items] | |||
Accrued research and development services current | $ 3,920,000 | $ 3,669,000 | |
Accrued compensation and benefits current | 4,329,000 | 5,711,000 | |
Operating Lease, Liability, Current | (789,000) | (1,089,000) | |
Other Accrued Liabilities, Current | 477,000 | 2,503,000 | |
Accrued Liabilities | $ 9,515,000 | $ 12,972,000 | |
Lexicon incremental borrowing rate | 900% |
Cash and Cash Equivalents and_3
Cash and Cash Equivalents and Investments (Details 1) - USD ($) $ in Thousands | Jun. 30, 2022 | Dec. 31, 2021 |
Fair Value | ||
Debt Securities, Available-for-Sale, Current | $ 40,518 | |
Cash and Cash Equivalents | ||
Fair Value | ||
Gross Unrealized Gains | $ 0 | |
Gross Unrealized Losses | (1) | |
Estimated Fair Value | 64,065 | |
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax | 0 | |
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax | 0 | |
Debt Securities, Available-for-Sale, Amortized Cost, Current | 21,450 | 64,066 |
Debt Securities, Available-for-Sale, Current | 21,450 | |
U.S. Treasury Securities | ||
Fair Value | ||
Estimated Fair Value | 7,561 | |
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax | 89 | 1 |
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax | 0 | 0 |
Debt Securities, Available-for-Sale, Amortized Cost, Current | 30,419 | 7,562 |
Debt Securities, Available-for-Sale, Current | 30,330 | |
Total Short-term Investments | ||
Fair Value | ||
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax | 150 | 9 |
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax | 0 | 0 |
Debt Securities, Available-for-Sale, Amortized Cost, Current | 40,668 | 22,687 |
Debt Securities, Available-for-Sale, Current | 40,518 | 22,678 |
Total Cash and Cash Equivalents and Investments | ||
Fair Value | ||
Gross Unrealized Gains | 0 | |
Gross Unrealized Losses | (10) | |
Estimated Fair Value | 86,743 | |
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax | 150 | |
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax | 0 | |
Debt Securities, Available-for-Sale, Amortized Cost, Current | 62,118 | 86,753 |
Debt Securities, Available-for-Sale, Current | 61,968 | |
Corporate Debt Securities | ||
Fair Value | ||
Estimated Fair Value | 15,117 | |
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax | 61 | 8 |
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax | 0 | 0 |
Debt Securities, Available-for-Sale, Amortized Cost, Current | 10,249 | $ 15,125 |
Debt Securities, Available-for-Sale, Current | $ 10,188 |
Cash and Cash Equivalents and_4
Cash and Cash Equivalents and Investments (Details 2) - USD ($) | 6 Months Ended | |
Jun. 30, 2022 | Jun. 30, 2021 | |
Schedule of Investments [Line Items] | ||
Realized Investment Gains (Losses) | $ 0 | $ 0 |
Fair Value Measurements (Detail
Fair Value Measurements (Details 1) - USD ($) $ in Thousands | Jun. 30, 2022 | Dec. 31, 2021 |
Fair Value | ||
Cash and Cash Equivalents | $ 21,450 | $ 64,065 |
Debt Securities, Available-for-Sale, Current | 40,518 | |
Short-term Investments | 22,678 | |
Total Cash and Cash Equivalents and Investments | 61,968 | 86,743 |
Fair Value, Level 1 | ||
Fair Value | ||
Cash and Cash Equivalents | 21,450 | 64,065 |
Debt Securities, Available-for-Sale, Current | 30,330 | |
Short-term Investments | 7,561 | |
Total Cash and Cash Equivalents and Investments | 51,780 | 71,626 |
Fair Value, Level 2 | ||
Fair Value | ||
Cash and Cash Equivalents | 0 | 0 |
Debt Securities, Available-for-Sale, Current | 10,188 | |
Short-term Investments | 15,117 | |
Total Cash and Cash Equivalents and Investments | 10,188 | 15,117 |
Fair Value, Level 3 | ||
Fair Value | ||
Cash and Cash Equivalents | 0 | 0 |
Debt Securities, Available-for-Sale, Current | 0 | |
Short-term Investments | 0 | |
Total Cash and Cash Equivalents and Investments | $ 0 | $ 0 |
Debt Obligations (Details)
Debt Obligations (Details) - USD ($) | 1 Months Ended | 3 Months Ended | 6 Months Ended | ||||||
Nov. 30, 2014 | Mar. 31, 2028 | Mar. 31, 2027 | Mar. 31, 2026 | Jun. 30, 2022 | Jun. 30, 2021 | Dec. 31, 2021 | Sep. 28, 2020 | Nov. 20, 2014 | |
Debt Instrument [Line Items] | |||||||||
Proceeds from Convertible Debt | $ 87,500,000 | ||||||||
Conv Debt Instrument Interest Rate Stated Percentage | 5.25% | ||||||||
Common stock, shares issued | 150,114,000 | 150,082,000 | |||||||
Convertible debt exchange Remaining Notes | $ 11,600,000 | ||||||||
Convertible debt exchange - Total Principal Amount | $ 75,800,000 | ||||||||
Long-term debt, net of deferred issuance costs | $ (23,631,000) | $ 0 | |||||||
Long-Term Debt | 23,600,000 | ||||||||
Term Loan B | 25,000,000 | ||||||||
Term Loan C | 50,000,000 | ||||||||
Term Loan D | 50,000,000 | ||||||||
Oxford Loan Facility | 150,000,000 | ||||||||
Term Loan A | $ 25,000,000 | ||||||||
Term Loan A&B Warrant % | 3.50% | ||||||||
Term Loan C Warrant % | 1.75% | ||||||||
Term Loan D Warrant % | 0.875% | ||||||||
Term Loan A Warrants Number | 420,673 | ||||||||
Term Loan A Warrant Exercise Price | $ 2.08 | ||||||||
Adjustments to Additional Paid in Capital, Warrant Issued | $ 700,000 | $ 0 | |||||||
Debt Instrument, Interest Rate, Stated Percentage | 7.90% | ||||||||
Long-Term Debt, Percentage Bearing Fixed Interest, Percentage Rate | 8.01% | ||||||||
Subordinated Borrowing, Interest Rate | 9.02% | ||||||||
Final Payment % with no extention | 6% | ||||||||
Final Payment % with extention | 7% | ||||||||
Term Loan A Final Payment | $ 1,500,000 | ||||||||
Term Loan A Net Cash Receipt | 24,200,000 | ||||||||
Term Loan A Debt Issuance Costs | 400,000 | ||||||||
Oxford Facility Fee | 500,000 | ||||||||
Term Loan A Debt Discount | 2,900,000 | ||||||||
Term Loan A Interest Expense | $ 800,000 | ||||||||
2027 Oxford Principal Payments | $ 13,000,000 | ||||||||
2027 Oxford Principal Payments2 | $ 4,800,000 | $ 8,700,000 |
Commitments and Contingencies (
Commitments and Contingencies (Details) | Jun. 30, 2022 USD ($) |
Other Commitments [Line Items] | |
Long-term Debt and Lease Obligation | $ 1,002,000 |
Lessee, Operating Lease, Liability, Payments, Due Next Twelve Months | 583,000 |
Lessee, Operating Lease, Liability, Payments, Due Year Two | 531,000 |
Lessee, Operating Lease, Liability, Payments, Due Year Three | 544,000 |
Lessee, Operating Lease, Liability, Payments, Due Year Four | 370,000 |
Lessee, Operating Lease, Liability, Payments, Due after Year Five | 0 |
Lessee, Operating Lease, Liability, Payments, Due | 2,028,000 |
Lessee, Operating Lease, Liability, Undiscounted Excess Amount | 237,000 |
Operating Lease, Liability | 1,791,000 |
Short-term Lease Commitment, Amount | 800,000 |
Operating Lease, Right-of-Use Asset | $ 1,800,000 |
Other Capital Agreements (Detai
Other Capital Agreements (Details) - USD ($) | 3 Months Ended | ||
Sep. 30, 2022 | Dec. 31, 2021 | Jun. 30, 2021 | |
Equity [Abstract] | |||
Shares sold in January 2021 ATM offering | 2,000,000 | ||
Share price in January 2021 ATM Offering | 8.463 | ||
Proceeds from January 2021 ATM Offering | $ 16,400,000 | ||
Shares sold in September 2021 ATM Offerring | 4,176,953 | ||
Share Price in September 2021 ATM Offerring | $ 4.732 | ||
Proceeds from September 2021 ATM Offering | $ 19.1 | ||
Share Price in July 2022 Offering | $ 2.50 | ||
Proceeds from July 2022 Offering | $ 82,200,000 |
Other Capital Agreements (Det_2
Other Capital Agreements (Details) shares in Thousands | 3 Months Ended |
Sep. 30, 2022 shares | |
Equity [Abstract] | |
Shares sold in July 2022 Offering | 34,000 |